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Denis Evseenko, MD, PhD

Title(s)Associate Professor of Orthopaedic Surgery
AddressNRT - 1450 Biggy Street, #4503
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 2422
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    Other Positions
    Title(s)Director of Skeletal Regeneration

    Title(s)Vice Chair for Research of Orthopaedic Surgery


    Collapse Biography 
    Collapse Awards and Honors
    Arthritis National Research Foundation2015James Klinenberg Award
    USC2016USC Stevens Technology Advancement Grant
    Wright Foundation2016Wright Foundation Award

    Collapse Overview 
    Collapse Overview
    Dr. Denis Evseenko is currently an Associate Professor of Orthopaedic Surgery, Stem Cell Research and Regenerative Medicine at USC. Dr Evseenko was trained in both medicine and molecular pharmacology. His research focuses on the development of novel translational stem cell and small molecule-based approaches for prevention of arthritis and restoration of damaged articular cartilage. Dr Evseenko has been involved in translational research for over 10 years and is the author of numerous peer-reviewed research articles, presentations and patents.

    Evseenko Lab Website

    Collapse Research 
    Collapse Research Activities and Funding
    GP130/STAT3 signalling in articular cartilage development and regeneration
    NIH/NIAMS R01AR071734May 1, 2020 - Jan 31, 2023
    Role: Principal Investigator
    Dissecting molecular mechanisms implicated in age- and osteoarthritis-related decline in anabolism in articular cartilage
    NIH/NIA R01AG058624Feb 1, 2019 - Nov 30, 2023
    Role: Principal Investigator
    Generation of human chondroprogenitor cells for cartilage restoration
    NIH/NIAMS K01AR061415Jul 20, 2011 - Jun 30, 2016
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. A Human Skeletal Muscle Atlas Identifies the Trajectories of Stem and Progenitor Cells across Development and from Human Pluripotent Stem Cells. Cell Stem Cell. 2020 Jul 02; 27(1):158-176.e10. Xi H, Langerman J, Sabri S, Chien P, Young CS, Younesi S, Hicks M, Gonzalez K, Fujiwara W, Marzi J, Liebscher S, Spencer M, Van Handel B, Evseenko D, Schenke-Layland K, Plath K, Pyle AD. PMID: 32396864.
      View in: PubMed   Mentions:    Fields:    
    2. Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis. Arthritis Rheumatol. 2020 Apr 05. Weber AE, Jalali O, Limfat S, Shkhyan R, Van Der Horst R, Lee S, Lin Y, Li L, Mayer EN, Wang L, Liu NQ, Petrigliano FA, Lieberman JR, Evseenko D. PMID: 32249508.
      View in: PubMed   Mentions:    Fields:    
    3. Lentiviral Gene Therapy for Bone Repair Using Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells. Hum Gene Ther. 2019 07; 30(7):906-917. Bougioukli S, Saitta B, Sugiyama O, Tang AH, Elphingstone J, Evseenko D, Lieberman JR. PMID: 30773946.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    4. Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nat Commun. 2018 09 07; 9(1):3634. Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. PMID: 30194383.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration. J Mol Med (Berl). 2018 10; 96(10):1049-1060. Shkhyan R, Lee S, Gullo F, Li L, Peleli M, Carlstrom M, Chagin AS, Banks NW, Limfat S, Liu NQ, Evseenko D. PMID: 30088034.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Molecular characterization of physis tissue by RNA sequencing. Gene. 2018 Aug 20; 668:87-96. Paradise CR, Galeano-Garces C, Galeano-Garces D, Dudakovic A, Milbrandt TA, Saris DBF, Krych AJ, Karperien M, Ferguson GB, Evseenko D, Riester SM, van Wijnen AJ, Larson AN. PMID: 29775757.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    7. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 05; 77(5):760-769. Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. PMID: 29436471.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    8. ERBB3 and NGFR mark a distinct skeletal muscle progenitor cell in human development and hPSCs. Nat Cell Biol. 2018 01; 20(1):46-57. Hicks MR, Hiserodt J, Paras K, Fujiwara W, Eskin A, Jan M, Xi H, Young CS, Evseenko D, Nelson SF, Spencer MJ, Handel BV, Pyle AD. PMID: 29255171.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    9. A Small Molecule Mimetic of the Humanin Peptide as a Candidate for Modulating NMDA-Induced Neurotoxicity. ACS Chem Neurosci. 2018 03 21; 9(3):462-468. Alam MP, Bilousova T, Spilman P, Vadivel K, Bai D, Elias CJ, Evseenko D, John V. PMID: 29161500.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    10. The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation. Stem Cells. 2017 11; 35(11):2280-2291. Dickinson SC, Sutton CA, Brady K, Salerno A, Katopodi T, Williams RL, West CC, Evseenko D, Wu L, Pang S, Ferro de Godoy R, Goodship AE, Péault B, Blom AW, Kafienah W, Hollander AP. PMID: 28833807.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansAnimalsCells
    11. Parylene scaffold for cartilage lesion. Biomed Microdevices. 2017 06; 19(2):26. Franciozi CEDS, Vangsness CT, Tibone JE, Martinez JC, Rodger D, Chou TC, Tai YC, Brant R, Wu L, Abdalla RJ, Han B, Evseenko D, Humayun M. PMID: 28391436.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    12. Perivascular Stem Cells Diminish Muscle Atrophy Following Massive Rotator Cuff Tears in a Small Animal Model. J Bone Joint Surg Am. 2017 Feb 15; 99(4):331-341. Eliasberg CD, Dar A, Jensen AR, Murray IR, Hardy WR, Kowalski TJ, Garagozlo CA, Natsuhara KM, Khan AZ, McBride OJ, Cha PI, Kelley BV, Evseenko D, Feeley BT, McAllister DR, Péault B, Petrigliano FA. PMID: 28196035.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    13. Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insight. 2017 01 12; 2(1):e88553. Wu L, Zhang S, Shkhyan R, Lee S, Gullo F, Eliasberg CD, Petrigliano FA, Ba K, Wang J, Lin Y, Evseenko D. PMID: 28097228.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    14. Right-Left Differences in Knee Extension Stiffness for the Normal Rat Knee: In Vitro Measurements Using a New Testing Apparatus. J Biomech Eng. 2016 Apr; 138(4):044501. Markolf KL, Evseenko D, Petrigliano F. PMID: 26863930.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    15. Genetic Tagging During Human Mesoderm Differentiation Reveals Tripotent Lateral Plate Mesodermal Progenitors. Stem Cells. 2016 05; 34(5):1239-50. Chin CJ, Cooper AR, Lill GR, Evseenko D, Zhu Y, He CB, Casero D, Pellegrini M, Kohn DB, Crooks GM. PMID: 26934332.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Chondrocytes Cocultured with Stromal Vascular Fraction of Adipose Tissue Present More Intense Chondrogenic Characteristics Than with Adipose Stem Cells. Tissue Eng Part A. 2016 Feb; 22(3-4):336-48. Wu L, Prins HJ, Leijten J, Helder MN, Evseenko D, Moroni L, van Blitterswijk CA, Lin Y, Karperien M. PMID: 26732248.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    17. Hypoxic culture conditions induce increased metabolic rate and collagen gene expression in ACL-derived cells. J Orthop Res. 2016 06; 34(6):985-94. Kowalski TJ, Leong NL, Dar A, Wu L, Kabir N, Khan AZ, Eliasberg CD, Pedron A, Karayan A, Lee S, Di Pauli von Treuheim T, Jiacheng J, Wu BM, Evseenko D, McAllister DR, Petrigliano FA. PMID: 26621359.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    18. Adventitial Cells and Perictyes Support Chondrogenesis Through Different Mechanisms in 3-Dimensional Cultures With or Without Nanoscaffolds. J Biomed Nanotechnol. 2015 Oct; 11(10):1799-807. Zhang S, Ba K, Wu L, Lee S, Peault B, Petrigliano FA, McAllister DR, Adams JS, Evseenko D, Lin Y. PMID: 26502642.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    19. Covalently conjugated transforming growth factor-ß1 in modular chitosan hydrogels for the effective treatment of articular cartilage defects. Biomater Sci. 2015 May; 3(5):742-52. Choi B, Kim S, Fan J, Kowalski T, Petrigliano F, Evseenko D, Lee M. PMID: 26222593.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    20. TGF-ß1 conjugated chitosan collagen hydrogels induce chondrogenic differentiation of human synovium-derived stem cells. J Biol Eng. 2015; 9:1. Kim J, Lin B, Kim S, Choi B, Evseenko D, Lee M. PMID: 25745515.
      View in: PubMed   Mentions:
    21. Visible-light-initiated hydrogels preserving cartilage extracellular signaling for inducing chondrogenesis of mesenchymal stem cells. Acta Biomater. 2015 Jan; 12:30-41. Choi B, Kim S, Lin B, Li K, Bezouglaia O, Kim J, Evseenko D, Aghaloo T, Lee M. PMID: 25462526.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Platelets contain tissue factor pathway inhibitor-2 derived from megakaryocytes and inhibits fibrinolysis. J Biol Chem. 2014 Nov 07; 289(45):31647-61. Vadivel K, Ponnuraj SM, Kumar Y, Zaiss AK, Bunce MW, Camire RM, Wu L, Evseenko D, Herschman HR, Bajaj MS, Bajaj SP. PMID: 25262870.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    23. Ensemble multivariate analysis to improve identification of articular cartilage disease in noisy Raman spectra. J Biophotonics. 2015 Jul; 8(7):555-66. Richardson W, Wilkinson D, Wu L, Petrigliano F, Dunn B, Evseenko D. PMID: 25264131.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Human developmental chondrogenesis as a basis for engineering chondrocytes from pluripotent stem cells. Stem Cell Reports. 2013; 1(6):575-89. Wu L, Bluguermann C, Kyupelyan L, Latour B, Gonzalez S, Shah S, Galic Z, Ge S, Zhu Y, Petrigliano FA, Nsair A, Miriuka SG, Li X, Lyons KM, Crooks GM, McAllister DR, Van Handel B, Adams JS, Evseenko D. PMID: 24371811.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansCells
    25. Rigid microenvironments promote cardiac differentiation of mouse and human embryonic stem cells. Sci Technol Adv Mater. 2013 Aug 01; 14(2). Arshi A, Nakashima Y, Nakano H, Eaimkhong S, Evseenko D, Reed J, Stieg AZ, Gimzewski JK, Nakano A. PMID: 24311969.
      View in: PubMed   Mentions:
    26. Extracellular matrix domain formation as an indicator of chondrocyte dedifferentiation and hypertrophy. Tissue Eng Part C Methods. 2014 Feb; 20(2):160-8. Wu L, Gonzalez S, Shah S, Kyupelyan L, Petrigliano FA, McAllister DR, Adams JS, Karperien M, Tuan TL, Benya PD, Evseenko D. PMID: 23758619.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    27. Lysophosphatidic acid mediates myeloid differentiation within the human bone marrow microenvironment. PLoS One. 2013; 8(5):e63718. Evseenko D, Latour B, Richardson W, Corselli M, Sahaghian A, Cardinal S, Zhu Y, Chan R, Dunn B, Crooks GM. PMID: 23696850.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    28. Perivascular support of human hematopoietic stem/progenitor cells. Blood. 2013 Apr 11; 121(15):2891-901. Corselli M, Chin CJ, Parekh C, Sahaghian A, Wang W, Ge S, Evseenko D, Wang X, Montelatici E, Lazzari L, Crooks GM, Péault B. PMID: 23412095.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    29. Novel aspects of parenchymal-mesenchymal interactions: from cell types to molecules and beyond. Cell Biochem Funct. 2013 Jun; 31(4):271-80. Bluguermann C, Wu L, Petrigliano F, McAllister D, Miriuka S, Evseenko DA. PMID: 23315627.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    30. Characterization and therapeutic potential of induced pluripotent stem cell-derived cardiovascular progenitor cells. PLoS One. 2012; 7(10):e45603. Nsair A, Schenke-Layland K, Van Handel B, Evseenko D, Kahn M, Zhao P, Mendelis J, Heydarkhan S, Awaji O, Vottler M, Geist S, Chyu J, Gago-Lopez N, Crooks GM, Plath K, Goldhaber J, Mikkola HK, MacLellan WR. PMID: 23056209.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    31. Dysregulated gene expression during hematopoietic differentiation from human embryonic stem cells. Mol Ther. 2011 Apr; 19(4):768-81. Dravid G, Zhu Y, Scholes J, Evseenko D, Crooks GM. PMID: 21179006.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    32. Mapping the first stages of mesoderm commitment during differentiation of human embryonic stem cells. Proc Natl Acad Sci U S A. 2010 Aug 03; 107(31):13742-7. Evseenko D, Zhu Y, Schenke-Layland K, Kuo J, Latour B, Ge S, Scholes J, Dravid G, Li X, MacLellan WR, Crooks GM. PMID: 20643952.
      View in: PubMed   Mentions: 87     Fields:    Translation:HumansAnimalsCells
    33. Identification of the critical extracellular matrix proteins that promote human embryonic stem cell assembly. Stem Cells Dev. 2009 Jul-Aug; 18(6):919-28. Evseenko D, Schenke-Layland K, Dravid G, Zhu Y, Hao QL, Scholes J, Wang XC, Maclellan WR, Crooks GM. PMID: 19021502.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimalsCells
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