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    Bangyan L Stiles, PhD

    TitleProfessor
    SchoolSchool of Pharmacy
    DepartmentPharmacology and Pharmaceutical Sciences
    AddressPSC 402C
    Health Sciences Campus
    Los Angeles California 90089-9121
    Phone+1 323 442 2184
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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. He L, Gubbins J, Peng Z, Medina V, Fei F, Asahina K, Wang J, Kahn M, Rountree CB, Stiles B. Activation of hepatic stellate cell in Pten null liver injury model. Fibrogenesis Tissue Repair. 2016; 9:8. PMID: 27307790; PMCID: PMC4908727.
      2. Johnson DL, Stiles B. Maf1, A New PTEN Target Linking RNA and Lipid Metabolism. Trends Endocrinol Metab. 2016 Oct; 27(10):742-750. PMID: 27296319; PMCID: PMC5035567 [Available on 10/01/17].
      3. Shearn CT, Orlicky DJ, McCullough RL, Jiang H, Maclean KN, Mercer KE, Stiles B, Saba LM, Ronis MJ, Petersen DR. Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage. PLoS One. 2016; 11(4):e0154152. PMID: 27124661; PMCID: PMC4849752.
      4. Bayan JA, Peng Z, Zeng N, He L, Chen J, Stiles B. Crosstalk Between Activated Myofibroblasts and ß Cells in Injured Mouse Pancreas. Pancreas. 2015 Oct; 44(7):1111-20. PMID: 26333110; PMCID: PMC4780408 [Available on 10/01/16].
      5. Liu Z, Patil IY, Jiang T, Sancheti H, Walsh JP, Stiles B, Yin F, Cadenas E. High-fat diet induces hepatic insulin resistance and impairment of synaptic plasticity. PLoS One. 2015; 10(5):e0128274. PMID: 26023930; PMCID: PMC4449222.
      6. Palian BM, Rohira AD, Johnson SA, He L, Zheng N, Dubeau L, Stiles B, Johnson DL. Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism. PLoS Genet. 2014 Dec; 10(12):e1004789. PMID: 25502566; PMCID: PMC4263377.
      7. Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A unified nomenclature and amino acid numbering for human PTEN. Sci Signal. 2014 Jul 01; 7(332):pe15. PMID: 24985344; PMCID: PMC4367864.
      8. Wu JB, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles B, Zhau HE, Shih JC, Chung LW. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908. PMID: 24865426; PMCID: PMC4071401.
      9. Shearn CT, Mercer KE, Orlicky DJ, Hennings L, Smathers-McCullough RL, Stiles B, Ronis MJ, Petersen DR. Short term feeding of a high fat diet exerts an additive effect on hepatocellular damage and steatosis in liver-specific PTEN knockout mice. PLoS One. 2014; 9(5):e96553. PMID: 24818992; PMCID: PMC4018288.
      10. Chen WT, Tseng CC, Pfaffenbach K, Kanel G, Luo B, Stiles B, Lee AS. Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis. Hepatology. 2014 Mar; 59(3):947-57. PMID: 24027047; PMCID: PMC4214272.
      11. Yang KT, Bayan JA, Zeng N, Aggarwal R, He L, Peng Z, Kassa A, Kim M, Luo Z, Shi Z, Medina V, Boddupally K, Stiles B. Adult-onset deletion of Pten increases islet mass and beta cell proliferation in mice. Diabetologia. 2014 Feb; 57(2):352-61. PMID: 24162585; PMCID: PMC3918745.
      12. Tsen F, Bhatia A, O'Brien K, Cheng CF, Chen M, Hay N, Stiles B, Woodley DT, Li W. Extracellular heat shock protein 90 signals through subdomain II and the NPVY motif of LRP-1 receptor to Akt1 and Akt2: a circuit essential for promoting skin cell migration in vitro and wound healing in vivo. Mol Cell Biol. 2013 Dec; 33(24):4947-59. PMID: 24126057; PMCID: PMC3889557.
      13. Zeng N, Yang KT, Bayan JA, He L, Aggarwal R, Stiles JW, Hou X, Medina V, Abad D, Palian BM, Al-Abdullah I, Kandeel F, Johnson DL, Stiles B. PTEN controls ß-cell regeneration in aged mice by regulating cell cycle inhibitor p16ink4a. Aging Cell. 2013 Dec; 12(6):1000-11. PMID: 23826727; PMCID: PMC3838454.
      14. Li Y, He L, Zeng N, Sahu D, Cadenas E, Shearn C, Li W, Stiles B. Phosphatase and tensin homolog deleted on chromosome 10 (PTEN) signaling regulates mitochondrial biogenesis and respiration via estrogen-related receptor a (ERRa). J Biol Chem. 2013 Aug 30; 288(35):25007-24. PMID: 23836899; PMCID: PMC3757167.
      15. Li C, Li Y, He L, Agarwal AR, Zeng N, Cadenas E, Stiles B. PI3K/AKT signaling regulates bioenergetics in immortalized hepatocytes. Free Radic Biol Med. 2013 Jul; 60:29-40. PMID: 23376468; PMCID: PMC3654039.
      16. Moon BC, Hernandez-Ono A, Stiles B, Wu H, Ginsberg HN. Apolipoprotein B secretion is regulated by hepatic triglyceride, and not insulin, in a model of increased hepatic insulin signaling. Arterioscler Thromb Vasc Biol. 2012 Feb; 32(2):236-46. PMID: 22155452; PMCID: PMC3870321.
      17. Zeng N, Li Y, He L, Xu X, Galicia V, Deng C, Stiles B. Adaptive basal phosphorylation of eIF2a is responsible for resistance to cellular stress-induced cell death in Pten-null hepatocytes. Mol Cancer Res. 2011 Dec; 9(12):1708-17. PMID: 22009178; PMCID: PMC4351767.
      18. Ko KS, Tomasi ML, Iglesias-Ara A, French BA, French SW, Ramani K, Lozano JJ, Oh P, He L, Stiles B, Li TW, Yang H, Martínez-Chantar ML, Mato JM, Lu SC. Liver-specific deletion of prohibitin 1 results in spontaneous liver injury, fibrosis, and hepatocellular carcinoma in mice. Hepatology. 2010 Dec; 52(6):2096-108. PMID: 20890892; PMCID: PMC3005187.
      19. Galicia VA, He L, Dang H, Kanel G, Vendryes C, French BA, Zeng N, Bayan JA, Ding W, Wang KS, French S, Birnbaum MJ, Rountree CB, Stiles B. Expansion of hepatic tumor progenitor cells in Pten-null mice requires liver injury and is reversed by loss of AKT2. Gastroenterology. 2010 Dec; 139(6):2170-82. PMID: 20837017; PMCID: PMC2997180.
      20. Ding W, You H, Dang H, LeBlanc F, Galicia V, Lu SC, Stiles B, Rountree CB. Epithelial-to-mesenchymal transition of murine liver tumor cells promotes invasion. Hepatology. 2010 Sep; 52(3):945-53. PMID: 20564331; PMCID: PMC3032356.
      21. He L, Hou X, Kanel G, Zeng N, Galicia V, Wang Y, Yang J, Wu H, Birnbaum MJ, Stiles B. The critical role of AKT2 in hepatic steatosis induced by PTEN loss. Am J Pathol. 2010 May; 176(5):2302-8. PMID: 20348245; PMCID: PMC2861095.
      22. Zeng N, Bayan JA, He L, Stiles B. The Role of PTEN in ß-Cell Growth. Open Endocrinol J. 2010; 4:23-32. PMID: 23853672.
        View in: PubMed
      23. Stiles B. PI-3-K and AKT: Onto the mitochondria. Adv Drug Deliv Rev. 2009 Nov 30; 61(14):1276-82. PMID: 19720099.
        View in: PubMed
      24. Rountree CB, Ding W, He L, Stiles B. Expansion of CD133-expressing liver cancer stem cells in liver-specific phosphatase and tensin homolog deleted on chromosome 10-deleted mice. Stem Cells. 2009 Feb; 27(2):290-9. PMID: 19008348; PMCID: PMC2847372.
      25. Stiles B. Phosphatase and tensin homologue deleted on chromosome 10: extending its PTENtacles. Int J Biochem Cell Biol. 2009 Apr; 41(4):757-61. PMID: 18950730; PMCID: PMC2940266.
      26. Valamehr B, Jonas SJ, Polleux J, Qiao R, Guo S, Gschweng EH, Stiles B, Kam K, Luo TJ, Witte ON, Liu X, Dunn B, Wu H. Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proc Natl Acad Sci U S A. 2008 Sep 23; 105(38):14459-64. PMID: 18791068; PMCID: PMC2567159.
      27. Xu X, Kobayashi S, Qiao W, Li C, Xiao C, Radaeva S, Stiles B, Wang RH, Ohara N, Yoshino T, LeRoith D, Torbenson MS, Gores GJ, Wu H, Gao B, Deng CX. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006 Jul; 116(7):1843-52. PMID: 16767220; PMCID: PMC1474816.
      28. Stiles B, Kuralwalla-Martinez C, Guo W, Gregorian C, Wang Y, Tian J, Magnuson MA, Wu H. Selective deletion of Pten in pancreatic beta cells leads to increased islet mass and resistance to STZ-induced diabetes. Mol Cell Biol. 2006 Apr; 26(7):2772-81. PMID: 16537919; PMCID: PMC1430339.
      29. Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y. Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer Cell. 2005 Sep; 8(3):185-95. PMID: 16169464.
        View in: PubMed
      30. Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H. Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Mol Cell Biol. 2005 Mar; 25(6):2498-510. PMID: 15743841; PMCID: PMC1061603.
      31. Stiles B, Groszer M, Wang S, Jiao J, Wu H. PTENless means more. Dev Biol. 2004 Sep 15; 273(2):175-84. PMID: 15328005.
        View in: PubMed
      32. Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H. Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004 Feb 17; 101(7):2082-7. PMID: 14769918; PMCID: PMC357055.
      33. Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H. Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002 Jun; 22(11):3842-51. PMID: 11997518; PMCID: PMC133830.