Ya-Chen Liang, PhD

Title(s)Assistant Professor Of Research Pathology
SchoolKeck School of Medicine of Usc
Address2011 Zonal Ave
University Park Campus
Los Angeles CA 90033
Phone+1 323 442 2985
ORCID ORCID Icon0000-0001-7813-8921 Additional info
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    Collapse Biography 
    Collapse Awards and Honors
    Ministry of Science and Technology, Taiwan2014  - 2016Overseas Postdoctoral Program for Frontier Technologies

    Collapse Overview 
    Collapse Overview
    Dr. Liang's long-term research goal seeks to decompose how genomes and sub-nuclear structures are functionally organized in cell nuclei while maintaining their flexibility to respond to biological cues during development and disease pathogenesis. She focuses on studying spatial regulations of gene clusters, which are widespread in genomes, but little is known about their inter-cluster and subnuclear organizations. Her research integrates state-of-the-art functional genomic, computational, and proteomic approaches to address long-standing questions at the intersection of topological chromatin states and spatial subnuclear protein scaffolds.

    *Dr. Liang's lab is actively recruiting graduate students and postdoctoral fellows. Please email your C.V. to ya-chen.liang@med.usc.edu.

    Collapse Research 
    Collapse Research Activities and Funding
    Intra- and Inter-cluster Regulations of Multiplex Gene Clusters
    NIH/NIGMS 1R35GM150714-01Sep 1, 2023 - Jul 31, 2028
    Role: Principle Investigator
    Description: Gene clusters are widespread in genomes, but mechanistic understanding of their within-cluster chromatin looping and among-cluster crosstalk is unclear. This study aims to illustrate a stepwise chromatin-protein cascade that spatially organizes complex gene clusters from a one-dimensional DNA sequence to a three-dimensional subnuclear structure.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Regional Specific Differentiation of Integumentary Organs: Regulation of Gene Clusters within the Avian Epidermal Differentiation Complex and Impacts of SATB2 Overexpression. Genes (Basel). 2021 08 23; 12(8). Lin GW, Lai YC, Liang YC, Widelitz RB, Wu P, Chuong CM. PMID: 34440465; PMCID: PMC8394334.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    2. Regional specific differentiation of integumentary organs: SATB2 is involved in α- and β-keratin gene cluster switching in the chicken. Dev Dyn. 2022 09; 251(9):1490-1508. Lin GW, Liang YC, Wu P, Chen CK, Lai YC, Jiang TX, Haung YH, Chuong CM. PMID: 34240503; PMCID: PMC8742846.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    3. Symmetry breaking of tissue mechanics in wound induced hair follicle regeneration of laboratory and spiny mice. Nat Commun. 2021 05 10; 12(1):2595. Harn HI, Wang SP, Lai YC, Van Handel B, Liang YC, Tsai S, Schiessl IM, Sarkar A, Xi H, Hughes M, Kaemmer S, Tang MJ, Peti-Peterdi J, Pyle AD, Woolley TE, Evseenko D, Jiang TX, Chuong CM. PMID: 33972536; PMCID: PMC8110808.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    4. Making region-specific integumentary organs in birds: evolution and modifications. Curr Opin Genet Dev. 2021 08; 69:103-111. Chen CK, Juan WT, Liang YC, Wu P, Chuong CM. PMID: 33780743; PMCID: PMC8364857.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    5. Folding Keratin Gene Clusters during Skin Regional Specification. Dev Cell. 2020 06 08; 53(5):561-576.e9. Liang YC, Wu P, Lin GW, Chen CK, Yeh CY, Tsai S, Yan J, Jiang TX, Lai YC, Huang D, Cai M, Choi R, Widelitz RB, Lu W, Chuong CM. PMID: 32516596; PMCID: PMC7386462.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    6. STAT3 signalling pathway is implicated in keloid pathogenesis by preliminary transcriptome and open chromatin analyses. Exp Dermatol. 2019 04; 28(4):480-484. Lee YS, Liang YC, Wu P, Kulber DA, Tanabe K, Chuong CM, Widelitz R, Tuan TL. PMID: 30916811; PMCID: PMC6488383.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    7. Instructive role of melanocytes during pigment pattern formation of the avian skin. Proc Natl Acad Sci U S A. 2019 04 02; 116(14):6884-6890. Inaba M, Jiang TX, Liang YC, Tsai S, Lai YC, Widelitz RB, Chuong CM. PMID: 30886106; PMCID: PMC6452743.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    8. Transcriptome analyses of reprogrammed feather / scale chimeric explants revealed co-expressed epithelial gene networks during organ specification. BMC Genomics. 2018 Oct 29; 19(1):780. Lai YC, Liang YC, Jiang TX, Widelitz RB, Wu P, Chuong CM. PMID: 30373532; PMCID: PMC6206740.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    9. DNA Methylation as an Epigenetic Memory Keeper during Skin Development and Regeneration. In: Botchkarev, V., Millar, S. (eds) Epigenetic Regulation of Skin Development and Regeneration. Stem Cell Biology and Regenerative Medicine. 2018; 57–73. Ya-Chen Liang, Randall Widelitz, and Cheng-Ming Chuong . View Publication.
    10. SUMO5, a Novel Poly-SUMO Isoform, Regulates PML Nuclear Bodies. Sci Rep. 2016 05 23; 6:26509. Liang YC, Lee CC, Yao YL, Lai CC, Schmitz ML, Yang WM. PMID: 27211601; PMCID: PMC4876461.
      View in: PubMed   Mentions: 101     Fields:    Translation:HumansAnimalsCells
    11. PARP-2 regulates cell cycle-related genes through histone deacetylation and methylation independently of poly(ADP-ribosyl)ation. Biochem Biophys Res Commun. 2013 Feb 01; 431(1):58-64. Liang YC, Hsu CY, Yao YL, Yang WM. PMID: 23291187.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    12. FKBPs in chromatin modification and cancer. Curr Opin Pharmacol. 2011 Aug; 11(4):301-7. Yao YL, Liang YC, Huang HH, Yang WM. PMID: 21489876.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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