Michael Bienkowski

Title(s)	Assistant Professor of Physiology and Neuroscience
School	Keck School of Medicine of Usc
Address	ZNI, 1501 San Pablo St. Health Sciences Campus Los Angeles CA 90033
Phone	+1 323 442 7246
ORCID	0000-0002-8231-8893
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Overview

Dr. Bienkowski is interested in characterizing brain cell types and understanding their susceptibility to neurodegenerative diseases like Alhzeimer's disease and retinal degenerative diseases. His translational research laboratory (USC Center for Integrative Connectomics) uses state-of-the-art connectomics and transcriptomics approaches to investigate cell type-specific progressive changes to gene expression and connectivity in rodent and human brain tissue. A major goal of the lab is to build translational cell type atlases to guide clinical drug development and enhance the effectiveness of treatment plans at progressive disease stages.

Websites

Laboratory of Neuro Imaging

Research

Research Activities and Funding

A Translational 3D Map of Hippocampal Cell Types To Drive Investigations of Alzheimer's Disease
NIH K01AG066847Aug 1, 2021 - Jul 31, 2026
Role: Principal Investigator

Alzheimer Disease Research Center
NIH P30AG066530Sep 1, 2020 - Feb 28, 2025
Role: Co-Principal Investigator

Structural and Functional Neural Network Mediating Fear Memory and PTSD
NIH F32MH107071Sep 16, 2015 - Sep 15, 2017
Role: Principal Investigator

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Bibliographic

Publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.

Altmetrics Details

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Machine Learning Classification of Alzheimer's Disease Pathology Reveals Diffuse Amyloid as a Major Predictor of Cognitive Impairment in Human Hippocampal Subregions. bioRxiv. 2023 Jun 05. Stephen TL, Korobkova L, Breningstall B, Nguyen K, Mehta S, Pachicano M, Jones KT, Hawes D, Cabeen RP, Bienkowski MS. PMID: 37333119; PMCID: PMC10274752.

View in: PubMed Mentions:
Further refining the boundaries of the hippocampus CA2 with gene expression and connectivity: Potential subregions and heterogeneous cell types. Hippocampus. 2023 03; 33(3):150-160. Bienkowski MS. PMID: 36786207; PMCID: PMC9987718.

View in: PubMed Mentions: 2 Fields:
Bra Brain
Translation:Animals
Cellular anatomy of the mouse primary motor cortex. Nature. 2021 10; 598(7879):159-166. Muñoz-Castañeda R, Zingg B, Matho KS, Chen X, Wang Q, Foster NN, Li A, Narasimhan A, Hirokawa KE, Huo B, Bannerjee S, Korobkova L, Park CS, Park YG, Bienkowski MS, Chon U, Wheeler DW, Li X, Wang Y, Naeemi M, Xie P, Liu L, Kelly K, An X, Attili SM, Bowman I, Bludova A, Cetin A, Ding L, Drewes R, D'Orazi F, Elowsky C, Fischer S, Galbavy W, Gao L, Gillis J, Groblewski PA, Gou L, Hahn JD, Hatfield JT, Hintiryan H, Huang JJ, Kondo H, Kuang X, Lesnar P, Li X, Li Y, Lin M, Lo D, Mizrachi J, Mok S, Nicovich PR, Palaniswamy R, Palmer J, Qi X, Shen E, Sun YC, Tao HW, Wakemen W, Wang Y, Yao S, Yuan J, Zhan H, Zhu M, Ng L, Zhang LI, Lim BK, Hawrylycz M, Gong H, Gee JC, Kim Y, Chung K, Yang XW, Peng H, Luo Q, Mitra PP, Zador AM, Zeng H, Ascoli GA, Josh Huang Z, Osten P, Harris JA, Dong HW. PMID: 34616071; PMCID: PMC8494646.

View in: PubMed Mentions: 44 Fields:
Sci Science
Translation:Animals Cells
The mouse cortico-basal ganglia-thalamic network. Nature. 2021 10; 598(7879):188-194. Foster NN, Barry J, Korobkova L, Garcia L, Gao L, Becerra M, Sherafat Y, Peng B, Li X, Choi JH, Gou L, Zingg B, Azam S, Lo D, Khanjani N, Zhang B, Stanis J, Bowman I, Cotter K, Cao C, Yamashita S, Tugangui A, Li A, Jiang T, Jia X, Feng Z, Aquino S, Mun HS, Zhu M, Santarelli A, Benavidez NL, Song M, Dan G, Fayzullina M, Ustrell S, Boesen T, Johnson DL, Xu H, Bienkowski MS, Yang XW, Gong H, Levine MS, Wickersham I, Luo Q, Hahn JD, Lim BK, Zhang LI, Cepeda C, Hintiryan H, Dong HW. PMID: 34616074; PMCID: PMC8494639.

View in: PubMed Mentions: 52 Fields:
Sci Science
Translation:Animals Cells
Organization of the inputs and outputs of the mouse superior colliculus. Nat Commun. 2021 06 28; 12(1):4004. Benavidez NL, Bienkowski MS, Zhu M, Garcia LH, Fayzullina M, Gao L, Bowman I, Gou L, Khanjani N, Cotter KR, Korobkova L, Becerra M, Cao C, Song MY, Zhang B, Yamashita S, Tugangui AJ, Zingg B, Rose K, Lo D, Foster NN, Boesen T, Mun HS, Aquino S, Wickersham IR, Ascoli GA, Hintiryan H, Dong HW. PMID: 34183678; PMCID: PMC8239028.

View in: PubMed Mentions: 23 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Connectivity characterization of the mouse basolateral amygdalar complex. Nat Commun. 2021 05 17; 12(1):2859. Hintiryan H, Bowman I, Johnson DL, Korobkova L, Zhu M, Khanjani N, Gou L, Gao L, Yamashita S, Bienkowski MS, Garcia L, Foster NN, Benavidez NL, Song MY, Lo D, Cotter KR, Becerra M, Aquino S, Cao C, Cabeen RP, Stanis J, Fayzullina M, Ustrell SA, Boesen T, Tugangui AJ, Zhang ZG, Peng B, Fanselow MS, Golshani P, Hahn JD, Wickersham IR, Ascoli GA, Zhang LI, Dong HW. PMID: 34001873; PMCID: PMC8129205.

View in: PubMed Mentions: 29 Fields:
Bio Biology Sci Science
Translation:Animals Cells
Homologous laminar organization of the mouse and human subiculum. Sci Rep. 2021 02 12; 11(1):3729. Bienkowski MS, Sepehrband F, Kurniawan ND, Stanis J, Korobkova L, Khanjani N, Clark K, Hintiryan H, Miller CA, Dong HW. PMID: 33580088; PMCID: PMC7881248.

View in: PubMed Mentions: 3 Fields:
Sci Science
Translation:Humans Animals Cells
An open access mouse brain flatmap and upgraded rat and human brain flatmaps based on current reference atlases. J Comp Neurol. 2021 02; 529(3):576-594. Hahn JD, Swanson LW, Bowman I, Foster NN, Zingg B, Bienkowski MS, Hintiryan H, Dong HW. PMID: 32511750; PMCID: PMC7721992.

View in: PubMed Mentions: 10 Fields:
Neu Neurology
Translation:Humans Animals
Precise segmentation of densely interweaving neuron clusters using G-Cut. Nat Commun. 2019 04 04; 10(1):1549. Li R, Zhu M, Li J, Bienkowski MS, Foster NN, Xu H, Ard T, Bowman I, Zhou C, Veldman MB, Yang XW, Hintiryan H, Zhang J, Dong HW. PMID: 30948706; PMCID: PMC6449501.

View in: PubMed Mentions: 16 Fields:
Bio Biology Sci Science
Translation:Cells
Extrastriate connectivity of the mouse dorsal lateral geniculate thalamic nucleus. J Comp Neurol. 2019 05 15; 527(9):1419-1442. Bienkowski MS, Benavidez NL, Wu K, Gou L, Becerra M, Dong HW. PMID: 30620046; PMCID: PMC6992387.

View in: PubMed Mentions: 5 Fields:
Neu Neurology
Translation:Animals Cells
Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks. Nat Neurosci. 2018 11; 21(11):1628-1643. Bienkowski MS, Bowman I, Song MY, Gou L, Ard T, Cotter K, Zhu M, Benavidez NL, Yamashita S, Abu-Jaber J, Azam S, Lo D, Foster NN, Hintiryan H, Dong HW. PMID: 30297807; PMCID: PMC6398347.

View in: PubMed Mentions: 73 Fields:
Neu Neurology
Translation:Animals Cells
The mouse cortico-striatal projectome. Nat Neurosci. 2016 08; 19(8):1100-14. Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW. PMID: 27322419; PMCID: PMC5564682.

View in: PubMed Mentions: 208 Fields:
Neu Neurology
Translation:Animals
Neural networks of the mouse neocortex. Cell. 2014 Feb 27; 156(5):1096-111. Zingg B, Hintiryan H, Gou L, Song MY, Bay M, Bienkowski MS, Foster NN, Yamashita S, Bowman I, Toga AW, Dong HW. PMID: 24581503; PMCID: PMC4169118.

View in: PubMed Mentions: 336 Fields:
Cel Cell Biology
Translation:Animals
Organization of multisynaptic circuits within and between the medial and the central extended amygdala. J Comp Neurol. 2013 Oct 15; 521(15):3406-31. Bienkowski MS, Wendel ES, Rinaman L. PMID: 23640841; PMCID: PMC3969337.

View in: PubMed Mentions: 7 Fields:
Neu Neurology
Translation:Animals Cells
Common and distinct neural inputs to the medial central nucleus of the amygdala and anterior ventrolateral bed nucleus of stria terminalis in rats. Brain Struct Funct. 2013 Jan; 218(1):187-208. Bienkowski MS, Rinaman L. PMID: 22362201; PMCID: PMC3662982.

View in: PubMed Mentions: 37 Fields:
Bra Brain
Translation:Animals Cells
Immune challenge activates neural inputs to the ventrolateral bed nucleus of the stria terminalis. Physiol Behav. 2011 Aug 03; 104(2):257-65. Bienkowski MS, Rinaman L. PMID: 21402087; PMCID: PMC3118915.

View in: PubMed Mentions: 9 Fields:
Beh Behavioral Sciences Phy Physiology Psy Psychophysiology
Translation:Animals Cells
Noradrenergic inputs to the paraventricular hypothalamus contribute to hypothalamic-pituitary-adrenal axis and central Fos activation in rats after acute systemic endotoxin exposure. Neuroscience. 2008 Oct 28; 156(4):1093-102. Bienkowski MS, Rinaman L. PMID: 18773942; PMCID: PMC2614295.

View in: PubMed Mentions: 41 Fields:
Neu Neurology
Translation:Animals Cells