Gianluca Lazzi

Title(s)Provost Professor of Ophthalmology and Electrical Engineering
SchoolKeck School of Medicine of USC
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    Collapse Biography 
    Collapse Education and Training
    University of Rome "La Sapienza", Rome, ITDr. Eng.1994Electronic Engineering
    University of Utah, Salt Lake City, UTPhD1998Electrical Engineering
    IE Business School, Madrid ESPMBA2015Business Administration
    Collapse Awards and Honors
    Bioelectromagnetics Society1996Curtis Carl Johnson Memorial Award
    International Union of Radio Science1996Young Investigator Award
    National Science Foundation2001Career Award
    The Whitaker Foundation Biomedical Engineering Grant2001Young Investigator Award
    North Carolina State University2003Outstanding Teacher Award
    North Carolina State University2003Alumni Outstanding Teacher Award
    North Carolina State University2003ALCOA Foundation Engineering Research Achievement Award
    North Carolina State University2003Featured Achiever, College of Engineering
    IEEE Trans.2005IEEE H.A. Wheeler Award for the best paper published
    IEEE Trans.2006IEEE H.A. Wheeler Award for best paper published
    IEEE GLOBECOM2008Best Paper Award
    IEEE2008Fellow, "Contributions to Bioelectromagnetics and Implantable Devices"
    North Carolina State University2009ALCOA Foundation Distinguished Engineering Research Achievement Award
    R&D Magazine2009R&D 100 Award and Editor's Choice Award
    AIMBE2015Fellow, "Contributions to Bioelectromagnetics and Design of Bioelectrical Implantable Devices"

    Collapse Overview 
    Collapse Overview
    Over the past 25 years, Gianluca Lazzi, PhD, has focused his research on biomedical electromagnetics, with particular interest to the application to wireless and biomedical devices. In the early stages of his career, he focused on understanding the interaction between electromagnetic fields and biological tissue, with particular interest in the potential hazards to the human body due to devices radiating or inducing electromagnetic fields in tissue. Lazzi's research contributed to define the computational methods that could be reliably used to assess the Specific Absorption Rate of power, or SAR, induced by wireless devices in the human body: this work directly impacted the acceptance of computational methods to demonstrate that wireless devices previously fulfilled IEEE safety standards prior to being marketed.

    The computational and experimental methods that Lazzi and his team developed progressively shifted to be used for medical device applications, and in particular an artificial retina to restore partial vision to the blind and hippocampal prosthesis. Lazzi has also been recognized for multiscale computational methods to calculate the electromagnetic distribution in neural tissue for optimization of neurostimulators, human body models for the safety assessment of wireless biomedical devices, implantable microantennas for high-data rate wireless biomedical devices, novel coils for wireless telemetry systems, methods for the minimization of the temperature increase in the human body due to implantable devices, and methods to optimize electrode shape and size for neurosimulators. For nearly 20 years, Lazzi and his team have been part of a team dedicated to the development a retinal prosthesis to restore partial vision to the blind, in collaboration with the company Second Sight Medical Products, Inc. He also been part of an NSF supported Engineering Research Center (ERC) on Biomimetic Devices led by the University of Southern California. Lazzi's contributions in the field of implantable devices have been recognized with the election as AIMBE Fellow for “contributions to bioelectromagnetics and design of bioelectrical implantable devices,” election as a IEEE Fellow for “contributions to Bioelectromagnetics and implantable devices,” the IEEE Wheeler Best paper Award for a manuscript on the invention of microwave microantennas for implantable devices, and a R&D100 Award in 2009 for one of the 100 most significant inventions of 2009 (artificial retina). His team recently presented research on neuroprosthetics and multiscale modeling at the IEEE Grand Challenges in Life Science Symposium at the National Academies: parts of this inspired a position paper on the future grand challenges in life science published in IEEE Trans. on Biomedical Engineering, jointly prepared by all the presenters.

    Collapse Research 
    Collapse Research Activities and Funding
    Connectomes and Computational Models of Degenerated Retina for Retinal Prosthetic Design
    NIH/NEI R21EY028744Apr 1, 2018 - Mar 31, 2020
    Role: Principal Investigator
    NIH/NIBIB U01EB025830Sep 15, 2012 - May 31, 2022
    Role: Principal Investigator
    Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
    NIH/NIGMS U01GM104604Sep 15, 2012 - Aug 31, 2017
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Karageorgos G, Andreadis I, Psychas K, Mourkousis G, Kiourti A, Lazzi G, Nikita KS. The Promise of Mobile Technologies for the Health Care System in the Developing World: A Systematic Review. IEEE Rev Biomed Eng. 2018 Sep 05. PMID: 30188840.
      View in: PubMed
    2. Loizos K, Marc R, Humayun M, Anderson JR, Jones BW, Lazzi G. Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model. IEEE Trans Neural Syst Rehabil Eng. 2018 Jun; 26(6):1111-1120. PMID: 29877835.
      View in: PubMed
    3. Bingham CS, Loizos K, Yu GJ, Gilbert A, Bouteiller JC, Song D, Lazzi G, Berger TW. Model-Based Analysis of Electrode Placement and Pulse Amplitude for Hippocampal Stimulation. IEEE Trans Biomed Eng. 2018 Oct; 65(10):2278-2289. PMID: 29993519.
      View in: PubMed
    4. Bingham CS, Loizos K, Gilbert A, Bouteiller JM, Lazzi G, Berger TW. A large-scale detailed neuronal model of electrical stimulation of the dentate gyrus and perforant path as a platform for electrode design and optimization. Conf Proc IEEE Eng Med Biol Soc. 2016 08; 2016:2794-2797. PMID: 28268898.
      View in: PubMed
    5. Loizos K, RamRakhyani AK, Anderson J, Marc R, Lazzi G. On the computation of a retina resistivity profile for applications in multi-scale modeling of electrical stimulation and absorption. Phys Med Biol. 2016 06 21; 61(12):4491-505. PMID: 27223656.
      View in: PubMed
    6. Loizos K, Cela C, Marc R, Lazzi G. Virtual electrode design for increasing spatial resolution in retinal prosthesis. Healthc Technol Lett. 2016 Jun; 3(2):93-7. PMID: 27382477; PMCID: PMC4916480 [Available on 04/27/17].
    7. Kagan ZB, RamRakhyani AK, Lazzi G, Normann RA, Warren DJ. In Vivo Magnetic Stimulation of Rat Sciatic Nerve With Centimeter- and Millimeter-Scale Solenoid Coils. IEEE Trans Neural Syst Rehabil Eng. 2016 11; 24(11):1138-1147. PMID: 27019496.
      View in: PubMed
    8. RamRakhyani AK, Kagan ZB, Warren DJ, Normann RA, Lazzi G. A µm-Scale Computational Model of Magnetic Neural Stimulation in Multifascicular Peripheral Nerves. IEEE Trans Biomed Eng. 2015 Dec; 62(12):2837-49. PMID: 26087483.
      View in: PubMed
    9. Gilbert A, Loizos K, RamRakhyani AK, Hendrickson P, Lazzi G, Berger TW. A 3-D admittance-level computational model of a rat hippocampus for improving prosthetic design. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:2295-8. PMID: 26736751; PMCID: PMC4877026.
    10. RamRakhyani AK, Lazzi G. Ferrite core non-linearity in coils for magnetic neurostimulation. Healthc Technol Lett. 2014 Oct; 1(4):87-91. PMID: 26609390; PMCID: PMC4614077 [Available on 12/16/15].
    11. RamRakhyani AK, Lazzi G. Multi-coil approach to reduce electromagnetic energy absorption for wirelessly powered implants. Healthc Technol Lett. 2014 Jan; 1(1):21-5. PMID: 26609371; PMCID: PMC4614348.
    12. Kagan ZB, RamRakhyani AK, Khan F, Lazzi G, Normann RA, Warren DJ. Magnetic stimulation of mammalian peripheral nerves in vivo: an alternative to functional electrical stimulation. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:2573-6. PMID: 25570516.
      View in: PubMed
    13. RamRakhyani AK, Kagan ZB, Khan F, Warren DJ, Normann RA, Lazzi G. A µm-resolution heterogeneous tissue model for the magnetic stimulation of multifascicular sciatic nerve. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:5679-82. PMID: 25571284.
      View in: PubMed
    14. Loizos K, Lazzi G, Lauritzen JS, Anderson J, Jones BW, Marc R. A multi-scale computational model for the study of retinal prosthetic stimulation. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:6100-3. PMID: 25571389; PMCID: PMC4490688.
    15. He B, Baird R, Butera R, Datta A, George S, Hecht B, Hero A, Lazzi G, Lee RC, Liang J, Neuman M, Peng GC, Perreault EJ, Ramasubramanian M, Wang MD, Wikswo J, Yang GZ, Zhang YT. Grand challenges in interfacing engineering with life sciences and medicine. IEEE Trans Biomed Eng. 2013 Mar; 60(3):589-98. PMID: 23380847.
      View in: PubMed
    16. Xie J, Wang GJ, Yow L, Humayun MS, Weiland JD, Cela CJ, Jadvar H, Lazzi G, Dhrami-Gavazi E, Tsang SH. Preservation of retinotopic map in retinal degeneration. Exp Eye Res. 2012 May; 98:88-96. PMID: 22685713; PMCID: PMC4310463.
    17. Cela CJ, Lee RC, Lazzi G. Modeling cellular lysis in skeletal muscle due to electric shock. IEEE Trans Biomed Eng. 2011 May; 58(5):1286-93. PMID: 21216705.
      View in: PubMed
    18. Xie J, Wang GJ, Yow L, J Cela C, Humayun MS, Weiland JD, Lazzi G, Jadvar H. Modeling and percept of transcorneal electrical stimulation in humans. IEEE Trans Biomed Eng. 2011 Jul; 58(7):1932-9. PMID: 20952323.
      View in: PubMed
    19. Lazzi G. Thermal effects of bioimplants. IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):75-81. PMID: 16248120.
      View in: PubMed
    20. Gosalia K, Weiland J, Humayun M, Lazzi G. Thermal elevation in the human eye and head due to the operation of a retinal prosthesis. IEEE Trans Biomed Eng. 2004 Aug; 51(8):1469-77. PMID: 15311834.
      View in: PubMed
    21. Eberdt M, Brown PK, Lazzi G. Two-dimensional SPICE-linked multiresolution impedance method for low-frequency electromagnetic interactions. IEEE Trans Biomed Eng. 2003 Jul; 50(7):881-9. PMID: 12848356.
      View in: PubMed
    22. Margalit E, Maia M, Weiland JD, Greenberg RJ, Fujii GY, Torres G, Piyathaisere DV, O'Hearn TM, Liu W, Lazzi G, Dagnelie G, Scribner DA, de Juan E, Humayun MS. Retinal prosthesis for the blind. Surv Ophthalmol. 2002 Jul-Aug; 47(4):335-56. PMID: 12161210.
      View in: PubMed