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Thomas Lozito, PhD

Title(s)Assistant Professor of Orthopaedic Surgery and Stem Cell Biology & Regenerative Medicine
Phone+1 323 442 0394
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    Dr. Thomas Lozito is currently an Assistant Professor of Orthopaedic Surgery, Stem Cell Biology and Regenerative Medicine at USC. Dr. Lozito received his Ph.D. in Stem Cell Biology at the Graduate Partnership Program University of Cambridge/NIH. His research studies limb and tail regeneration in salamanders and lizards with the long-term goal of developing strategies for improving mammalian regeneration. He is particularly interested in what accounts for divergent regenerative capabilities among vertebrates, and his lab at USC is one of the only labs in the world that studies both lizard and salamander tissue regeneration.

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    Why don't lizards regenerate perfect tails like salamanders?
    NIH/NIGMS R01GM115444May 1, 2016 - Apr 30, 2021
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Lin H, Tang Y, Lozito TP, Oyster N, Wang B, Tuan RS. Efficient in vivo bone formation by BMP-2 engineered human mesenchymal stem cells encapsulated in a projection stereolithographically fabricated hydrogel scaffold. Stem Cell Res Ther. 2019 Aug 14; 10(1):254. PMID: 31412905.
      View in: PubMed
    2. Sun AX, Londono R, Hudnall ML, Tuan RS, Lozito TP. Differences in neural stem cell identity and differentiation capacity drive divergent regenerative outcomes in lizards and salamanders. Proc Natl Acad Sci U S A. 2018 08 28; 115(35):E8256-E8265. PMID: 30104374.
      View in: PubMed
    3. Londono R, Sun AX, Tuan RS, Lozito TP. TISSUE REPAIR AND EPIMORPHIC REGENERATION: AN OVERVIEW. Curr Pathobiol Rep. 2018 Mar; 6(1):61-69. PMID: 29967714.
      View in: PubMed
    4. Londono R, Wenzhong W, Wang B, Tuan RS, Lozito TP. Cartilage and Muscle Cell Fate and Origins during Lizard Tail Regeneration. Front Bioeng Biotechnol. 2017; 5:70. PMID: 29164111.
      View in: PubMed
    5. Lin H, Tang Y, Lozito TP, Oyster N, Kang RB, Fritch MR, Wang B, Tuan RS. Projection Stereolithographic Fabrication of BMP-2 Gene-activated Matrix for Bone Tissue Engineering. Sci Rep. 2017 09 12; 7(1):11327. PMID: 28900122.
      View in: PubMed
    6. Lozito TP, Tuan RS. Lizard tail regeneration as an instructive model of enhanced healing capabilities in an adult amniote. Connect Tissue Res. 2017 Mar; 58(2):145-154. PMID: 27459585.
      View in: PubMed
    7. Lozito TP, Tuan RS. Lizard tail skeletal regeneration combines aspects of fracture healing and blastema-based regeneration. Development. 2016 08 15; 143(16):2946-57. PMID: 27387871.
      View in: PubMed
    8. Pohl PH, Lozito TP, Cuperman T, Yurube T, Moon HJ, Ngo K, Tuan RS, St Croix C, Sowa GA, Rodrigues LM, Kang JD, Vo NV. Catabolic effects of endothelial cell-derived microparticles on disc cells: Implications in intervertebral disc neovascularization and degeneration. J Orthop Res. 2016 08; 34(8):1466-74. PMID: 27246627.
      View in: PubMed
    9. Lozito TP, Tuan RS. Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog. Dev Biol. 2015 Mar 15; 399(2):249-62. PMID: 25596336.
      View in: PubMed
    10. Lozito TP, Tuan RS. Endothelial and cancer cells interact with mesenchymal stem cells via both microparticles and secreted factors. J Cell Mol Med. 2014 Dec; 18(12):2372-84. PMID: 25250510.
      View in: PubMed
    11. Alexander PG, Gottardi R, Lin H, Lozito TP, Tuan RS. Three-dimensional osteogenic and chondrogenic systems to model osteochondral physiology and degenerative joint diseases. Exp Biol Med (Maywood). 2014 Sep; 239(9):1080-95. PMID: 24994814.
      View in: PubMed
    12. Lin H, Lozito TP, Alexander PG, Gottardi R, Tuan RS. Stem cell-based microphysiological osteochondral system to model tissue response to interleukin-1ß. Mol Pharm. 2014 Jul 07; 11(7):2203-12. PMID: 24830762.
      View in: PubMed
    13. Boyette LB, Creasey OA, Guzik L, Lozito T, Tuan RS. Human bone marrow-derived mesenchymal stem cells display enhanced clonogenicity but impaired differentiation with hypoxic preconditioning. Stem Cells Transl Med. 2014 Feb; 3(2):241-54. PMID: 24436440.
      View in: PubMed
    14. Lozito TP, Alexander PG, Lin H, Gottardi R, Cheng AW, Tuan RS. Three-dimensional osteochondral microtissue to model pathogenesis of osteoarthritis. Stem Cell Res Ther. 2013; 4 Suppl 1:S6. PMID: 24564995.
      View in: PubMed
    15. Moon HJ, Yurube T, Lozito TP, Pohl P, Hartman RA, Sowa GA, Kang JD, Vo NV. Effects of secreted factors in culture medium of annulus fibrosus cells on microvascular endothelial cells: elucidating the possible pathomechanisms of matrix degradation and nerve in-growth in disc degeneration. Osteoarthritis Cartilage. 2014 Feb; 22(2):344-54. PMID: 24361793.
      View in: PubMed
    16. Cui C, Chatterjee B, Lozito TP, Zhang Z, Francis RJ, Yagi H, Swanhart LM, Sanker S, Francis D, Yu Q, San Agustin JT, Puligilla C, Chatterjee T, Tansey T, Liu X, Kelley MW, Spiliotis ET, Kwiatkowski AV, Tuan R, Pazour GJ, Hukriede NA, Lo CW. Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov; 11(11):e1001720. PMID: 24302887.
      View in: PubMed
    17. Lozito TP, Jackson WM, Nesti LJ, Tuan RS. Human mesenchymal stem cells generate a distinct pericellular zone of MMP activities via binding of MMPs and secretion of high levels of TIMPs. Matrix Biol. 2014 Feb; 34:132-43. PMID: 24140982.
      View in: PubMed
    18. Lozito TP, Tuan RS. Endothelial cell microparticles act as centers of matrix metalloproteinsase-2 (MMP-2) activation and vascular matrix remodeling. J Cell Physiol. 2012 Feb; 227(2):534-49. PMID: 21437907.
      View in: PubMed
    19. Jackson WM, Lozito TP, Djouad F, Kuhn NZ, Nesti LJ, Tuan RS. Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med. 2011 Nov; 15(11):2377-88. PMID: 21129154.
      View in: PubMed
    20. Lozito TP, Tuan RS. Mesenchymal stem cells inhibit both endogenous and exogenous MMPs via secreted TIMPs. J Cell Physiol. 2011 Feb; 226(2):385-96. PMID: 20665704.
      View in: PubMed
    21. Lozito TP, Kuo CK, Taboas JM, Tuan RS. Human mesenchymal stem cells express vascular cell phenotypes upon interaction with endothelial cell matrix. J Cell Biochem. 2009 Jul 01; 107(4):714-22. PMID: 19415687.
      View in: PubMed
    22. Lozito TP, Taboas JM, Kuo CK, Tuan RS. Mesenchymal stem cell modification of endothelial matrix regulates their vascular differentiation. J Cell Biochem. 2009 Jul 01; 107(4):706-13. PMID: 19415686.
      View in: PubMed
    23. Husain FT, Lozito TP, Ulloa A, Horwitz B. Investigating the neural basis of the auditory continuity illusion. J Cogn Neurosci. 2005 Aug; 17(8):1275-92. PMID: 16197683.
      View in: PubMed
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