Isaac Asante, PhD

Title(s)Assistant Professor of Research Ophthalmology
SchoolKeck School of Medicine of Usc
Phone+1 323 442 1357
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    Collapse Biography 
    Collapse Education and Training
    University of Science and Technology, GhanaBPharm2005
    University of Science and Technology, GhanaMBA2010
    Maastricht University, NetherlandsMS2014Health Professions Education
    USC, Los AngelesMS2015Drug Regulation and Development
    USC, Los Angeles, CAPhD2017Clinical and Experimental Therapeutics
    USC, Los Angeles, CAPostdoctoral Scholar2020
    Collapse Awards and Honors
    Kintampo Health Research Center2011Institutional Research Grant
    Forum on Microbial Infections2011Travel Grant
    USC School of Pharmacy2014Travel Grant
    American Society for Mass Spectrometry2015Travel Grant
    USC School of Pharmacy2015Third Prize Award
    Dean’s Innovation Award2017USC School of Pharmacy

    Collapse Overview 
    Collapse Overview
    Isaac Asante, PhD, is a translational scientist who combines expertise from pharmacology, metabolomics/lipidomics, and biomedical engineering to develop novel interventions for inflammatory and neurodegenerative conditions. Dr. Asante has conducted preclinical and clinical development of novel interventions that have had an impact on millions of lives across the world. Early in his research career, he partnered with industry to produce the maiden malaria vaccine. Later, he focused his efforts on using novel biomarkers for cancer and other inflammatory conditions. He researched the role of folate one-carbon metabolism in patients who developed colorectal cancer, reviewed a previously unknown metabolic pathway. Most recently, he used a novel renin-angiotensin system (RAS) metabolomics to probe mechanistic processes that underlie various inflammatory and neurodegenerative diseases. In addition, he was able to develop and validate a lipidomic test that can serve as an accurate “liquid biopsy” of patients with inflammatory and neurodegeneration. These “omics” developments were able to guide intervention development and differentiate various types of age-related macular degeneration (AMD), retinitis pigmentosa, and traumatic brain injury. His efforts have spanned from developing interventions for traumatic brain injury to developing novel therapeutics to address ophthalmic regeneration of cornea and preservation of the retina. Dr. Asante also develops biomarkers and models them into predictive algorithms for diagnosis, prognosis, and therapeutic monitoring. Such models have been used in acute respiratory distress syndrome and colorectal cancer. Dr. Asante joined the USC Roski Eye institute in 2020, as an Assistant Professor of Research.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Loss of 15-Lipoxygenase in Retinodegenerative RCS Rats. Int J Mol Sci. 2024 Feb 15; 25(4). Mead AJ, Ahluwalia K, Ebright B, Zhang Z, Dave P, Li Z, Zhou E, Naik AA, Ngu R, Chester C, Lu A, Asante I, Pollalis D, Martinez JC, Humayun M, Louie S. PMID: 38396985; PMCID: PMC10889776.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    2. Hydroxypropyl-Beta Cyclodextrin Barrier Prevents Respiratory Viral Infections: A Preclinical Study. Int J Mol Sci. 2024 Feb 08; 25(4). Lu A, Ebright B, Naik A, Tan HL, Cohen NA, Bouteiller JC, Lazzi G, Louie SG, Humayun MS, Asante I. PMID: 38396738; PMCID: PMC10888609.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Analysis of Contact Allergens in Polyvinyl Chloride Examination Gloves in the United States. Dermatitis. 2024 Mar-Apr; 35(2):160-166. Norman T, Guenther J, Asante I, Adler BL. PMID: 37669114.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Computational optimization of delivery parameters to guide the development of targeted Nasal spray. Sci Rep. 2023 03 12; 13(1):4099. Du J, Shao X, Bouteiller JC, Lu A, Asante I, Louie S, Humayun MS, Lazzi G. PMID: 36907909; PMCID: PMC10008197.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Alterations in Renin-Angiotensin System (RAS) Peptide Levels in Patients with HIV. Metabolites. 2022 Dec 31; 13(1). Asante I, Lu A, Mitchell BI, Boisvert WA, Shikuma CM, Chow DC, Louie SG. PMID: 36676986; PMCID: PMC9860813.
      View in: PubMed   Mentions:
    6. Uncovering mechanisms of brain inflammation in Alzheimer's disease with APOE4: Application of single cell-type lipidomics. Ann N Y Acad Sci. 2022 12; 1518(1):84-105. Asante I, Louie S, Yassine HN. PMID: 36200578; PMCID: PMC10092192.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Development of Moderate Intensity Focused Ultrasound (MIFU) for Ocular Drug Delivery. BME Front. 2022; 2022:9840678. Gonzalez-Calle A, Li R, Asante I, Martinez-Camarillo JC, Louie S, Zhou Q, Humayun MS. PMID: 37850188; PMCID: PMC10521715.
      View in: PubMed   Mentions: 1  
    8. Lipidomics in Understanding Pathophysiology and Pharmacologic Effects in Inflammatory Diseases: Considerations for Drug Development. Metabolites. 2022 Apr 07; 12(4). Ahluwalia K, Ebright B, Chow K, Dave P, Mead A, Poblete R, Louie SG, Asante I. PMID: 35448520; PMCID: PMC9030008.
      View in: PubMed   Mentions: 6  
    9. Prevalence and Risk Factors for Intimate Partner Physical Violence-Related Acquired Brain Injury Among Visitors to Justice Center in New York. J Head Trauma Rehabil. 2022 Jan-Feb 01; 37(1):E10-E19. Saleem GT, Champagne M, Haider MN, Leddy JJ, Willer B, Asante I, Kent A, Joseph T, Fitzpatrick JM. PMID: 34985036.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. NAP1051, a Lipoxin A4 Biomimetic Analogue, Demonstrates Antitumor Activity Against the Tumor Microenvironment. Mol Cancer Ther. 2021 12; 20(12):2384-2397. Dong T, Dave P, Yoo E, Ebright B, Ahluwalia K, Zhou E, Asante I, Salimova M, Pei H, Lin T, Mead A, Li Z, Humayun M, Petasis NA, Epstein AL, Louie SG. PMID: 34607931.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    11. Genomic and Phenotypic Diversity of Cultivated and Wild Tomatoes with Varying Levels of Heat Tolerance. Genes (Basel). 2021 03 29; 12(4). Ayenan MAT, Danquah A, Agre PA, Hanson P, Asante IK, Danquah EY. PMID: 33805499; PMCID: PMC8067180.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    12. Genotype by Environment Interaction on Resistance to Cassava Green Mite Associated Traits and Effects on Yield Performance of Cassava Genotypes in Nigeria. Front Plant Sci. 2020; 11:572200. Jiwuba L, Danquah A, Asante I, Blay E, Onyeka J, Danquah E, Egesi C. PMID: 33013995; PMCID: PMC7498573.
      View in: PubMed   Mentions: 12  
    13. Cyanine Nanocage Activated by Near-IR Light for the Targeted Delivery of Cyclosporine A to Traumatic Brain Injury Sites. Mol Pharm. 2020 12 07; 17(12):4499-4509. Black CE, Zhou E, DeAngelo C, Asante I, Yang R, Petasis NA, Louie SG, Humayun M. PMID: 32813533.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    14. Cyanine Nanocages Activated by Near-Infrared Light for the Targeted Treatment of Traumatic Brain Injury. Front Chem. 2020; 8:769. Black CE, Zhou E, DeAngelo CM, Asante I, Louie SG, Petasis NA, Humayun MS. PMID: 33062635; PMCID: PMC7489144.
      View in: PubMed   Mentions: 3  
    15. Optimizing pollencounter for high throughput phenotyping of pollen quality in tomatoes. MethodsX. 2020; 7:100977. Ayenan MAT, Danquah A, Ampomah-Dwamena C, Hanson P, Asante IK, Danquah EY. PMID: 32670805; PMCID: PMC7338780.
      View in: PubMed   Mentions: 1  
    16. Genetic Studies on the Inheritance of Storage-Induced Cooking Time in Cowpeas [Vigna unguiculata (L.) Walp]. Front Plant Sci. 2020; 11:444. Addy SNTT, Cichy KA, Adu-Dapaah H, Asante IK, Emmanuel A, Offei SK. PMID: 32431718; PMCID: PMC7214927.
      View in: PubMed   Mentions:
    17. Evaluation of nutritional and phytochemical variability of cowpea Recombinant Inbred Lines under contrasting soil moisture conditions in the Guinea and Sudan Savanna Agro-ecologies. Heliyon. 2020 Feb; 6(2):e03406. Alidu MS, Asante IK, Mensah HK. PMID: 32095650; PMCID: PMC7033356.
      View in: PubMed   Mentions: 4  
    18. A latent unknown clustering integrating multi-omics data (LUCID) with phenotypic traits. Bioinformatics. 2020 02 01; 36(3):842-850. Peng C, Wang J, Asante I, Louie S, Jin R, Chatzi L, Casey G, Thomas DC, Conti DV. PMID: 31504184; PMCID: PMC7986585.
      View in: PubMed   Mentions: 11     Fields:    
    19. Genetic diversity and population structure analysis of Ghanaian and exotic cassava accessions using simple sequence repeat (SSR) markers. Heliyon. 2020 Jan; 6(1):e03154. Adjebeng-Danquah J, Manu-Aduening J, Asante IK, Agyare RY, Gracen V, Offei SK. PMID: 32042951; PMCID: PMC7002781.
      View in: PubMed   Mentions: 9  
    20. Genome-wide association study of circulating folate one-carbon metabolites. Genet Epidemiol. 2019 12; 43(8):1030-1045. Wang J, Asante I, Baron JA, Figueiredo JC, Haile R, Joan Levine A, Newcomb PA, Templeton AS, Schumacher FR, Louie SG, Casey G, Conti DV. PMID: 31502714; PMCID: PMC6829035.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    21. Effect of Vitamin D Supplementation on Bone Turnover Markers During HIV Pre-Exposure Prophylaxis Using Tenofovir Disoproxil Fumarate-Emtricitabine in Men Who Have Sex with Men. AIDS Res Hum Retroviruses. 2019 07; 35(7):608-614. Nanayakkara DD, Sun X, Morris S, Louie S, Mulligan K, Overton T, Asante I, Corado K, Jain S, Dubé MP. PMID: 30907095.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansPHPublic Health
    22. Alterations in folate-dependent one-carbon metabolism as colon cell transition from normal to cancerous. J Nutr Biochem. 2019 07; 69:1-9. Asante I, Chui D, Pei H, Zhou E, De Giovanni C, Conti D, Louie S. PMID: 31035100; PMCID: PMC6570572.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    23. Circulating angiotensin peptides levels in Acute Respiratory Distress Syndrome correlate with clinical outcomes: A pilot study. PLoS One. 2019; 14(3):e0213096. Reddy R, Asante I, Liu S, Parikh P, Liebler J, Borok Z, Rodgers K, Baydur A, Louie SG. PMID: 30845246; PMCID: PMC6405137.
      View in: PubMed   Mentions: 54     Fields:    Translation:Humans
    24. Exploratory metabolomic study to identify blood-based biomarkers as a potential screen for colorectal cancer. Mol Omics. 2019 02 11; 15(1):21-29. Asante I, Pei H, Zhou E, Liu S, Chui D, Yoo E, Conti DV, Louie SG. PMID: 30515501; PMCID: PMC6413524.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. The effects of land cover change on carbon stock dynamics in a dry Afromontane forest in northern Ethiopia. Carbon Balance Manag. 2018 Sep 06; 13(1):14. Solomon N, Pabi O, Annang T, Asante IK, Birhane E. PMID: 30191432; PMCID: PMC6127076.
      View in: PubMed   Mentions: 4  
    26. Simultaneous quantitation of folates, flavins and B6 metabolites in human plasma by LC-MS/MS assay: Applications in colorectal cancer. J Pharm Biomed Anal. 2018 Sep 05; 158:66-73. Asante I, Pei H, Zhou E, Liu S, Chui D, Yoo E, Louie SG. PMID: 29860180; PMCID: PMC7473779.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    27. Surveillance of pesticide residues in fruits and vegetables from Accra Metropolis markets, Ghana, 2010-2012: a case study in Sub-Saharan Africa. Environ Sci Pollut Res Int. 2017 Jul; 24(20):17187-17205. Fosu PO, Donkor A, Ziwu C, Dubey B, Kingsford-Adaboh R, Asante I, Nyarko S, Tawiah R, Nazzah N. PMID: 28589271.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsPHPublic Health
    28. Stakeholders' perceptions on competency and assessment program of entry-level pharmacists in developing countries. Curr Pharm Teach Learn. 2017 05; 9(3):360-368. Asante I, Andoh I, Muijtjens AMM, Donkers J. PMID: 29233272.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Quality of Artemisinin-based Combination Therapy for malaria found in Ghanaian markets and public health implications of their use. BMC Pharmacol Toxicol. 2016 10 28; 17(1):48. Tivura M, Asante I, van Wyk A, Gyaase S, Malik N, Mahama E, Hostetler DM, Fernandez FM, Asante KP, Kaur H, Owusu-Agyei S. PMID: 27788677; PMCID: PMC5084396.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansPHPublic Health
    30. Pesticide residues in fruits and vegetables in Ghana: a review. Environ Sci Pollut Res Int. 2016 Oct; 23(19):18966-87. Donkor A, Osei-Fosu P, Dubey B, Kingsford-Adaboh R, Ziwu C, Asante I. PMID: 27530198.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsPHPublic Health
    31. Ethnopharmacological reports on anti-Buruli ulcer medicinal plants in three West African countries. J Ethnopharmacol. 2015 Aug 22; 172:297-311. Tsouh Fokou PV, Nyarko AK, Appiah-Opong R, Tchokouaha Yamthe LR, Addo P, Asante IK, Boyom FF. PMID: 26099634.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    32. Validation of QuEChERS method for the determination of 36 pesticide residues in fruits and vegetables from Ghana, using gas chromatography with electron capture and pulsed flame photometric detectors. J Environ Sci Health B. 2015; 50(8):560-70. Donkor A, Osei-Fosu P, Nyarko S, Kingsford-Adaboh R, Dubey B, Asante I. PMID: 26065516.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsPHPublic Health
    33. Monitoring of pesticide residues of five notable vegetables at Agbogbloshie market in Accra, Ghana. Environ Monit Assess. 2014 Nov; 186(11):7157-63. Osei-Fosu P, Donkor AK, Nyarko S, Nazzah NK, Asante IK, Kingsford-Adabo R, Arkorful NA. PMID: 25007773.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsPHPublic Health
    34. A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants. N Engl J Med. 2012 Dec 13; 367(24):2284-95. RTS, S Clinical Trials Partnership, Agnandji ST, Lell B, Fernandes JF, Abossolo BP, Methogo BG, Kabwende AL, Adegnika AA, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Machevo S, Acacio S, Bulo H, Sigauque B, Macete E, Alonso P, Abdulla S, Salim N, Minja R, Mpina M, Ahmed S, Ali AM, Mtoro AT, Hamad AS, Mutani P, Tanner M, Tinto H, D'Alessandro U, Sorgho H, Valea I, Bihoun B, Guiraud I, Kaboré B, Sombié O, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Oneko M, Odero C, Otieno K, Awino N, McMorrow M, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Otsyula N, Gondi S, Otieno A, Owira V, Oguk E, Odongo G, Woods JB, Ogutu B, Njuguna P, Chilengi R, Akoo P, Kerubo C, Maingi C, Lang T, Olotu A, Bejon P, Marsh K, Mwambingu G, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Dosoo D, Asante I, Adjei G, Kwara E, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Mahende C, Liheluka E, Malle L, Lemnge M, Theander TG, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Sarfo A, Agyekum A, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Tembo T, Tegha G, Tsidya M, Kilembe J, Chawinga C, Ballou WR, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Olivier A, Vekemans J, Carter T, Kaslow D, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P. PMID: 23136909; PMCID: PMC10915853.
      View in: PubMed   Mentions: 371     Fields:    Translation:HumansAnimalsCTClinical Trials
    35. First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children. N Engl J Med. 2011 11 17; 365(20):1863-75. RTS, S Clinical Trials Partnership, Agnandji ST, Lell B, Soulanoudjingar SS, Fernandes JF, Abossolo BP, Conzelmann C, Methogo BG, Doucka Y, Flamen A, Mordmüller B, Issifou S, Kremsner PG, Sacarlal J, Aide P, Lanaspa M, Aponte JJ, Nhamuave A, Quelhas D, Bassat Q, Mandjate S, Macete E, Alonso P, Abdulla S, Salim N, Juma O, Shomari M, Shubis K, Machera F, Hamad AS, Minja R, Mtoro A, Sykes A, Ahmed S, Urassa AM, Ali AM, Mwangoka G, Tanner M, Tinto H, D'Alessandro U, Sorgho H, Valea I, Tahita MC, Kaboré W, Ouédraogo S, Sandrine Y, Guiguemdé RT, Ouédraogo JB, Hamel MJ, Kariuki S, Odero C, Oneko M, Otieno K, Awino N, Omoto J, Williamson J, Muturi-Kioi V, Laserson KF, Slutsker L, Otieno W, Otieno L, Nekoye O, Gondi S, Otieno A, Ogutu B, Wasuna R, Owira V, Jones D, Onyango AA, Njuguna P, Chilengi R, Akoo P, Kerubo C, Gitaka J, Maingi C, Lang T, Olotu A, Tsofa B, Bejon P, Peshu N, Marsh K, Owusu-Agyei S, Asante KP, Osei-Kwakye K, Boahen O, Ayamba S, Kayan K, Owusu-Ofori R, Dosoo D, Asante I, Adjei G, Adjei G, Chandramohan D, Greenwood B, Lusingu J, Gesase S, Malabeja A, Abdul O, Kilavo H, Mahende C, Liheluka E, Lemnge M, Theander T, Drakeley C, Ansong D, Agbenyega T, Adjei S, Boateng HO, Rettig T, Bawa J, Sylverken J, Sambian D, Agyekum A, Owusu L, Martinson F, Hoffman I, Mvalo T, Kamthunzi P, Nkomo R, Msika A, Jumbe A, Chome N, Nyakuipa D, Chintedza J, Ballou WR, Bruls M, Cohen J, Guerra Y, Jongert E, Lapierre D, Leach A, Lievens M, Ofori-Anyinam O, Vekemans J, Carter T, Leboulleux D, Loucq C, Radford A, Savarese B, Schellenberg D, Sillman M, Vansadia P. PMID: 22007715.
      View in: PubMed   Mentions: 417     Fields:    Translation:HumansAnimalsCTClinical Trials
    36. Genetic structure of seventy cocoyam (Xanthosoma sagittifolium, Linn, Schott) accessions in Ghana based on RAPD. Hereditas. 2004; 140(2):123-8. Offei SK, Asante IK, Danquah EY. PMID: 15061789.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
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