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Denis Evseenko, MD, PhD

TitleAssociate Professor of Orthopaedic Surgery
InstitutionUniversity of Southern California
DepartmentOrthopaedic Surgery
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2422
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    Collapse Biography 
    Collapse Awards and Honors
    Arthritis National Research Foundation2015James Klinenberg Award
    USC2016USC Stevens Technology Advancement Grant
    Wright Foundation2016Wright Foundation Award

    Collapse Overview 
    Collapse Overview
    Dr. Denis Evseenko is currently an Associate Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations and patents.

    Evseenko Lab Website


    Collapse Research 
    Collapse Research Activities and Funding
    GP130/STAT3 signalling in articular cartilage development and regeneration
    NIH/NIAMS R01AR071734Apr 1, 2018 - Jan 31, 2023
    Role: Principal Investigator
    Generation of human chondroprogenitor cells for cartilage restoration
    NIH/NIAMS K01AR061415Jul 20, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Featured Publications
    Collapse In The News

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 May; 77(5):760-769. PMID: 29436471.
      View in: PubMed
    2. Dickinson SC, Sutton CA, Brady K, Salerno A, Katopodi T, Williams RL, West CC, Evseenko D, Wu L, Pang S, Ferro de Godoy R, Goodship AE, Péault B, Blom AW, Kafienah W, Hollander AP. The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation. Stem Cells. 2017 Nov; 35(11):2280-2291. PMID: 28833807.
      View in: PubMed
    3. Franciozi CEDS, Vangsness CT, Tibone JE, Martinez JC, Rodger D, Chou TC, Tai YC, Brant R, Wu L, Abdalla RJ, Han B, Evseenko D, Humayun M. Parylene scaffold for cartilage lesion. Biomed Microdevices. 2017 06; 19(2):26. PMID: 28391436.
      View in: PubMed
    4. Eliasberg CD, Dar A, Jensen AR, Murray IR, Hardy WR, Kowalski TJ, Garagozlo CA, Natsuhara KM, Khan AZ, McBride OJ, Cha PI, Kelley BV, Evseenko D, Feeley BT, McAllister DR, Péault B, Petrigliano FA. Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model. J Bone Joint Surg Am. 2017 Feb 15; 99(4):331-341. PMID: 28196035.
      View in: PubMed
    5. Wu L, Zhang S, Shkhyan R, Lee S, Gullo F, Eliasberg CD, Petrigliano FA, Ba K, Wang J, Lin Y, Evseenko D. Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insight. 2017 Jan 12; 2(1):e88553. PMID: 28097228.
      View in: PubMed
    6. Markolf KL, Evseenko D, Petrigliano F. Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus. J Biomech Eng. 2016 Apr; 138(4):044501. PMID: 26863930.
      View in: PubMed
    7. Chin CJ, Cooper AR, Lill GR, Evseenko D, Zhu Y, He CB, Casero D, Pellegrini M, Kohn DB, Crooks GM. Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. Stem Cells. 2016 05; 34(5):1239-50. PMID: 26934332.
      View in: PubMed
    8. Wu L, Prins HJ, Leijten J, Helder MN, Evseenko D, Moroni L, van Blitterswijk CA, Lin Y, Karperien M. Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells. Tissue Eng Part A. 2016 Feb; 22(3-4):336-48. PMID: 26732248.
      View in: PubMed
    9. Kowalski TJ, Leong NL, Dar A, Wu L, Kabir N, Khan AZ, Eliasberg CD, Pedron A, Karayan A, Lee S, Di Pauli von Treuheim T, Jiacheng J, Wu BM, Evseenko D, McAllister DR, Petrigliano FA. Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells. J Orthop Res. 2016 06; 34(6):985-94. PMID: 26621359.
      View in: PubMed
    10. Zhang S, Ba K, Wu L, Lee S, Peault B, Petrigliano FA, McAllister DR, Adams JS, Evseenko D, Lin Y. Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds. J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. PMID: 26502642.
      View in: PubMed
    11. Choi B, Kim S, Fan J, Kowalski T, Petrigliano F, Evseenko D, Lee M. Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects. Biomater Sci. 2015 May; 3(5):742-52. PMID: 26222593.
      View in: PubMed
    12. Kim J, Lin B, Kim S, Choi B, Evseenko D, Lee M. TGF-ß1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells. J Biol Eng. 2015; 9:1. PMID: 25745515; PMCID: PMC4350967.
    13. Choi B, Kim S, Lin B, Li K, Bezouglaia O, Kim J, Evseenko D, Aghaloo T, Lee M. Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells. Acta Biomater. 2015 Jan; 12:30-41. PMID: 25462526.
      View in: PubMed
    14. Vadivel K, Ponnuraj SM, Kumar Y, Zaiss AK, Bunce MW, Camire RM, Wu L, Evseenko D, Herschman HR, Bajaj MS, Bajaj SP. Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J Biol Chem. 2014 Nov 07; 289(45):31647-61. PMID: 25262870; PMCID: PMC4223360.
    15. Richardson W, Wilkinson D, Wu L, Petrigliano F, Dunn B, Evseenko D. Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra. J Biophotonics. 2015 Jul; 8(7):555-66. PMID: 25264131; PMCID: PMC4472573.
    16. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. PMID: 24371811; PMCID: PMC3871393.
    17. Arshi A, Nakashima Y, Nakano H, Eaimkhong S, Evseenko D, Reed J, Stieg AZ, Gimzewski JK, Nakano A. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci Technol Adv Mater. 2013 Aug 01; 14(2). PMID: 24311969.
      View in: PubMed
    18. Wu L, Gonzalez S, Shah S, Kyupelyan L, Petrigliano FA, McAllister DR, Adams JS, Karperien M, Tuan TL, Benya PD, Evseenko D. Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy. Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. PMID: 23758619; PMCID: PMC3910562.
    19. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One. 2013; 8(5):e63718. PMID: 23696850; PMCID: PMC3655943.
    20. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013 Apr 11; 121(15):2891-901. PMID: 23412095; PMCID: PMC3707421.
    21. Bluguermann C, Wu L, Petrigliano F, McAllister D, Miriuka S, Evseenko D. Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond. Cell Biochem Funct. 2013 Jun; 31(4):271-80. PMID: 23315627.
      View in: PubMed
    22. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. PMID: 23056209; PMCID: PMC3467279.
    23. Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr; 19(4):768-81. PMID: 21179006; PMCID: PMC3070091.
    24. Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. PMID: 20643952; PMCID: PMC2922221.
    25. Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. PMID: 19021502.
      View in: PubMed