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Jianfu Chen

Title(s)Associate Professor
Address2250 Alcazar Street
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Research 
    Collapse Research Activities and Funding
    Mechanisms regulating neural progenitor expansion in the developing brain
    NIH/NINDS R01NS097231Sep 1, 2016 - Aug 31, 2021
    Role: Principal Investigator
    Genetic analysis of a microRNA pathway regulating neural tube closure
    NIH/NINDS R01NS096176Apr 1, 2016 - Jan 31, 2021
    Role: Principal Investigator
    Wdr62 in neural development and malformations of cortical development disease
    NIH/NICHD R00HD073269Aug 1, 2012 - Dec 31, 2016
    Role: Principal Investigator
    Wdr62 in neural development and malformations of cortical development disease
    NIH/NICHD K99HD073269Aug 1, 2012 - Jul 31, 2014
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zika virus infection disrupts neurovascular development and results in postnatal microcephaly with brain damage. Development. 2016 11 15; 143(22):4127-4136. Shao Q, Herrlinger S, Yang SL, Lai F, Moore JM, Brindley MA, Chen JF. PMID: 27729407.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    2. A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy. Sci Adv. 2016 09; 2(9):e1601167. Yang M, Liang C, Swaminathan K, Herrlinger S, Lai F, Shiekhattar R, Chen JF. PMID: 27617292.
      View in: PubMed   Mentions: 63     Fields:    Translation:HumansAnimalsCells
    3. MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Dev Biol. 2015 Dec 01; 408(1):140-50. Yang SL, Yang M, Herrlinger S, Liang C, Lai F, Chen JF. PMID: 26441343.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    4. Lin28 promotes the proliferative capacity of neural progenitor cells in brain development. Development. 2015 May 01; 142(9):1616-27. Yang M, Yang SL, Herrlinger S, Liang C, Dzieciatkowska M, Hansen KC, Desai R, Nagy A, Niswander L, Moss EG, Chen JF. PMID: 25922525.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    5. Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size. Nat Commun. 2014 May 30; 5:3885. Chen JF, Zhang Y, Wilde J, Hansen KC, Lai F, Niswander L. PMID: 24875059.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    6. A unique missense allele of BAF155, a core BAF chromatin remodeling complex protein, causes neural tube closure defects in mice. Dev Neurobiol. 2014 May; 74(5):483-97. Harmacek L, Watkins-Chow DE, Chen J, Jones KL, Pavan WJ, Salbaum JM, Niswander L. PMID: 24170322.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    7. The ubiquitin ligase mLin41 temporally promotes neural progenitor cell maintenance through FGF signaling. Genes Dev. 2012 Apr 15; 26(8):803-15. Chen J, Lai F, Niswander L. PMID: 22508726.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    8. CIP, a cardiac Isl1-interacting protein, represses cardiomyocyte hypertrophy. Circ Res. 2012 Mar 16; 110(6):818-30. Huang ZP, Young Seok H, Zhou B, Chen J, Chen JF, Tao Y, Pu WT, Wang DZ. PMID: 22343712.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    9. The histone methyltransferase Set7/9 promotes myoblast differentiation and myofibril assembly. J Cell Biol. 2011 Aug 22; 194(4):551-65. Tao Y, Neppl RL, Huang ZP, Chen J, Tang RH, Cao R, Zhang Y, Jin SW, Wang DZ. PMID: 21859860.
      View in: PubMed   Mentions: 42     Fields:    Translation:HumansAnimalsCells
    10. Transgenic overexpression of miR-133a in skeletal muscle. BMC Musculoskelet Disord. 2011 May 26; 12:115. Deng Z, Chen JF, Wang DZ. PMID: 21615921.
      View in: PubMed   Mentions: 15     Fields:    Translation:AnimalsCells
    11. Loss of microRNAs in neural crest leads to cardiovascular syndromes resembling human congenital heart defects. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2575-86. Huang ZP, Chen JF, Regan JN, Maguire CT, Tang RH, Dong XR, Majesky MW, Wang DZ. PMID: 20884876.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimals
    12. microRNA-1 and microRNA-206 regulate skeletal muscle satellite cell proliferation and differentiation by repressing Pax7. J Cell Biol. 2010 Sep 06; 190(5):867-79. Chen JF, Tao Y, Li J, Deng Z, Yan Z, Xiao X, Wang DZ. PMID: 20819939.
      View in: PubMed   Mentions: 188     Fields:    Translation:AnimalsCells
    13. MicroRNA-208a is a regulator of cardiac hypertrophy and conduction in mice. J Clin Invest. 2009 Sep; 119(9):2772-86. Callis TE, Pandya K, Seok HY, Tang RH, Tatsuguchi M, Huang ZP, Chen JF, Deng Z, Gunn B, Shumate J, Willis MS, Selzman CH, Wang DZ. PMID: 19726871.
      View in: PubMed   Mentions: 301     Fields:    Translation:AnimalsCells
    14. microRNAs and muscle disorders. J Cell Sci. 2009 Jan 01; 122(Pt 1):13-20. Chen JF, Callis TE, Wang DZ. PMID: 19092056.
      View in: PubMed   Mentions: 60     Fields:    Translation:HumansAnimalsCells
    15. Myocardin marks the earliest cardiac gene expression and plays an important role in heart development. Anat Rec (Hoboken). 2008 Oct; 291(10):1200-11. Chen JF, Wang S, Wu Q, Cao D, Nguyen T, Chen Y, Wang DZ. PMID: 18780304.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    16. Targeted deletion of Dicer in the heart leads to dilated cardiomyopathy and heart failure. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2111-6. Chen JF, Murchison EP, Tang R, Callis TE, Tatsuguchi M, Deng Z, Rojas M, Hammond SM, Schneider MD, Selzman CH, Meissner G, Patterson C, Hannon GJ, Wang DZ. PMID: 18256189.
      View in: PubMed   Mentions: 217     Fields:    Translation:HumansAnimals
    17. Muscling through the microRNA world. Exp Biol Med (Maywood). 2008 Feb; 233(2):131-8. Callis TE, Deng Z, Chen JF, Wang DZ. PMID: 18222968.
      View in: PubMed   Mentions: 56     Fields:    Translation:HumansAnimals
    18. Expression of microRNAs is dynamically regulated during cardiomyocyte hypertrophy. J Mol Cell Cardiol. 2007 Jun; 42(6):1137-41. Tatsuguchi M, Seok HY, Callis TE, Thomson JM, Chen JF, Newman M, Rojas M, Hammond SM, Wang DZ. PMID: 17498736.
      View in: PubMed   Mentions: 165     Fields:    Translation:AnimalsCells
    19. MicroRNAs in skeletal and cardiac muscle development. DNA Cell Biol. 2007 Apr; 26(4):219-25. Callis TE, Chen JF, Wang DZ. PMID: 17465888.
      View in: PubMed   Mentions: 61     Fields:    Translation:HumansAnimalsCells
    20. The role of microRNA-1 and microRNA-133 in skeletal muscle proliferation and differentiation. Nat Genet. 2006 Feb; 38(2):228-33. Chen JF, Mandel EM, Thomson JM, Wu Q, Callis TE, Hammond SM, Conlon FL, Wang DZ. PMID: 16380711.
      View in: PubMed   Mentions: 987     Fields:    Translation:AnimalsCells
    21. The HopPtoF locus of Pseudomonas syringae pv. tomato DC3000 encodes a type III chaperone and a cognate effector. Mol Plant Microbe Interact. 2004 May; 17(5):447-55. Shan L, Oh HS, Chen J, Guo M, Zhou J, Alfano JR, Collmer A, Jia X, Tang X. PMID: 15141948.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
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