Albert Almada, PhD

Title(s)Assistant Professor of Orthopaedic Surgery and Stem Cell Biology & Regenerative Medicine
SchoolKeck School of Medicine of Usc
AddressNRT - 1450 Biggy Street, #4505
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Biography 
    Collapse Education and Training
    University of California, Irvine, Irvine, CABS2007Biological Sciences
    Massachusetts Institute of Technology (MIT), Boston, MAPhD2013Biology
    Harvard University, Cambridge, MA2020Stem Cell & Regenerative Biology

    Collapse Overview 
    Collapse Overview
    Albert E. Almada, PhD is investigating one of the greatest mysteries in muscle regenerative biology—how stem cells rebuild functional muscle tissue after traumatic injury. His multidisciplinary team integrates state-of-the-art experimental and bioinformatic approaches to study this biological phenomenon at the molecular, cellular, and organ level in various animal models and in humans.

    Recently, his laboratory discovered a new “Super-Healing” gene regulatory program, and they are exploring the biology and therapeutic potential of these pro-regenerative molecules in pre-clinical mouse models. Dr. Almada’s long-term goal is to translate his basic science discoveries into effective stem cell-based therapies that restore muscle function to injured athletes, wounded soldiers, the elderly, and patients suffering from degenerative muscular pathologies.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Prolonged FOS activity disrupts a global myogenic transcriptional program by altering 3D chromatin architecture in primary muscle progenitor cells. Skelet Muscle. 2022 08 15; 12(1):20. Barutcu AR, Elizalde G, Gonzalez AE, Soni K, Rinn JL, Wagers AJ, Almada AE. PMID: 35971133; PMCID: PMC9377060.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. Dissecting dual roles of MyoD during lineage conversion to mature myocytes and myogenic stem cells. Genes Dev. 2021 09 01; 35(17-18):1209-1228. Yagi M, Ji F, Charlton J, Cristea S, Messemer K, Horwitz N, Di Stefano B, Tsopoulidis N, Hoetker MS, Huebner AJ, Bar-Nur O, Almada AE, Yamamoto M, Patelunas A, Goldhamer DJ, Wagers AJ, Michor F, Meissner A, Sadreyev RI, Hochedlinger K. PMID: 34413137; PMCID: PMC8415322.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    3. FOS licenses early events in stem cell activation driving skeletal muscle regeneration. Cell Rep. 2021 01 26; 34(4):108656. Almada AE, Horwitz N, Price FD, Gonzalez AE, Ko M, Bolukbasi OV, Messemer KA, Chen S, Sinha M, Rubin LL, Wagers AJ. PMID: 33503437; PMCID: PMC9112118.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    4. Direct Reprogramming of Mouse Fibroblasts into Functional Skeletal Muscle Progenitors. Stem Cell Reports. 2018 05 08; 10(5):1505-1521. Bar-Nur O, Gerli MFM, Di Stefano B, Almada AE, Galvin A, Coffey A, Huebner AJ, Feige P, Verheul C, Cheung P, Payzin-Dogru D, Paisant S, Anselmo A, Sadreyev RI, Ott HC, Tajbakhsh S, Rudnicki MA, Wagers AJ, Hochedlinger K. PMID: 29742392; PMCID: PMC5995754.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    5. Established cell surface markers efficiently isolate highly overlapping populations of skeletal muscle satellite cells by fluorescence-activated cell sorting. Skelet Muscle. 2016; 6:35. Maesner CC, Almada AE, Wagers AJ. PMID: 27826411; PMCID: PMC5100091.
      View in: PubMed   Mentions: 41     Fields:    Translation:AnimalsCells
    6. Molecular circuitry of stem cell fate in skeletal muscle regeneration, ageing and disease. Nat Rev Mol Cell Biol. 2016 05; 17(5):267-79. Almada AE, Wagers AJ. PMID: 26956195; PMCID: PMC4918817.
      View in: PubMed   Mentions: 135     Fields:    Translation:HumansAnimalsCells
    7. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS One. 2015; 10(6):e0128094. Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, Almada AE, Mondino A, Wagers AJ, Manfredi AA, Rovere-Querini P. PMID: 26039259; PMCID: PMC4454513.
      View in: PubMed   Mentions: 82     Fields:    Translation:AnimalsCells
    8. Promoter directionality is controlled by U1 snRNP and polyadenylation signals. Nature. 2013 Jul 18; 499(7458):360-3. Almada AE, Wu X, Kriz AJ, Burge CB, Sharp PA. PMID: 23792564; PMCID: PMC3720719.
      View in: PubMed   Mentions: 232     Fields:    Translation:AnimalsCells
    9. Divergent transcription of long noncoding RNA/mRNA gene pairs in embryonic stem cells. Proc Natl Acad Sci U S A. 2013 Feb 19; 110(8):2876-81. Sigova AA, Mullen AC, Molinie B, Gupta S, Orlando DA, Guenther MG, Almada AE, Lin C, Sharp PA, Giallourakis CC, Young RA. PMID: 23382218; PMCID: PMC3581948.
      View in: PubMed   Mentions: 261     Fields:    Translation:HumansAnimalsCells
    10. Antisense RNA polymerase II divergent transcripts are P-TEFb dependent and substrates for the RNA exosome. Proc Natl Acad Sci U S A. 2011 Jun 28; 108(26):10460-5. Flynn RA, Almada AE, Zamudio JR, Sharp PA. PMID: 21670248; PMCID: PMC3127934.
      View in: PubMed   Mentions: 115     Fields:    Translation:AnimalsCells
    11. ProfileGrids as a new visual representation of large multiple sequence alignments: a case study of the RecA protein family. BMC Bioinformatics. 2008 Dec 22; 9:554. Roca AI, Almada AE, Abajian AC. PMID: 19102758; PMCID: PMC2663765.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    12. Effects of ribose supplementation prior to and during intense exercise on anaerobic capacity and metabolic markers. Int J Sport Nutr Exerc Metab. 2005 Dec; 15(6):653-64. Kerksick C, Rasmussen C, Bowden R, Leutholtz B, Harvey T, Earnest C, Greenwood M, Almada A, Kreider R. PMID: 16521849.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    13. Effects of oral D-ribose supplementation on anaerobic capacity and selected metabolic markers in healthy males. Int J Sport Nutr Exerc Metab. 2003 Mar; 13(1):76-86. Kreider RB, Melton C, Greenwood M, Rasmussen C, Lundberg J, Earnest C, Almada A. PMID: 12660407.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCellsCTClinical Trials
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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