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Thomas Lozito, PhD

Title(s)Assistant Professor of Orthopaedic Surgery and Stem Cell Biology & Regenerative Medicine
AddressNRT - 1450 Biggy Street, #4504
University Park Campus
Los Angeles CA 90033
Phone+1 323 442 0394
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    Dr. Thomas Lozito is currently an Assistant Professor of Orthopaedic Surgery, Stem Cell Biology and Regenerative Medicine at USC. Dr. Lozito received his Ph.D. in Stem Cell Biology at the Graduate Partnership Program University of Cambridge/NIH. His research studies limb and tail regeneration in salamanders and lizards with the long-term goal of developing strategies for improving mammalian regeneration. He is particularly interested in what accounts for divergent regenerative capabilities among vertebrates, and his lab at USC is one of the only labs in the world that studies both lizard and salamander tissue regeneration.

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    Why don't lizards regenerate perfect tails like salamanders?
    NIH/NIGMS R01GM115444May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Single Cell Sequencing Analysis of Lizard Phagocytic Cell Populations and Their Role in Tail Regeneration. J Immunol Regen Med. 2020 Jun; 8. Londono R, Tighe S, Milnes B, DeMoya C, Quijano LM, Hudnall ML, Nguyen J, Tran E, Badylak S, Lozito TP. PMID: 32337387.
      View in: PubMed   Mentions:
    2. Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold. Stem Cell Res Ther. 2019 08 14; 10(1):254. Lin H, Tang Y, Lozito TP, Oyster N, Wang B, Tuan RS. PMID: 31412905.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimalsCells
    3. Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8256-E8265. Sun AX, Londono R, Hudnall ML, Tuan RS, Lozito TP. PMID: 30104374.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    4. TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW. Curr Pathobiol Rep. 2018 Mar; 6(1):61-69. Londono R, Sun AX, Tuan RS, Lozito TP. PMID: 29967714.
      View in: PubMed   Mentions:
    5. Cartilage and Muscle Cell Fate and Origins during Lizard Tail Regeneration. Front Bioeng Biotechnol. 2017; 5:70. Londono R, Wenzhong W, Wang B, Tuan RS, Lozito TP. PMID: 29164111.
      View in: PubMed   Mentions:
    6. Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering. Sci Rep. 2017 09 12; 7(1):11327. Lin H, Tang Y, Lozito TP, Oyster N, Kang RB, Fritch MR, Wang B, Tuan RS. PMID: 28900122.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    7. Lizard tail regeneration as an instructive model of enhanced healing capabilities in an adult amniote. Connect Tissue Res. 2017 Mar; 58(2):145-154. Lozito TP, Tuan RS. PMID: 27459585.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    8. Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. Development. 2016 08 15; 143(16):2946-57. Lozito TP, Tuan RS. PMID: 27387871.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    9. Catabolic effects of endothelial cell-derived microparticles on disc cells: Implications in intervertebral disc neovascularization and degeneration. J Orthop Res. 2016 08; 34(8):1466-74. Pohl PH, Lozito TP, Cuperman T, Yurube T, Moon HJ, Ngo K, Tuan RS, St Croix C, Sowa GA, Rodrigues LM, Kang JD, Vo NV. PMID: 27246627.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog. Dev Biol. 2015 Mar 15; 399(2):249-62. Lozito TP, Tuan RS. PMID: 25596336.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    11. Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors. J Cell Mol Med. 2014 Dec; 18(12):2372-84. Lozito TP, Tuan RS. PMID: 25250510.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    12. Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. Exp Biol Med (Maywood). 2014 Sep; 239(9):1080-95. Alexander PG, Gottardi R, Lin H, Lozito TP, Tuan RS. PMID: 24994814.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    13. Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1ß. Mol Pharm. 2014 Jul 07; 11(7):2203-12. Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS. PMID: 24830762.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    14. Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning. Stem Cells Transl Med. 2014 Feb; 3(2):241-54. Boyette LB, Creasey OA, Guzik L, Lozito T, Tuan RS. PMID: 24436440.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    15. Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. Stem Cell Res Ther. 2013; 4 Suppl 1:S6. Lozito TP, Alexander PG, Lin H, Gottardi R, Cheng AW, Tuan RS. PMID: 24564995.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    16. Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration. Osteoarthritis Cartilage. 2014 Feb; 22(2):344-54. Moon HJ, Yurube T, Lozito TP, Pohl P, Hartman RA, Sowa GA, Kang JD, Vo NV. PMID: 24361793.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    17. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov; 11(11):e1001720. Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW. PMID: 24302887.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    18. Human mesenchymal stem cells generate a distinct pericellular zone of MMP activities via binding of MMPs and secretion of high levels of TIMPs. Matrix Biol. 2014 Feb; 34:132-43. Lozito TP, Jackson WM, Nesti LJ, Tuan RS. PMID: 24140982.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    19. Endothelial cell microparticles act as centers of matrix metalloproteinsase-2 (MMP-2) activation and vascular matrix remodeling. J Cell Physiol. 2012 Feb; 227(2):534-49. Lozito TP, Tuan RS. PMID: 21437907.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    20. Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med. 2011 Nov; 15(11):2377-88. Jackson WM, Lozito TP, Djouad F, Kuhn NZ, Nesti LJ, Tuan RS. PMID: 21129154.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    21. Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs. J Cell Physiol. 2011 Feb; 226(2):385-96. Lozito TP, Tuan RS. PMID: 20665704.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCells
    22. Human mesenchymal stem cells express vascular cell phenotypes upon interaction with endothelial cell matrix. J Cell Biochem. 2009 Jul 01; 107(4):714-22. Lozito TP, Kuo CK, Taboas JM, Tuan RS. PMID: 19415687.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansCells
    23. Mesenchymal stem cell modification of endothelial matrix regulates their vascular differentiation. J Cell Biochem. 2009 Jul 01; 107(4):706-13. Lozito TP, Taboas JM, Kuo CK, Tuan RS. PMID: 19415686.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    24. Investigating the neural basis of the auditory continuity illusion. J Cogn Neurosci. 2005 Aug; 17(8):1275-92. Husain FT, Lozito TP, Ulloa A, Horwitz B. PMID: 16197683.
      View in: PubMed   Mentions: 8     Fields:    Translation:Cells
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