Robert Rissman

Title(s)Professor of Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
Address1501 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Director of the Neuroscience Translational Research Division of ATRI


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Epigenetic and genetic risk of Alzheimer disease from autopsied brains in two ethnic groups. Acta Neuropathol. 2024 Aug 23; 148(1):27. Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. PMID: 39177846; PMCID: PMC11343944.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. The Alzheimer's Association Global Biomarker Standardization Consortium (GBSC) plasma phospho-tau Round Robin study. medRxiv. 2024 Aug 22. Ashton NJ, Keshavan A, Brum WS, Andreasson U, Arslan B, Droescher M, Barghorn S, Vanbrabant J, Lambrechts C, Van Loo M, Stoops E, Iyengar S, Ji H, Xu X, Forrest-Hay A, Zhang B, Luo Y, Jeromin A, Vandijck M, Bastard NL, Kolb H, Triana-Baltzer G, Bali D, Janelidze S, Yang SY, Demos C, Romero D, Sigal G, Wohlstadter J, Malyavantham K, Khare M, Jethwa A, Stoeckl L, Gobom J, Kac PR, Gonzalez-Ortiz F, Montoliu-Gaya L, Hansson O, Rissman RA, Carillo MC, Shaw LM, Blennow K, Schott JM, Zetterberg H. PMID: 39228740; PMCID: PMC11370527.
      View in: PubMed   Mentions:
    3. Testing the causal impact of amyloidosis on total Tau using a genetically informative sample of adult male twins. bioRxiv. 2024 Jul 26. Gillespie NA, Neale MC, Panizzon MS, McKenzie RE, Tu XM, Xian H, Reynolds CA, Lyons MJ, Rissman RA, Elman JA, Franz C, Kremen WS. PMID: 39091865; PMCID: PMC11291022.
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    4. A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease. Alzheimers Res Ther. 2024 07 05; 16(1):151. Galasko D, Farlow MR, Lucey BP, Honig LS, Elbert D, Bateman R, Momper J, Thomas RG, Rissman RA, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman HH. PMID: 38970127; PMCID: PMC11225352.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    5. Deciphering Distinct Genetic Risk Factors for FTLD-TDP Pathological Subtypes via Whole-Genome Sequencing. medRxiv. 2024 Jun 25. Pottier C, Küçükali F, Baker M, Batzler A, Jenkins GD, van Blitterswijk M, Vicente CT, De Coster W, Wynants S, Van de Walle P, Ross OA, Murray ME, Faura J, Haggarty SJ, van Rooij JG, Mol MO, Hsiung GR, Graff C, Öijerstedt L, Neumann M, Asmann Y, McDonnell SK, Baheti S, Josephs KA, Whitwell JL, Bieniek KF, Forsberg L, Heuer H, Lago AL, Geier EG, Yokoyama JS, Oddi AP, Flanagan M, Mao Q, Hodges JR, Kwok JB, Domoto-Reilly K, Synofzik M, Wilke C, Onyike C, Dickerson BC, Evers BM, Dugger BN, Munoz DG, Keith J, Zinman L, Rogaeva E, Suh E, Gefen T, Geula C, Weintraub S, Diehl-Schmid J, Farlow MR, Edbauer D, Woodruff BK, Caselli RJ, Donker Kaat LL, Huey ED, Reiman EM, Mead S, King A, Roeber S, Nana AL, Ertekin-Taner N, Knopman DS, Petersen RC, Petrucelli L, Uitti RJ, Wszolek ZK, Ramos EM, Grinberg LT, Gorno Tempini ML, Rosen HJ, Spina S, Piguet O, Grossman M, Trojanowski JQ, Keene DC, Lee-Way J, Prudlo J, Geschwind DH, Rissman RA, Cruchaga C, Ghetti B, Halliday GM, Beach TG, Serrano GE, Arzberger T, Herms J, Boxer AL, Honig LS, Vonsattel JP, Lopez OL, Kofler J, White CL, Gearing M, Glass J, Rohrer JD, Irwin DJ, Lee EB, Van Deerlin V, Castellani R, Mesulam MM, Tartaglia MC, Finger EC, Troakes C, Al-Sarraj S, Miller BL, Seelaar H, Graff-Radford NR, Boeve BF, Mackenzie IR, van Swieten JC, Seeley WW, Sleegers K, Dickson DW, Biernacka JM, Rademakers R. PMID: 38978643; PMCID: PMC11230325.
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    6. Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview. Alzheimers Dement. 2024 07; 20(7):4411-4422. Badhwar A, Hirschberg Y, Valle-Tamayo N, Iulita MF, Udeh-Momoh CT, Matton A, Tarawneh RM, Rissman RA, Ledreux A, Winston CN, Haqqani AS, Alzheimer's Association International Society to Advance Alzheimer's Research and Treatment: Bioflui. PMID: 38864416; PMCID: PMC11247682.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    7. The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathol Commun. 2024 05 24; 12(1):81. Wang HP, Scalco R, Saito N, Beckett L, Nguyen ML, Huie EZ, Honig LS, DeCarli C, Rissman RA, Teich AF, Mungas DM, Jin LW, Dugger BN. PMID: 38790074; PMCID: PMC11127432.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    8. A mutation in the PRKAR1B gene drives pathological mechanisms of neurodegeneration across species. Brain. 2024 May 14. Benjamin-Zukerman T, Shimon G, Gaine ME, Dakwar A, Peled N, Aboraya M, Masri-Ismail A, Safadi-Safa R, Solomon M, Lev-Ram V, Rissman RA, Mayrhofer JE, Raffeiner A, Mol MO, Argue BMR, McCool S, Doan B, van Swieten J, Stefan E, Abel T, Ilouz R. PMID: 38743596.
      View in: PubMed   Mentions:    Fields:    
    9. Associations of plasma neurofilament light chain with cognition and neuroimaging measures in community-dwelling early old age men. Alzheimers Res Ther. 2024 04 25; 16(1):90. Tang R, Buchholz E, Dale AM, Rissman RA, Fennema-Notestine C, Gillespie NA, Hagler DJ, Lyons MJ, Neale MC, Panizzon MS, Puckett OK, Reynolds CA, Franz CE, Kremen WS, Elman JA. PMID: 38664843; PMCID: PMC11044425.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    10. Racial and ethnic differences in plasma biomarker eligibility for a preclinical Alzheimer's disease trial. Alzheimers Dement. 2024 06; 20(6):3827-3838. Molina-Henry DP, Raman R, Liu A, Langford O, Johnson K, Shum LK, Glover CM, Dhadda S, Irizarry M, Jimenez-Maggiora G, Braunstein JB, Yarasheski K, Venkatesh V, West T, Verghese PB, Rissman RA, Aisen P, Grill JD, Sperling RA. PMID: 38629508; PMCID: PMC11180863.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. Immunotherapy with an antibody against CD1d modulates neuroinflammation in an α-synuclein transgenic model of Lewy body like disease. J Neuroinflammation. 2024 Apr 15; 21(1):93. Iba M, Kwon S, Kim C, Szabo M, Horan-Portelance L, Lopez-Ocasio M, Dagur P, Overk C, Rissman RA, Masliah E. PMID: 38622654; PMCID: PMC11017481.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    12. From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approach. Alzheimers Dement (Amst). 2024 Apr-Jun; 16(2):e12580. Sukreet S, Rafii MS, Rissman RA. PMID: 38623383; PMCID: PMC11016820.
      View in: PubMed   Mentions: 1  
    13. Amyloid precursor protein induces reactive astrogliosis. Acta Physiol (Oxf). 2024 06; 240(6):e14142. Velezmoro Jauregui G, Vukic D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovacovicova KL, Polakova N, Zelinkova J, Carna M, Lacovich V, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connell MA, Rissman R, Stokin GB. PMID: 38584589.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    14. AIBP controls TLR4 inflammarafts and mitochondrial dysfunction in a mouse model of Alzheimer's disease. bioRxiv. 2024 Mar 27. Kim YS, Choi SH, Kim KY, Navia-Pelaez JM, Perkins GA, Choi S, Kim J, Nazarenkov N, Rissman RA, Ju WK, Ellisman MH, Miller YI. PMID: 38586011; PMCID: PMC10996524.
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    15. A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with Early Alzheimer's Disease. medRxiv. 2024 Mar 22. Galasko D, Farlow MR, Lucey BP, Honig LS, Elbert D, Bateman R, Momper J, Thomas R, Rissman RA, Pa J, Aslanyan V, Balasubramanian A, West T, Maccecchini M, Feldman HH. PMID: 38562783; PMCID: PMC10984053.
      View in: PubMed   Mentions:
    16. Midlife cumulative deficit frailty predicts Alzheimer's disease-related plasma biomarkers in older adults. Age Ageing. 2024 03 01; 53(3). Buchholz E, Gillespie NA, Hunt JF, Reynolds CA, Rissman RA, Schroeder A, Cortes I, Bell T, Lyons MJ, Kremen WS, Franz CE. PMID: 38454901; PMCID: PMC10921085.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Multi-omics Characterization of Epigenetic and Genetic Risk of Alzheimer Disease in Autopsied Brains from two Ethnic Groups. medRxiv. 2024 Feb 14. Ma Y, Reyes-Dumeyer D, Piriz A, Recio P, Mejia DR, Medrano M, Lantigua RA, Vonsattel JPG, Tosto G, Teich AF, Ciener B, Leskinen S, Sivakumar S, DeTure M, Ranjan D, Dickson D, Murray M, Lee E, Wolk DA, Jin LW, Dugger BN, Hiniker A, Rissman RA, Mayeux R, Vardarajan BN. PMID: 38405911; PMCID: PMC10889011.
      View in: PubMed   Mentions:
    18. CSF1R-mediated myeloid cell depletion shifts the ratio of motor cortical excitatory to inhibitory neurons in a multiple system atrophy model. Exp Neurol. 2024 Apr; 374:114706. Gauer C, Battis K, Schneider Y, Florio JB, Mante M, Kim HY, Rissman RA, Hoffmann A, Winkler J. PMID: 38311020.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    19. Correction: GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice. J Neurovirol. 2024 Feb; 30(1):101-102. Kulbe JR, Le AA, Mante M, Florio J, Laird AE, Swinton MK, Rissman RA, Fields JA. PMID: 38177832; PMCID: PMC11035418.
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    20. Corrigendum to " Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy Body Disease" [Neurobiology of Disease127 (2019) 163-177]. Neurobiol Dis. 2024 Feb; 191:106397. Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. PMID: 38216383.
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    21. Hippocampal ΔFosB expression is associated with cognitive impairment in a subgroup of patients with childhood epilepsies. Front Neurol. 2023; 14:1331194. Fu CH, You JC, Mohila C, Rissman RA, Yoshor D, Viaene AN, Chin J. PMID: 38274865; PMCID: PMC10808715.
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    22. Amyloid and Tau Prediction of Cognitive and Functional Decline in Unimpaired Older Individuals: Longitudinal Data from the A4 and LEARN Studies. J Prev Alzheimers Dis. 2024; 11(4):802-813. Sperling RA, Donohue MC, Rissman RA, Johnson KA, Rentz DM, Grill JD, Heidebrink JL, Jenkins C, Jimenez-Maggiora G, Langford O, Liu A, Raman R, Yaari R, Holdridge KC, Sims JR, Aisen PS. PMID: 39044488; PMCID: PMC11266444.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Relationship between Plasma P-Tau217 and Amyloid PET in Racial and Ethnic Underrepresented Groups (RE-URG) Compared with Non RE-URG in LEARN and A4. J Prev Alzheimers Dis. 2024; 11(4):831-837. Molina-Henry D, Langford O, Donohue MC, Raman R, Aisen P, Johnson KA, Rissman RA, Sperling R. PMID: 39044491; PMCID: PMC11266219.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    24. Longitudinal Phospho-tau217 Predicts Amyloid Positron Emission Tomography in Asymptomatic Alzheimer's Disease. J Prev Alzheimers Dis. 2024; 11(4):823-830. Rissman RA, Donohue MC, Langford O, Raman R, Abdel-Latif S, Yaari R, Holdridge KC, Sims JR, Molina-Henry D, Jimenez-Maggiora G, Johnson KA, Aisen PS, Sperling RA. PMID: 39044490; PMCID: PMC11266279.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    25. Maximizing the Utility of Alzheimer's Disease Trial Data: Sharing of Baseline A4 and LEARN Data. J Prev Alzheimers Dis. 2024; 11(4):889-894. Jimenez-Maggiora GA, Schulz AP, Donohue MC, Qiu H, Jaiswal SN, Adegoke O, Gallardo R, Baryshnikava O, Rissman RA, Abdel-Latif S, Sperling RA, Aisen PS. PMID: 39044498; PMCID: PMC11266269.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Characterization of Ptau181 Among a Diverse Community-Based Cohort: A HABS-HD Study. J Alzheimers Dis. 2024; 100(s1):S63-S73. Petersen ME, Zhang F, Hall JR, Julovich D, Rissman RA, Meeker KL, Phillips N, Large S, Ances BM, O'Bryant SE, HABS-HD Study Team. PMID: 39177606.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Amyloid precursor protein induces reactive astrogliosis. bioRxiv. 2023 Dec 18. Jauregui GV, Vukic D, Onyango IG, Arias C, Novotný JS, Texlová K, Wang S, Kovacovicova KL, Polakova N, Zelinkova J, Carna M, Strašil VL, Head BP, Havas D, Mistrik M, Zorec R, Verkhratsky A, Keegan L, O'Connel M, Rissman R, Stokin GB. PMID: 38187544; PMCID: PMC10769227.
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    28. Emerging evidence for dysregulated proteome cargoes of tau-propagating extracellular vesicles driven by familial mutations of tau and presenilin. Extracell Vesicles Circ Nucl Acids. 2023; 4(4):588-598. Hook V, Podvin S, Mosier C, Boyarko B, Seyffert L, Stringer H, Rissman RA. PMID: 38125374; PMCID: PMC10732590.
      View in: PubMed   Mentions: 2  
    29. Association between military service and Alzheimer's disease neuropathology at autopsy. Alzheimers Dement. 2024 02; 20(2):1468-1474. Powell WR, Vilen L, Zuelsdorff M, Goutman SA, Salamat S, Rissman RA, Bendlin BB, Kind AJH. PMID: 37965965; PMCID: PMC10917028.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    30. Plasma Aβ42/Aβ40 and phospho-tau217 concentration ratios increase the accuracy of amyloid PET classification in preclinical Alzheimer's disease. Alzheimers Dement. 2024 02; 20(2):1214-1224. Rissman RA, Langford O, Raman R, Donohue MC, Abdel-Latif S, Meyer MR, Wente-Roth T, Kirmess KM, Ngolab J, Winston CN, Jimenez-Maggiora G, Rafii MS, Sachdev P, West T, Yarasheski KE, Braunstein JB, Irizarry M, Johnson KA, Aisen PS, Sperling RA, AHEAD 3-45 Study team. PMID: 37932961; PMCID: PMC10916957.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    31. Retina pathology as a target for biomarkers for Alzheimer's disease: Current status, ophthalmopathological background, challenges, and future directions. Alzheimers Dement. 2024 01; 20(1):728-740. Alber J, Bouwman F, den Haan J, Rissman RA, De Groef L, Koronyo-Hamaoui M, Lengyel I, Thal DR, Alzheimer's Association ISTAART “The Eye as a Biomarker for AD” Professional Interest Area. PMID: 37917365; PMCID: PMC10917008.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    32. GP120 and tenofovir alafenamide alter cannabinoid receptor 1 expression in hippocampus of mice. J Neurovirol. 2023 10; 29(5):564-576. Kulbe JR, Le AA, Mante M, Florio J, Laird AE, Swinton MK, Rissman RA, Fields JA. PMID: 37801175; PMCID: PMC10645617.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    33. Assessment of brain-derived extracellular vesicle enrichment for blood biomarker analysis in age-related neurodegenerative diseases: An international overview. bioRxiv. 2023 Oct 02. Badhwar A, Hirschberg Y, Tamayo NV, Iulita MF, Udeh-Momoh CT, Matton A, Tarawneh RM, Rissman RA, Ledreux A, Winston CN, Haqqani AS, Alzheimer’s Association International Society to Advance Alzheimer's Research and Treatment, BBB-EWG. PMID: 37873207; PMCID: PMC10592861.
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    34. Novel systemic delivery of a peptide-conjugated antisense oligonucleotide to reduce α-synuclein in a mouse model of Alzheimer's disease. Neurobiol Dis. 2023 10 01; 186:106285. Leitão ADG, Ahammad RU, Spencer B, Wu C, Masliah E, Rissman RA. PMID: 37690676; PMCID: PMC10584037.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    35. Nicotine-mediated effects in neuronal and mouse models of synucleinopathy. Front Neurosci. 2023; 17:1239009. Fares MB, Alijevic O, Johne S, Overk C, Hashimoto M, Kondylis A, Adame A, Dulize R, Peric D, Nury C, Battey J, Guedj E, Sierro N, Mc Hugh D, Rockenstein E, Kim C, Rissman RA, Hoeng J, Peitsch MC, Masliah E, Mathis C. PMID: 37719154; PMCID: PMC10501483.
      View in: PubMed   Mentions: 2  
    36. The heritability of blood-based biomarkers related to risk of Alzheimer's disease in a population-based sample of early old-age men. Alzheimers Dement. 2024 01; 20(1):356-365. Gillespie NA, Elman JA, McKenzie RE, Tu XM, Xian H, Reynolds CA, Panizzon MS, Lyons MJ, Eglit GML, Neale MC, Rissman RA, Franz C, Kremen WS. PMID: 37622539; PMCID: PMC10843753.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    37. Evaluation of Neighborhood-Level Disadvantage and Cognition in Mexican American and Non-Hispanic White Adults 50 Years and Older in the US. JAMA Netw Open. 2023 08 01; 6(8):e2325325. Wong CG, Miller JB, Zhang F, Rissman RA, Raman R, Hall JR, Petersen M, Yaffe K, Kind AJ, O'Bryant SE, HABS-HD Study Team. PMID: 37647071; PMCID: PMC10469291.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease. Acta Neuropathol Commun. 2023 06 29; 11(1):105. Scalco R, Saito N, Beckett L, Nguyen ML, Huie E, Wang HP, Flaherty DA, Honig LS, DeCarli C, Rissman RA, Teich AF, Jin LW, Dugger BN. PMID: 37386610; PMCID: PMC10311731.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    39. Establishment of a consensus protocol to explore the brain pathobiome in patients with mild cognitive impairment and Alzheimer's disease: Research outline and call for collaboration. Alzheimers Dement. 2023 11; 19(11):5209-5231. Lathe R, Schultek NM, Balin BJ, Ehrlich GD, Auber LA, Perry G, Breitschwerdt EB, Corry DB, Doty RL, Rissman RA, Nara PL, Itzhaki R, Eimer WA, Tanzi RE, Intracell Research Group Consortium Collaborators. PMID: 37283269; PMCID: PMC10918877.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    40. Clinical utility of an antibody-free LC-MS method to detect brain amyloid deposition in cognitively unimpaired individuals from the screening visit of the A4 Study. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12451. Allué JA, Pascual-Lucas M, Sarasa L, Castillo S, Sarasa M, Sáez ME, Abdel-Latif S, Rissman RA, Terencio J. PMID: 37274930; PMCID: PMC10236000.
      View in: PubMed   Mentions: 2  
    41. Inhibition of p38α MAPK restores neuronal p38γ MAPK and ameliorates synaptic degeneration in a mouse model of DLB/PD. Sci Transl Med. 2023 05 10; 15(695):eabq6089. Iba M, Kim C, Kwon S, Szabo M, Horan-Portelance L, Peer CJ, Figg WD, Reed X, Ding J, Lee SJ, Rissman RA, Cookson MR, Overk C, Wrasidlo W, Masliah E. PMID: 37163617.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    42. Characterization of altered molecular mechanisms in Parkinson's disease through cell type-resolved multiomics analyses. Sci Adv. 2023 04 14; 9(15):eabo2467. Lee AJ, Kim C, Park S, Joo J, Choi B, Yang D, Jun K, Eom J, Lee SJ, Chung SJ, Rissman RA, Chung J, Masliah E, Jung I. PMID: 37058563; PMCID: PMC10104466.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    43. Differential involvement of hippocampal subfields in the relationship between Alzheimer's pathology and memory interference in older adults. Alzheimers Dement (Amst). 2023 Apr-Jun; 15(2):e12419. Adams JN, Márquez F, Larson MS, Janecek JT, Miranda BA, Noche JA, Taylor L, Hollearn MK, McMillan L, Keator DB, Head E, Rissman RA, Yassa MA. PMID: 37035460; PMCID: PMC10075195.
      View in: PubMed   Mentions: 2  
    44. Diminished Neuronal ESCRT-0 Function Exacerbates AMPA Receptor Derangement and Accelerates Prion-Induced Neurodegeneration. J Neurosci. 2023 05 24; 43(21):3970-3984. Lawrence JA, Aguilar-Calvo P, Ojeda-Juárez D, Khuu H, Soldau K, Pizzo DP, Wang J, Malik A, Shay TF, Sullivan EE, Aulston B, Song SM, Callender JA, Sanchez H, Geschwind MD, Roy S, Rissman RA, Trejo J, Tanaka N, Wu C, Chen X, Patrick GN, Sigurdson CJ. PMID: 37019623; PMCID: PMC10219035.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    45. Missorting of plasma miRNAs in aging and Alzheimer's disease. J Neurochem. 2023 04; 165(2):149-161. Carna M, Novotny JS, Dragišic N, Slavik H, Sheardova K, Geda YE, Vyhnalek M, Laczo J, Hort J, Mao Z, Rissman RA, Hajduch M, Dammer EB, Stokin GB. PMID: 36892419.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    46. Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study. Alzheimers Dement (Amst). 2023 Jan-Mar; 15(1):e12394. Jiang X, O'Bryant SE, Johnson LA, Rissman RA, Yaffe K, Health and Aging Brain Study (HABS-HD) Study Team. PMID: 36911361; PMCID: PMC9994160.
      View in: PubMed   Mentions: 2  
    47. Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus. Alzheimers Dement. 2023 08; 19(8):3537-3554. Carna M, Onyango IG, Katina S, Holub D, Novotny JS, Nezvedova M, Jha D, Nedelska Z, Lacovich V, Vyvere TV, Houbrechts R, Garcia-Mansfield K, Sharma R, David-Dirgo V, Vyhnalek M, Texlova K, Chaves H, Bakkar N, Pertierra L, Vinkler M, Markova H, Laczo J, Sheardova K, Hortova-Kohoutkova M, Fric J, Forte G, Kanovsky P, Belaškova S, Damborsky J, Hort J, Seyfried NT, Bowser R, Sevlever G, Rissman RA, Smith RA, Hajduch M, Pirrotte P, Spacil Z, Dammer EB, Limbäck-Stokin C, Stokin GB. PMID: 36825691; PMCID: PMC10634590.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    48. The Independent Walking for Brain Health Intervention for Older Adults: Protocol for a Pilot Randomized Controlled Trial. JMIR Res Protoc. 2023 Feb 13; 12:e42980. Hays Weeks CC, Moore AA, Allison M, Patrick K, Bondi MW, Nebeker C, Liu TT, Wing D, Higgins M, Hartman SJ, Rissman RA, Zlatar ZZ. PMID: 36535765; PMCID: PMC9972211.
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    49. D-685 Reverses Motor Deficits and Reduces Accumulation of Human α-Synuclein Protein in Two Different Parkinson's Disease Animal Models. ACS Chem Neurosci. 2023 03 01; 14(5):885-896. Dutta AK, Armstrong C, Luo D, Das B, Spencer B, Rissman RA. PMID: 36749600.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
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    64. Safety, Tolerability, and Immunogenicity of the ACI-24 Vaccine in Adults With Down Syndrome: A Phase 1b Randomized Clinical Trial. JAMA Neurol. 2022 06 01; 79(6):565-574. Rafii MS, Sol O, Mobley WC, Delpretti S, Skotko BG, Burke AD, Sabbagh MN, Yuan SH, Rissman RA, Pulsifer M, Evans C, Evans AC, Beth G, Fournier N, Gray JA, Dos Santos AM, Hliva V, Vukicevic M, Kosco-Vilbois M, Streffer J, Pfeifer A, Feldman HH. PMID: 35532913; PMCID: PMC9086937.
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    70. Developing Biomarkers of Mild Traumatic Brain Injury: Promise and Progress of CNS-Derived Exosomes. Front Neurol. 2021; 12:698206. Vaughn MN, Winston CN, Levin N, Rissman RA, Risbrough VB. PMID: 35222223; PMCID: PMC8866179.
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    103. Correction to: Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology. Acta Neuropathol Commun. 2020 08 04; 8(1):123. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman RA. PMID: 32753049; PMCID: PMC7405419.
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    107. DTI-identified microstructural changes in the gray matter of mice overexpressing CRF in the forebrain. Psychiatry Res Neuroimaging. 2020 10 30; 304:111137. Deslauriers J, Toth M, Scadeng M, McKenna BS, Bussell R, Gresack J, Rissman R, Risbrough VB, Brown GG. PMID: 32731113; PMCID: PMC7508966.
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    108. Diverse proteins aggregate in mild cognitive impairment and Alzheimer's disease brain. Alzheimers Res Ther. 2020 06 19; 12(1):75. Kepchia D, Huang L, Dargusch R, Rissman RA, Shokhirev MN, Fischer W, Schubert D. PMID: 32560738; PMCID: PMC7305608.
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    117. Role of Alterations in Protein Kinase p38γ in the Pathogenesis of the Synaptic Pathology in Dementia With Lewy Bodies and α-Synuclein Transgenic Models. Front Neurosci. 2020; 14:286. Iba M, Kim C, Florio J, Mante M, Adame A, Rockenstein E, Kwon S, Rissman R, Masliah E. PMID: 32296304; PMCID: PMC7138105.
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    119. The Trial-Ready Cohort for Preclinical/Prodromal Alzheimer's Disease (TRC-PAD) Project: An Overview. J Prev Alzheimers Dis. 2020; 7(4):208-212. Aisen PS, Sperling RA, Cummings J, Donohue MC, Langford O, Jimenez-Maggiora GA, Rissman RA, Rafii MS, Walter S, Clanton T, Raman R. PMID: 32920621; PMCID: PMC7735207.
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    120. Reflections on the Utility of the Retina as a Biomarker for Alzheimer's Disease: A Literature Review. Neurol Ther. 2019 Dec; 8(Suppl 2):57-72. Ngolab J, Honma P, Rissman RA. PMID: 31833024; PMCID: PMC6908534.
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    123. Safety and Efficacy of Edonerpic Maleate for Patients With Mild to Moderate Alzheimer Disease: A Phase 2 Randomized Clinical Trial. JAMA Neurol. 2019 Nov 01; 76(11):1330-1339. Schneider LS, Thomas RG, Hendrix S, Rissman RA, Brewer JB, Salmon DP, Oltersdorf T, Okuda T, Feldman HH, Alzheimer’s Disease Cooperative Study TCAD Study Group. PMID: 31282954; PMCID: PMC6618817.
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    124. High-Throughput Mass Spectrometry Assay for Quantifying β-Amyloid 40 and 42 in Cerebrospinal Fluid. Clin Chem. 2019 12; 65(12):1572-1580. Weber DM, Tran D, Goldman SM, Taylor SW, Ginns EI, Lagier RJ, Rissman RA, Brewer JB, Clarke NJ. PMID: 31628138.
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    125. Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity. Front Neurosci. 2019; 13:1005. Winston CN, Romero HK, Ellisman M, Nauss S, Julovich DA, Conger T, Hall JR, Campana W, O'Bryant SE, Nievergelt CM, Baker DG, Risbrough VB, Rissman RA. PMID: 31680797; PMCID: PMC6797846.
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    126. Effect of AZD0530 on Cerebral Metabolic Decline in Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2019 Oct 01; 76(10):1219-1229. van Dyck CH, Nygaard HB, Chen K, Donohue MC, Raman R, Rissman RA, Brewer JB, Koeppe RA, Chow TW, Rafii MS, Gessert D, Choi J, Turner RS, Kaye JA, Gale SA, Reiman EM, Aisen PS, Strittmatter SM. PMID: 31329216; PMCID: PMC6646979.
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    130. Early neuronal accumulation of DNA double strand breaks in Alzheimer's disease. Acta Neuropathol Commun. 2019 05 17; 7(1):77. Shanbhag NM, Evans MD, Mao W, Nana AL, Seeley WW, Adame A, Rissman RA, Masliah E, Mucke L. PMID: 31101070; PMCID: PMC6524256.
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    131. Systemic peptide mediated delivery of an siRNA targeting α-syn in the CNS ameliorates the neurodegenerative process in a transgenic model of Lewy body disease. Neurobiol Dis. 2019 07; 127:163-177. Spencer B, Trinh I, Rockenstein E, Mante M, Florio J, Adame A, El-Agnaf OMA, Kim C, Masliah E, Rissman RA. PMID: 30849508; PMCID: PMC6588505.
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    135. Extracellular Vesicles Isolated from Familial Alzheimer's Disease Neuronal Cultures Induce Aberrant Tau Phosphorylation in the Wild-Type Mouse Brain. J Alzheimers Dis. 2019; 72(2):575-585. Aulston B, Liu Q, Mante M, Florio J, Rissman RA, Yuan SH. PMID: 31594233; PMCID: PMC8373022.
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    137. Effects of Novel Calpain Inhibitors in Transgenic Animal Model of Parkinson's disease/dementia with Lewy bodies. Sci Rep. 2018 12 27; 8(1):18083. Hassen GW, Kesner L, Stracher A, Shulman A, Rockenstein E, Mante M, Adame A, Overk C, Rissman RA, Masliah E. PMID: 30591714; PMCID: PMC6308237.
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    139. Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System. Front Aging Neurosci. 2018; 10:373. Yang W, Sung K, Zhou F, Xu W, Rissman RA, Ding J, Wu C. PMID: 30524266; PMCID: PMC6262302.
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    142. Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation. Mol Neurodegener. 2018 08 09; 13(1):43. Kim C, Spencer B, Rockenstein E, Yamakado H, Mante M, Adame A, Fields JA, Masliah D, Iba M, Lee HJ, Rissman RA, Lee SJ, Masliah E. PMID: 30092810; PMCID: PMC6085656.
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    143. Adeno-Associated Viral Vector (Serotype 2)-Nerve Growth Factor for Patients With Alzheimer Disease: A Randomized Clinical Trial. JAMA Neurol. 2018 07 01; 75(7):834-841. Rafii MS, Tuszynski MH, Thomas RG, Barba D, Brewer JB, Rissman RA, Siffert J, Aisen PS, AAV2-NGF Study Team. PMID: 29582053; PMCID: PMC5885277.
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    145. Potential genetic modifiers of disease risk and age at onset in patients with frontotemporal lobar degeneration and GRN mutations: a genome-wide association study. Lancet Neurol. 2018 06; 17(6):548-558. Pottier C, Zhou X, Perkerson RB, Baker M, Jenkins GD, Serie DJ, Ghidoni R, Benussi L, Binetti G, López de Munain A, Zulaica M, Moreno F, Le Ber I, Pasquier F, Hannequin D, Sánchez-Valle R, Antonell A, Lladó A, Parsons TM, Finch NA, Finger EC, Lippa CF, Huey ED, Neumann M, Heutink P, Synofzik M, Wilke C, Rissman RA, Slawek J, Sitek E, Johannsen P, Nielsen JE, Ren Y, van Blitterswijk M, DeJesus-Hernandez M, Christopher E, Murray ME, Bieniek KF, Evers BM, Ferrari C, Rollinson S, Richardson A, Scarpini E, Fumagalli GG, Padovani A, Hardy J, Momeni P, Ferrari R, Frangipane F, Maletta R, Anfossi M, Gallo M, Petrucelli L, Suh E, Lopez OL, Wong TH, van Rooij JGJ, Seelaar H, Mead S, Caselli RJ, Reiman EM, Noel Sabbagh M, Kjolby M, Nykjaer A, Karydas AM, Boxer AL, Grinberg LT, Grafman J, Spina S, Oblak A, Mesulam MM, Weintraub S, Geula C, Hodges JR, Piguet O, Brooks WS, Irwin DJ, Trojanowski JQ, Lee EB, Josephs KA, Parisi JE, Ertekin-Taner N, Knopman DS, Nacmias B, Piaceri I, Bagnoli S, Sorbi S, Gearing M, Glass J, Beach TG, Black SE, Masellis M, Rogaeva E, Vonsattel JP, Honig LS, Kofler J, Bruni AC, Snowden J, Mann D, Pickering-Brown S, Diehl-Schmid J, Winkelmann J, Galimberti D, Graff C, Öijerstedt L, Troakes C, Al-Sarraj S, Cruchaga C, Cairns NJ, Rohrer JD, Halliday GM, Kwok JB, van Swieten JC, White CL, Ghetti B, Murell JR, Mackenzie IRA, Hsiung GR, Borroni B, Rossi G, Tagliavini F, Wszolek ZK, Petersen RC, Bigio EH, Grossman M, Van Deerlin VM, Seeley WW, Miller BL, Graff-Radford NR, Boeve BF, Dickson DW, Biernacka JM, Rademakers R. PMID: 29724592; PMCID: PMC6237181.
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    146. A Precision Medicine Model for Targeted NSAID Therapy in Alzheimer's Disease. J Alzheimers Dis. 2018; 66(1):97-104. O'Bryant SE, Zhang F, Johnson LA, Hall J, Edwards M, Grammas P, Oh E, Lyketsos CG, Rissman RA. PMID: 30198872; PMCID: PMC6428063.
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    147. Growth Hormone-Releasing Hormone Modulation of Neuronal Exosome Biomarkers in Mild Cognitive Impairment. J Alzheimers Dis. 2018; 66(3):971-981. Winston CN, Goetzl EJ, Baker LD, Vitiello MV, Rissman RA. PMID: 30372675; PMCID: PMC6487872.
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    148. Clinical-Neuropathological Correlations of Alzheimer's Disease and Related Dementias in Latino Volunteers. J Alzheimers Dis. 2018; 66(4):1539-1548. Soria JA, Huisa BN, Edland SD, Litvan I, Peavy GM, Salmon DP, Hansen LA, Galasko DR, Brewer JB, González HM, Rissman RA. PMID: 30412501.
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    149. Increased Vulnerability of the Hippocampus in Transgenic Mice Overexpressing APP and Triple Repeat Tau. J Alzheimers Dis. 2018; 61(3):1201-1219. Arner A, Rockenstein E, Mante M, Florio J, Masliah D, Salehi B, Adame A, Overk C, Masliah E, Rissman RA. PMID: 29332037; PMCID: PMC6508863.
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    150. Combined Active Humoral and Cellular Immunization Approaches for the Treatment of Synucleinopathies. J Neurosci. 2018 01 24; 38(4):1000-1014. Rockenstein E, Ostroff G, Dikengil F, Rus F, Mante M, Florio J, Adame A, Trinh I, Kim C, Overk C, Masliah E, Rissman RA. PMID: 29246926; PMCID: PMC5783958.
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    151. NitroSynapsin therapy for a mouse MEF2C haploinsufficiency model of human autism. Nat Commun. 2017 11 14; 8(1):1488. Tu S, Akhtar MW, Escorihuela RM, Amador-Arjona A, Swarup V, Parker J, Zaremba JD, Holland T, Bansal N, Holohan DR, Lopez K, Ryan SD, Chan SF, Yan L, Zhang X, Huang X, Sultan A, McKercher SR, Ambasudhan R, Xu H, Wang Y, Geschwind DH, Roberts AJ, Terskikh AV, Rissman RA, Masliah E, Lipton SA, Nakanishi N. PMID: 29133852; PMCID: PMC5684358.
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    152. Epigenetic suppression of hippocampal calbindin-D28k by ΔFosB drives seizure-related cognitive deficits. Nat Med. 2017 Nov; 23(11):1377-1383. You JC, Muralidharan K, Park JW, Petrof I, Pyfer MS, Corbett BF, LaFrancois JJ, Zheng Y, Zhang X, Mohila CA, Yoshor D, Rissman RA, Nestler EJ, Scharfman HE, Chin J. PMID: 29035369; PMCID: PMC5747956.
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    153. Corticotropin-releasing factor receptor-1 modulates biomarkers of DNA oxidation in Alzheimer's disease mice. PLoS One. 2017; 12(7):e0181367. Zhang C, Rissman RA. PMID: 28750017; PMCID: PMC5531470.
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    154. Synuclein impairs trafficking and signaling of BDNF in a mouse model of Parkinson's disease. Sci Rep. 2017 06 20; 7(1):3868. Fang F, Yang W, Florio JB, Rockenstein E, Spencer B, Orain XM, Dong SX, Li H, Chen X, Sung K, Rissman RA, Masliah E, Ding J, Wu C. PMID: 28634349; PMCID: PMC5478665.
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    155. Novel human neuronal tau model exhibiting neurofibrillary tangles and transcellular propagation. Neurobiol Dis. 2017 Oct; 106:222-234. Reilly P, Winston CN, Baron KR, Trejo M, Rockenstein EM, Akers JC, Kfoury N, Diamond M, Masliah E, Rissman RA, Yuan SH. PMID: 28610892; PMCID: PMC5593133.
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    156. Brain-derived exosomes from dementia with Lewy bodies propagate α-synuclein pathology. Acta Neuropathol Commun. 2017 06 09; 5(1):46. Ngolab J, Trinh I, Rockenstein E, Mante M, Florio J, Trejo M, Masliah D, Adame A, Masliah E, Rissman RA. PMID: 28599681; PMCID: PMC5466770.
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    157. Differential effects of immunotherapy with antibodies targeting α-synuclein oligomers and fibrils in a transgenic model of synucleinopathy. Neurobiol Dis. 2017 Aug; 104:85-96. El-Agnaf O, Overk C, Rockenstein E, Mante M, Florio J, Adame A, Vaikath N, Majbour N, Lee SJ, Kim C, Masliah E, Rissman RA. PMID: 28476636; PMCID: PMC5954414.
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    158. Pharmacological and Toxicological Properties of the Potent Oral γ-Secretase Modulator BPN-15606. J Pharmacol Exp Ther. 2017 07; 362(1):31-44. Wagner SL, Rynearson KD, Duddy SK, Zhang C, Nguyen PD, Becker A, Vo U, Masliah D, Monte L, Klee JB, Echmalian CM, Xia W, Quinti L, Johnson G, Lin JH, Kim DY, Mobley WC, Rissman RA, Tanzi RE. PMID: 28416568; PMCID: PMC5454592.
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    159. A phase 3 trial of IV immunoglobulin for Alzheimer disease. Neurology. 2017 May 02; 88(18):1768-1775. Relkin NR, Thomas RG, Rissman RA, Brewer JB, Rafii MS, van Dyck CH, Jack CR, Sano M, Knopman DS, Raman R, Szabo P, Gelmont DM, Fritsch S, Aisen PS, Alzheimer's Disease Cooperative Study. PMID: 28381506; PMCID: PMC5409846.
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    160. Anti-α-synuclein immunotherapy reduces α-synuclein propagation in the axon and degeneration in a combined viral vector and transgenic model of synucleinopathy. Acta Neuropathol Commun. 2017 01 13; 5(1):7. Spencer B, Valera E, Rockenstein E, Overk C, Mante M, Adame A, Zago W, Seubert P, Barbour R, Schenk D, Games D, Rissman RA, Masliah E. PMID: 28086964; PMCID: PMC5237270.
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    161. Resveratrol regulates neuro-inflammation and induces adaptive immunity in Alzheimer's disease. J Neuroinflammation. 2017 01 03; 14(1):1. Moussa C, Hebron M, Huang X, Ahn J, Rissman RA, Aisen PS, Turner RS. PMID: 28086917; PMCID: PMC5234138.
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    162. PET Imaging of Tau Pathology and Relationship to Amyloid, Longitudinal MRI, and Cognitive Change in Down Syndrome: Results from the Down Syndrome Biomarker Initiative (DSBI). J Alzheimers Dis. 2017; 60(2):439-450. Rafii MS, Lukic AS, Andrews RD, Brewer J, Rissman RA, Strother SC, Wernick MN, Pennington C, Mobley WC, Ness S, Matthews DC, Down Syndrome Biomarker Initiative and the Alzheimer’s Disease Neuroimaging Initiative. PMID: 28946567.
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    163. Deleterious Effect of Butyrylcholinesterase K-Variant in Donepezil Treatment of Mild Cognitive Impairment. J Alzheimers Dis. 2017; 56(1):229-237. Sokolow S, Li X, Chen L, Taylor KD, Rotter JI, Rissman RA, Aisen PS, Apostolova LG. PMID: 27911294; PMCID: PMC5534361.
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    164. Blood-based biomarkers in Alzheimer disease: Current state of the science and a novel collaborative paradigm for advancing from discovery to clinic. Alzheimers Dement. 2017 01; 13(1):45-58. O'Bryant SE, Mielke MM, Rissman RA, Lista S, Vanderstichele H, Zetterberg H, Lewczuk P, Posner H, Hall J, Johnson L, Fong YL, Luthman J, Jeromin A, Batrla-Utermann R, Villarreal A, Britton G, Snyder PJ, Henriksen K, Grammas P, Gupta V, Martins R, Hampel H, Biofluid Based Biomarker Professional Interest Area. PMID: 27870940; PMCID: PMC5218961.
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    165. Meditation and vacation effects have an impact on disease-associated molecular phenotypes. Transl Psychiatry. 2016 08 30; 6(8):e880. Epel ES, Puterman E, Lin J, Blackburn EH, Lum PY, Beckmann ND, Zhu J, Lee E, Gilbert A, Rissman RA, Tanzi RE, Schadt EE. PMID: 27576169; PMCID: PMC5022094.
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    166. Reducing Endogenous α-Synuclein Mitigates the Degeneration of Selective Neuronal Populations in an Alzheimer's Disease Transgenic Mouse Model. J Neurosci. 2016 07 27; 36(30):7971-84. Spencer B, Desplats PA, Overk CR, Valera-Martin E, Rissman RA, Wu C, Mante M, Adame A, Florio J, Rockenstein E, Masliah E. PMID: 27466341; PMCID: PMC4961781.
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    167. Lack of Influence of Apolipoprotein E Status on Cognition or Brain Structure in Professional Fighters. J Neurotrauma. 2017 01 15; 34(2):380-384. Banks SJ, Miller JB, Rissman RA, Bernick CB. PMID: 27245878; PMCID: PMC5220568.
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    168. Higher Brain Perfusion May Not Support Memory Functions in Cognitively Normal Carriers of the ApoE ε4 Allele Compared to Non-Carriers. Front Aging Neurosci. 2016; 8:151. Zlatar ZZ, Bischoff-Grethe A, Hays CC, Liu TT, Meloy MJ, Rissman RA, Bondi MW, Wierenga CE. PMID: 27445794; PMCID: PMC4919360.
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    169. Demonstration of safety of intravenous immunoglobulin in geriatric patients in a long-term, placebo-controlled study of Alzheimer's disease. Alzheimers Dement (N Y). 2016 Jun; 2(2):131-139. Gelmont D, Thomas RG, Britt J, Dyck-Jones JA, Doralt J, Fritsch S, Brewer JB, Rissman RA, Aisen P. PMID: 29067300; PMCID: PMC5644268.
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    170. Dissociation of Down syndrome and Alzheimer's disease effects with imaging. Alzheimers Dement (N Y). 2016 Jun; 2(2):69-81. Matthews DC, Lukic AS, Andrews RD, Marendic B, Brewer J, Rissman RA, Mosconi L, Strother SC, Wernick MN, Mobley WC, Ness S, Schmidt ME, Rafii MS. PMID: 28642933; PMCID: PMC5477635.
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    171. Prediction of conversion from mild cognitive impairment to dementia with neuronally derived blood exosome protein profile. Alzheimers Dement (Amst). 2016; 3:63-72. Winston CN, Goetzl EJ, Akers JC, Carter BS, Rockenstein EM, Galasko D, Masliah E, Rissman RA. PMID: 27408937; PMCID: PMC4925777.
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    172. Functional Impact of Corticotropin-Releasing Factor Exposure on Tau Phosphorylation and Axon Transport. PLoS One. 2016; 11(1):e0147250. Le MH, Weissmiller AM, Monte L, Lin PH, Hexom TC, Natera O, Wu C, Rissman RA. PMID: 26790099; PMCID: PMC4720402.
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    173. Comparing biological markers of Alzheimer's disease across blood fraction and platforms: Comparing apples to oranges. Alzheimers Dement (Amst). 2016; 3:27-34. O'Bryant SE, Lista S, Rissman RA, Edwards M, Zhang F, Hall J, Zetterberg H, Lovestone S, Gupta V, Graff-Radford N, Martins R, Jeromin A, Waring S, Oh E, Kling M, Baker LD, Hampel H. PMID: 27019866; PMCID: PMC4802360.
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    174. Corticotropin-releasing factor receptor-1 antagonism mitigates beta amyloid pathology and cognitive and synaptic deficits in a mouse model of Alzheimer's disease. Alzheimers Dement. 2016 05; 12(5):527-37. Zhang C, Kuo CC, Moghadam SH, Monte L, Campbell SN, Rice KC, Sawchenko PE, Masliah E, Rissman RA. PMID: 26555315; PMCID: PMC4860182.
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    175. Reproductive Stage and Modulation of Stress-Induced Tau Phosphorylation in Female Rats. J Neuroendocrinol. 2015 Nov; 27(11):827-34. Steinmetz D, Ramos E, Campbell SN, Morales T, Rissman RA. PMID: 26510116; PMCID: PMC4625411.
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    176. The down syndrome biomarker initiative (DSBI) pilot: proof of concept for deep phenotyping of Alzheimer's disease biomarkers in down syndrome. Front Behav Neurosci. 2015; 9:239. Rafii MS, Wishnek H, Brewer JB, Donohue MC, Ness S, Mobley WC, Aisen PS, Rissman RA. PMID: 26441570; PMCID: PMC4568340.
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    177. A randomized, double-blind, placebo-controlled trial of resveratrol for Alzheimer disease. Neurology. 2015 Oct 20; 85(16):1383-91. Turner RS, Thomas RG, Craft S, van Dyck CH, Mintzer J, Reynolds BA, Brewer JB, Rissman RA, Raman R, Aisen PS, Alzheimer's Disease Cooperative Study. PMID: 26362286; PMCID: PMC4626244.
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    178. Oral glucose tolerance testing to modulate plasma amyloid levels: A novel biomarker. Alzheimers Dement (Amst). 2015 Sep; 1(3):311-315. Oh ES, Marano CM, Leoutsakos JM, Lee RW, Rissman RA, Smith GS, Craft S, Lyketsos CG. PMID: 26413562; PMCID: PMC4578701.
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    179. Elevated cerebrovascular resistance index is associated with cognitive dysfunction in the very-old. Alzheimers Res Ther. 2015 01 21; 7(1):3. Clark LR, Nation DA, Wierenga CE, Bangen KJ, Dev SI, Shin DD, Delano-Wood L, Liu TT, Rissman RA, Bondi MW. PMID: 27391477; PMCID: PMC4942967.
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    180. Differential Effects of Meal Challenges on Cognition, Metabolism, and Biomarkers for Apolipoprotein E ɛ4 Carriers and Adults with Mild Cognitive Impairment. J Alzheimers Dis. 2015; 48(1):205-18. Hanson AJ, Bayer JL, Baker LD, Cholerton B, VanFossen B, Trittschuh E, Rissman RA, Donohue MC, Moghadam SH, Plymate SR, Craft S. PMID: 26401941.
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    181. Increased tau phosphorylation and aggregation in the hippocampus of mice overexpressing corticotropin-releasing factor. J Alzheimers Dis. 2015; 43(3):967-76. Campbell SN, Zhang C, Monte L, Roe AD, Rice KC, Taché Y, Masliah E, Rissman RA. PMID: 25125464; PMCID: PMC4258165.
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    182. Corticotropin-Releasing Factor Receptor-1 Antagonism Reduces Oxidative Damage in an Alzheimer’s Disease Transgenic Mouse Model. J Alzheimers Dis. 2015; 45(2):639-50. Zhang C, Kuo CC, Moghadam SH, Monte L, Rice KC, Rissman RA. PMID: 25649650; PMCID: PMC4486520.
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    183. Impact of CRFR1 Ablation on Amyloid-β Production and Accumulation in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis. 2015; 45(4):1175-84. Campbell SN, Zhang C, Roe AD, Lee N, Lao KU, Monte L, Donohue MC, Rissman RA. PMID: 25697705; PMCID: PMC4459491.
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    184. Characterization of ATP alternations in an Alzheimer's disease transgenic mouse model. J Alzheimers Dis. 2015; 44(2):375-8. Zhang C, Rissman RA, Feng J. PMID: 25261448; PMCID: PMC4305018.
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    185. Longitudinal plasma amyloid beta in Alzheimer's disease clinical trials. Alzheimers Dement. 2015 Sep; 11(9):1069-79. Donohue MC, Moghadam SH, Roe AD, Sun CK, Edland SD, Thomas RG, Petersen RC, Sano M, Galasko D, Aisen PS, Rissman RA. PMID: 25301682; PMCID: PMC4387108.
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    186. Guidelines for the standardization of preanalytic variables for blood-based biomarker studies in Alzheimer's disease research. Alzheimers Dement. 2015 May; 11(5):549-60. O'Bryant SE, Gupta V, Henriksen K, Edwards M, Jeromin A, Lista S, Bazenet C, Soares H, Lovestone S, Hampel H, Montine T, Blennow K, Foroud T, Carrillo M, Graff-Radford N, Laske C, Breteler M, Shaw L, Trojanowski JQ, Schupf N, Rissman RA, Fagan AM, Oberoi P, Umek R, Weiner MW, Grammas P, Posner H, Martins R, STAR-B and BBBIG working groups. PMID: 25282381; PMCID: PMC4414664.
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    187. Long-Term Electrophysiological and Behavioral Analysis on the Improvement of Visual Working Memory Load, Training Gains, and Transfer Benefits. J Behav Brain Sci. 2014 May 01; 4(5):234-246. Kuo CC, Zhang C, Rissman RA, Chiu AW. PMID: 25045590; PMCID: PMC4101919.
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    188. Detection and quantification of 8-hydroxy-2'-deoxyguanosine in Alzheimer's transgenic mouse urine using capillary electrophoresis. Electrophoresis. 2013 Aug; 34(15):2268-74. Zhang C, Nestorova G, Rissman RA, Feng J. PMID: 23712533; PMCID: PMC3789118.
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    189. CSF biomarker variability in the Alzheimer's Association quality control program. Alzheimers Dement. 2013 May; 9(3):251-61. Mattsson N, Andreasson U, Persson S, Carrillo MC, Collins S, Chalbot S, Cutler N, Dufour-Rainfray D, Fagan AM, Heegaard NH, Robin Hsiung GY, Hyman B, Iqbal K, Kaeser SA, Käser SA, Lachno DR, Lleó A, Lewczuk P, Molinuevo JL, Parchi P, Regeniter A, Rissman RA, Rissman R, Rosenmann H, Sancesario G, Schröder J, Shaw LM, Teunissen CE, Trojanowski JQ, Vanderstichele H, Vandijck M, Verbeek MM, Zetterberg H, Blennow K, Alzheimer's Association QC Program Work Group. PMID: 23622690; PMCID: PMC3707386.
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    190. Cortical and subcortical cerebrovascular resistance index in mild cognitive impairment and Alzheimer's disease. J Alzheimers Dis. 2013; 36(4):689-98. Nation DA, Wierenga CE, Clark LR, Dev SI, Stricker NH, Jak AJ, Salmon DP, Delano-Wood L, Bangen KJ, Rissman RA, Liu TT, Bondi MW. PMID: 23666173; PMCID: PMC4089500.
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    191. Interaction of age and APOE genotype on cerebral blood flow at rest. J Alzheimers Dis. 2013; 34(4):921-35. Wierenga CE, Clark LR, Dev SI, Shin DD, Jurick SM, Rissman RA, Liu TT, Bondi MW. PMID: 23302659; PMCID: PMC4124882.
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    192. Effect of mild cognitive impairment and APOE genotype on resting cerebral blood flow and its association with cognition. J Cereb Blood Flow Metab. 2012 Aug; 32(8):1589-99. Wierenga CE, Dev SI, Shin DD, Clark LR, Bangen KJ, Jak AJ, Rissman RA, Liu TT, Salmon DP, Bondi MW. PMID: 22549621; PMCID: PMC3421098.
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    193. Corticotropin-releasing factor receptor-dependent effects of repeated stress on tau phosphorylation, solubility, and aggregation. Proc Natl Acad Sci U S A. 2012 Apr 17; 109(16):6277-82. Rissman RA, Staup MA, Lee AR, Justice NJ, Rice KC, Vale W, Sawchenko PE. PMID: 22451915; PMCID: PMC3341026.
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    194. Longitudinal plasma amyloid beta as a biomarker of Alzheimer's disease. J Neural Transm (Vienna). 2012 Jul; 119(7):843-50. Rissman RA, Trojanowski JQ, Shaw LM, Aisen PS. PMID: 22354745; PMCID: PMC4305447.
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    195. Lipopolysaccharide-induced tau phosphorylation and kinase activity--modulation, but not mediation, by corticotropin-releasing factor receptors. Eur J Neurosci. 2011 Aug; 34(3):448-56. Roe AD, Staup MA, Serrats J, Sawchenko PE, Rissman RA. PMID: 21722209; PMCID: PMC3148267.
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    196. The Alzheimer's Association external quality control program for cerebrospinal fluid biomarkers. Alzheimers Dement. 2011 Jul; 7(4):386-395.e6. Mattsson N, Andreasson U, Persson S, Arai H, Batish SD, Bernardini S, Bocchio-Chiavetto L, Blankenstein MA, Carrillo MC, Chalbot S, Coart E, Chiasserini D, Cutler N, Dahlfors G, Duller S, Fagan AM, Forlenza O, Frisoni GB, Galasko D, Galimberti D, Hampel H, Handberg A, Heneka MT, Herskovits AZ, Herukka SK, Holtzman DM, Humpel C, Hyman BT, Iqbal K, Jucker M, Kaeser SA, Kaiser E, Kapaki E, Kidd D, Klivenyi P, Knudsen CS, Kummer MP, Lui J, Lladó A, Lewczuk P, Li QX, Martins R, Masters C, McAuliffe J, Mercken M, Moghekar A, Molinuevo JL, Montine TJ, Nowatzke W, O'Brien R, Otto M, Paraskevas GP, Parnetti L, Petersen RC, Prvulovic D, de Reus HP, Rissman RA, Scarpini E, Stefani A, Soininen H, Schröder J, Shaw LM, Skinningsrud A, Skrogstad B, Spreer A, Talib L, Teunissen C, Trojanowski JQ, Tumani H, Umek RM, Van Broeck B, Vanderstichele H, Vecsei L, Verbeek MM, Windisch M, Zhang J, Zetterberg H, Blennow K. PMID: 21784349; PMCID: PMC3710290.
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    197. Implications for treatment: GABAA receptors in aging, Down syndrome and Alzheimer's disease. J Neurochem. 2011 May; 117(4):613-22. Rissman RA, Mobley WC. PMID: 21388375; PMCID: PMC3127285.
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    198. Functional amyloids as natural storage of peptide hormones in pituitary secretory granules. Science. 2009 Jul 17; 325(5938):328-32. Maji SK, Perrin MH, Sawaya MR, Jessberger S, Vadodaria K, Rissman RA, Singru PS, Nilsson KP, Simon R, Schubert D, Eisenberg D, Rivier J, Sawchenko P, Vale W, Riek R. PMID: 19541956; PMCID: PMC2865899.
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    199. Stress-induced tau phosphorylation: functional neuroplasticity or neuronal vulnerability? J Alzheimers Dis. 2009; 18(2):453-7. Rissman RA. PMID: 19584431; PMCID: PMC2906152.
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    200. GABA(A) receptors in aging and Alzheimer's disease. J Neurochem. 2007 Nov; 103(4):1285-92. Rissman RA, De Blas AL, Armstrong DM. PMID: 17714455.
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    201. Corticotropin-releasing factor receptors differentially regulate stress-induced tau phosphorylation. J Neurosci. 2007 Jun 13; 27(24):6552-62. Rissman RA, Lee KF, Vale W, Sawchenko PE. PMID: 17567816; PMCID: PMC6672442.
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    202. Age-related alterations in GABA(A) receptor subunits in the nonhuman primate hippocampus. Brain Res. 2006 Feb 16; 1073-1074:120-30. Rissman RA, Nocera R, Fuller LM, Kordower JH, Armstrong DM. PMID: 16430870.
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    203. Caspase-cleaved tau accumulation in neurodegenerative diseases associated with tau and alpha-synuclein pathology. Acta Neuropathol. 2005 Aug; 110(2):135-44. Newman J, Rissman RA, Sarsoza F, Kim RC, Dick M, Bennett DA, Cotman CW, Rohn TT, Head E. PMID: 15986225.
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    204. The role of caspase cleavage of tau in Alzheimer disease neuropathology. J Neuropathol Exp Neurol. 2005 Feb; 64(2):104-12. Cotman CW, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15751224.
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    205. Subregional analysis of GABA(A) receptor subunit mRNAs in the hippocampus of older persons with and without cognitive impairment. J Chem Neuroanat. 2004 Sep; 28(1-2):17-25. Rissman RA, Bennett DA, Armstrong DM. PMID: 15363487.
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    206. Caspase-mediated degeneration in Alzheimer's disease. Am J Pathol. 2004 Aug; 165(2):353-5. Cribbs DH, Poon WW, Rissman RA, Blurton-Jones M. PMID: 15277211; PMCID: PMC1618562.
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    207. Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. J Clin Invest. 2004 Jul; 114(1):121-30. Rissman RA, Poon WW, Blurton-Jones M, Oddo S, Torp R, Vitek MP, LaFerla FM, Rohn TT, Cotman CW. PMID: 15232619; PMCID: PMC437967.
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    208. Differential preservation of AMPA receptor subunits in the hippocampi of Alzheimer's disease patients according to Braak stage. Exp Neurol. 2004 Jun; 187(2):299-309. Carter TL, Rissman RA, Mishizen-Eberz AJ, Wolfe BB, Hamilton RL, Gandy S, Armstrong DM. PMID: 15144856.
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    209. Biochemical and molecular studies of NMDA receptor subunits NR1/2A/2B in hippocampal subregions throughout progression of Alzheimer's disease pathology. Neurobiol Dis. 2004 Feb; 15(1):80-92. Mishizen-Eberz AJ, Rissman RA, Carter TL, Ikonomovic MD, Wolfe BB, Armstrong DM. PMID: 14751773.
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    210. Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease. Cell Mol Neurobiol. 2003 Oct; 23(4-5):491-505. Armstrong DM, Sheffield R, Mishizen-Eberz AJ, Carter TL, Rissman RA, Mizukami K, Ikonomovic MD. PMID: 14514010.
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    211. Biochemical analysis of GABA(A) receptor subunits alpha 1, alpha 5, beta 1, beta 2 in the hippocampus of patients with Alzheimer's disease neuropathology. Neuroscience. 2003; 120(3):695-704. Rissman RA, Mishizen-Eberz AJ, Carter TL, Wolfe BB, De Blas AL, Miralles CP, Ikonomovic MD, Armstrong DM. PMID: 12895510.
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    212. Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous. Drug News Perspect. 2002 Nov; 15(9):549-557. Rohn TT, Rissman RA, Head E, Cotman CW. PMID: 12677194.
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