Gianluca Lazzi

Title(s)Provost Professor of Ophthalmology, Electrical Engineering, Clinical Entrepreneurship and Biomedical Engineering
SchoolKeck School of Medicine of Usc
AddressStevens Hall Institute
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Fred H. Cole Professorship in Engineering

    Title(s)Director, Institute for Technology and Medical Systems (ITEMS)

    Title(s)Director for Bioengineering Mentorship

    Collapse Biography 
    Collapse Education and Training
    University of Rome "La Sapienza", Rome, ITDr. Eng.1994Electronic Engineering
    University of Utah, Salt Lake City, UTPhD1998Electrical Engineering
    IE Business School, Madrid ESPMBA2015Business Administration
    Collapse Awards and Honors
    Bioelectromagnetics Society1996Curtis Carl Johnson Memorial Award
    International Union of Radio Science1996Young Investigator Award
    National Science Foundation2001Career Award
    The Whitaker Foundation Biomedical Engineering Grant2001Young Investigator Award
    North Carolina State University2003Outstanding Teacher Award
    North Carolina State University2003Alumni Outstanding Teacher Award
    North Carolina State University2003ALCOA Foundation Engineering Research Achievement Award
    North Carolina State University2003Featured Achiever, College of Engineering
    IEEE Trans.2005IEEE H.A. Wheeler Award for the best paper published
    IEEE Trans.2006IEEE H.A. Wheeler Award for best paper published
    IEEE GLOBECOM2008Best Paper Award
    IEEE2008Fellow, "Contributions to Bioelectromagnetics and Implantable Devices"
    North Carolina State University2009ALCOA Foundation Distinguished Engineering Research Achievement Award
    R&D Magazine2009R&D 100 Award and Editor's Choice Award
    AIMBE2015Fellow, "Contributions to Bioelectromagnetics and Design of Bioelectrical Implantable Devices"

    Collapse Overview 
    Collapse Overview
    Over the past 25 years, Gianluca Lazzi, PhD, has focused his research on biomedical electromagnetics, with particular interest to the application to wireless and biomedical devices. In the early stages of his career, he focused on understanding the interaction between electromagnetic fields and biological tissue, with particular interest in the potential hazards to the human body due to devices radiating or inducing electromagnetic fields in tissue. Lazzi's research contributed to define the computational methods that could be reliably used to assess the Specific Absorption Rate of power, or SAR, induced by wireless devices in the human body: this work directly impacted the acceptance of computational methods to demonstrate that wireless devices previously fulfilled IEEE safety standards prior to being marketed.

    The computational and experimental methods that Lazzi and his team developed progressively shifted to be used for medical device applications, and in particular an artificial retina to restore partial vision to the blind and hippocampal prosthesis. Lazzi has also been recognized for multiscale computational methods to calculate the electromagnetic distribution in neural tissue for optimization of neurostimulators, human body models for the safety assessment of wireless biomedical devices, implantable microantennas for high-data rate wireless biomedical devices, novel coils for wireless telemetry systems, methods for the minimization of the temperature increase in the human body due to implantable devices, and methods to optimize electrode shape and size for neurosimulators. For nearly 20 years, Lazzi and his team have been part of a team dedicated to the development a retinal prosthesis to restore partial vision to the blind, in collaboration with the company Second Sight Medical Products, Inc. He also been part of an NSF supported Engineering Research Center (ERC) on Biomimetic Devices led by the University of Southern California. Lazzi's contributions in the field of implantable devices have been recognized with the election as AIMBE Fellow for “contributions to bioelectromagnetics and design of bioelectrical implantable devices,” election as a IEEE Fellow for “contributions to Bioelectromagnetics and implantable devices,” the IEEE Wheeler Best paper Award for a manuscript on the invention of microwave microantennas for implantable devices, and a R&D100 Award in 2009 for one of the 100 most significant inventions of 2009 (artificial retina). His team recently presented research on neuroprosthetics and multiscale modeling at the IEEE Grand Challenges in Life Science Symposium at the National Academies: parts of this inspired a position paper on the future grand challenges in life science published in IEEE Trans. on Biomedical Engineering, jointly prepared by all the presenters.

    Collapse Research 
    Collapse Research Activities and Funding
    CRCNS: US-Spain Research Proposal: Computational Modeling of PNS Stimulation
    NIH R01EB029271Sep 1, 2019 - May 31, 2022
    Role: Principal Investigator
    Connectomes and Computational Models of Degenerated Retina for Retinal Prosthetic Design
    NIH R21EY028744Apr 1, 2018 - Mar 31, 2021
    Role: Principal Investigator
    NIH U01EB025830Sep 15, 2012 - May 31, 2022
    Role: Principal Investigator
    Predictive modeling of bioelectric activity on mammalian multilayered neuronal st
    NIH U01GM104604Sep 15, 2012 - Aug 31, 2018
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Selective Activation of Retinal Ganglion Cell Subtypes Through Targeted Electrical Stimulation Parameters. IEEE Trans Neural Syst Rehabil Eng. 2022; 30:350-359. Paknahad J, Humayun M, Lazzi G. PMID: 35130164; PMCID: PMC8904155.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    2. Mechanisms underlying activation of retinal bipolar cells through targeted electrical stimulation: a computational study. J Neural Eng. 2021 12 15; 18(6). Paknahad J, Kosta P, Bouteiller JC, Humayun MS, Lazzi G. PMID: 34826830; PMCID: PMC8765079.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    3. Electrode Spacing and Current Distribution in Electrical Stimulation of Peripheral Nerve: A Computational Modeling Study using Realistic Nerve Models. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:4416-4419. Du J, Morales A, Paknahad J, Kosta P, Bouteiller JC, Fernandez E, Lazzi G. PMID: 34892199.
      View in: PubMed   Mentions:    Fields:    
    4. A Computational Model Simulates Light-Evoked Responses in the Retinal Cone Pathway. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:4482-4486. Iseri E, Kosta P, Paknahad J, Bouteiller JC, Lazzi G. PMID: 34892214.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    5. Modeling ON Cone Bipolar Cells for Electrical Stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:6547-6550. Paknahad J, Kosta P, Iseri E, Farzad S, Bouteiller JC, Humayun MS, Lazzi G. PMID: 34892609; PMCID: PMC8754156.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    6. On the Design of an Efficient Inductive Wireless Power Transfer for Passive Neurostimulation Systems. Annu Int Conf IEEE Eng Med Biol Soc. 2021 11; 2021:7497-7501. Machnoor M, Shao X, Paknahad J, Humayun M, Lazzi G. PMID: 34892827.
      View in: PubMed   Mentions:    Fields:    
    7. Publisher Correction: Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation. Sci Rep. 2021 Jun 14; 11(1):12855. Paknahad J, Loizos K, Yue L, Humayun MS, Lazzi G. PMID: 34127749; PMCID: PMC8203640.
      View in: PubMed   Mentions:    Fields:    
    8. Model-based comparison of current flow in rod bipolar cells of healthy and early-stage degenerated retina. Exp Eye Res. 2021 06; 207:108554. Kosta P, Iseri E, Loizos K, Paknahad J, Pfeiffer RL, Sigulinsky CL, Anderson JR, Jones BW, Lazzi G. PMID: 33794197; PMCID: PMC8187309.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    9. Color and cellular selectivity of retinal ganglion cell subtypes through frequency modulation of electrical stimulation. Sci Rep. 2021 03 04; 11(1):5177. Paknahad J, Loizos K, Yue L, Humayun MS, Lazzi G. PMID: 33664347; PMCID: PMC7933163.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    10. Simulation-Based Optimization of Figure-of-Eight Coil Designs and Orientations for Magnetic Stimulation of Peripheral Nerve. IEEE Trans Neural Syst Rehabil Eng. 2020 12; 28(12):2901-2913. Kosta P, Mize J, Warren DJ, Lazzi G. PMID: 33201821.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    11. Targeted Stimulation of Retinal Ganglion Cells in Epiretinal Prostheses: A Multiscale Computational Study. IEEE Trans Neural Syst Rehabil Eng. 2020 11; 28(11):2548-2556. Paknahad J, Loizos K, Humayun M, Lazzi G. PMID: 32991284; PMCID: PMC7737501.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    12. Admittance Method for Estimating Local Field Potentials Generated in a Multi-Scale Neuron Model of the Hippocampus. Front Comput Neurosci. 2020; 14:72. Bingham CS, Paknahad J, Girard CBC, Loizos K, Bouteiller JC, Song D, Lazzi G, Berger TW. PMID: 32848687; PMCID: PMC7417331.
      View in: PubMed   Mentions: 5  
    13. Responsiveness of Retinal Ganglion Cells Through Frequency Modulation of Electrical Stimulation: A Computational Modeling Study. Annu Int Conf IEEE Eng Med Biol Soc. 2020 07; 2020:3393-3398. Paknahad J, Loizos K, Humayun M, Lazzi G. PMID: 33018732; PMCID: PMC7997733.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    14. Stimulus waveform design for decreasing charge and increasing stimulation selectivity in retinal prostheses. Healthc Technol Lett. 2020 Jun; 7(3):66-71. Kosta P, Loizos K, Lazzi G. PMID: 32754340; PMCID: PMC7353818.
      View in: PubMed   Mentions: 5  
    15. ROOTS: An Algorithm to Generate Biologically Realistic Cortical Axons and an Application to Electroceutical Modeling. Front Comput Neurosci. 2020; 14:13. Bingham CS, Mergenthal A, Bouteiller JC, Song D, Lazzi G, Berger TW. PMID: 32153379; PMCID: PMC7047217.
      View in: PubMed   Mentions: 2  
    16. Selective stimulation of rat sciatic nerve using an array of mm-size magnetic coils: a simulation study. Healthc Technol Lett. 2019 Jun; 6(3):70-75. Kosta P, Warren DJ, Lazzi G. PMID: 31341631; PMCID: PMC6595541.
      View in: PubMed   Mentions: 3  
    17. Reduced Heat Generation During Magnetic Stimulation of Rat Sciatic Nerve Using Current Waveform Truncation. IEEE Trans Neural Syst Rehabil Eng. 2019 05; 27(5):937-946. Kagan ZB, Mize JT, Kosta P, Lazzi G, Normann RA, Warren DJ. PMID: 30990431.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    18. The Promise of Mobile Technologies for the Health Care System in the Developing World: A Systematic Review. IEEE Rev Biomed Eng. 2019; 12:100-122. Karageorgos G, Andreadis I, Psychas K, Mourkousis G, Kiourti A, Lazzi G, Nikita KS. PMID: 30188840.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    19. Increasing Electrical Stimulation Efficacy in Degenerated Retina: Stimulus Waveform Design in a Multiscale Computational Model. IEEE Trans Neural Syst Rehabil Eng. 2018 06; 26(6):1111-1120. Loizos K, Marc R, Humayun M, Anderson JR, Jones BW, Lazzi G. PMID: 29877835; PMCID: PMC6005361.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    20. Model-Based Analysis of Electrode Placement and Pulse Amplitude for Hippocampal Stimulation. IEEE Trans Biomed Eng. 2018 10; 65(10):2278-2289. Bingham CS, Loizos K, Yu GJ, Gilbert A, Bouteiller JC, Song D, Lazzi G, Berger TW. PMID: 29993519; PMCID: PMC6224291.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    21. A large-scale detailed neuronal model of electrical stimulation of the dentate gyrus and perforant path as a platform for electrode design and optimization. Annu Int Conf IEEE Eng Med Biol Soc. 2016 Aug; 2016:2794-2797. Bingham CS, Loizos K, Gilbert A, Bouteiller JM, Lazzi G, Berger TW. PMID: 28268898.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. On the computation of a retina resistivity profile for applications in multi-scale modeling of electrical stimulation and absorption. Phys Med Biol. 2016 06 21; 61(12):4491-505. Loizos K, RamRakhyani AK, Anderson J, Marc R, Lazzi G. PMID: 27223656; PMCID: PMC4916774.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    23. Virtual electrode design for increasing spatial resolution in retinal prosthesis. Healthc Technol Lett. 2016 Jun; 3(2):93-7. Loizos K, Cela C, Marc R, Lazzi G. PMID: 27382477; PMCID: PMC4916480.
      View in: PubMed   Mentions: 5  
    24. In Vivo Magnetic Stimulation of Rat Sciatic Nerve With Centimeter- and Millimeter-Scale Solenoid Coils. IEEE Trans Neural Syst Rehabil Eng. 2016 11; 24(11):1138-1147. Kagan ZB, RamRakhyani AK, Lazzi G, Normann RA, Warren DJ. PMID: 27019496.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    25. A μm-Scale Computational Model of Magnetic Neural Stimulation in Multifascicular Peripheral Nerves. IEEE Trans Biomed Eng. 2015 Dec; 62(12):2837-49. RamRakhyani AK, Kagan ZB, Warren DJ, Normann RA, Lazzi G. PMID: 26087483.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    26. A 3-D admittance-level computational model of a rat hippocampus for improving prosthetic design. Annu Int Conf IEEE Eng Med Biol Soc. 2015; 2015:2295-8. Gilbert A, Loizos K, RamRakhyani AK, Hendrickson P, Lazzi G, Berger TW. PMID: 26736751; PMCID: PMC4877026.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    27. Ferrite core non-linearity in coils for magnetic neurostimulation. Healthc Technol Lett. 2014 Oct; 1(4):87-91. RamRakhyani AK, Lazzi G. PMID: 26609390; PMCID: PMC4614077.
      View in: PubMed   Mentions: 1  
    28. Multi-coil approach to reduce electromagnetic energy absorption for wirelessly powered implants. Healthc Technol Lett. 2014 Jan; 1(1):21-5. RamRakhyani AK, Lazzi G. PMID: 26609371; PMCID: PMC4613696.
      View in: PubMed   Mentions:
    29. A μm-resolution heterogeneous tissue model for the magnetic stimulation of multifascicular sciatic nerve. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:5679-82. RamRakhyani AK, Kagan ZB, Khan F, Warren DJ, Normann RA, Lazzi G. PMID: 25571284.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    30. Magnetic stimulation of mammalian peripheral nerves in vivo: an alternative to functional electrical stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:2573-6. Kagan ZB, RamRakhyani AK, Khan F, Lazzi G, Normann RA, Warren DJ. PMID: 25570516.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    31. A multi-scale computational model for the study of retinal prosthetic stimulation. Annu Int Conf IEEE Eng Med Biol Soc. 2014; 2014:6100-3. Loizos K, Lazzi G, Lauritzen JS, Anderson J, Jones BW, Marc R. PMID: 25571389; PMCID: PMC4490688.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    32. On the design of efficient multi-coil telemetry system for biomedical implants. IEEE Trans Biomed Circuits Syst. 2013 Feb; 7(1):11-23. Ramrakhyani AK, Lazzi G. PMID: 23853275.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    33. Grand challenges in interfacing engineering with life sciences and medicine. IEEE Trans Biomed Eng. 2013 Mar; 60(3):589-98. He B, Baird R, Butera R, Datta A, George S, Hecht B, Hero A, Lazzi G, Lee RC, Liang J, Neuman M, Peng GC, Perreault EJ, Ramasubramanian M, Wang MD, Wikswo J, Yang GZ, Zhang YT. PMID: 23380847.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    34. Preservation of retinotopic map in retinal degeneration. Exp Eye Res. 2012 May; 98:88-96. Xie J, Wang GJ, Yow L, Humayun MS, Weiland JD, Cela CJ, Jadvar H, Lazzi G, Dhrami-Gavazi E, Tsang SH. PMID: 22685713; PMCID: PMC4310463.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    35. Modeling cellular lysis in skeletal muscle due to electric shock. IEEE Trans Biomed Eng. 2011 May; 58(5):1286-93. Cela CJ, Lee RC, Lazzi G. PMID: 21216705.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. Modeling and percept of transcorneal electrical stimulation in humans. IEEE Trans Biomed Eng. 2011 Jul; 58(7):1932-9. Xie J, Wang GJ, Yow L, J Cela C, Humayun MS, Weiland JD, Lazzi G, Jadvar H. PMID: 20952323.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    37. Spatial characterization of electric potentials generated by pulsed microelectrode arrays. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:6243-6. Kandagor V, Cela CJ, Sanders CA, Greenbaum E, Lazzi G, Humayun MS, Zhou DM, Castro R, Gaikwad S, Little J. PMID: 21097346.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    38. On the thermal elevation of a 60-electrode epiretinal prosthesis for the blind. IEEE Trans Biomed Circuits Syst. 2008 Dec; 2(4):289-300. Singh V, Roy A, Castro R, McClure K, Dai R, Agrawal R, Greenberg RJ, Weiland JD, Humayun MS, Lazzi G. PMID: 23853132.
      View in: PubMed   Mentions: 3     Fields:    
    39. Thermal effects of bioimplants. IEEE Eng Med Biol Mag. 2005 Sep-Oct; 24(5):75-81. Lazzi G. PMID: 16248120.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimalsCells
    40. Thermal elevation in the human eye and head due to the operation of a retinal prosthesis. IEEE Trans Biomed Eng. 2004 Aug; 51(8):1469-77. Gosalia K, Weiland J, Humayun M, Lazzi G. PMID: 15311834.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    41. Two-dimensional SPICE-linked multiresolution impedance method for low-frequency electromagnetic interactions. IEEE Trans Biomed Eng. 2003 Jul; 50(7):881-9. Eberdt M, Brown PK, Lazzi G. PMID: 12848356.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansAnimals
    42. Retinal prosthesis for the blind. Surv Ophthalmol. 2002 Jul-Aug; 47(4):335-56. Margalit E, Maia M, Weiland JD, Greenberg RJ, Fujii GY, Torres G, Piyathaisere DV, O'Hearn TM, Liu W, Lazzi G, Dagnelie G, Scribner DA, de Juan E, Humayun MS. PMID: 12161210.
      View in: PubMed   Mentions: 60     Fields:    Translation:Humans
    43. Currents induced in anatomic models of the human for uniform and nonuniform power frequency magnetic fields. Bioelectromagnetics. 2001 Feb; 22(2):112-21. Gandhi OP, Kang G, Wu D, Lazzi G. PMID: 11180257.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    44. Comparison of numerical and experimental methods for determination of SAR and radiation patterns of handheld wireless telephones. Bioelectromagnetics. 1999; Suppl 4:93-101. Gandhi OP, Lazzi G, Tinniswood A, Yu QS. PMID: 10334718.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
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