Ruzanna O Shkhyan

Title(s)Research Associate
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Pharmacological inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet. Sci Rep. 2024 12 28; 14(1):31151. Lee Y, Tassey J, Sarkar A, Levi JN, Lee S, Liu NQ, Drake AC, Nguyen F, Magallanes J, Stevic U, Lu J, Ge D, Tang H, Mkaratigwa T, Yang J, Bian F, Shkhyan R, Bonaguidi MA, Evseenko D. PMID: 39732741; PMCID: PMC11682372.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    2. Inactivation of a non-canonical gp130 signaling arm attenuates chronic systemic inflammation and multimorbidity induced by a high-fat diet. bioRxiv. 2024 Apr 11. Lee Y, Sarkar A, Tassey J, Levi JN, Lee S, Liu NQ, Drake AC, Magallanes J, Stevic U, Lu J, Ge D, Tang H, Mkaratigwa T, Bian F, Shkhyan R, Bonaguidi M, Evseenko D. PMID: 38645030; PMCID: PMC11030339.
      View in: PubMed   Mentions:
    3. Inhibition of a signaling modality within the gp130 receptor enhances tissue regeneration and mitigates osteoarthritis. Sci Transl Med. 2023 03 22; 15(688):eabq2395. Shkhyan R, Flynn C, Lamoure E, Sarkar A, Van Handel B, Li J, York J, Banks N, Van der Horst R, Liu NQ, Lee S, Bajaj P, Vadivel K, Harn HI, Tassey J, Lozito T, Lieberman JR, Chuong CM, Hurtig MS, Evseenko D. PMID: 36947594; PMCID: PMC10792550.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    4. STAT3 promotes a youthful epigenetic state in articular chondrocytes. Aging Cell. 2023 02; 22(2):e13773. Sarkar A, Liu NQ, Magallanes J, Tassey J, Lee S, Shkhyan R, Lee Y, Lu J, Ouyang Y, Tang H, Bian F, Tao L, Segil N, Ernst J, Lyons K, Horvath S, Evseenko D. PMID: 36638270; PMCID: PMC9924946.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    5. Author Correction: gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes. Commun Biol. 2022 Feb 25; 5(1):200. Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. PMID: 35217719; PMCID: PMC8881627.
      View in: PubMed   Mentions:
    6. gp130/STAT3 signaling is required for homeostatic proliferation and anabolism in postnatal growth plate and articular chondrocytes. Commun Biol. 2022 01 17; 5(1):64. Liu NQ, Lin Y, Li L, Lu J, Geng D, Zhang J, Jashashvili T, Buser Z, Magallanes J, Tassey J, Shkhyan R, Sarkar A, Lopez N, Lee S, Lee Y, Wang L, Petrigliano FA, Van Handel B, Lyons K, Evseenko D. PMID: 35039652; PMCID: PMC8763901.
      View in: PubMed   Mentions: 10  Translation:AnimalsCells
    7. Long-term repair of porcine articular cartilage using cryopreservable, clinically compatible human embryonic stem cell-derived chondrocytes. NPJ Regen Med. 2021 Nov 23; 6(1):77. Petrigliano FA, Liu NQ, Lee S, Tassey J, Sarkar A, Lin Y, Li L, Yu Y, Geng D, Zhang J, Shkhyan R, Bogdanov J, Van Handel B, Ferguson GB, Lee Y, Hinderer S, Tseng KC, Kavanaugh A, Crump JG, Pyle AD, Schenke-Layland K, Billi F, Wang L, Lieberman J, Hurtig M, Evseenko D. PMID: 34815400; PMCID: PMC8611001.
      View in: PubMed   Mentions: 8  
    8. Modulation of Hedgehog Signaling by Kappa Opioids to Attenuate Osteoarthritis. Arthritis Rheumatol. 2020 08; 72(8):1278-1288. Weber AE, Jalali O, Limfat S, Shkhyan R, Van Der Horst R, Lee S, Lin Y, Li L, Mayer EN, Wang L, Liu NQ, Petrigliano FA, Lieberman JR, Evseenko D. PMID: 32249508; PMCID: PMC7541630.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. CaMKII inhibition in human primary and pluripotent stem cell-derived chondrocytes modulates effects of TGFβ and BMP through SMAD signaling. Osteoarthritis Cartilage. 2019 01; 27(1):158-171. Saitta B, Elphingstone J, Limfat S, Shkhyan R, Evseenko D. PMID: 30205161; PMCID: PMC6309757.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    10. Mapping molecular landmarks of human skeletal ontogeny and pluripotent stem cell-derived articular chondrocytes. Nat Commun. 2018 09 07; 9(1):3634. Ferguson GB, Van Handel B, Bay M, Fiziev P, Org T, Lee S, Shkhyan R, Banks NW, Scheinberg M, Wu L, Saitta B, Elphingstone J, Larson AN, Riester SM, Pyle AD, Bernthal NM, Mikkola HK, Ernst J, van Wijnen AJ, Bonaguidi M, Evseenko D. PMID: 30194383; PMCID: PMC6128860.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    11. Genetic ablation of adenosine receptor A3 results in articular cartilage degeneration. J Mol Med (Berl). 2018 10; 96(10):1049-1060. Shkhyan R, Lee S, Gullo F, Li L, Peleli M, Carlstrom M, Chagin AS, Banks NW, Limfat S, Liu NQ, Evseenko D. PMID: 30088034; PMCID: PMC8493638.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    12. Drug-induced modulation of gp130 signalling prevents articular cartilage degeneration and promotes repair. Ann Rheum Dis. 2018 05; 77(5):760-769. Shkhyan R, Van Handel B, Bogdanov J, Lee S, Yu Y, Scheinberg M, Banks NW, Limfat S, Chernostrik A, Franciozi CE, Alam MP, John V, Wu L, Ferguson GB, Nsair A, Petrigliano FA, Vangsness CT, Vadivel K, Bajaj P, Wang L, Liu NQ, Evseenko D. PMID: 29436471; PMCID: PMC8444286.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    13. Kappa opioid receptor signaling protects cartilage tissue against posttraumatic degeneration. JCI Insight. 2017 01 12; 2(1):e88553. Wu L, Zhang S, Shkhyan R, Lee S, Gullo F, Eliasberg CD, Petrigliano FA, Ba K, Wang J, Lin Y, Evseenko D. PMID: 28097228; PMCID: PMC5214705.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    14. Low CD38 Identifies Progenitor-like Inflammation-Associated Luminal Cells that Can Initiate Human Prostate Cancer and Predict Poor Outcome. Cell Rep. 2016 12 06; 17(10):2596-2606. Liu X, Grogan TR, Hieronymus H, Hashimoto T, Mottahedeh J, Cheng D, Zhang L, Huang K, Stoyanova T, Park JW, Shkhyan RO, Nowroozizadeh B, Rettig MB, Sawyers CL, Elashoff D, Horvath S, Huang J, Witte ON, Goldstein AS. PMID: 27926864; PMCID: PMC5367888.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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