April Shu, PhD

Title(s)Assistant Professor of Population and Public Health Sciences
SchoolKeck School of Medicine of Usc
Address1450 Biggy St.
Health Sciences Campus
Los Angeles CA 90089
ORCID ORCID Icon0000-0002-3730-5102 Additional info
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    Collapse Biography 
    Collapse Education and Training
    Columbia University, New York, NYAssociate Research Scientist2023Psychiatric Genetics
    Yale University, New Haven, CTPostdoc2020Psychiatric Genetics and Epigenetics
    Johns Hopkins University, Baltimore, MDPhD2018Mental Health
    Johns Hopkins University, Baltimore, MDMHS2018Biostatistics
    Harvard University, Boston, MAMS2014Epidemiology
    Tsinghua University, Beijing, ChinaBS2012Chemistry
    Collapse Awards and Honors
    College on Problems of Drug Dependence2020Early Career Investigators Awards
    the DREAM challenge2018Winner of single-cell transcriptome prediction
    Phi Beta Kappa Honor Society2018Phi Beta Kappa
    Johns Hopkins Bloomberg School of Public Health2016Lucy Shum Memorial Scholarship for excellence in public health research

    Collapse Overview 
    Collapse Overview
    Chang Shu, also known as April Shu, is an Assistant Professor in the Center for Genetic Epidemiology and the Department of Population and Public Health Sciences at Keck School of Medicine of USC. Dr. Shu specializes in psychiatric genetics and epidemiology. Her work focuses on autism genetics, substance use epigenetics, and single-cell transcriptomics. She utilizes advanced statistical and machine learning techniques to uncover novel genetic and epigenetic factors in mental and behavioral disorders. Dr. Shu received her Ph.D. in Mental Health focusing on psychiatric genetics and a concurrent master's degree in Biostatistics from Johns Hopkins Bloomberg School of Public Health. She also holds an additional master's degree in Epidemiology from Harvard School of Public Health. Her current lab website is: https://www.aprilshulab.com/.
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Integrating de novo and inherited variants in 42,607 autism cases identifies mutations in new moderate-risk genes. Nat Genet. 2022 09; 54(9):1305-1319. Zhou X, Feliciano P, Shu C, Wang T, Astrovskaya I, Hall JB, Obiajulu JU, Wright JR, Murali SC, Xu SX, Brueggeman L, Thomas TR, Marchenko O, Fleisch C, Barns SD, Snyder LG, Han B, Chang TS, Turner TN, Harvey WT, Nishida A, O'Roak BJ, Geschwind DH, SPARK Consortium, Michaelson JJ, Volfovsky N, Eichler EE, Shen Y, Chung WK. PMID: 35982159; PMCID: PMC9470534.
      View in: PubMed   Mentions: 61     Fields:    Translation:Humans
    2. Sex Difference and Interaction of SIRT1 and FOXO3 Candidate Longevity Genes on Life Expectancy: A 10-Year Prospective Longitudinal Cohort Study. J Gerontol A Biol Sci Med Sci. 2022 08 12; 77(8):1557-1563. Ji JS, Liu L, Shu C, Yan LL, Zeng Y. PMID: 34928346; PMCID: PMC9373943.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    3. Epigenome-wide association analyses of active injection drug use. Drug Alcohol Depend. 2022 06 01; 235:109431. Shu C, Jaffe AE, Sabunciyan S, Ji H, Astemborski J, Sun J, Bakulski KM, Sosnowski DW, Mehta SH, Kirk GD, Maher BS. PMID: 35395503.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. Differential expression of NPAS4 in the dorsolateral prefrontal cortex following opioid overdose. Drug Alcohol Depend Rep. 2022 Jun; 3:100040. Sosnowski DW, Jaffe AE, Tao R, Deep-Soboslay A, Shu C, Sabunciyan S, Kleinman JE, Hyde TM, Maher BS. PMID: 36845993; PMCID: PMC9948892.
      View in: PubMed   Mentions: 4  
    5. Imputing cognitive impairment in SPARK, a large autism cohort. Autism Res. 2022 01; 15(1):156-170. Shu C, Green Snyder L, Shen Y, Chung WK, SPARK Consortium. PMID: 34636158.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    6. Interaction of greenness and polygenic risk score of Alzheimer's disease on risk of cognitive impairment. Sci Total Environ. 2021 Nov 20; 796:148767. Jin X, Shu C, Zeng Y, Liang L, Ji JS. PMID: 34273838.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    7. Epigenome-wide study of brain DNA methylation following acute opioid intoxication. Drug Alcohol Depend. 2021 04 01; 221:108658. Shu C, Sosnowski DW, Tao R, Deep-Soboslay A, Kleinman JE, Hyde TM, Jaffe AE, Sabunciyan S, Maher BS. PMID: 33667780; PMCID: PMC8026744.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    8. Epigenome-wide association scan identifies methylation sites associated with HIV infection. Epigenomics. 2020 11; 12(21):1917-1927. Shu C, Jaffe AE, Sabunciyan S, Ji H, Astemborski J, Sun J, Bakulski KM, Mehta SH, Kirk GD, Maher BS. PMID: 33232214; PMCID: PMC7788472.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    9. Comparison of methylation capture sequencing and Infinium MethylationEPIC array in peripheral blood mononuclear cells. Epigenetics Chromatin. 2020 11 23; 13(1):51. Shu C, Zhang X, Aouizerat BE, Xu K. PMID: 33228774; PMCID: PMC7684759.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    10. DNA methylation biomarker selected by an ensemble machine learning approach predicts mortality risk in an HIV-positive veteran population. Epigenetics. 2021 Jun-Jul; 16(7):741-753. Shu C, Justice AC, Zhang X, Marconi VC, Hancock DB, Johnson EO, Xu K. PMID: 33092459; PMCID: PMC8216205.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    11. Gene selection for optimal prediction of cell position in tissues from single-cell transcriptomics data. Life Sci Alliance. 2020 11; 3(11). Tanevski J, Nguyen T, Truong B, Karaiskos N, Ahsen ME, Zhang X, Shu C, Xu K, Liang X, Hu Y, Pham HV, Xiaomei L, Le TD, Tarca AL, Bhatti G, Romero R, Karathanasis N, Loher P, Chen Y, Ouyang Z, Mao D, Zhang Y, Zand M, Ruan J, Hafemeister C, Qiu P, Tran D, Nguyen T, Gabor A, Yu T, Guinney J, Glaab E, Krause R, Banda P, DREAM SCTC Consortium, Stolovitzky G, Rajewsky N, Saez-Rodriguez J, Meyer P. PMID: 32972997; PMCID: PMC7536825.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    12. DNA methylation mediates the effect of cocaine use on HIV severity. Clin Epigenetics. 2020 09 14; 12(1):140. Shu C, Justice AC, Zhang X, Wang Z, Hancock DB, Johnson EO, Xu K. PMID: 32928285; PMCID: PMC7491141.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    13. Gene-Environment Interaction of FOXO and Residential Greenness on Mortality Among Older Adults. Rejuvenation Res. 2021 Feb; 24(1):49-61. Liu L, Zhu A, Shu C, Zeng Y, Ji JS. PMID: 32364002.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Single-cell Transcriptome Mapping Identifies Common and Cell-type Specific Genes Affected by Acute Delta9-tetrahydrocannabinol in Humans. Sci Rep. 2020 02 26; 10(1):3450. Hu Y, Ranganathan M, Shu C, Liang X, Ganesh S, Osafo-Addo A, Yan C, Zhang X, Aouizerat BE, Krystal JH, D'Souza DC, Xu K. PMID: 32103029; PMCID: PMC7044203.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    15. APOE ε4 Modifies Effect of Residential Greenness on Cognitive Function among Older Adults: A Longitudinal Analysis in China. Sci Rep. 2020 01 09; 10(1):82. Zhu A, Yan L, Shu C, Zeng Y, Ji JS. PMID: 31919381; PMCID: PMC6952401.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansPHPublic Health
    16. National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies. Genes Brain Behav. 2019 07; 18(6):e12577. Cates HM, Benca-Bachman CE, de Guglielmo G, Schoenrock SA, Shu C, Kallupi M. PMID: 31012252; PMCID: PMC7891887.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimals
    17. Presence of an epigenetic signature of prenatal cigarette smoke exposure in childhood. Environ Res. 2016 Jan; 144(Pt A):139-148. Ladd-Acosta C, Shu C, Lee BK, Gidaya N, Singer A, Schieve LA, Schendel DE, Jones N, Daniels JL, Windham GC, Newschaffer CJ, Croen LA, Feinberg AP, Daniele Fallin M. PMID: 26610292; PMCID: PMC4915563.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansCells
    18. Examining the association between substance use disorder treatment and smoking cessation. Addiction. 2015 Jun; 110(6):1015-24. Shu C, Cook BL. PMID: 25683883.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    19. Trends in smoking among adults with mental illness and association between mental health treatment and smoking cessation. JAMA. 2014 Jan 08; 311(2):172-82. Cook BL, Wayne GF, Kafali EN, Liu Z, Shu C, Flores M. PMID: 24399556; PMCID: PMC5555156.
      View in: PubMed   Mentions: 225     Fields:    Translation:Humans
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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