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Jean Chen Shih, PhD

Title(s)University Professor
Phone+1 323 442 1441
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    Dr. Shih received her B.S. in biochemistry from the National Taiwan University, where she graduated as the valedictorian. She earned her Ph.D. in biochemistry from a joint program at the University of California, Riverside (UCR) and Los Angeles (UCLA). Dr. Shih continued as a postdoctoral research fellow at UCLA and, in 1974, she joined the School of Pharmacy faculty at USC.

    She is currently a University Professor and holds the Boyd and Elsie Welin endowed chair. She is the founding Director of USC – Taiwan Center for Translational Research
    She has received numerous honors: She received two Research Scientist Awards and two MERIT awards from the National Institutes of Health (NIH), each providing a 10-year support to investigators whose research competence and productivity are distinctly superior and who are likely to continue to perform in an outstanding manner. The MERIT award is given to the top 1% investigators of the country. She is a Fellow of Academia Sinica, Taiwan , Fellow of the American College of Neuropsychopharmacology; a recipient of the Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy (AACP); USC. Associates Award for Creativity in Research and Scholarship; among many others. A Distinguish Series Kaiser Lecturer at University of Hawaii.

    Dr. Shih is a member of the NIH study sections (Psycho Clinical Biology, 1984-88; Neurobiology, 1990-94; NICHD Mental Retardation Committee, 1997-2001). She is also a member of the International Brain Research Committee of the National Academy of Sciences (1995-2000). She is a current member and past president of the Society of Chinese Bioscientists in America (2002-2004). She is a mentor of American. NIH Director and Pioneer Award review committee (2011-2014).

    Research objectives in Shih Lab are to understand the roles of neurotransmitters on gene expression, signal transduction behaviors and ultimately diseases. They are studying the role of serotonin and dopamine in neuronal development, regulation of transcription factors in a series of monoamine oxidase (MAO) gene knock-out mice, which are animal models for anxiety, aggression and autistic-like-behavior and aggression. Recently, they showed these gene knockout mice also slowed down the progression and metastasis of prostate and brain cancers Thus provides unique animal models to study the interaction between tumors and microenvironment. Currently, Shih Lab used these KO mice model to develop novel targets for the treatment and early diagnosis of autistic-like behaviors and prostate and brain cancer.

    Recent work from the lab of Dr. Shih has shown that elimination of the gene that encodes monoamine oxidase (MAO) prevents the growth of prostate cancer in mice. As MAO is an important regulator of mood and motivation in the brain, there are already a number of drugs that effectively inhibit its function, called MAOI (MAO inhibitors), which are used clinically as antidepressants.Given the urgent and unmet need for more effective target-based therapies to significantly reduce the lethal outcome of prostate cancer, the repurposing of these drugs may represent a rapid and cost-effective solution. This presents an extraordinary opportunity to translate scientific discovery to patient therapies on an accelerated timeframe.

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    THE TRANSCRIPTIONAL REGULATION OF MONOAMINE OXIDASE A
    NIH/NIMH R01MH067968Aug 1, 2004 - Jun 30, 2010
    Role: Principal Investigator
    MOLECULAR STUDIES OF MONOAMINE OXIDASES
    NIH/NIMH K05MH000796Apr 1, 1989 - Apr 30, 2000
    Role: Principal Investigator
    Two Types of Monoamine Oxidase
    NIH/NIMH R01MH039085Sep 1, 1985 - Nov 30, 2014
    Role: Principal Investigator
    TWO TYPES OF MONOAMINE OXIDASE
    NIH/NIMH R37MH039085Sep 1, 1985 - Dec 28, 2008
    Role: Principal Investigator
    PROTEIN(S) INVOLVED IN NEUROTRANSMISSION
    NIH/NIMH R01MH037020May 1, 1982 - Dec 31, 2003
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Shih JC, Ma GC, Cheng WC, Chen CY, Wu WJ, Chen M. SMAD2 as risk locus for human left atrial isomerism detected by mother-fetus-pair exome sequencing and imaging studies. Ultrasound Obstet Gynecol. 2019 May; 53(5):702-705. PMID: 29786156.
      View in: PubMed
    2. Godar SC, Mosher LJ, Scheggi S, Devoto P, Moench KM, Strathman HJ, Jones CM, Frau R, Melis M, Gambarana C, Wilkinson B, DeMontis MG, Fowler SC, Coba MP, Wellman CL, Shih JC, Bortolato M. Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation. Neuropharmacology. 2019 Nov 15; 159:107513. PMID: 30716416.
      View in: PubMed
    3. Gaur S, Gross ME, Liao CP, Qian B, Shih JC. Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells. Prostate. 2019 May; 79(6):667-677. PMID: 30693539.
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    4. Shih JC. Monoamine oxidase isoenzymes: genes, functions and targets for behavior and cancer therapy. J Neural Transm (Vienna). 2018 11; 125(11):1553-1566. PMID: 30259128.
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    5. Shih JC, Riederer P, Maruyama W, Naoi M. Introduction to the special issue on monoamine oxidase A and B: eternally enigmatic isoenzymes. J Neural Transm (Vienna). 2018 11; 125(11):1517-1518. PMID: 30259129.
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    6. Shih JC, Liu KL, Kang J, Yang JH, Lin MW, Yu CU. 'Nausicaa' compression suture: a simple and effective alternative to hysterectomy in placenta accreta spectrum and other causes of severe postpartum haemorrhage. BJOG. 2019 Feb; 126(3):412-417. PMID: 30009547.
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    7. Lin TP, Li J, Li Q, Li X, Liu C, Zeng N, Huang JM, Chu GC, Lin CH, Zhau HE, Chung LWK, Wu BJ, Shih JC. R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc. Mol Cancer Res. 2018 12; 16(12):1940-1951. PMID: 30042175.
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    8. Liao CP, Lin TP, Li PC, Geary LA, Chen K, Vaikari VP, Wu JB, Lin CH, Gross ME, Shih JC. Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate. Oncogene. 2018 09; 37(38):5175-5190. PMID: 29844571.
      View in: PubMed
    9. Bortolato M, Floris G, Shih JC. From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency. J Neural Transm (Vienna). 2018 11; 125(11):1589-1599. PMID: 29748850.
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    10. Wang Z, Olenyuk BZ, Shih JC, Wang J. Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharm Anal. 2018 Jun; 8(3):153-159. PMID: 29922483.
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    11. Li PC, Siddiqi IN, Mottok A, Loo EY, Wu CH, Cozen W, Steidl C, Shih JC. Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma. J Pathol. 2017 10; 243(2):220-229. PMID: 28722111.
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    12. Chen K, Kardys A, Chen Y, Flink S, Tabakoff B, Shih JC. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain Res. 2017 Aug 15; 1669:18-26. PMID: 28535982.
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    13. Lin YC, Chang YT, Campbell M, Lin TP, Pan CC, Lee HC, Shih JC, Chang PC. MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. Sci Rep. 2017 04 12; 7:46338. PMID: 28402333.
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    14. Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW. The mouse cortico-striatal projectome. Nat Neurosci. 2016 08; 19(8):1100-14. PMID: 27322419.
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    15. Oanca G, Purg M, Mavri J, Shih JC, Stare J. Insights into enzyme point mutation effect by molecular simulation: phenylethylamine oxidation catalyzed by monoamine oxidase A. Phys Chem Chem Phys. 2016 05 21; 18(19):13346-56. PMID: 27121693.
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    16. Kushal S, Wang W, Vaikari VP, Kota R, Chen K, Yeh TS, Jhaveri N, Groshen SL, Olenyuk BZ, Chen TC, Hofman FM, Shih JC. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression. Oncotarget. 2016 Mar 22; 7(12):13842-53. PMID: 26871599.
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    17. Tu YA, Lin WC, Chen HJ, Shih JC. Prenatal imaging and immunohistochemical analysis of congenital peribronchial myofibroblastic tumor. Ultrasound Obstet Gynecol. 2015 Aug; 46(2):247-9. PMID: 25600064.
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    18. Godar SC, Bortolato M, Richards SE, Li FG, Chen K, Wellman CL, Shih JC. Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress. Int J Neuropsychopharmacol. 2015 Apr 08; 18(9). PMID: 25857821.
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    19. Yang PK, Chang CI, Lee CC, Lin MW, Shih JC. Cor triatriatum sinister presenting in the fetus: beware of association with total anomalous pulmonary venous connection. Ultrasound Obstet Gynecol. 2015 May; 45(5):622-4. PMID: 25359606.
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    20. Wu JB, Lin TP, Gallagher JD, Kushal S, Chung LW, Zhau HE, Olenyuk BZ, Shih JC. Monoamine oxidase A inhibitor-near-infrared dye conjugate reduces prostate tumor growth. J Am Chem Soc. 2015 Feb 18; 137(6):2366-74. PMID: 25585152.
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    21. Wu JB, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles BL, Zhau HE, Shih JC, Chung LW. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908. PMID: 24865426.
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    22. Godar SC, Bortolato M, Castelli MP, Casti A, Casu A, Chen K, Ennas MG, Tambaro S, Shih JC. The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. J Psychiatr Res. 2014 Sep; 56:1-9. PMID: 24882701.
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    23. Chen M, Yang YS, Shih JC, Lin WH, Lee DJ, Lin YS, Chou CH, Cameron AD, Ginsberg NA, Chen CA, Lee ML, Ma GC. Microdeletions/duplications involving TBX1 gene in fetuses with conotruncal heart defects which are negative for 22q11.2 deletion on fluorescence in-situ hybridization. Ultrasound Obstet Gynecol. 2014 Apr; 43(4):396-403. PMID: 23828768.
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    24. Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. 2013 Dec; 75:223-32. PMID: 23871843.
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    25. Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, Shih JC. Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12816-21. PMID: 23858446.
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    26. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. PLoS One. 2013; 8(5):e64128. PMID: 23734187.
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    27. Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N. Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. Antioxid Redox Signal. 2014 Jan 10; 20(2):267-80. PMID: 23581564.
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    28. Fox MA, Panessiti MG, Moya PR, Tolliver TJ, Chen K, Shih JC, Murphy DL. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. Pharmacogenomics J. 2013 Dec; 13(6):551-7. PMID: 22964922.
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    29. Lin TH, Lin CH, Shih JC, Su YN, Wu ET, Lee CN. Effect of arterioarterial anastomosis on early-onset umbilical artery flow abnormality in a monochorionic-diamniotic twin. Ultrasound Obstet Gynecol. 2012 Sep; 40(3):371-2. PMID: 22302609.
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    30. Alzghoul L, Bortolato M, Delis F, Thanos PK, Darling RD, Godar SC, Zhang J, Grant S, Wang GJ, Simpson KL, Chen K, Volkow ND, Lin RC, Shih JC. Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. 2012 Dec; 63(7):1208-17. PMID: 22971542.
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    31. Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, Bini V, Chen K, Wellman CL, Lin RC, Shih JC. Monoamine oxidase A and A/B knockout mice display autistic-like features. Int J Neuropsychopharmacol. 2013 May; 16(4):869-88. PMID: 22850464.
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    32. Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC. NMDARs mediate the role of monoamine oxidase A in pathological aggression. J Neurosci. 2012 Jun 20; 32(25):8574-82. PMID: 22723698.
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    33. Lee CN, Lin SY, Lin CH, Shih JC, Lin TH, Su YN. Re: Microarray application in prenatal diagnosis: a position statement from the cytogenetics working group of the Italian Society of Human Genetics (SIGU), November 2011. Ultrasound Obstet Gynecol. 2012 May; 39(5):603-4; author reply 604-6. PMID: 22539494.
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    34. Lee CN, Lin SY, Lin CH, Shih JC, Lin TH, Su YN. Clinical utility of array comparative genomic hybridisation for prenatal diagnosis: a cohort study of 3171 pregnancies. BJOG. 2012 Apr; 119(5):614-25. PMID: 22313859.
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    35. O'Leary RE, Shih JC, Hyland K, Kramer N, Asher YJ, Graham JM. De novo microdeletion of Xp11.3 exclusively encompassing the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine. Eur J Med Genet. 2012 May; 55(5):349-53. PMID: 22365943.
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    36. Zhang J, Darling RD, Paul IA, Simpson KL, Chen K, Shih JC, Lin RC. Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice. Anat Rec (Hoboken). 2011 Oct; 294(10):1685-97. PMID: 21901841.
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    37. Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I, Farrell MR, Scott AL, Wellman CL, Shih JC. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology. 2011 Dec; 36(13):2674-88. PMID: 21832987.
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    38. Wu JB, Shih JC. Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation. Mol Pharmacol. 2011 Oct; 80(4):714-23. PMID: 21775495.
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    39. Wang ZQ, Chen K, Ying QL, Li P, Shih JC. Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells. J Neural Transm (Vienna). 2011 Jul; 118(7):997-1001. PMID: 21607742.
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    40. Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21; 472(7343):347-50. PMID: 21512572.
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    41. Li D, London SJ, Liu J, Lee W, Jiang X, Van Den Berg D, Bergen AW, Nishita D, Waleh N, Swan GE, Gallaher P, Chou CP, Shih JC, Unger JB, Gauderman WJ, Gilliland F, Johnson CA, Conti DV. Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. Am J Epidemiol. 2011 May 01; 173(9):1039-48. PMID: 21415033.
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    42. Shih JC, Wu JB, Chen K. Transcriptional regulation and multiple functions of MAO genes. J Neural Transm (Vienna). 2011 Jul; 118(7):979-86. PMID: 21359973.
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    43. Bortolato M, Shih JC. Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. Int Rev Neurobiol. 2011; 100:13-42. PMID: 21971001.
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    44. Godar SC, Bortolato M, Frau R, Dousti M, Chen K, Shih JC. Maladaptive defensive behaviours in monoamine oxidase A-deficient mice. Int J Neuropsychopharmacol. 2011 Oct; 14(9):1195-207. PMID: 21156093.
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    45. Chen K, Ou XM, Wu JB, Shih JC. Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B. Mol Pharmacol. 2011 Feb; 79(2):308-17. PMID: 20980443.
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    46. Cheng A, Scott AL, Ladenheim B, Chen K, Ouyang X, Lathia JD, Mughal M, Cadet JL, Mattson MP, Shih JC. Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development. J Neurosci. 2010 Aug 11; 30(32):10752-62. PMID: 20702706.
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    47. Ou XM, Stockmeier CA, Meltzer HY, Overholser JC, Jurjus GJ, Dieter L, Chen K, Lu D, Johnson C, Youdim MB, Austin MC, Luo J, Sawa A, May W, Shih JC. A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol Psychiatry. 2010 May 01; 67(9):855-63. PMID: 20022592.
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    48. Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N. Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res. 2010 Jan 08; 106(1):193-202. PMID: 19910579.
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    49. Yin HS, Chen K, Shih JC, Tien TW. Down-regulated GABAergic expression in the olfactory bulb layers of the mouse deficient in monoamine oxidase B and administered with amphetamine. Cell Mol Neurobiol. 2010 May; 30(4):511-9. PMID: 19902350.
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    50. Chen CH, Chen TH, Kuo SJ, Chen CP, Lee DJ, Ke YY, Yeh KT, Ma GC, Liu CS, Shih JC, Chen M. Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome. Lymphology. 2009 Sep; 42(3):134-8. PMID: 19927903.
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    51. Bortolato M, Godar SC, Davarian S, Chen K, Shih JC. Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology. 2009 Dec; 34(13):2746-57. PMID: 19710633.
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    52. Wu JB, Chen K, Li Y, Lau YF, Shih JC. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J. 2009 Nov; 23(11):4029-38. PMID: 19661285.
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    53. Ou XM, Lu D, Johnson C, Chen K, Youdim MB, Rajkowska G, Shih JC. Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res. 2009 Aug; 16(2):148-59. PMID: 19526291.
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    54. Wu JB, Chen K, Ou XM, Shih JC. Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. J Biol Chem. 2009 Jun 19; 284(25):16723-35. PMID: 19401466.
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    55. Chang WC, Huang SC, Sheu BC, Shih JC, Hsu WC, Chen SY, Chang DY. Changes in uterine blood flow following laparoscopic myomectomy with or without uterine artery ligation on two- and three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol. 2009 Feb; 33(2):221-7. PMID: 19086039.
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    56. Shih JC, Palacios Jaraquemada JM, Su YN, Shyu MK, Lin CH, Lin SY, Lee CN. Role of three-dimensional power Doppler in the antenatal diagnosis of placenta accreta: comparison with gray-scale and color Doppler techniques. Ultrasound Obstet Gynecol. 2009 Feb; 33(2):193-203. PMID: 19173239.
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    57. Shih JC, Shyu MK, Su YN, Chiang YC, Lin CH, Lee CN. 'Big-eyed frog' sign on spatiotemporal image correlation (STIC) in the antenatal diagnosis of transposition of the great arteries. Ultrasound Obstet Gynecol. 2008 Nov; 32(6):762-8. PMID: 18780310.
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    58. Bortolato M, Chen K, Shih JC. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1527-33. PMID: 18652859.
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    59. Scott AL, Bortolato M, Chen K, Shih JC. Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport. 2008 May 07; 19(7):739-43. PMID: 18418249.
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    60. Guo G, Ou XM, Roettger M, Shih JC. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet. 2008 May; 16(5):626-34. PMID: 18212819.
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    61. Shih JC. Monoamine oxidases: from tissue homogenates to transgenic mice. Neurochem Res. 2007 Oct; 32(10):1757-61. PMID: 17551828.
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    62. Shyu MK, Yuan RH, Shih JC, Wu MZ, Chen HL, Kuo YC, Chien CL, Chow LP, Chen HL, Hsieh FJ. Kinetics and functional assay of liver repopulation after human cord blood transplantation. Dig Liver Dis. 2007 May; 39(5):455-65. PMID: 17379589.
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    63. Yin HS, Chen K, Kalpana S, Shih JC. Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice. Synapse. 2006 Dec 15; 60(8):573-84. PMID: 16983645.
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    64. Chen K, Cases O, Rebrin I, Wu W, Gallaher TK, Seif I, Shih JC. Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. J Biol Chem. 2007 Jan 05; 282(1):115-23. PMID: 17090537.
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    65. Guo G, Roettger ME, Shih JC. Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. Hum Genet. 2007 Mar; 121(1):125-36. PMID: 17120049.
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    66. Wang TJ, Huang SY, Lin WW, Lo HY, Wu PL, Wang YS, Wu YS, Ko HC, Shih JC, Lu RB. Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30; 31(1):108-14. PMID: 17007976.
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    67. Agatsuma S, Lee M, Zhu H, Chen K, Shih JC, Seif I, Hiroi N. Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli. Hum Mol Genet. 2006 Sep 15; 15(18):2721-31. PMID: 16893910.
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    68. Ou XM, Chen K, Shih JC. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10923-8. PMID: 16829576.
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    69. Ou XM, Chen K, Shih JC. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem. 2006 Jul 28; 281(30):21512-25. PMID: 16728402.
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    70. Squires LN, Jakubowski JA, Stuart JN, Rubakhin SS, Hatcher NG, Kim WS, Chen K, Shih JC, Seif I, Sweedler JV. Serotonin catabolism and the formation and fate of 5-hydroxyindole thiazolidine carboxylic acid. J Biol Chem. 2006 May 12; 281(19):13463-70. PMID: 16537538.
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    71. Zhang Z, Chen K, Shih JC, Teng CT. Estrogen-related receptors-stimulated monoamine oxidase B promoter activity is down-regulated by estrogen receptors. Mol Endocrinol. 2006 Jul; 20(7):1547-61. PMID: 16484337.
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    72. Shih JC, Chien CL, Ho HN, Lee WC, Hsieh FJ. Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy. Hum Reprod. 2006 May; 21(5):1299-304. PMID: 16410327.
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    73. Yi H, Akao Y, Maruyama W, Chen K, Shih J, Naoi M. Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells. J Neurochem. 2006 Jan; 96(2):541-9. PMID: 16336631.
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    74. Yang CK, Shih JC, Hsu WM, Peng SS, Shyu MK, Lee CN, Hsieh FJ. Isolated right diaphragmatic eventration mimicking congenital heart disease in utero. Prenat Diagn. 2005 Oct; 25(10):872-5. PMID: 16193461.
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    75. Odetallah NH, Wang JJ, Garlich JD, Shih JC. Versazyme supplementation of broiler diets improves market growth performance. Poult Sci. 2005 Jun; 84(6):858-64. PMID: 15971521.
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    76. Chen K, Ou XM, Chen G, Choi SH, Shih JC. R1, a novel repressor of the human monoamine oxidase A. J Biol Chem. 2005 Mar 25; 280(12):11552-9. PMID: 15654081.
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    77. Shih JC, Hsu WC, Chou HC, Peng SS, Chen LK, Chang YL, Hsieh FJ. Prenatal three-dimensional ultrasound and magnetic resonance imaging evaluation of a fetal oral tumor in preparation for the ex-utero intrapartum treatment (EXIT) procedure. Ultrasound Obstet Gynecol. 2005 Jan; 25(1):76-9; discussion 79. PMID: 15619317.
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    78. Wang JJ, Greenhut WB, Shih JC. Development of an asporogenic Bacillus licheniformis for the production of keratinase. J Appl Microbiol. 2005; 98(3):761-7. PMID: 15715880.
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    79. Yeung Lam P, Chen K, Shih JC. The circadian rhythm of 5-HT biosynthetic and degradative enzymes in immortalized mouse neuroendocrine pineal cell line--a model for studying circadian rhythm. Life Sci. 2004 Nov 05; 75(25):3017-26. PMID: 15474553.
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    80. Shih JC, Chen K. Regulation of MAO-A and MAO-B gene expression. Curr Med Chem. 2004 Aug; 11(15):1995-2005. PMID: 15279563.
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    81. Lee M, Chen K, Shih JC, Hiroi N. MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake. Genes Brain Behav. 2004 Aug; 3(4):216-27. PMID: 15248867.
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    82. Shih JC, Ko TL, Lin MC, Shyu MK, Lee CN, Hsieh FJ. Quantitative three-dimensional power Doppler ultrasound predicts the outcome of placental chorioangioma. Ultrasound Obstet Gynecol. 2004 Aug; 24(2):202-6. PMID: 15287061.
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    83. Chen K, Holschneider DP, Wu W, Rebrin I, Shih JC. A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. J Biol Chem. 2004 Sep 17; 279(38):39645-52. PMID: 15272015.
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    84. Shih JC, Peng SS, Hsiao SM, Wang JH, Shyu MK, Lee CN, Hsieh FJ. Three-dimensional ultrasound diagnosis of Larsen syndrome with further characterization of neurological sequelae. Ultrasound Obstet Gynecol. 2004 Jul; 24(1):89-93. PMID: 15229923.
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    85. Maragos WF, Young KL, Altman CS, Pocernich CB, Drake J, Butterfield DA, Seif I, Holschneider DP, Chen K, Shih JC. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. Neurochem Res. 2004 Apr; 29(4):741-6. PMID: 15098936.
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    86. Ou XM, Chen K, Shih JC. Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene. J Biol Chem. 2004 May 14; 279(20):21021-8. PMID: 15024015.
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    87. Shih JC. Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. Neurotoxicology. 2004 Jan; 25(1-2):21-30. PMID: 14697877.
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    88. Vitalis T, Alvarez C, Chen K, Shih JC, Gaspar P, Cases O. Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives. J Comp Neurol. 2003 Sep 22; 464(3):392-403. PMID: 12900932.
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    89. Chen CP, Shih JC, Shih SL, Huang JK, Huang JP, Lin YH, Wang W. Prenatal diagnosis of cephalothoracopagus janiceps disymmetros using three-dimensional power Doppler ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol. 2003 Sep; 22(3):299-304. PMID: 12942505.
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    90. Wong WK, Chen K, Shih JC. Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem. 2003 Sep 19; 278(38):36227-35. PMID: 12855685.
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    91. Lu RB, Lin WW, Lee JF, Ko HC, Shih JC. Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. Alcohol Clin Exp Res. 2003 Jun; 27(6):889-93. PMID: 12824808.
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    92. Chen CP, Shih JC, Huang JK, Chin DT, Tzen CY, Lin YH, Wang W. Two- and three-dimensional ultrasound demonstration of a giant epignathus. Ultrasound Obstet Gynecol. 2003 Apr; 21(4):407-9. PMID: 12704754.
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    93. Odetallah NH, Wang JJ, Garlich JD, Shih JC. Keratinase in starter diets improves growth of broiler chicks. Poult Sci. 2003 Apr; 82(4):664-70. PMID: 12710489.
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    94. Holschneider DP, Scremin OU, Chialvo DR, Chen K, Shih JC. Heart rate dynamics in monoamine oxidase-A- and -B-deficient mice. Am J Physiol Heart Circ Physiol. 2002 May; 282(5):H1751-9. PMID: 11959640.
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    95. Wong WK, Ou XM, Chen K, Shih JC. Activation of human monoamine oxidase B gene expression by a protein kinase C MAPK signal transduction pathway involves c-Jun and Egr-1. J Biol Chem. 2002 Jun 21; 277(25):22222-30. PMID: 11956220.
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    96. Lu RB, Lee JF, Ko HC, Lin WW, Chen K, Shih JC. No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Apr; 26(3):457-61. PMID: 11999895.
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    97. Holschneider DP, Scremin OU, Roos KP, Chialvo DR, Chen K, Shih JC. Increased baroreceptor response in mice deficient in monoamine oxidase A and B. Am J Physiol Heart Circ Physiol. 2002 Mar; 282(3):H964-72. PMID: 11834493.
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    98. Geha RM, Chen K, Wouters J, Ooms F, Shih JC. Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling. J Biol Chem. 2002 May 10; 277(19):17209-16. PMID: 11861643.
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    99. Chen CP, Shih JC, Tzen CY, Wang W. Three-dimensional ultrasound in the evaluation of complex anomalies associated with fetal ventral midline defects. Ultrasound Obstet Gynecol. 2002 Jan; 19(1):102-4. PMID: 11851978.
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    100. Levant B, Morgan KA, Ahlgren-Beckendorf JA, Grandy DK, Chen K, Shih JC, Seif I. Modulation of [3H]quinpirole binding at striatal D2 dopamine receptors by a monoamine oxidaseA-like site: evidence from radioligand binding studies and D2 receptor- and MAO(A)-deficient mice. Life Sci. 2001 Nov 30; 70(2):229-41. PMID: 11787947.
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    101. Holschneider DP, Chen K, Seif I, Shih JC. Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B. Brain Res Bull. 2001 Nov 15; 56(5):453-62. PMID: 11750790.
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    102. Rebrin I, Geha RM, Chen K, Shih JC. Effects of carboxyl-terminal truncations on the activity and solubility of human monoamine oxidase B. J Biol Chem. 2001 Aug 03; 276(31):29499-506. PMID: 11371556.
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    103. Wong WK, Chen K, Shih JC. Regulation of human monoamine oxidase B gene by Sp1 and Sp3. Mol Pharmacol. 2001 Apr; 59(4):852-9. PMID: 11259630.
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    104. Fornai F, Giorgi FS, Gesi M, Chen K, Alessrì MG, Shih JC. Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice. Synapse. 2001 Mar 01; 39(3):213-21. PMID: 11169770.
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    105. Hauptmann N, Shih JC. 2-Naphthylamine, a compound found in cigarette smoke, decreases both monoamine oxidase A and B catalytic activity. Life Sci. 2001 Feb 02; 68(11):1231-41. PMID: 11233991.
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    106. Chen CP, Chern SR, Shih JC, Wang W, Yeh LF, Chang TY, Tzen CY. Prenatal diagnosis and genetic analysis of type I and type II thanatophoric dysplasia. Prenat Diagn. 2001 Feb; 21(2):89-95. PMID: 11241532.
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    107. Shih JC, Jaffe R, Hsieh FJ. Three-dimensional ultrasonography in early pregnancy. Semin Perinatol. 2001 Feb; 25(1):3-10. PMID: 11254157.
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    108. Geha RM, Rebrin I, Chen K, Shih JC. Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid. J Biol Chem. 2001 Mar 30; 276(13):9877-82. PMID: 11134050.
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    109. Chen CP, Shih JC, Chan YJ. Current awareness in prenatal diagnosis. Prenat Diagn. 2000 Dec; 20(12):1021-7. PMID: 11113922.
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    110. Remaury A, Raddatz R, Ordener C, Savic S, Shih JC, Chen K, Seif I, De Maeyer E, Lanier SM, Parini A. Analysis of the pharmacological and molecular heterogeneity of I(2)-imidazoline-binding proteins using monoamine oxidase-deficient mouse models. Mol Pharmacol. 2000 Nov; 58(5):1085-90. PMID: 11040057.
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    111. Holschneider DP, Shih JC. Genotype to phenotype: challenges and opportunities. Int J Dev Neurosci. 2000 Oct; 18(6):615-8. PMID: 10884606.
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    112. Geha RM, Chen K, Shih JC. Phe(208) and Ile(199) in human monoamine oxidase A and B do not determine substrate and inhibitor specificities as in rat. J Neurochem. 2000 Sep; 75(3):1304-9. PMID: 10936214.
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    113. Shih JC, Tsao PN, Huang SF, Yen BL, Lin JH, Lee CN, Hsieh FJ. Antenatal diagnosis of congenital hepatoblastoma in utero. Ultrasound Obstet Gynecol. 2000 Jul; 16(1):94-7. PMID: 11084976.
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    114. Shih JC, Tsao PN, Huang SF, Yen BL, Lin JH, Lee CN, Hsieh FJ. Congenital hepatoblastoma. Ultrasound Obstet Gynecol. 2000 Jul; 16(1):103. PMID: 11084980.
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    115. Wang RM, Shih JC, Ko TM. Prenatal sonographic depiction of fetal mediastinal immature teratoma. J Ultrasound Med. 2000 Apr; 19(4):289-92. PMID: 10759355.
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    116. Lee TH, Shih JC, Peng SS, Lee CN, Shyu MK, Hsieh FJ. Prenatal depiction of angioarchitecture of an aneurysm of the vein of Galen with three-dimensional color power angiography. Ultrasound Obstet Gynecol. 2000 Apr; 15(4):337-40. PMID: 10895457.
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    117. Yang M, Chen K, Shih JC. Yang-gan-wan protects mice against apoptosis induced by anti-Fas antibody (Jo2). Am J Chin Med. 2000; 28(3-4):325-30. PMID: 11154045.
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    118. Shih JC, Chen K, Ridd MJ, Seif I. Ginkgo biloba abolishes aggression in mice lacking MAO A. Antioxid Redox Signal. 2000; 2(3):467-71. PMID: 11229360.
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    119. Yang M, Chen K, Shih JC. Yang-Gan-Wan protects mice against experimental liver damage. Am J Chin Med. 2000; 28(2):155-62. PMID: 10999434.
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    120. Holschneider DP, Scremin OU, Huynh L, Chen K, Seif I, Shih JC. Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine. Neuroscience. 2000; 101(4):869-77. PMID: 11113335.
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    121. Fornai F, Chen K, Giorgi FS, Gesi M, Alessandri MG, Shih JC. Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study. J Neurochem. 1999 Dec; 73(6):2434-40. PMID: 10582603.
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    122. Shih JC, Shyu MK, Hunag SF, Jou HJ, Su YN, Hsieh FJ. Doppler waveform analysis of the intertwin blood flow in acardiac pregnancy: implications for pathogenesis. Ultrasound Obstet Gynecol. 1999 Dec; 14(6):375-9. PMID: 10658274.
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    123. Chen M, Shih JC, Chiu WT, Hsieh FJ. Separation of cesarean scar during second-trimester intravaginal misoprostol abortion. Obstet Gynecol. 1999 Nov; 94(5 Pt 2):840. PMID: 10546751.
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    124. Su YN, Shih JC, Chiu WH, Lee CN, Cheng WF, Hsieh FJ. Cervical pregnancy: assessment with three-dimensional power Doppler imaging and successful management with selective uterine artery embolization. Ultrasound Obstet Gynecol. 1999 Oct; 14(4):284-7. PMID: 10586481.
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    125. Chen CP, Shih JC, Lee CC, Chen LF, Wang W, Wang TY. Prenatal diagnosis of a fetus with distal 10q trisomy. Prenat Diagn. 1999 Sep; 19(9):876-8. PMID: 10521850.
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    126. Shih JC, Thompson RF. Monoamine oxidase in neuropsychiatry and behavior. Am J Hum Genet. 1999 Sep; 65(3):593-8. PMID: 10441564.
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    127. Shih JC, Ridd MJ, Chen K, Meehan WP, Kung MP, Seif I, De Maeyer E. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A. Brain Res. 1999 Jul 24; 835(2):104-12. PMID: 10415365.
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    128. Peng SS, Lin JH, Lee WT, Tsao PN, Shih JC, Liu HM, Li YW, Hsieh FJ, Tsou KI. 3-D power Doppler cerebral angiography in neonates and young infants: comparison with 2-D power Doppler angiography. Ultrasound Med Biol. 1999 Jul; 25(6):947-51. PMID: 10461723.
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    129. Steinberg MI, Wiest SA, Pickard RT, Chen K, Shih JC. Binding of the imidazoline ligand 3H-2-benzofuranyl-2-imidazoline (BFI) to human brain and platelets. Potentiation by tranylcypromine and role of MAO isoforms. Ann N Y Acad Sci. 1999 Jun 21; 881:193-8. PMID: 10415915.
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    130. Scremin OU, Holschneider DP, Chen K, Li MG, Shih JC. Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice. Brain Res. 1999 Apr 03; 824(1):36-44. PMID: 10095040.
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    131. Simpson GM, Shih JC, Chen K, Flowers C, Kumazawa T, Spring B. Schizophrenia, monoamine oxidase activity, and cigarette smoking. Neuropsychopharmacology. 1999 Apr; 20(4):392-4. PMID: 10088141.
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    132. Peng SS, Shih JC, Liu HM, Li YW, Hsieh FJ. Ultrafast fetal MR images of intracranial teratoma. J Comput Assist Tomogr. 1999 Mar-Apr; 23(2):318-9. PMID: 10096346.
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    133. Holschneider DP, Scremin OU, Huynh L, Chen K, Shih JC. Lack of protection from ischemic injury of monoamine oxidase B-deficient mice following middle cerebral artery occlusion. Neurosci Lett. 1999 Jan 15; 259(3):161-4. PMID: 10025583.
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    134. Shih JC, Chen K. MAO-A and -B gene knock-out mice exhibit distinctly different behavior. Neurobiology (Bp). 1999; 7(2):235-46. PMID: 10591056.
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    135. Shih JC, Chen K, Ridd MJ. Role of MAO A and B in neurotransmitter metabolism and behavior. Pol J Pharmacol. 1999 Jan-Feb; 51(1):25-9. PMID: 10389141.
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    136. Shih JC, Chen K, Ridd MJ. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci. 1999; 22:197-217. PMID: 10202537.
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    137. Shih JC, Shyu MK, Cheng WF, Lee CN, Jou HJ, Wang RM, Hsieh FJ. Arteriovenous malformation of mesosalpinx associated with a 'vanishing' ectopic pregnancy: diagnosis with three-dimensional color power angiography. Ultrasound Obstet Gynecol. 1999 Jan; 13(1):63-6. PMID: 10201089.
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    138. Holschneider DP, Scremin OU, Chen K, Shih JC. Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the Morris water maze. Life Sci. 1999; 65(17):1757-63. PMID: 10576555.
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    139. Ekblom J, Garpenstrand H, Damberg M, Chen K, Shih JC, Oreland L. Transcription factor binding to the core promoter of the human monoamine oxidase B gene in the cerebral cortex and in blood cells. Neurosci Lett. 1998 Dec 18; 258(2):101-4. PMID: 9875537.
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    140. Voncken JW, Baram TZ, Gonzales-Gomez I, Van Schaick H, Shih JC, Chen K, Groffen J, Heisterkamp N. Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998 Nov; 2(5):577-83. PMID: 9858655.
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    141. Wu CH, Shih JC, Chang YL, Lee SY, Hsieh FJ. Two-dimensional and three-dimensional power Doppler sonographic classification of vascular patterns in cervical lymphadenopathies. J Ultrasound Med. 1998 Jul; 17(7):459-64. PMID: 9669305.
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    142. Shih JC, Shyu MK, Lee CN, Wu CH, Lin GJ, Hsieh FJ. Antenatal depiction of the fetal ear with three-dimensional ultrasonography. Obstet Gynecol. 1998 Apr; 91(4):500-5. PMID: 9540930.
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    143. Shih JC, Shyu MK, Chang CY, Lee CN, Lin GJ, Chen WH, Fan YT, Hsieh FJ. Application of the surface rendering technique of three-dimensional ultrasound in prenatal diagnosis and counselling of Klippel-Trenaunay-Weber syndrome. Prenat Diagn. 1998 Mar; 18(3):298-302. PMID: 9556049.
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    144. Ekblom J, Oreland L, Chen K, Shih JC. Is there a "non-MAO" macromolecular target for L-deprenyl?: Studies on MAOB mutant mice. Life Sci. 1998; 63(12):PL181-6. PMID: 9749831.
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    145. Holschneider DP, Kumazawa T, Chen K, Shih JC. Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. Life Sci. 1998; 63(3):155-60. PMID: 9698044.
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    146. Chung YP, Hwa HL, Tseng LH, Shyu MK, Lee CN, Shih JC, Hsieh FJ. Prenatal diagnosis of monosomy 10q25 associated with single umbilical artery and sex reversal: report of a case. Prenat Diagn. 1998 Jan; 18(1):73-7. PMID: 9483644.
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    147. Shih JC, Chen K, Geha RM. Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities. J Neural Transm Suppl. 1998; 52:1-8. PMID: 9564602.
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    148. Chen K, Shih JC. Monoamine oxidase A and B: structure, function, and behavior. Adv Pharmacol. 1998; 42:292-6. PMID: 9327898.
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    149. Zhu Q, Shih JC. An extensive repeat structure down-regulates human monoamine oxidase A promoter activity independent of an initiator-like sequence. J Neurochem. 1997 Oct; 69(4):1368-73. PMID: 9326264.
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    150. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997 Oct; 17(2):206-10. PMID: 9326944.
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    151. Lu HF, Sheu BC, Shih JC, Chang YL, Torng PL, Huang SC. Intramural ectopic pregnancy. Sonographic picture and its relation with adenomyosis. Acta Obstet Gynecol Scand. 1997 Oct; 76(9):886-9. PMID: 9351419.
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    152. Kim JJ, Shih JC, Chen K, Chen L, Bao S, Maren S, Anagnostaras SG, Fanselow MS, De Maeyer E, Seif I, Thompson RF. Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5929-33. PMID: 9159177.
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    153. Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K, Ohara K, Ohara K. Serotonin2A receptor gene polymorphism in mood disorders. Biol Psychiatry. 1997 Apr 01; 41(7):768-73. PMID: 9084895.
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    154. Jahng JW, Houpt TA, Wessel TC, Chen K, Shih JC, Joh TH. Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization. Synapse. 1997 Jan; 25(1):30-6. PMID: 8987145.
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    155. Hauptmann N, Grimsby J, Shih JC, Cadenas E. The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA. Arch Biochem Biophys. 1996 Nov 15; 335(2):295-304. PMID: 8914926.
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    156. Ishigaki T, Xie DW, Liu JC, Nakamura Y, Zhang HY, Tani K, Shimazu Y, Chen K, Shih JC, Miyasato K, Ohara K, Ohara K. Intact 5-HT2A receptor exons and the adjoining intron regions in schizophrenia. Neuropsychopharmacology. 1996 May; 14(5):339-47. PMID: 8703302.
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    157. Lu G, Unge T, Owera-Atepo JB, Shih JC, Ekblom J, Oreland L. Characterization and partial purification of human monoamine oxidase-B expressed in Escherichia coli. Protein Expr Purif. 1996 May; 7(3):315-22. PMID: 8860658.
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    158. Erdmann J, Shimron-Abarbanell D, Rietschel M, Albus M, Maier W, Körner J, Bondy B, Chen K, Shih JC, Knapp M, Propping P, Nöthen MM. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet. 1996 May; 97(5):614-9. PMID: 8655141.
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    159. Shih JC, Shyu MK, Hwa SL, Lee CN, Jeng YM, Lin GJ, Hsieh FJ. Concordant body stalk anomaly in monozygotic twinning--early embryo cleavage disorder. Prenat Diagn. 1996 May; 16(5):467-70. PMID: 8844008.
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    160. Chen K, Wu HF, Shih JC. Influence of C terminus on monoamine oxidase A and B catalytic activity. J Neurochem. 1996 Feb; 66(2):797-803. PMID: 8592154.
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    161. Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, Shih JC, Malherbe P, Da Prada M, Richards JG. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience. 1996 Feb; 70(3):755-74. PMID: 9045087.
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    162. Grimsby J, Zentner M, Shih JC. Identification of a region important for human monoamine oxidase B substrate and inhibitor selectivity. Life Sci. 1996; 58(9):777-87. PMID: 8632725.
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    163. Shih JC, Zhu Q, Chen K. Determination of transcription initiation sites and promoter activity of the human 5-HT2A receptor gene. Behav Brain Res. 1996; 73(1-2):59-62. PMID: 8788478.
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    165. Zhu QS, Chen K, Shih JC. Characterization of the human 5-HT2A receptor gene promoter. J Neurosci. 1995 Jul; 15(7 Pt 1):4885-95. PMID: 7623119.
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    166. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih JC. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science. 1995 Jun 23; 268(5218):1763-6. PMID: 7792602.
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    168. Chen K, Wu HF, Grimsby J, Shih JC. Cloning of a novel monoamine oxidase cDNA from trout liver. Mol Pharmacol. 1994 Dec; 46(6):1226-33. PMID: 7808446.
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    171. Shih JC, Chen K, Gallaher TK. Structure and function of serotonin 5-HT2 receptors. NIDA Res Monogr. 1994; 146:284-97. PMID: 8742804.
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    172. Chen K, Wu HF, Shih JC. The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. J Neurochem. 1993 Jul; 61(1):187-90. PMID: 8515265.
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    173. Wu HF, Chen K, Shih JC. Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. Mol Pharmacol. 1993 Jun; 43(6):888-93. PMID: 8316221.
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    174. Wang CD, Gallaher TK, Shih JC. Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation. Mol Pharmacol. 1993 Jun; 43(6):931-40. PMID: 8316224.
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    180. Grimsby J, Chen K, Devor EJ, Cloninger CR, Shih JC. Dinucleotide repeat (TG)23 polymorphism in the MAOB gene. Nucleic Acids Res. 1992 Feb 25; 20(4):924. PMID: 1542591.
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    187. Derry JM, Lan NC, Shih JC, Barnard EA, Barnard PJ. Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25; 17(20):8403. PMID: 2573045.
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    188. Lan NC, Chen CH, Shih JC. Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells. J Neurochem. 1989 May; 52(5):1652-4. PMID: 2496202.
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    189. Lan NC, Heinzmann C, Gal A, Klisak I, Orth U, Lai E, Grimsby J, Sparkes RS, Mohandas T, Shih JC. Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics. 1989 May; 4(4):552-9. PMID: 2744764.
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    190. Takeuchi Y, Yang W, Shih JC. Identification of 5-hydroxytryptamine1A receptor proteins in bovine frontal cortex. J Neurochem. 1988 Nov; 51(5):1343-9. PMID: 3171582.
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    191. Lee MR, Shih JC. Effect of anaerobic digestion on oocysts of the protozoan Eimeria tenella. Appl Environ Microbiol. 1988 Oct; 54(10):2335-41. PMID: 3202626.
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    192. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4934-8. PMID: 3387449.
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    193. Hsu MC, Shih JC. Photoaffinity labeling of human placental monoamine oxidase-A by 4-fluoro-3-nitrophenyl azide. Mol Pharmacol. 1988 Feb; 33(2):237-41. PMID: 3340083.
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    194. Lee JD, Shih JC. Evidence for two conformational states of 5-hydroxytryptamine carrier in rat cortical synaptosomes. Neuropharmacology. 1987 Dec; 26(12):1667-71. PMID: 3501842.
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    195. Chen SA, Shih JC, Hsu MC, Xu QP. Photoaffinity labeling of beef liver monoamine oxidase-B by 4-fluoro-3-nitrophenyl azide. Biochem Pharmacol. 1987 Mar 15; 36(6):937-43. PMID: 3566791.
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    196. Hsu MC, Chen S, Shih JC. 4-Fluoro-3-nitrophenyl azide binding sites on purified beef liver monoamine oxidase B. Neurochem Int. 1987; 10(2):167-72. PMID: 20501066.
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    197. Andresen JW, Shih JC. Necessity of ascorbic acid in the radioligand binding assay for [3H]5-hydroxytryptamine. Neuropharmacology. 1986 Aug; 25(8):869-75. PMID: 3774116.
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    198. Ransom RW, Asarch KB, Shih JC. [3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain. J Neurochem. 1986 Jan; 46(1):68-75. PMID: 2933490.
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    199. Chen S, Shih JC, Xu QP. Inhibition of monoamine oxidase by phenyl azides. J Neurochem. 1985 Sep; 45(3):940-5. PMID: 4031869.
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    200. Ransom RW, Lee JD, Bolger MB, Shih JC. Photoinactivation of serotonin uptake by an arylazido derivative of 5-hydroxytryptamine. Mol Pharmacol. 1985 Aug; 28(2):185-90. PMID: 4022001.
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    201. Asarch KB, Ransom RW, Shih JC. 5-HT-1a and 5-HT-1b selectivity of two phenylpiperazine derivatives: evidence for 5-HT-1b heterogeneity. Life Sci. 1985 Apr 01; 36(13):1265-73. PMID: 3982214.
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    202. Chen S, Shih JC, Xu QP. 4-Fluoro-3-nitrophenyl azide, a selective photoaffinity label for type B monoamine oxidase. Biochem Pharmacol. 1985 Mar 15; 34(6):781-8. PMID: 3977955.
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    203. Chen S, Shih JC, Xu QP. Interaction of N-(2-nitro-4-azidophenyl)-serotonin with two types of monoamine oxidase in rat brain. J Neurochem. 1984 Dec; 43(6):1680-7. PMID: 6491673.
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    204. Shih JC, Ohsawa R. Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites. Neurochem Res. 1983 Jun; 8(6):701-10. PMID: 6621769.
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    205. Shih JC, Cheng SH. Identification of serotonin-binding proteins using a photoaffinity labeling probe. Adv Exp Med Biol. 1981; 133:319-25. PMID: 6459006.
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    206. Cheng SH, Shih JC. Photoaffinity labeling of serotonin-binding proteins. Life Sci. 1979 Dec 24; 25(26):2197-203. PMID: 542097.
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    207. Shih JC, Young H. The alteration of serotonin binding sites in aged human brain. Life Sci. 1978 Oct 09; 23(14):1441-8. PMID: 713701.
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    208. Huang RH, Eiduson S, Shih JC. Determination of monoamine oxidase in rat brain by electron spin resonance techniques. J Neurochem. 1976 Apr; 26(4):799-803. PMID: 184246.
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    209. Shih JC. Separation of L-phenylalanine: pyruvate transaminase and L-phenylalanine: alpha-ketoglutarate transaminase by sephadex-electrophoresis. Life Sci. 1975 Aug 15; 17(4):627-32. PMID: 1186430.
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    210. Shih JC, Eiduson S. Proceedings: Some interrelated properties of brain monoamine oxidase. Psychopharmacol Bull. 1974 Jul; 10(3):7-8. PMID: 4472723.
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    211. Thompson JH, Su C, Shih JC, Aures D, Choi L, Butcher S, Loskota WS, Simon M, Silva D. Effects of chronic nicotine administration and age on various neurotransmitters and associated enzymes in male Fischer-344 rats. Toxicol Appl Pharmacol. 1974 Jan; 27(1):41-59. PMID: 4152860.
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    212. Shih JC, Eiduson S. Some interrelated properties of brain monoamine oxidase. Adv Biochem Psychopharmacol. 1974; 12(0):29-36. PMID: 4417151.
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    213. Shih JC, Eiduson S. Monoamine oxidase (EC 1.4.3.4): isolation and characterization of multiple forms of the brain enzyme. J Neurochem. 1973 Jul; 21(1):41-9. PMID: 4720902.
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    214. Shih JC, Eiduson S. Multiple forms of monoamine oxidase in the developing brain. Nature. 1969 Dec 27; 224(5226):1309-10. PMID: 5359296.
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