Jian Xu, PhD

TitleAssistant Professor
InstitutionUniversity of Southern California
DepartmentBiomedical Engineering
AddressClinical Science Annex
Health Sciences Campus
Los Angeles CA 90089-9062
Phone+1 323 442 4835
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    Collapse Biography 
    Collapse Awards and Honors
    2011  - 2014American Heart Association National Scientist Development Grant
    2012FASEB Biological Methylation Conference Best Seminar Award
    2011Tokyo Global Center of Excellence Retreat Poster Award
    2009  - 2010Foundation Independent Postdoctoral Research Fellowship
    2007  - 2009American Heart Association Postdoctoral Fellowship
    2003University of Cincinnati Graduate Student Poster Forum, Poster Award
    2001  - 2003American Heart Association Pre-doctoral Fellowship
    2000Peking University Health Science Center Undergraduate Dissertation Award
    1995  - 2000Peking University Outstanding Student Scholarship

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Xu J, Derynck R. Does Smad6 methylation control BMP signaling in cancer? Cell Cycle. 2014; 13(8):1209-10. PMID: 24621505; PMCID: PMC4049950.
    2. Lamouille S, Xu J, Derynck R. Molecular mechanisms of epithelial-mesenchymal transition. Nat Rev Mol Cell Biol. 2014 Mar; 15(3):178-96. PMID: 24556840; PMCID: PMC4240281.
    3. Xu J, Wang AH, Oses-Prieto J, Makhijani K, Katsuno Y, Pei M, Yan L, Zheng YG, Burlingame A, Brückner K, Derynck R. Arginine Methylation Initiates BMP-Induced Smad Signaling. Mol Cell. 2013 Jul 11; 51(1):5-19. PMID: 23747011; PMCID: PMC3951972.
    4. Heineke J, Auger-Messier M, Correll RN, Xu J, Benard MJ, Yuan W, Drexler H, Parise LV, Molkentin JD. CIB1 is a regulator of pathological cardiac hypertrophy. Nat Med. 2010 Aug; 16(8):872-9. PMID: 20639889; PMCID: PMC2917617.
    5. Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD. Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure. Circulation. 2010 Jan 26; 121(3):419-25. PMID: 20065166; PMCID: PMC2823256.
    6. Liu C, Xu P, Lamouille S, Xu J, Derynck R. TACE-mediated ectodomain shedding of the type I TGF-beta receptor downregulates TGF-beta signaling. Mol Cell. 2009 Jul 10; 35(1):26-36. PMID: 19595713; PMCID: PMC2740991.
    7. Xu J, Lamouille S, Derynck R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009 Feb; 19(2):156-72. PMID: 19153598; PMCID: PMC4720263.
    8. Heineke J, Auger-Messier M, Xu J, Oka T, Sargent MA, York A, Klevitsky R, Vaikunth S, Duncan SA, Aronow BJ, Robbins J, Crombleholme TM, Cromblehol TM, Molkentin JD. Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest. 2007 Nov; 117(11):3198-210. PMID: 17975667; PMCID: PMC2045611.
    9. Oka T, Xu J, Kaiser RA, Melendez J, Hambleton M, Sargent MA, Lorts A, Brunskill EW, Dorn GW, Conway SJ, Aronow BJ, Robbins J, Molkentin JD. Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res. 2007 Aug 03; 101(3):313-21. PMID: 17569887; PMCID: PMC2680305.
    10. Oka T, Xu J, Molkentin JD. Re-employment of developmental transcription factors in adult heart disease. Semin Cell Dev Biol. 2007 Feb; 18(1):117-31. PMID: 17161634; PMCID: PMC1855184.
    11. Xu J, Gong NL, Bodi I, Aronow BJ, Backx PH, Molkentin JD. Myocyte enhancer factors 2A and 2C induce dilated cardiomyopathy in transgenic mice. J Biol Chem. 2006 Apr 07; 281(14):9152-62. PMID: 16469744.
      View in: PubMed
    12. Kempf T, Eden M, Strelau J, Naguib M, Willenbockel C, Tongers J, Heineke J, Kotlarz D, Xu J, Molkentin JD, Niessen HW, Drexler H, Wollert KC. The transforming growth factor-beta superfamily member growth-differentiation factor-15 protects the heart from ischemia/reperfusion injury. Circ Res. 2006 Feb 17; 98(3):351-60. PMID: 16397141.
      View in: PubMed
    13. Xu J, Kimball TR, Lorenz JN, Brown DA, Bauskin AR, Klevitsky R, Hewett TE, Breit SN, Molkentin JD. GDF15/MIC-1 functions as a protective and antihypertrophic factor released from the myocardium in association with SMAD protein activation. Circ Res. 2006 Feb 17; 98(3):342-50. PMID: 16397142.
      View in: PubMed
    14. Dai YS, Xu J, Molkentin JD. The DnaJ-related factor Mrj interacts with nuclear factor of activated T cells c3 and mediates transcriptional repression through class II histone deacetylase recruitment. Mol Cell Biol. 2005 Nov; 25(22):9936-48. PMID: 16260608; PMCID: PMC1280278.
    15. Lynch J, Guo L, Gelebart P, Chilibeck K, Xu J, Molkentin JD, Agellon LB, Michalak M. Calreticulin signals upstream of calcineurin and MEF2C in a critical Ca(2+)-dependent signaling cascade. J Cell Biol. 2005 Jul 04; 170(1):37-47. PMID: 15998798; PMCID: PMC2171392.
    16. Wilkins BJ, Dai YS, Bueno OF, Parsons SA, Xu J, Plank DM, Jones F, Kimball TR, Molkentin JD. Calcineurin/NFAT coupling participates in pathological, but not physiological, cardiac hypertrophy. Circ Res. 2004 Jan 09; 94(1):110-8. PMID: 14656927.
      View in: PubMed
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