Huizhong Tao, PhD

Title(s)Associate Professor of Physiology and Neuroscience
SchoolKeck School of Medicine of USC
Phone+1 323 442 2426
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    Collapse Research 
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    Cell atlas of mouse brain-spinal cord connectome
    NIH/NIMH U01MH116990Sep 1, 2018 - May 31, 2023
    Role: Co-Principal Investigator
    Synaptic circuitry mechanisms underlying functional development of visual cortex
    NIH/NEI R01EY025722Aug 1, 2015 - Jul 31, 2018
    Role: Principal Investigator
    Inhibitory circuitry mechanisms underlying visual cortical development and plasti
    NIH/NEI R21EY022478May 1, 2012 - Apr 30, 2014
    Role: Principal Investigator
    Cortical Synaptic Circuitry Underlying Visual Processing
    NIH/NEI R01EY019049Sep 30, 2008 - Apr 30, 2022
    Role: Principal Investigator
    Receptive field properties of GABAergic neurons in mouse visual cortex
    NIH/NEI R21EY018718Dec 1, 2007 - Nov 30, 2010
    Role: Principal Investigator
    Stimulus-timing-dependent visual cortical plasticity
    NIH/NEI F32EY015019Sep 1, 2003 - Jul 31, 2004
    Role: Principal Investigator

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu X, An H, Zhang D, Tao H, Dou Y, Li X, Huang J, Zhang J. A self-illuminating nanoparticle for inflammation imaging and cancer therapy. Sci Adv. 2019 Jan; 5(1):eaat2953. PMID: 30662940.
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    2. Sun YJ, Liu BH, Tao HW, Zhang LI. Selective Strengthening of Intracortical Excitatory Input Leads to Receptive Field Refinement during Auditory Cortical Development. J Neurosci. 2019 Feb 13; 39(7):1195-1205. PMID: 30587538.
      View in: PubMed
    3. Cheng J, Zhang R, Li C, Tao H, Dou Y, Wang Y, Hu H, Zhang J. A Targeting Nanotherapy for Abdominal Aortic Aneurysms. J Am Coll Cardiol. 2018 Nov 27; 72(21):2591-2605. PMID: 30466517.
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    4. Liang F, Li H, Chou XL, Zhou M, Zhang NK, Xiao Z, Zhang KK, Tao HW, Zhang LI. Sparse Representation in Awake Auditory Cortex: Cell-type Dependence, Synaptic Mechanisms, Developmental Emergence, and Modulation. Cereb Cortex. 2018 Oct 11. PMID: 30307493.
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    5. Zingg B, Dong HW, Tao HW, Zhang LI. Input-output organization of the mouse claustrum. J Comp Neurol. 2018 Oct 15; 526(15):2428-2443. PMID: 30252130.
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    6. Ibrahim LA, Huang JJ, Wang SZ, Kim YJ, Zhang LI, Tao HW. Sparse Labeling and Neural Tracing in Brain Circuits by STARS Strategy: Revealing Morphological Development of Type II Spiral Ganglion Neurons. Cereb Cortex. 2018 Aug 28. PMID: 30169555.
      View in: PubMed
    7. Zhang GW, Shen L, Zhong W, Xiong Y, Zhang LI, Tao HW. Transforming Sensory Cues into Aversive Emotion via Septal-Habenular Pathway. Neuron. 2018 Sep 05; 99(5):1016-1028.e5. PMID: 30122379.
      View in: PubMed
    8. Li L, Guo J, Wang Y, Xiong X, Tao H, Li J, Jia Y, Hu H, Zhang J. A Broad-Spectrum ROS-Eliminating Material for Prevention of Inflammation and Drug-Induced Organ Toxicity. Adv Sci (Weinh). 2018 Oct; 5(10):1800781. PMID: 30356945.
      View in: PubMed
    9. Li H, Liang F, Zhong W, Yan L, Mesik L, Xiao Z, Tao HW, Zhang LI. Synaptic Mechanisms for Bandwidth Tuning in Awake Mouse Primary Auditory Cortex. Cereb Cortex. 2018 Jul 12. PMID: 30010857.
      View in: PubMed
    10. Li YT, Fang Q, Zhang LI, Tao HW. Spatial Asymmetry and Short-Term Suppression Underlie Direction Selectivity of Synaptic Excitation in the Mouse Visual Cortex. Cereb Cortex. 2018 Jun 01; 28(6):2059-2070. PMID: 28498898.
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    11. Han S, Chen S, Li L, Li J, An H, Tao H, Jia Y, Lu S, Wang R, Zhang J. Multiscale and Multifunctional Emulsions by Host-Guest Interaction-Mediated Self-Assembly. ACS Cent Sci. 2018 May 23; 4(5):600-605. PMID: 29806006.
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    12. Chou XL, Wang X, Zhang ZG, Shen L, Zingg B, Huang J, Zhong W, Mesik L, Zhang LI, Tao HW. Inhibitory gain modulation of defense behaviors by zona incerta. Nat Commun. 2018 03 20; 9(1):1151. PMID: 29559622.
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    13. Han S, An H, Tao H, Li L, Qi Y, Ma Y, Li X, Wang R, Zhang J. Advanced emulsions via noncovalent interaction-mediated interfacial self-assembly. Chem Commun (Camb). 2018 Mar 28; 54(25):3174-3177. PMID: 29528077.
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    14. Wang Y, Liu G, Gao X, Zhao Z, Li L, Chen W, Tao H, Yu B, Lin P. Prognostic Value of Type D Personality for In-stent Restenosis in Coronary Artery Disease Patients Treated With Drug-Eluting Stent. Psychosom Med. 2018 01; 80(1):95-102. PMID: 28938244.
      View in: PubMed
    15. Zhang GW, Sun WJ, Zingg B, Shen L, He J, Xiong Y, Tao HW, Zhang LI. A Non-canonical Reticular-Limbic Central Auditory Pathway via Medial Septum Contributes to Fear Conditioning. Neuron. 2018 Jan 17; 97(2):406-417.e4. PMID: 29290554.
      View in: PubMed
    16. Chen G, Zhang Y, Li X, Zhao X, Ye Q, Lin Y, Tao HW, Rasch MJ, Zhang X. Distinct Inhibitory Circuits Orchestrate Cortical beta and gamma Band Oscillations. Neuron. 2017 Dec 20; 96(6):1403-1418.e6. PMID: 29268099.
      View in: PubMed
    17. Liu X, Xiang X, Tao H, Cui Z, Zhang L. [Chemical agents modulating bacterial biofilm formation and development]. Sheng Wu Gong Cheng Xue Bao. 2017 Sep 25; 33(9):1433-1465. PMID: 28956393.
      View in: PubMed
    18. Xiang X, Liu X, Tao H, Cui Z, Zhang L. [Progress in c-di-GMP inhibitors]. Sheng Wu Gong Cheng Xue Bao. 2017 Sep 25; 33(9):1466-1477. PMID: 28956394.
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    19. Fang Q, Tao HW. Direction selectivity starts early. Nat Neurosci. 2017 Jun 27; 20(7):899-901. PMID: 28653688.
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    20. Lin P, Li L, Wang Y, Zhao Z, Liu G, Chen W, Tao H, Gao X. Type D personality, but not Type A behavior pattern, is associated with coronary plaque vulnerability. Psychol Health Med. 2018 Feb; 23(2):216-223. PMID: 28635311.
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    21. Tao C, Zhang G, Zhou C, Wang L, Yan S, Tao HW, Zhang LI, Zhou Y, Xiong Y. Diversity in Excitation-Inhibition Mismatch Underlies Local Functional Heterogeneity in the Rat Auditory Cortex. Cell Rep. 2017 04 18; 19(3):521-531. PMID: 28423316.
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    22. Xu Q, Zhang L, Hao C, Jiang W, Tao H, Sun H, Huang L, Zhou J, Fan L. Prediction of Bronchial Mucus Plugs Formation in Patients with Refractory Mycoplasma Pneumoniae Pneumonia. J Trop Pediatr. 2017 04 01; 63(2):148-154. PMID: 27686558.
      View in: PubMed
    23. Wang D, Wang F, Shi KH, Tao H, Li Y, Zhao R, Lu H, Duan W, Qiao B, Zhao SM, Wang H, Zhao JY. Lower Circulating Folate Induced by a Fidgetin Intronic Variant Is Associated With Reduced Congenital Heart Disease Susceptibility. Circulation. 2017 May 02; 135(18):1733-1748. PMID: 28302752.
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    24. Zingg B, Chou XL, Zhang ZG, Mesik L, Liang F, Tao HW, Zhang LI. AAV-Mediated Anterograde Transsynaptic Tagging: Mapping Corticocollicular Input-Defined Neural Pathways for Defense Behaviors. Neuron. 2017 Jan 04; 93(1):33-47. PMID: 27989459.
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    25. Zhang Q, Tao H, Lin Y, Hu Y, An H, Zhang D, Feng S, Hu H, Wang R, Li X, Zhang J. A superoxide dismutase/catalase mimetic nanomedicine for targeted therapy of inflammatory bowel disease. Biomaterials. 2016 10; 105:206-221. PMID: 27525680.
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    26. Feng S, Hu Y, Peng S, Han S, Tao H, Zhang Q, Xu X, Zhang J, Hu H. Nanoparticles responsive to the inflammatory microenvironment for targeted treatment of arterial restenosis. Biomaterials. 2016 10; 105:167-184. PMID: 27522252.
      View in: PubMed
    27. Kim YJ, Wang SZ, Tymanskyj S, Ma L, Tao HW, Zhang LI. Dcc Mediates Functional Assembly of Peripheral Auditory Circuits. Sci Rep. 2016 Apr 04; 6:23799. PMID: 27040640; PMCID: PMC4819185.
    28. Ibrahim LA, Mesik L, Ji XY, Fang Q, Li HF, Li YT, Zingg B, Zhang LI, Tao HW. Cross-Modality Sharpening of Visual Cortical Processing through Layer-1-Mediated Inhibition and Disinhibition. Neuron. 2016 Mar 02; 89(5):1031-45. PMID: 26898778; PMCID: PMC4874809 [Available on 03/02/17].
    29. Li YT, Liu BH, Chou XL, Zhang LI, Tao HW. Synaptic Basis for Differential Orientation Selectivity between Complex and Simple Cells in Mouse Visual Cortex. J Neurosci. 2015 Aug 05; 35(31):11081-93. PMID: 26245969; PMCID: PMC4524977.
    30. Tao H, Wu Y, Li H, Wang C, Zhang Y, Li C, Wen T, Wang X, He Q, Wang D, Ruan D. BMP7-Based Functionalized Self-Assembling Peptides for Nucleus Pulposus Tissue Engineering. ACS Appl Mater Interfaces. 2015 Aug 12; 7(31):17076-87. PMID: 26197234.
      View in: PubMed
    31. Kim YJ, Ibrahim LA, Wang SZ, Yuan W, Evgrafov OV, Knowles JA, Wang K, Tao HW, Zhang LI. EphA7 regulates spiral ganglion innervation of cochlear hair cells. Dev Neurobiol. 2016 Apr; 76(4):452-69. PMID: 26178595; PMCID: PMC4853368 [Available on 04/01/17].
    32. Xiong XR, Liang F, Zingg B, Ji XY, Ibrahim LA, Tao HW, Zhang LI. Auditory cortex controls sound-driven innate defense behaviour through corticofugal projections to inferior colliculus. Nat Commun. 2015 Jun 11; 6:7224. PMID: 26068082.
      View in: PubMed
    33. Mesik L, Ma WP, Li LY, Ibrahim LA, Huang ZJ, Zhang LI, Tao HW. Functional response properties of VIP-expressing inhibitory neurons in mouse visual and auditory cortex. Front Neural Circuits. 2015; 9:22. PMID: 26106301; PMCID: PMC4460767.
    34. Ji XY, Zingg B, Mesik L, Xiao Z, Zhang LI, Tao HW. Thalamocortical Innervation Pattern in Mouse Auditory and Visual Cortex: Laminar and Cell-Type Specificity. Cereb Cortex. 2016 06; 26(6):2612-25. PMID: 25979090; PMCID: PMC4869808 [Available on 06/01/17].
    35. Liang F, Xiong XR, Zingg B, Ji XY, Zhang LI, Tao HW. Sensory Cortical Control of a Visually Induced Arrest Behavior via Corticotectal Projections. Neuron. 2015 May 06; 86(3):755-67. PMID: 25913860; PMCID: PMC4452020.
    36. Saiepour MH, Rajendran R, Omrani A, Ma WP, Tao HW, Heimel JA, Levelt CN. Ocular dominance plasticity disrupts binocular inhibition-excitation matching in visual cortex. Curr Biol. 2015 Mar 16; 25(6):713-721. PMID: 25754642.
      View in: PubMed
    37. Zhou M, Li YT, Yuan W, Tao HW, Zhang LI. Synaptic mechanisms for generating temporal diversity of auditory representation in the dorsal cochlear nucleus. J Neurophysiol. 2015 Mar 01; 113(5):1358-68. PMID: 25475349; PMCID: PMC4346730.
    38. Liang F, Bai L, Tao HW, Zhang LI, Xiao Z. Thresholding of auditory cortical representation by background noise. Front Neural Circuits. 2014; 8:133. PMID: 25426029; PMCID: PMC4226155.
    39. Li LY, Ji XY, Liang F, Li YT, Xiao Z, Tao HW, Zhang LI. A feedforward inhibitory circuit mediates lateral refinement of sensory representation in upper layer 2/3 of mouse primary auditory cortex. J Neurosci. 2014 Oct 08; 34(41):13670-83. PMID: 25297094; PMCID: PMC4188965.
    40. Tao HW, Li YT, Zhang LI. Formation of excitation-inhibition balance: inhibition listens and changes its tune. Trends Neurosci. 2014 Oct; 37(10):528-30. PMID: 25248294; PMCID: PMC4189014.
    41. Zhou M, Liang F, Xiong XR, Li L, Li H, Xiao Z, Tao HW, Zhang LI. Scaling down of balanced excitation and inhibition by active behavioral states in auditory cortex. Nat Neurosci. 2014 Jun; 17(6):841-50. PMID: 24747575; PMCID: PMC4108079.
    42. Li YT, Liu BH, Chou XL, Zhang LI, Tao HW. Strengthening of Direction Selectivity by Broadly Tuned and Spatiotemporally Slightly Offset Inhibition in Mouse Visual Cortex. Cereb Cortex. 2015 Sep; 25(9):2466-77. PMID: 24654259; PMCID: PMC4537420.
    43. Li YT, Chou XL, Tao HW. Monocular Deprivation in Mice. Bio Protoc. 2014 Jan 20; 4(2). PMID: 27471734.
      View in: PubMed
    44. Li LY, Xiong XR, Ibrahim LA, Yuan W, Tao HW, Zhang LI. Differential Receptive Field Properties of Parvalbumin and Somatostatin Inhibitory Neurons in Mouse Auditory Cortex. Cereb Cortex. 2015 Jul; 25(7):1782-91. PMID: 24425250; PMCID: PMC4459283.
    45. Xiong XR, Liang F, Li H, Mesik L, Zhang KK, Polley DB, Tao HW, Xiao Z, Zhang LI. Interaural level difference-dependent gain control and synaptic scaling underlying binaural computation. Neuron. 2013 Aug 21; 79(4):738-53. PMID: 23972599; PMCID: PMC3755964.
    46. Li YT, Ibrahim LA, Liu BH, Zhang LI, Tao HW. Linear transformation of thalamocortical input by intracortical excitation. Nat Neurosci. 2013 Sep; 16(9):1324-30. PMID: 23933750; PMCID: PMC3855439.
    47. Li LY, Li YT, Zhou M, Tao HW, Zhang LI. Intracortical multiplication of thalamocortical signals in mouse auditory cortex. Nat Neurosci. 2013 Sep; 16(9):1179-81. PMID: 23933752; PMCID: PMC3844430.
    48. Wang SZ, Ibrahim LA, Kim YJ, Gibson DA, Leung HC, Yuan W, Zhang KK, Tao HW, Ma L, Zhang LI. Slit/Robo signaling mediates spatial positioning of spiral ganglion neurons during development of cochlear innervation. J Neurosci. 2013 Jul 24; 33(30):12242-54. PMID: 23884932; PMCID: PMC3721837.
    49. Ma WP, Li YT, Tao HW. Downregulation of cortical inhibition mediates ocular dominance plasticity during the critical period. J Neurosci. 2013 Jul 03; 33(27):11276-80. PMID: 23825430; PMCID: PMC3718365.
    50. Sun YJ, Kim YJ, Ibrahim LA, Tao HW, Zhang LI. Synaptic mechanisms underlying functional dichotomy between intrinsic-bursting and regular-spiking neurons in auditory cortical layer 5. J Neurosci. 2013 Mar 20; 33(12):5326-39. PMID: 23516297; PMCID: PMC3714095.
    51. Zhou M, Tao HW, Zhang LI. Generation of intensity selectivity by differential synaptic tuning: fast-saturating excitation but slow-saturating inhibition. J Neurosci. 2012 Dec 12; 32(50):18068-78. PMID: 23238722; PMCID: PMC3685279.
    52. Li YT, Ma WP, Li LY, Ibrahim LA, Wang SZ, Tao HW. Broadening of inhibitory tuning underlies contrast-dependent sharpening of orientation selectivity in mouse visual cortex. J Neurosci. 2012 Nov 14; 32(46):16466-77. PMID: 23152629; PMCID: PMC3548445.
    53. Zhou Y, Mesik L, Sun YJ, Liang F, Xiao Z, Tao HW, Zhang LI. Generation of spike latency tuning by thalamocortical circuits in auditory cortex. J Neurosci. 2012 Jul 18; 32(29):9969-80. PMID: 22815511; PMCID: PMC3470470.
    54. Li YT, Ma WP, Pan CJ, Zhang LI, Tao HW. Broadening of cortical inhibition mediates developmental sharpening of orientation selectivity. J Neurosci. 2012 Mar 21; 32(12):3981-91. PMID: 22442065; PMCID: PMC3372461.
    55. Zhang LI, Zhou Y, Tao HW. Perspectives on: information and coding in mammalian sensory physiology: inhibitory synaptic mechanisms underlying functional diversity in auditory cortex. J Gen Physiol. 2011 Sep; 138(3):311-20. PMID: 21875980; PMCID: PMC3171074.
    56. Liu BH, Li YT, Ma WP, Pan CJ, Zhang LI, Tao HW. Broad inhibition sharpens orientation selectivity by expanding input dynamic range in mouse simple cells. Neuron. 2011 Aug 11; 71(3):542-54. PMID: 21835349; PMCID: PMC3154747.
    57. Yang HY, Tao H, Yu MC, Yang C, Qu RM, Zeng WQ, Duan FH, Yu L, Dai JX, Yuan L. [Effect of allogenic adipose-derived stem cell grafting on serum biochemical indicators and sporting ability of endurance trained rats]. Nan Fang Yi Ke Da Xue Xue Bao. 2011 Jun; 31(7):1159-63. PMID: 21764685.
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    58. Wu GK, Tao HW, Zhang LI. From elementary synaptic circuits to information processing in primary auditory cortex. Neurosci Biobehav Rev. 2011 Nov; 35(10):2094-104. PMID: 21609731; PMCID: PMC3184206.
    59. Zhang M, Liu Y, Wang SZ, Zhong W, Liu BH, Tao HW. Functional elimination of excitatory feedforward inputs underlies developmental refinement of visual receptive fields in zebrafish. J Neurosci. 2011 Apr 06; 31(14):5460-9. PMID: 21471382; PMCID: PMC3095389.
    60. Ma WP, Liu BH, Li YT, Huang ZJ, Zhang LI, Tao HW. Visual representations by cortical somatostatin inhibitory neurons--selective but with weak and delayed responses. J Neurosci. 2010 Oct 27; 30(43):14371-9. PMID: 20980594; PMCID: PMC3001391.
    61. Sun YJ, Wu GK, Liu BH, Li P, Zhou M, Xiao Z, Tao HW, Zhang LI. Fine-tuning of pre-balanced excitation and inhibition during auditory cortical development. Nature. 2010 Jun 17; 465(7300):927-31. PMID: 20559386; PMCID: PMC2909826.
    62. Zhou Y, Liu BH, Wu GK, Kim YJ, Xiao Z, Tao HW, Zhang LI. Preceding inhibition silences layer 6 neurons in auditory cortex. Neuron. 2010 Mar 11; 65(5):706-17. PMID: 20223205; PMCID: PMC2904750.
    63. Liu BH, Li P, Sun YJ, Li YT, Zhang LI, Tao HW. Intervening inhibition underlies simple-cell receptive field structure in visual cortex. Nat Neurosci. 2010 Jan; 13(1):89-96. PMID: 19946318; PMCID: PMC2818750.
    64. Wang SZ, Tao HW. History matters: illuminating metaplasticity in the developing brain. Neuron. 2009 Oct 29; 64(2):155-7. PMID: 19874782; PMCID: PMC3180909.
    65. Liu BH, Li P, Li YT, Sun YJ, Yanagawa Y, Obata K, Zhang LI, Tao HW. Visual receptive field structure of cortical inhibitory neurons revealed by two-photon imaging guided recording. J Neurosci. 2009 Aug 26; 29(34):10520-32. PMID: 19710305; PMCID: PMC2779138.
    66. Wang SZ, Liu BH, Tao HW, Xia K, Zhang LI. A genetic strategy for stochastic gene activation with regulated sparseness (STARS). PLoS One. 2009; 4(1):e4200. PMID: 19145242; PMCID: PMC2615212.
    67. Wu GK, Arbuckle R, Liu BH, Tao HW, Zhang LI. Lateral sharpening of cortical frequency tuning by approximately balanced inhibition. Neuron. 2008 Apr 10; 58(1):132-43. PMID: 18400169; PMCID: PMC2447869.
    68. Liu BH, Wu GK, Arbuckle R, Tao HW, Zhang LI. Defining cortical frequency tuning with recurrent excitatory circuitry. Nat Neurosci. 2007 Dec; 10(12):1594-600. PMID: 17994013; PMCID: PMC2447868.
    69. Liu Y, Zhang LI, Tao HW. Heterosynaptic scaling of developing GABAergic synapses: dependence on glutamatergic input and developmental stage. J Neurosci. 2007 May 16; 27(20):5301-12. PMID: 17507553; PMCID: PMC3232185.
    70. Smear MC, Tao HW, Staub W, Orger MB, Gosse NJ, Liu Y, Takahashi K, Poo MM, Baier H. Vesicular glutamate transport at a central synapse limits the acuity of visual perception in zebrafish. Neuron. 2007 Jan 04; 53(1):65-77. PMID: 17196531; PMCID: PMC1828615.
    71. Wu GK, Li P, Tao HW, Zhang LI. Nonmonotonic synaptic excitation and imbalanced inhibition underlying cortical intensity tuning. Neuron. 2006 Nov 22; 52(4):705-15. PMID: 17114053; PMCID: PMC1764440.
    72. Tao HW, Poo MM. Activity-dependent matching of excitatory and inhibitory inputs during refinement of visual receptive fields. Neuron. 2005 Mar 24; 45(6):829-36. PMID: 15797545.
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    73. Zou Y, Engert F, Tao HW. The assembly of neural circuits. Neuron. 2004 Jul 22; 43(2):159-63. PMID: 15260951.
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    74. Zhou Q, Tao HW, Poo MM. Reversal and stabilization of synaptic modifications in a developing visual system. Science. 2003 Jun 20; 300(5627):1953-7. PMID: 12817152.
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    75. Engert F, Tao HW, Zhang LI, Poo MM. Moving visual stimuli rapidly induce direction sensitivity of developing tectal neurons. Nature. 2002 Oct 03; 419(6906):470-5. PMID: 12368854.
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