 Albert Almada
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| Title(s) | Assistant Professor of Orthopaedic Surgery and Stem Cell Biology & Regenerative Medicine |
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| Address | NRT - 1450 Biggy Street, #4505
Health Sciences Campus
Los Angeles CA 90033
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| vCard | Download vCard |
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 Biography | University of California, Irvine, Irvine, CA | BS | 2007 | Biological Sciences | | Massachusetts Institute of Technology (MIT), Boston, MA | PhD | 2013 | Biology | | Harvard University, Cambridge, MA | | 2020 | Stem Cell & Regenerative Biology |
Overview Albert E. Almada, PhD is investigating one of the greatest mysteries in muscle regenerative biology—how stem cells rebuild functional muscle tissue after traumatic injury. His multidisciplinary team integrates state-of-the-art experimental and bioinformatic approaches to study this biological phenomenon at the molecular, cellular, and organ level in various animal models and in humans.
Recently, his laboratory discovered a new “Super-Healing” gene regulatory program, and they are exploring the biology and therapeutic potential of these pro-regenerative molecules in pre-clinical mouse models. Dr. Almada’s long-term goal is to translate his basic science discoveries into effective stem cell-based therapies that restore muscle function to injured athletes, wounded soldiers, the elderly, and patients suffering from degenerative muscular pathologies.
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FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Rep. 2021 Jan 26; 34(4):108656.
Almada AE, Horwitz N, Price FD, Gonzalez AE, Ko M, Bolukbasi OV, Messemer KA, Chen S, Sinha M, Rubin LL, Wagers AJ. PMID: 33503437.
View in: PubMed Mentions: Fields:
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Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 05 08; 10(5):1505-1521.
Bar-Nur O, Gerli MFM, Di Stefano B, Almada AE, Galvin A, Coffey A, Huebner AJ, Feige P, Verheul C, Cheung P, Payzin-Dogru D, Paisant S, Anselmo A, Sadreyev RI, Ott HC, Tajbakhsh S, Rudnicki MA, Wagers AJ, Hochedlinger K. PMID: 29742392.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
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Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting. Skelet Muscle. 2016; 6:35.
Maesner CC, Almada AE, Wagers AJ. PMID: 27826411.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
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Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. Nat Rev Mol Cell Biol. 2016 05; 17(5):267-79.
Almada AE, Wagers AJ. PMID: 26956195.
View in: PubMed Mentions: 67 Fields: Translation: HumansAnimalsCells
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FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS One. 2015; 10(6):e0128094.
Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, Almada AE, Mondino A, Wagers AJ, Manfredi AA, Rovere-Querini P. PMID: 26039259.
View in: PubMed Mentions: 39 Fields: Translation: AnimalsCells
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Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature. 2013 Jul 18; 499(7458):360-3.
Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. PMID: 23792564.
View in: PubMed Mentions: 171 Fields: Translation: AnimalsCells
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Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2876-81.
Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. PMID: 23382218.
View in: PubMed Mentions: 196 Fields: Translation: HumansAnimalsCells
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Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10460-5.
Flynn RA, Almada AE, Zamudio JR, Sharp PA. PMID: 21670248.
View in: PubMed Mentions: 87 Fields: Translation: AnimalsCells
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ProfileGrids as a new visual representation of large multiple sequence alignments: a case study of the RecA protein family. BMC Bioinformatics. 2008 Dec 22; 9:554.
Roca AI, Almada AE, Abajian AC. PMID: 19102758.
View in: PubMed Mentions: 4 Fields: Translation: Cells
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Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers. Int J Sport Nutr Exerc Metab. 2005 Dec; 15(6):653-64.
Kerksick C, Rasmussen C, Bowden R, Leutholtz B, Harvey T, Earnest C, Greenwood M, Almada A, Kreider R. PMID: 16521849.
View in: PubMed Mentions: 4 Fields: Translation: HumansCells
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Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males. Int J Sport Nutr Exerc Metab. 2003 Mar; 13(1):76-86.
Kreider RB, Melton C, Greenwood M, Rasmussen C, Lundberg J, Earnest C, Almada A. PMID: 12660407.
View in: PubMed Mentions: 4 Fields: Translation: HumansCellsCTClinical Trials
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| Year | Publications |
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| 2003 | 1 | | 2005 | 1 | | 2008 | 1 | | 2011 | 1 | | 2013 | 2 | | 2015 | 1 | | 2016 | 2 | | 2018 | 1 | | 2021 | 1 |
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