Jean Chen Shih, PhD

Title(s)University Professor
SchoolUSC School of Pharmacy
AddressPSC 518
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 1441
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    Dr. Shih received her B.S. in biochemistry from the National Taiwan University, where she graduated as the valedictorian. She earned her Ph.D. in biochemistry from a joint program at the University of California, Riverside (UCR) and Los Angeles (UCLA). Dr. Shih continued as a postdoctoral research fellow at UCLA and, in 1974, she joined the School of Pharmacy faculty at USC.

    She is currently a University Professor and holds the Boyd and Elsie Welin endowed chair. She is the founding Director of USC – Taiwan Center for Translational Research
    She has received numerous honors: She received two Research Scientist Awards and two MERIT awards from the National Institutes of Health (NIH), each providing a 10-year support to investigators whose research competence and productivity are distinctly superior and who are likely to continue to perform in an outstanding manner. The MERIT award is given to the top 1% investigators of the country. She is a Fellow of Academia Sinica, Taiwan , Fellow of the American College of Neuropsychopharmacology; a recipient of the Volwiler Research Achievement Award from the American Association of Colleges of Pharmacy (AACP); USC. Associates Award for Creativity in Research and Scholarship; among many others. A Distinguish Series Kaiser Lecturer at University of Hawaii.

    Dr. Shih is a member of the NIH study sections (Psycho Clinical Biology, 1984-88; Neurobiology, 1990-94; NICHD Mental Retardation Committee, 1997-2001). She is also a member of the International Brain Research Committee of the National Academy of Sciences (1995-2000). She is a current member and past president of the Society of Chinese Bioscientists in America (2002-2004). She is a mentor of American. NIH Director and Pioneer Award review committee (2011-2014).

    Research objectives in Shih Lab are to understand the roles of neurotransmitters on gene expression, signal transduction behaviors and ultimately diseases. They are studying the role of serotonin and dopamine in neuronal development, regulation of transcription factors in a series of monoamine oxidase (MAO) gene knock-out mice, which are animal models for anxiety, aggression and autistic-like-behavior and aggression. Recently, they showed these gene knockout mice also slowed down the progression and metastasis of prostate and brain cancers Thus provides unique animal models to study the interaction between tumors and microenvironment. Currently, Shih Lab used these KO mice model to develop novel targets for the treatment and early diagnosis of autistic-like behaviors and prostate and brain cancer.

    Recent work from the lab of Dr. Shih has shown that elimination of the gene that encodes monoamine oxidase (MAO) prevents the growth of prostate cancer in mice. As MAO is an important regulator of mood and motivation in the brain, there are already a number of drugs that effectively inhibit its function, called MAOI (MAO inhibitors), which are used clinically as antidepressants.Given the urgent and unmet need for more effective target-based therapies to significantly reduce the lethal outcome of prostate cancer, the repurposing of these drugs may represent a rapid and cost-effective solution. This presents an extraordinary opportunity to translate scientific discovery to patient therapies on an accelerated timeframe.

    Collapse Research 
    Collapse Research Activities and Funding
    NIH R01MH067968Aug 1, 2004 - Jun 30, 2010
    Role: Principal Investigator
    NIH K05MH000796Apr 1, 1989 - Apr 30, 2000
    Role: Principal Investigator
    Two Types of Monoamine Oxidase
    NIH R01MH039085Sep 1, 1985 - Nov 30, 2015
    Role: Principal Investigator
    NIH R37MH039085Sep 1, 1985 - Dec 28, 2008
    Role: Principal Investigator
    NIH R01MH037020May 1, 1982 - Dec 31, 2003
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. Design, synthesis, and biological activity of dual monoamine oxidase A and heat shock protein 90 inhibitors, N-Methylpropargylamine-conjugated 4-isopropylresorcinol for glioblastoma. Eur J Med Chem. 2023 May 05; 256:115459. Tseng HJ, Banerjee S, Qian B, Lai MJ, Wu TY, Hsu TI, Lin TE, Hsu KC, Chuang KH, Liou JP, Shih JC. PMID: 37172473.
      View in: PubMed   Mentions:    Fields:    
    2. Breast cancer and neurotransmitters: emerging insights on mechanisms and therapeutic directions. Oncogene. 2023 02; 42(9):627-637. Jayachandran P, Battaglin F, Strelez C, Lenz A, Algaze S, Soni S, Lo JH, Yang Y, Millstein J, Zhang W, Shih JC, Lu J, Mumenthaler SM, Spicer D, Neman J, Roussos Torres ET, Lenz HJ. PMID: 36650218; PMCID: PMC9957733.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. In Vitro and In Vivo Assays Characterizing MAO A Function in Cancers. Methods Mol Biol. 2023; 2558:171-182. Wu BJ, Shih JC. PMID: 36169863; PMCID: PMC9651040.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Autoantibody profiling of monoamine oxidase A knockout mice, an autism spectrum disorder model. Brain Behav Immun. 2023 01; 107:193-200. Syu GD, Sutandy FXR, Chen K, Cheng Y, Chen CS, Shih JC. PMID: 36243286.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    5. Deletion of monoamine oxidase A in a prostate cancer model enhances anti-tumor immunity through reduced immune suppression. Biochem Biophys Res Commun. 2022 12 17; 634:100-107. Lapierre JA, Geary LA, Jang JK, Epstein AL, Hong F, Shih JC. PMID: 36242915.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    6. Neurotransmitter signaling: a new frontier in colorectal cancer biology and treatment. Oncogene. 2022 10; 41(43):4769-4778. Battaglin F, Jayachandran P, Strelez C, Lenz A, Algaze S, Soni S, Lo JH, Yang Y, Millstein J, Zhang W, Roussos Torres ET, Shih JC, Mumenthaler SM, Neman J, Lenz HJ. PMID: 36182970.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    7. Monoamine oxidase A and organic cation transporter 3 coordinate intracellular β1AR signaling to calibrate cardiac contractile function. Basic Res Cardiol. 2022 07 17; 117(1):37. Wang Y, Zhao M, Xu B, Bahriz SMF, Zhu C, Jovanovic A, Ni H, Jacobi A, Kaludercic N, Di Lisa F, Hell JW, Shih JC, Paolocci N, Xiang YK. PMID: 35842861; PMCID: PMC9288959.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    8. N-Methylpropargylamine-Conjugated Hydroxamic Acids as Dual Inhibitors of Monoamine Oxidase A and Histone Deacetylase for Glioma Treatment. J Med Chem. 2022 02 10; 65(3):2208-2224. Mehndiratta S, Qian B, Chuang JY, Liou JP, Shih JC. PMID: 35005974.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    9. Brain injury and inflammation genes common to a number of neurological diseases and the genes involved in the genesis of GABAnergic neurons are altered in monoamine oxidase B knockout mice. Brain Res. 2022 01 01; 1774:147724. Chen K, Palagashvili T, Hsu W, Chen Y, Tabakoff B, Hong F, Shih AT, Shih JC. PMID: 34780749; PMCID: PMC8638699.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCells
    10. Near-Infrared MAO A Inhibitor (NMI) Outperformed FDA-Approved Chemotherapeutic Agents in Brain and Other Cancers: A Bioinformatic Analysis of NCI60 Screening Data. Brain Sci. 2021 Oct 04; 11(10). Feng Q, Lian Y, Qian Y, Shih JC. PMID: 34679383; PMCID: PMC8534240.
      View in: PubMed   Mentions:
    11. Near-Infrared Monoamine Oxidase Inhibitor Biodistribution in a Glioma Mouse Model. Pharm Res. 2021 Mar; 38(3):461-471. Irwin RW, Escobedo AR, Shih JC. PMID: 33709330.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    12. PAMs inhibits monoamine oxidase a activity and reduces glioma tumor growth, a potential adjuvant treatment for glioma. BMC Complement Med Ther. 2020 Aug 15; 20(1):252. Li PC, Chen SY, Xiangfei D, Mao C, Wu CH, Shih JC. PMID: 32799864; PMCID: PMC7429690.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    13. Phase 2 trial of monoamine oxidase inhibitor phenelzine in biochemical recurrent prostate cancer. Prostate Cancer Prostatic Dis. 2021 03; 24(1):61-68. Gross ME, Agus DB, Dorff TB, Pinski JK, Quinn DI, Castellanos O, Gilmore P, Shih JC. PMID: 32123315; PMCID: PMC7483294.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    14. Author Correction: Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci. 2020 Feb; 23(2):293. Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. PMID: 31911656; PMCID: PMC7333455.
      View in: PubMed   Mentions: 2     Fields:    
    15. Dopamine metabolism by a monoamine oxidase mitochondrial shuttle activates the electron transport chain. Nat Neurosci. 2020 01; 23(1):15-20. Graves SM, Xie Z, Stout KA, Zampese E, Burbulla LF, Shih JC, Kondapalli J, Patriarchi T, Tian L, Brichta L, Greengard P, Krainc D, Schumacker PT, Surmeier DJ. PMID: 31844313; PMCID: PMC7257994.
      View in: PubMed   Mentions: 38     Fields:    Translation:HumansAnimalsCells
    16. Mitochondrial 4-HNE derived from MAO-A promotes mitoCa2+ overload in chronic postischemic cardiac remodeling. Cell Death Differ. 2020 06; 27(6):1907-1923. Santin Y, Fazal L, Sainte-Marie Y, Sicard P, Maggiorani D, Tortosa F, Yücel YY, Teyssedre L, Rouquette J, Marcellin M, Vindis C, Shih JC, Lairez O, Burlet-Schiltz O, Parini A, Lezoualc'h F, Mialet-Perez J. PMID: 31819159; PMCID: PMC7244724.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    17. SMAD2 as risk locus for human left atrial isomerism detected by mother-fetus-pair exome sequencing and imaging studies. Ultrasound Obstet Gynecol. 2019 May; 53(5):702-705. Shih JC, Ma GC, Cheng WC, Chen CY, Wu WJ, Chen M. PMID: 29786156.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Gene-environment interactions in antisocial behavior are mediated by early-life 5-HT2A receptor activation. Neuropharmacology. 2019 11 15; 159:107513. Godar SC, Mosher LJ, Scheggi S, Devoto P, Moench KM, Strathman HJ, Jones CM, Frau R, Melis M, Gambarana C, Wilkinson B, DeMontis MG, Fowler SC, Coba MP, Wellman CL, Shih JC, Bortolato M. PMID: 30716416; PMCID: PMC7578912.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    19. Effect of Monoamine oxidase A (MAOA) inhibitors on androgen-sensitive and castration-resistant prostate cancer cells. Prostate. 2019 05; 79(6):667-677. Gaur S, Gross ME, Liao CP, Qian B, Shih JC. PMID: 30693539; PMCID: PMC7462252.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    20. Monoamine oxidase isoenzymes: genes, functions and targets for behavior and cancer therapy. J Neural Transm (Vienna). 2018 11; 125(11):1553-1566. Shih JC. PMID: 30259128; PMCID: PMC6245662.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansAnimals
    21. Introduction to the special issue on monoamine oxidase A and B: eternally enigmatic isoenzymes. J Neural Transm (Vienna). 2018 11; 125(11):1517-1518. Shih JC, Riederer P, Maruyama W, Naoi M. PMID: 30259129; PMCID: PMC6467517.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    22. 'Nausicaa' compression suture: a simple and effective alternative to hysterectomy in placenta accreta spectrum and other causes of severe postpartum haemorrhage. BJOG. 2019 Feb; 126(3):412-417. Shih JC, Liu KL, Kang J, Yang JH, Lin MW, Yu CU. PMID: 30009547; PMCID: PMC6585672.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    23. R1 Regulates Prostate Tumor Growth and Progression By Transcriptional Suppression of the E3 Ligase HUWE1 to Stabilize c-Myc. Mol Cancer Res. 2018 12; 16(12):1940-1951. Lin TP, Li J, Li Q, Li X, Liu C, Zeng N, Huang JM, Chu GC, Lin CH, Zhau HE, Chung LWK, Wu BJ, Shih JC. PMID: 30042175.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    24. Loss of MAOA in epithelia inhibits adenocarcinoma development, cell proliferation and cancer stem cells in prostate. Oncogene. 2018 09; 37(38):5175-5190. Liao CP, Lin TP, Li PC, Geary LA, Chen K, Vaikari VP, Wu JB, Lin CH, Gross ME, Shih JC. PMID: 29844571; PMCID: PMC7500062.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimalsCells
    25. From aggression to autism: new perspectives on the behavioral sequelae of monoamine oxidase deficiency. J Neural Transm (Vienna). 2018 11; 125(11):1589-1599. Bortolato M, Floris G, Shih JC. PMID: 29748850; PMCID: PMC6215718.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimals
    26. Quantification and pharmacokinetic study of tumor-targeting agent MHI148-clorgyline amide in mouse plasma using liquid chromatography-electrospray ionization tandem mass spectrometry. J Pharm Anal. 2018 Jun; 8(3):153-159. Wang Z, Olenyuk BZ, Shih JC, Wang J. PMID: 29922483; PMCID: PMC6004616.
      View in: PubMed   Mentions: 1  
    27. Monoamine oxidase A is highly expressed in classical Hodgkin lymphoma. J Pathol. 2017 10; 243(2):220-229. Li PC, Siddiqi IN, Mottok A, Loo EY, Wu CH, Cozen W, Steidl C, Shih JC. PMID: 28722111; PMCID: PMC5605421.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    28. Altered gene expression in early postnatal monoamine oxidase A knockout mice. Brain Res. 2017 Aug 15; 1669:18-26. Chen K, Kardys A, Chen Y, Flink S, Tabakoff B, Shih JC. PMID: 28535982; PMCID: PMC5531263.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. MAOA-a novel decision maker of apoptosis and autophagy in hormone refractory neuroendocrine prostate cancer cells. Sci Rep. 2017 04 12; 7:46338. Lin YC, Chang YT, Campbell M, Lin TP, Pan CC, Lee HC, Shih JC, Chang PC. PMID: 28402333; PMCID: PMC5389346.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    30. The mouse cortico-striatal projectome. Nat Neurosci. 2016 08; 19(8):1100-14. Hintiryan H, Foster NN, Bowman I, Bay M, Song MY, Gou L, Yamashita S, Bienkowski MS, Zingg B, Zhu M, Yang XW, Shih JC, Toga AW, Dong HW. PMID: 27322419; PMCID: PMC5564682.
      View in: PubMed   Mentions: 200     Fields:    Translation:Animals
    31. Insights into enzyme point mutation effect by molecular simulation: phenylethylamine oxidation catalyzed by monoamine oxidase A. Phys Chem Chem Phys. 2016 05 21; 18(19):13346-56. Oanca G, Purg M, Mavri J, Shih JC, Stare J. PMID: 27121693.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    32. Monoamine oxidase A (MAO A) inhibitors decrease glioma progression. Oncotarget. 2016 Mar 22; 7(12):13842-53. Kushal S, Wang W, Vaikari VP, Kota R, Chen K, Yeh TS, Jhaveri N, Groshen SL, Olenyuk BZ, Chen TC, Hofman FM, Shih JC. PMID: 26871599; PMCID: PMC4924682.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansAnimalsCells
    33. Prenatal imaging and immunohistochemical analysis of congenital peribronchial myofibroblastic tumor. Ultrasound Obstet Gynecol. 2015 Aug; 46(2):247-9. Tu YA, Lin WC, Chen HJ, Shih JC. PMID: 25600064.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    34. Monoamine Oxidase A is Required for Rapid Dendritic Remodeling in Response to Stress. Int J Neuropsychopharmacol. 2015 Apr 08; 18(9). Godar SC, Bortolato M, Richards SE, Li FG, Chen K, Wellman CL, Shih JC. PMID: 25857821; PMCID: PMC4576521.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    35. Cor triatriatum sinister presenting in the fetus: beware of association with total anomalous pulmonary venous connection. Ultrasound Obstet Gynecol. 2015 May; 45(5):622-4. Yang PK, Chang CI, Lee CC, Lin MW, Shih JC. PMID: 25359606.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Monoamine oxidase A inhibitor-near-infrared dye conjugate reduces prostate tumor growth. J Am Chem Soc. 2015 Feb 18; 137(6):2366-74. Wu JB, Lin TP, Gallagher JD, Kushal S, Chung LW, Zhau HE, Olenyuk BZ, Shih JC. PMID: 25585152.
      View in: PubMed   Mentions: 37     Fields:    Translation:Animals
    37. Monoamine oxidase A mediates prostate tumorigenesis and cancer metastasis. J Clin Invest. 2014 Jul; 124(7):2891-908. Wu JB, Shao C, Li X, Li Q, Hu P, Shi C, Li Y, Chen YT, Yin F, Liao CP, Stiles BL, Zhau HE, Shih JC, Chung LW. PMID: 24865426; PMCID: PMC4071401.
      View in: PubMed   Mentions: 91     Fields:    Translation:HumansAnimalsCells
    38. The aggression and behavioral abnormalities associated with monoamine oxidase A deficiency are rescued by acute inhibition of serotonin reuptake. J Psychiatr Res. 2014 Sep; 56:1-9. Godar SC, Bortolato M, Castelli MP, Casti A, Casu A, Chen K, Ennas MG, Tambaro S, Shih JC. PMID: 24882701; PMCID: PMC4114985.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    39. Microdeletions/duplications involving TBX1 gene in fetuses with conotruncal heart defects which are negative for 22q11.2 deletion on fluorescence in-situ hybridization. Ultrasound Obstet Gynecol. 2014 Apr; 43(4):396-403. Chen M, Yang YS, Shih JC, Lin WH, Lee DJ, Lin YS, Chou CH, Cameron AD, Ginsberg NA, Chen CA, Lee ML, Ma GC. PMID: 23828768.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    40. Early postnatal inhibition of serotonin synthesis results in long-term reductions of perseverative behaviors, but not aggression, in MAO A-deficient mice. Neuropharmacology. 2013 Dec; 75:223-32. Bortolato M, Godar SC, Tambaro S, Li FG, Devoto P, Coba MP, Chen K, Shih JC. PMID: 23871843; PMCID: PMC3849223.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    41. Cognitive abnormalities and hippocampal alterations in monoamine oxidase A and B knockout mice. Proc Natl Acad Sci U S A. 2013 Jul 30; 110(31):12816-21. Singh C, Bortolato M, Bali N, Godar SC, Scott AL, Chen K, Thompson RF, Shih JC. PMID: 23858446; PMCID: PMC3732950.
      View in: PubMed   Mentions: 28     Fields:    Translation:HumansAnimals
    42. Prenatal exposure to urban air nanoparticles in mice causes altered neuronal differentiation and depression-like responses. PLoS One. 2013; 8(5):e64128. Davis DA, Bortolato M, Godar SC, Sander TK, Iwata N, Pakbin P, Shih JC, Berhane K, McConnell R, Sioutas C, Finch CE, Morgan TE. PMID: 23734187; PMCID: PMC3667185.
      View in: PubMed   Mentions: 48     Fields:    Translation:HumansAnimalsCells
    43. Monoamine oxidase B prompts mitochondrial and cardiac dysfunction in pressure overloaded hearts. Antioxid Redox Signal. 2014 Jan 10; 20(2):267-80. Kaludercic N, Carpi A, Nagayama T, Sivakumaran V, Zhu G, Lai EW, Bedja D, De Mario A, Chen K, Gabrielson KL, Lindsey ML, Pacak K, Takimoto E, Shih JC, Kass DA, Di Lisa F, Paolocci N. PMID: 23581564; PMCID: PMC3887464.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    44. Mutations in monoamine oxidase (MAO) genes in mice lead to hypersensitivity to serotonin-enhancing drugs: implications for drug side effects in humans. Pharmacogenomics J. 2013 Dec; 13(6):551-7. Fox MA, Panessiti MG, Moya PR, Tolliver TJ, Chen K, Shih JC, Murphy DL. PMID: 22964922; PMCID: PMC3562558.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    45. Effect of arterioarterial anastomosis on early-onset umbilical artery flow abnormality in a monochorionic-diamniotic twin. Ultrasound Obstet Gynecol. 2012 Sep; 40(3):371-2. Lin TH, Lin CH, Shih JC, Su YN, Wu ET, Lee CN. PMID: 22302609.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Altered cerebellar organization and function in monoamine oxidase A hypomorphic mice. Neuropharmacology. 2012 Dec; 63(7):1208-17. Alzghoul L, Bortolato M, Delis F, Thanos PK, Darling RD, Godar SC, Zhang J, Grant S, Wang GJ, Simpson KL, Chen K, Volkow ND, Lin RC, Shih JC. PMID: 22971542; PMCID: PMC3442946.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    47. Monoamine oxidase A and A/B knockout mice display autistic-like features. Int J Neuropsychopharmacol. 2013 May; 16(4):869-88. Bortolato M, Godar SC, Alzghoul L, Zhang J, Darling RD, Simpson KL, Bini V, Chen K, Wellman CL, Lin RC, Shih JC. PMID: 22850464; PMCID: PMC3517692.
      View in: PubMed   Mentions: 51     Fields:    Translation:Animals
    48. NMDARs mediate the role of monoamine oxidase A in pathological aggression. J Neurosci. 2012 Jun 20; 32(25):8574-82. Bortolato M, Godar SC, Melis M, Soggiu A, Roncada P, Casu A, Flore G, Chen K, Frau R, Urbani A, Castelli MP, Devoto P, Shih JC. PMID: 22723698; PMCID: PMC3417343.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    49. Re: Microarray application in prenatal diagnosis: a position statement from the cytogenetics working group of the Italian Society of Human Genetics (SIGU), November 2011. Ultrasound Obstet Gynecol. 2012 May; 39(5):603-4; author reply 604-6. Lee CN, Lin SY, Lin CH, Shih JC, Lin TH, Su YN. PMID: 22539494.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Clinical utility of array comparative genomic hybridisation for prenatal diagnosis: a cohort study of 3171 pregnancies. BJOG. 2012 Apr; 119(5):614-25. Lee CN, Lin SY, Lin CH, Shih JC, Lin TH, Su YN. PMID: 22313859.
      View in: PubMed   Mentions: 31     Fields:    Translation:Humans
    51. De novo microdeletion of Xp11.3 exclusively encompassing the monoamine oxidase A and B genes in a male infant with episodic hypotonia: a genomics approach to personalized medicine. Eur J Med Genet. 2012 May; 55(5):349-53. O'Leary RE, Shih JC, Hyland K, Kramer N, Asher YJ, Graham JM. PMID: 22365943; PMCID: PMC3468330.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    52. Altered expression of tyrosine hydroxylase in the locus coeruleus noradrenergic system in citalopram neonatally exposed rats and monoamine oxidase a knock out mice. Anat Rec (Hoboken). 2011 Oct; 294(10):1685-97. Zhang J, Darling RD, Paul IA, Simpson KL, Chen K, Shih JC, Lin RC. PMID: 21901841; PMCID: PMC3177426.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    53. Social deficits and perseverative behaviors, but not overt aggression, in MAO-A hypomorphic mice. Neuropsychopharmacology. 2011 Dec; 36(13):2674-88. Bortolato M, Chen K, Godar SC, Chen G, Wu W, Rebrin I, Farrell MR, Scott AL, Wellman CL, Shih JC. PMID: 21832987; PMCID: PMC3230491.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    54. Valproic acid induces monoamine oxidase A via Akt/forkhead box O1 activation. Mol Pharmacol. 2011 Oct; 80(4):714-23. Wu JB, Shih JC. PMID: 21775495; PMCID: PMC3187529.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimalsCells
    55. Monoamine oxidase A regulates neural differentiation of murine embryonic stem cells. J Neural Transm (Vienna). 2011 Jul; 118(7):997-1001. Wang ZQ, Chen K, Ying QL, Li P, Shih JC. PMID: 21607742; PMCID: PMC3435112.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    56. A transient placental source of serotonin for the fetal forebrain. Nature. 2011 Apr 21; 472(7343):347-50. Bonnin A, Goeden N, Chen K, Wilson ML, King J, Shih JC, Blakely RD, Deneris ES, Levitt P. PMID: 21512572; PMCID: PMC3084180.
      View in: PubMed   Mentions: 228     Fields:    Translation:HumansAnimals
    57. Association of the calcyon neuron-specific vesicular protein gene (CALY) with adolescent smoking initiation in China and California. Am J Epidemiol. 2011 May 01; 173(9):1039-48. Li D, London SJ, Liu J, Lee W, Jiang X, Van Den Berg D, Bergen AW, Nishita D, Waleh N, Swan GE, Gallaher P, Chou CP, Shih JC, Unger JB, Gauderman WJ, Gilliland F, Johnson CA, Conti DV. PMID: 21415033; PMCID: PMC3121219.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    58. Transcriptional regulation and multiple functions of MAO genes. J Neural Transm (Vienna). 2011 Jul; 118(7):979-86. Shih JC, Wu JB, Chen K. PMID: 21359973; PMCID: PMC3125068.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    59. Behavioral outcomes of monoamine oxidase deficiency: preclinical and clinical evidence. Int Rev Neurobiol. 2011; 100:13-42. Bortolato M, Shih JC. PMID: 21971001; PMCID: PMC3371272.
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    60. Maladaptive defensive behaviours in monoamine oxidase A-deficient mice. Int J Neuropsychopharmacol. 2011 Oct; 14(9):1195-207. Godar SC, Bortolato M, Frau R, Dousti M, Chen K, Shih JC. PMID: 21156093; PMCID: PMC3435117.
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    61. Transcription factor E2F-associated phosphoprotein (EAPP), RAM2/CDCA7L/JPO2 (R1), and simian virus 40 promoter factor 1 (Sp1) cooperatively regulate glucocorticoid activation of monoamine oxidase B. Mol Pharmacol. 2011 Feb; 79(2):308-17. Chen K, Ou XM, Wu JB, Shih JC. PMID: 20980443; PMCID: PMC3033708.
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    62. Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development. J Neurosci. 2010 Aug 11; 30(32):10752-62. Cheng A, Scott AL, Ladenheim B, Chen K, Ouyang X, Lathia JD, Mughal M, Cadet JL, Mattson MP, Shih JC. PMID: 20702706; PMCID: PMC2967387.
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    63. A novel role for glyceraldehyde-3-phosphate dehydrogenase and monoamine oxidase B cascade in ethanol-induced cellular damage. Biol Psychiatry. 2010 May 01; 67(9):855-63. Ou XM, Stockmeier CA, Meltzer HY, Overholser JC, Jurjus GJ, Dieter L, Chen K, Lu D, Johnson C, Youdim MB, Austin MC, Luo J, Sawa A, May W, Shih JC. PMID: 20022592; PMCID: PMC2854240.
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    64. Monoamine oxidase A-mediated enhanced catabolism of norepinephrine contributes to adverse remodeling and pump failure in hearts with pressure overload. Circ Res. 2010 Jan 08; 106(1):193-202. Kaludercic N, Takimoto E, Nagayama T, Feng N, Lai EW, Bedja D, Chen K, Gabrielson KL, Blakely RD, Shih JC, Pacak K, Kass DA, Di Lisa F, Paolocci N. PMID: 19910579; PMCID: PMC2804073.
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    65. Down-regulated GABAergic expression in the olfactory bulb layers of the mouse deficient in monoamine oxidase B and administered with amphetamine. Cell Mol Neurobiol. 2010 May; 30(4):511-9. Yin HS, Chen K, Shih JC, Tien TW. PMID: 19902350; PMCID: PMC2875355.
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    66. Genetic evaluation and management of fetal chylothorax: review and insights from a case of Noonan syndrome. Lymphology. 2009 Sep; 42(3):134-8. Chen CH, Chen TH, Kuo SJ, Chen CP, Lee DJ, Ke YY, Yeh KT, Ma GC, Liu CS, Shih JC, Chen M. PMID: 19927903.
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    67. Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice. Neuropsychopharmacology. 2009 Dec; 34(13):2746-57. Bortolato M, Godar SC, Davarian S, Chen K, Shih JC. PMID: 19710633; PMCID: PMC2783894.
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    68. Regulation of monoamine oxidase A by the SRY gene on the Y chromosome. FASEB J. 2009 Nov; 23(11):4029-38. Wu JB, Chen K, Li Y, Lau YF, Shih JC. PMID: 19661285; PMCID: PMC2775015.
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    69. Glyceraldehyde-3-phosphate dehydrogenase-monoamine oxidase B-mediated cell death-induced by ethanol is prevented by rasagiline and 1-R-aminoindan. Neurotox Res. 2009 Aug; 16(2):148-59. Ou XM, Lu D, Johnson C, Chen K, Youdim MB, Rajkowska G, Shih JC. PMID: 19526291; PMCID: PMC2862453.
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    70. Retinoic acid activates monoamine oxidase B promoter in human neuronal cells. J Biol Chem. 2009 Jun 19; 284(25):16723-16735. Wu JB, Chen K, Ou XM, Shih JC. PMID: 19401466; PMCID: PMC2719307.
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    71. Changes in uterine blood flow following laparoscopic myomectomy with or without uterine artery ligation on two- and three-dimensional power Doppler ultrasound. Ultrasound Obstet Gynecol. 2009 Feb; 33(2):221-7. Chang WC, Huang SC, Sheu BC, Shih JC, Hsu WC, Chen SY, Chang DY. PMID: 19086039.
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    72. Role of three-dimensional power Doppler in the antenatal diagnosis of placenta accreta: comparison with gray-scale and color Doppler techniques. Ultrasound Obstet Gynecol. 2009 Feb; 33(2):193-203. Shih JC, Palacios Jaraquemada JM, Su YN, Shyu MK, Lin CH, Lin SY, Lee CN. PMID: 19173239.
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    73. 'Big-eyed frog' sign on spatiotemporal image correlation (STIC) in the antenatal diagnosis of transposition of the great arteries. Ultrasound Obstet Gynecol. 2008 Nov; 32(6):762-8. Shih JC, Shyu MK, Su YN, Chiang YC, Lin CH, Lee CN. PMID: 18780310.
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    74. Monoamine oxidase inactivation: from pathophysiology to therapeutics. Adv Drug Deliv Rev. 2008 Oct-Nov; 60(13-14):1527-33. Bortolato M, Chen K, Shih JC. PMID: 18652859; PMCID: PMC2630537.
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    75. Novel monoamine oxidase A knock out mice with human-like spontaneous mutation. Neuroreport. 2008 May 07; 19(7):739-43. Scott AL, Bortolato M, Chen K, Shih JC. PMID: 18418249; PMCID: PMC3435113.
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    76. The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity. Eur J Hum Genet. 2008 May; 16(5):626-34. Guo G, Ou XM, Roettger M, Shih JC. PMID: 18212819; PMCID: PMC2922855.
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    77. Monoamine oxidases: from tissue homogenates to transgenic mice. Neurochem Res. 2007 Oct; 32(10):1757-61. Shih JC. PMID: 17551828.
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    78. Kinetics and functional assay of liver repopulation after human cord blood transplantation. Dig Liver Dis. 2007 May; 39(5):455-65. Shyu MK, Yuan RH, Shih JC, Wu MZ, Chen HL, Kuo YC, Chien CL, Chow LP, Chen HL, Hsieh FJ. PMID: 17379589.
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    79. Differential effects of chronic amphetamine and baclofen administration on cAMP levels and phosphorylation of CREB in distinct brain regions of wild type and monoamine oxidase B-deficient mice. Synapse. 2006 Dec 15; 60(8):573-84. Yin HS, Chen K, Kalpana S, Shih JC. PMID: 16983645.
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    80. Forebrain-specific expression of monoamine oxidase A reduces neurotransmitter levels, restores the brain structure, and rescues aggressive behavior in monoamine oxidase A-deficient mice. J Biol Chem. 2007 Jan 05; 282(1):115-23. Chen K, Cases O, Rebrin I, Wu W, Gallaher TK, Seif I, Shih JC. PMID: 17090537; PMCID: PMC2844870.
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    81. Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults. Hum Genet. 2007 Mar; 121(1):125-36. Guo G, Roettger ME, Shih JC. PMID: 17120049.
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    82. Tongue teratoma--a rare form of fetal extragonadal teratoma diagnosed at 30 weeks' gestation. Ultrasound Obstet Gynecol. 2006 Oct; 28(5):737-41. Chiang YC, Shih JC, Peng SS, Hsu WC, Lee CN. PMID: 16969784.
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    83. Possible interaction between MAOA and DRD2 genes associated with antisocial alcoholism among Han Chinese men in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Jan 30; 31(1):108-14. Wang TJ, Huang SY, Lin WW, Lo HY, Wu PL, Wang YS, Wu YS, Ko HC, Shih JC, Lu RB. PMID: 17007976.
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    84. Monoamine oxidase A knockout mice exhibit impaired nicotine preference but normal responses to novel stimuli. Hum Mol Genet. 2006 Sep 15; 15(18):2721-31. Agatsuma S, Lee M, Zhu H, Chen K, Shih JC, Seif I, Hiroi N. PMID: 16893910.
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    85. Monoamine oxidase A and repressor R1 are involved in apoptotic signaling pathway. Proc Natl Acad Sci U S A. 2006 Jul 18; 103(29):10923-8. Ou XM, Chen K, Shih JC. PMID: 16829576; PMCID: PMC1544150.
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    86. Glucocorticoid and androgen activation of monoamine oxidase A is regulated differently by R1 and Sp1. J Biol Chem. 2006 Jul 28; 281(30):21512-21525. Ou XM, Chen K, Shih JC. PMID: 16728402.
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    87. Serotonin catabolism and the formation and fate of 5-hydroxyindole thiazolidine carboxylic acid. J Biol Chem. 2006 May 12; 281(19):13463-13470. Squires LN, Jakubowski JA, Stuart JN, Rubakhin SS, Hatcher NG, Kim WS, Chen K, Shih JC, Seif I, Sweedler JV. PMID: 16537538.
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    88. Estrogen-related receptors-stimulated monoamine oxidase B promoter activity is down-regulated by estrogen receptors. Mol Endocrinol. 2006 Jul; 20(7):1547-61. Zhang Z, Chen K, Shih JC, Teng CT. PMID: 16484337.
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    89. Stellate transformation of invasive trophoblast: a distinct phenotype of trophoblast that is involved in decidual vascular remodelling and controlled invasion during pregnancy. Hum Reprod. 2006 May; 21(5):1299-304. Shih JC, Chien CL, Ho HN, Lee WC, Hsieh FJ. PMID: 16410327.
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    90. Type A monoamine oxidase is the target of an endogenous dopaminergic neurotoxin, N-methyl(R)salsolinol, leading to apoptosis in SH-SY5Y cells. J Neurochem. 2006 Jan; 96(2):541-9. Yi H, Akao Y, Maruyama W, Chen K, Shih J, Naoi M. PMID: 16336631.
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    91. Isolated right diaphragmatic eventration mimicking congenital heart disease in utero. Prenat Diagn. 2005 Oct; 25(10):872-5. Yang CK, Shih JC, Hsu WM, Peng SS, Shyu MK, Lee CN, Hsieh FJ. PMID: 16193461.
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    92. Versazyme supplementation of broiler diets improves market growth performance. Poult Sci. 2005 Jun; 84(6):858-64. Odetallah NH, Wang JJ, Garlich JD, Shih JC. PMID: 15971521.
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    93. R1, a novel repressor of the human monoamine oxidase A. J Biol Chem. 2005 Mar 25; 280(12):11552-9. Chen K, Ou XM, Chen G, Choi SH, Shih JC. PMID: 15654081; PMCID: PMC2861901.
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    94. Development of an asporogenic Bacillus licheniformis for the production of keratinase. J Appl Microbiol. 2005; 98(3):761-7. Wang JJ, Greenhut WB, Shih JC. PMID: 15715880.
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    95. Prenatal three-dimensional ultrasound and magnetic resonance imaging evaluation of a fetal oral tumor in preparation for the ex-utero intrapartum treatment (EXIT) procedure. Ultrasound Obstet Gynecol. 2005 Jan; 25(1):76-9; discussion 79. Shih JC, Hsu WC, Chou HC, Peng SS, Chen LK, Chang YL, Hsieh FJ. PMID: 15619317.
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    96. The circadian rhythm of 5-HT biosynthetic and degradative enzymes in immortalized mouse neuroendocrine pineal cell line--a model for studying circadian rhythm. Life Sci. 2004 Nov 05; 75(25):3017-26. Yeung Lam P, Chen K, Shih JC. PMID: 15474553.
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    97. Regulation of MAO-A and MAO-B gene expression. Curr Med Chem. 2004 Aug; 11(15):1995-2005. Shih JC, Chen K. PMID: 15279563.
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    98. Quantitative three-dimensional power Doppler ultrasound predicts the outcome of placental chorioangioma. Ultrasound Obstet Gynecol. 2004 Aug; 24(2):202-6. Shih JC, Ko TL, Lin MC, Shyu MK, Lee CN, Hsieh FJ. PMID: 15287061.
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    99. MAO-B knockout mice exhibit deficient habituation of locomotor activity but normal nicotine intake. Genes Brain Behav. 2004 Aug; 3(4):216-27. Lee M, Chen K, Shih JC, Hiroi N. PMID: 15248867.
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    100. A spontaneous point mutation produces monoamine oxidase A/B knock-out mice with greatly elevated monoamines and anxiety-like behavior. J Biol Chem. 2004 Sep 17; 279(38):39645-52. Chen K, Holschneider DP, Wu W, Rebrin I, Shih JC. PMID: 15272015; PMCID: PMC2861902.
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    101. Three-dimensional ultrasound diagnosis of Larsen syndrome with further characterization of neurological sequelae. Ultrasound Obstet Gynecol. 2004 Jul; 24(1):89-93. Shih JC, Peng SS, Hsiao SM, Wang JH, Shyu MK, Lee CN, Hsieh FJ. PMID: 15229923.
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    102. Striatal damage and oxidative stress induced by the mitochondrial toxin malonate are reduced in clorgyline-treated rats and MAO-A deficient mice. Neurochem Res. 2004 Apr; 29(4):741-6. Maragos WF, Young KL, Altman CS, Pocernich CB, Drake J, Butterfield DA, Seif I, Holschneider DP, Chen K, Shih JC. PMID: 15098936.
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    103. Dual functions of transcription factors, transforming growth factor-beta-inducible early gene (TIEG)2 and Sp3, are mediated by CACCC element and Sp1 sites of human monoamine oxidase (MAO) B gene. J Biol Chem. 2004 May 14; 279(20):21021-8. Ou XM, Chen K, Shih JC. PMID: 15024015.
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    104. Cloning, after cloning, knock-out mice, and physiological functions of MAO A and B. Neurotoxicology. 2004 Jan; 25(1-2):21-30. Shih JC. PMID: 14697877.
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    105. Developmental expression pattern of monoamine oxidases in sensory organs and neural crest derivatives. J Comp Neurol. 2003 Sep 22; 464(3):392-403. Vitalis T, Alvarez C, Chen K, Shih JC, Gaspar P, Cases O. PMID: 12900932.
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    106. Prenatal diagnosis of cephalothoracopagus janiceps disymmetros using three-dimensional power Doppler ultrasound and magnetic resonance imaging. Ultrasound Obstet Gynecol. 2003 Sep; 22(3):299-304. Chen CP, Shih JC, Shih SL, Huang JK, Huang JP, Lin YH, Wang W. PMID: 12942505.
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    107. Decreased methylation and transcription repressor Sp3 up-regulated human monoamine oxidase (MAO) B expression during Caco-2 differentiation. J Biol Chem. 2003 Sep 19; 278(38):36227-35. Wong WK, Chen K, Shih JC. PMID: 12855685.
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    108. Neither antisocial personality disorder nor antisocial alcoholism is associated with the MAO-A gene in Han Chinese males. Alcohol Clin Exp Res. 2003 Jun; 27(6):889-93. Lu RB, Lin WW, Lee JF, Ko HC, Shih JC. PMID: 12824808.
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    109. Two- and three-dimensional ultrasound demonstration of a giant epignathus. Ultrasound Obstet Gynecol. 2003 Apr; 21(4):407-9. Chen CP, Shih JC, Huang JK, Chin DT, Tzen CY, Lin YH, Wang W. PMID: 12704754.
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    110. Keratinase in starter diets improves growth of broiler chicks. Poult Sci. 2003 Apr; 82(4):664-70. Odetallah NH, Wang JJ, Garlich JD, Shih JC. PMID: 12710489.
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    111. No association of the MAOA gene with alcoholism among Han Chinese males in Taiwan. Prog Neuropsychopharmacol Biol Psychiatry. 2002 Apr; 26(3):457-61. Lu RB, Lee JF, Ko HC, Lin WW, Chen K, Shih JC. PMID: 11999895.
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    112. Analysis of conserved active site residues in monoamine oxidase A and B and their three-dimensional molecular modeling. J Biol Chem. 2002 May 10; 277(19):17209-16. Geha RM, Chen K, Wouters J, Ooms F, Shih JC. PMID: 11861643; PMCID: PMC2844881.
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    113. Three-dimensional ultrasound in the evaluation of complex anomalies associated with fetal ventral midline defects. Ultrasound Obstet Gynecol. 2002 Jan; 19(1):102-4. Chen CP, Shih JC, Tzen CY, Wang W. PMID: 11851978.
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    114. Modulation of [3H]quinpirole binding at striatal D2 dopamine receptors by a monoamine oxidaseA-like site: evidence from radioligand binding studies and D2 receptor- and MAO(A)-deficient mice. Life Sci. 2001 Nov 30; 70(2):229-41. Levant B, Morgan KA, Ahlgren-Beckendorf JA, Grandy DK, Chen K, Shih JC, Seif I. PMID: 11787947.
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    115. Biochemical, behavioral, physiologic, and neurodevelopmental changes in mice deficient in monoamine oxidase A or B. Brain Res Bull. 2001 Nov 15; 56(5):453-62. Holschneider DP, Chen K, Seif I, Shih JC. PMID: 11750790; PMCID: PMC4109811.
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    116. Effects of carboxyl-terminal truncations on the activity and solubility of human monoamine oxidase B. J Biol Chem. 2001 Aug 03; 276(31):29499-506. Rebrin I, Geha RM, Chen K, Shih JC. PMID: 11371556.
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    117. Regulation of human monoamine oxidase B gene by Sp1 and Sp3. Mol Pharmacol. 2001 Apr; 59(4):852-9. Wong WK, Chen K, Shih JC. PMID: 11259630.
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    118. Biochemical effects of the monoamine neurotoxins DSP-4 and MDMA in specific brain regions of MAO-B-deficient mice. Synapse. 2001 Mar 01; 39(3):213-21. Fornai F, Giorgi FS, Gesi M, Chen K, Alessrì MG, Shih JC. PMID: 11169770.
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    119. 2-Naphthylamine, a compound found in cigarette smoke, decreases both monoamine oxidase A and B catalytic activity. Life Sci. 2001 Feb 02; 68(11):1231-41. Hauptmann N, Shih JC. PMID: 11233991.
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    120. Prenatal diagnosis and genetic analysis of type I and type II thanatophoric dysplasia. Prenat Diagn. 2001 Feb; 21(2):89-95. Chen CP, Chern SR, Shih JC, Wang W, Yeh LF, Chang TY, Tzen CY. PMID: 11241532.
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    121. Three-dimensional ultrasonography in early pregnancy. Semin Perinatol. 2001 Feb; 25(1):3-10. Shih JC, Jaffe R, Hsieh FJ. PMID: 11254157.
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    122. Substrate and inhibitor specificities for human monoamine oxidase A and B are influenced by a single amino acid. J Biol Chem. 2001 Mar 30; 276(13):9877-82. Geha RM, Rebrin I, Chen K, Shih JC. PMID: 11134050.
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    123. Current awareness in prenatal diagnosis. Prenat Diagn. 2000 Dec; 20(12):1021-7. Chen CP, Shih JC, Chan YJ. PMID: 11113922.
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    124. Analysis of the pharmacological and molecular heterogeneity of I(2)-imidazoline-binding proteins using monoamine oxidase-deficient mouse models. Mol Pharmacol. 2000 Nov; 58(5):1085-90. Remaury A, Raddatz R, Ordener C, Savic S, Shih JC, Chen K, Seif I, De Maeyer E, Lanier SM, Parini A. PMID: 11040057.
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    125. Genotype to phenotype: challenges and opportunities. Int J Dev Neurosci. 2000 Oct; 18(6):615-8. Holschneider DP, Shih JC. PMID: 10884606; PMCID: PMC4108069.
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    126. Phe(208) and Ile(199) in human monoamine oxidase A and B do not determine substrate and inhibitor specificities as in rat. J Neurochem. 2000 Sep; 75(3):1304-9. Geha RM, Chen K, Shih JC. PMID: 10936214.
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    127. Antenatal diagnosis of congenital hepatoblastoma in utero. Ultrasound Obstet Gynecol. 2000 Jul; 16(1):94-7. Shih JC, Tsao PN, Huang SF, Yen BL, Lin JH, Lee CN, Hsieh FJ. PMID: 11084976.
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    128. Congenital hepatoblastoma. Ultrasound Obstet Gynecol. 2000 Jul; 16(1):103. Shih JC, Tsao PN, Huang SF, Yen BL, Lin JH, Lee CN, Hsieh FJ. PMID: 11084980.
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    129. Prenatal sonographic depiction of fetal mediastinal immature teratoma. J Ultrasound Med. 2000 Apr; 19(4):289-92. Wang RM, Shih JC, Ko TM. PMID: 10759355.
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    130. Prenatal depiction of angioarchitecture of an aneurysm of the vein of Galen with three-dimensional color power angiography. Ultrasound Obstet Gynecol. 2000 Apr; 15(4):337-40. Lee TH, Shih JC, Peng SS, Lee CN, Shyu MK, Hsieh FJ. PMID: 10895457.
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    131. Ginkgo biloba abolishes aggression in mice lacking MAO A. Antioxid Redox Signal. 2000; 2(3):467-71. Shih JC, Chen K, Ridd MJ, Seif I. PMID: 11229360.
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    132. Yang-gan-wan protects mice against apoptosis induced by anti-Fas antibody (Jo2). Am J Chin Med. 2000; 28(3-4):325-30. Yang M, Chen K, Shih JC. PMID: 11154045.
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    133. Yang-Gan-Wan protects mice against experimental liver damage. Am J Chin Med. 2000; 28(2):155-62. Yang M, Chen K, Shih JC. PMID: 10999434.
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    134. Regional cerebral cortical activation in monoamine oxidase A-deficient mice: differential effects of chronic versus acute elevations in serotonin and norepinephrine. Neuroscience. 2000; 101(4):869-77. Holschneider DP, Scremin OU, Huynh L, Chen K, Seif I, Shih JC. PMID: 11113335; PMCID: PMC4108068.
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    135. Doppler waveform analysis of the intertwin blood flow in acardiac pregnancy: implications for pathogenesis. Ultrasound Obstet Gynecol. 1999 Dec; 14(6):375-9. Shih JC, Shyu MK, Hunag SF, Jou HJ, Su YN, Hsieh FJ. PMID: 10658274.
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    136. Striatal dopamine metabolism in monoamine oxidase B-deficient mice: a brain dialysis study. J Neurochem. 1999 Dec; 73(6):2434-40. Fornai F, Chen K, Giorgi FS, Gesi M, Alessandri MG, Shih JC. PMID: 10582603.
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    137. Separation of cesarean scar during second-trimester intravaginal misoprostol abortion. Obstet Gynecol. 1999 Nov; 94(5 Pt 2):840. Chen M, Shih JC, Chiu WT, Hsieh FJ. PMID: 10546751.
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    138. Cervical pregnancy: assessment with three-dimensional power Doppler imaging and successful management with selective uterine artery embolization. Ultrasound Obstet Gynecol. 1999 Oct; 14(4):284-7. Su YN, Shih JC, Chiu WH, Lee CN, Cheng WF, Hsieh FJ. PMID: 10586481.
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    139. Monoamine oxidase in neuropsychiatry and behavior. Am J Hum Genet. 1999 Sep; 65(3):593-8. Shih JC, Thompson RF. PMID: 10441564; PMCID: PMC1377964.
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    140. Prenatal diagnosis of a fetus with distal 10q trisomy. Prenat Diagn. 1999 Sep; 19(9):876-8. Chen CP, Shih JC, Lee CC, Chen LF, Wang W, Wang TY. PMID: 10521850.
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    141. Ketanserin and tetrabenazine abolish aggression in mice lacking monoamine oxidase A. Brain Res. 1999 Jul 24; 835(2):104-12. Shih JC, Ridd MJ, Chen K, Meehan WP, Kung MP, Seif I, De Maeyer E. PMID: 10415365.
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    142. 3-D power Doppler cerebral angiography in neonates and young infants: comparison with 2-D power Doppler angiography. Ultrasound Med Biol. 1999 Jul; 25(6):947-51. Peng SS, Lin JH, Lee WT, Tsao PN, Shih JC, Liu HM, Li YW, Hsieh FJ, Tsou KI. PMID: 10461723.
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    143. Binding of the imidazoline ligand 3H-2-benzofuranyl-2-imidazoline (BFI) to human brain and platelets. Potentiation by tranylcypromine and role of MAO isoforms. Ann N Y Acad Sci. 1999 Jun 21; 881:193-8. Steinberg MI, Wiest SA, Pickard RT, Chen K, Shih JC. PMID: 10415915.
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    144. Cerebral cortical blood flow maps are reorganized in MAOB-deficient mice. Brain Res. 1999 Apr 03; 824(1):36-44. Scremin OU, Holschneider DP, Chen K, Li MG, Shih JC. PMID: 10095040; PMCID: PMC4075434.
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    145. Schizophrenia, monoamine oxidase activity, and cigarette smoking. Neuropsychopharmacology. 1999 Apr; 20(4):392-4. Simpson GM, Shih JC, Chen K, Flowers C, Kumazawa T, Spring B. PMID: 10088141.
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    146. Ultrafast fetal MR images of intracranial teratoma. J Comput Assist Tomogr. 1999 Mar-Apr; 23(2):318-9. Peng SS, Shih JC, Liu HM, Li YW, Hsieh FJ. PMID: 10096346.
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    147. Lack of protection from ischemic injury of monoamine oxidase B-deficient mice following middle cerebral artery occlusion. Neurosci Lett. 1999 Jan 15; 259(3):161-4. Holschneider DP, Scremin OU, Huynh L, Chen K, Shih JC. PMID: 10025583.
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    148. Role of MAO A and B in neurotransmitter metabolism and behavior. Pol J Pharmacol. 1999 Jan-Feb; 51(1):25-9. Shih JC, Chen K, Ridd MJ. PMID: 10389141.
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    149. MAO-A and -B gene knock-out mice exhibit distinctly different behavior. Neurobiology (Bp). 1999; 7(2):235-46. Shih JC, Chen K. PMID: 10591056.
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    150. Monoamine oxidase: from genes to behavior. Annu Rev Neurosci. 1999; 22:197-217. Shih JC, Chen K, Ridd MJ. PMID: 10202537; PMCID: PMC2844879.
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    151. Lack of protection of monoamine oxidase B-deficient mice from age-related spatial learning deficits in the Morris water maze. Life Sci. 1999; 65(17):1757-63. Holschneider DP, Scremin OU, Chen K, Shih JC. PMID: 10576555.
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    152. Arteriovenous malformation of mesosalpinx associated with a 'vanishing' ectopic pregnancy: diagnosis with three-dimensional color power angiography. Ultrasound Obstet Gynecol. 1999 Jan; 13(1):63-6. Shih JC, Shyu MK, Cheng WF, Lee CN, Jou HJ, Wang RM, Hsieh FJ. PMID: 10201089.
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    153. Transcription factor binding to the core promoter of the human monoamine oxidase B gene in the cerebral cortex and in blood cells. Neurosci Lett. 1998 Dec 18; 258(2):101-4. Ekblom J, Garpenstrand H, Damberg M, Chen K, Shih JC, Oreland L. PMID: 9875537.
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    154. Abnormal stress response and increased fighting behavior in mice lacking the bcr gene product. Int J Mol Med. 1998 Nov; 2(5):577-83. Voncken JW, Baram TZ, Gonzales-Gomez I, Van Schaick H, Shih JC, Chen K, Groffen J, Heisterkamp N. PMID: 9858655.
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    155. Two-dimensional and three-dimensional power Doppler sonographic classification of vascular patterns in cervical lymphadenopathies. J Ultrasound Med. 1998 Jul; 17(7):459-64. Wu CH, Shih JC, Chang YL, Lee SY, Hsieh FJ. PMID: 9669305.
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    156. Antenatal depiction of the fetal ear with three-dimensional ultrasonography. Obstet Gynecol. 1998 Apr; 91(4):500-5. Shih JC, Shyu MK, Lee CN, Wu CH, Lin GJ, Hsieh FJ. PMID: 9540930.
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    157. Application of the surface rendering technique of three-dimensional ultrasound in prenatal diagnosis and counselling of Klippel-Trenaunay-Weber syndrome. Prenat Diagn. 1998 Mar; 18(3):298-302. Shih JC, Shyu MK, Chang CY, Lee CN, Lin GJ, Chen WH, Fan YT, Hsieh FJ. PMID: 9556049.
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    158. Is there a "non-MAO" macromolecular target for L-deprenyl?: Studies on MAOB mutant mice. Life Sci. 1998; 63(12):PL181-6. Ekblom J, Oreland L, Chen K, Shih JC. PMID: 9749831.
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    159. Prenatal diagnosis of monosomy 10q25 associated with single umbilical artery and sex reversal: report of a case. Prenat Diagn. 1998 Jan; 18(1):73-7. Chung YP, Hwa HL, Tseng LH, Shyu MK, Lee CN, Shih JC, Hsieh FJ. PMID: 9483644.
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    160. Determination of regions important for monoamine oxidase (MAO) A and B substrate and inhibitor selectivities. J Neural Transm Suppl. 1998; 52:1-8. Shih JC, Chen K, Geha RM. PMID: 9564602.
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    161. Monoamine oxidase A and B: structure, function, and behavior. Adv Pharmacol. 1998; 42:292-6. Chen K, Shih JC. PMID: 9327898.
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    162. Tissue-specific effects of estrogen on monoamine oxidase A and B in the rat. Life Sci. 1998; 63(3):155-60. Holschneider DP, Kumazawa T, Chen K, Shih JC. PMID: 9698044.
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    163. An extensive repeat structure down-regulates human monoamine oxidase A promoter activity independent of an initiator-like sequence. J Neurochem. 1997 Oct; 69(4):1368-73. Zhu Q, Shih JC. PMID: 9326264.
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    164. Increased stress response and beta-phenylethylamine in MAOB-deficient mice. Nat Genet. 1997 Oct; 17(2):206-10. Grimsby J, Toth M, Chen K, Kumazawa T, Klaidman L, Adams JD, Karoum F, Gal J, Shih JC. PMID: 9326944.
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    165. Intramural ectopic pregnancy. Sonographic picture and its relation with adenomyosis. Acta Obstet Gynecol Scand. 1997 Oct; 76(9):886-9. Lu HF, Sheu BC, Shih JC, Chang YL, Torng PL, Huang SC. PMID: 9351419.
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    166. Selective enhancement of emotional, but not motor, learning in monoamine oxidase A-deficient mice. Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5929-33. Kim JJ, Shih JC, Chen K, Chen L, Bao S, Maren S, Anagnostaras SG, Fanselow MS, De Maeyer E, Seif I, Thompson RF. PMID: 9159177; PMCID: PMC20883.
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    167. Serotonin2A receptor gene polymorphism in mood disorders. Biol Psychiatry. 1997 Apr 01; 41(7):768-73. Zhang HY, Ishigaki T, Tani K, Chen K, Shih JC, Miyasato K, Ohara K, Ohara K. PMID: 9084895.
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    168. Localization of monoamine oxidase A and B mRNA in the rat brain by in situ hybridization. Synapse. 1997 Jan; 25(1):30-6. Jahng JW, Houpt TA, Wessel TC, Chen K, Shih JC, Joh TH. PMID: 8987145.
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    169. The metabolism of tyramine by monoamine oxidase A/B causes oxidative damage to mitochondrial DNA. Arch Biochem Biophys. 1996 Nov 15; 335(2):295-304. Hauptmann N, Grimsby J, Shih JC, Cadenas E. PMID: 8914926.
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    170. Intact 5-HT2A receptor exons and the adjoining intron regions in schizophrenia. Neuropsychopharmacology. 1996 May; 14(5):339-47. Ishigaki T, Xie DW, Liu JC, Nakamura Y, Zhang HY, Tani K, Shimazu Y, Chen K, Shih JC, Miyasato K, Ohara K, Ohara K. PMID: 8703302.
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    171. Characterization and partial purification of human monoamine oxidase-B expressed in Escherichia coli. Protein Expr Purif. 1996 May; 7(3):315-22. Lu G, Unge T, Owera-Atepo JB, Shih JC, Ekblom J, Oreland L. PMID: 8860658.
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    172. Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia. Hum Genet. 1996 May; 97(5):614-9. Erdmann J, Shimron-Abarbanell D, Rietschel M, Albus M, Maier W, Körner J, Bondy B, Chen K, Shih JC, Knapp M, Propping P, Nöthen MM. PMID: 8655141.
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    173. Concordant body stalk anomaly in monozygotic twinning--early embryo cleavage disorder. Prenat Diagn. 1996 May; 16(5):467-70. Shih JC, Shyu MK, Hwa SL, Lee CN, Jeng YM, Lin GJ, Hsieh FJ. PMID: 8844008.
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    174. Molecular neuroanatomy of human monoamine oxidases A and B revealed by quantitative enzyme radioautography and in situ hybridization histochemistry. Neuroscience. 1996 Feb; 70(3):755-74. Saura J, Bleuel Z, Ulrich J, Mendelowitsch A, Chen K, Shih JC, Malherbe P, Da Prada M, Richards JG. PMID: 9045087.
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    175. Influence of C terminus on monoamine oxidase A and B catalytic activity. J Neurochem. 1996 Feb; 66(2):797-803. Chen K, Wu HF, Shih JC. PMID: 8592154.
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    176. Identification of a region important for human monoamine oxidase B substrate and inhibitor selectivity. Life Sci. 1996; 58(9):777-87. Grimsby J, Zentner M, Shih JC. PMID: 8632725.
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    177. Determination of transcription initiation sites and promoter activity of the human 5-HT2A receptor gene. Behav Brain Res. 1996; 73(1-2):59-62. Shih JC, Zhu Q, Chen K. PMID: 8788478.
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    178. Monoamine oxidase gene transcription in human cell lines: treatment with psychoactive drugs and ethanol. J Neural Transm (Vienna). 1996; 103(6):681-92. Ekblom J, Zhu QS, Chen K, Shih JC. PMID: 8836930.
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    179. Characterization of the human 5-HT2A receptor gene promoter. J Neurosci. 1995 Jul; 15(7 Pt 1):4885-95. Zhu QS, Chen K, Shih JC. PMID: 7623119; PMCID: PMC6577879.
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    180. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science. 1995 Jun 23; 268(5218):1763-6. Cases O, Seif I, Grimsby J, Gaspar P, Chen K, Pournin S, Müller U, Aguet M, Babinet C, Shih JC, et al. PMID: 7792602; PMCID: PMC2844866.
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    181. Expression of human monoamine oxidase (MAO) A gene controlled by transcription factor Sp1. Prog Brain Res. 1995; 106:49-56. Shih JC, Zhu QS, Chen K. PMID: 8584673.
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    182. Cloning of a novel monoamine oxidase cDNA from trout liver. Mol Pharmacol. 1994 Dec; 46(6):1226-33. Chen K, Wu HF, Grimsby J, Shih JC. PMID: 7808446.
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    183. Bidirectional promoter of human monoamine oxidase A (MAO A) controlled by transcription factor Sp1. J Neurosci. 1994 Dec; 14(12):7393-403. Zhu QS, Chen K, Shih JC. PMID: 7996184; PMCID: PMC6576875.
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    184. Identification of human monoamine oxidase (MAO) A and B gene promoters. J Neural Transm Suppl. 1994; 41:27-33. Shih JC, Zhu QS, Grimsby J, Chen K. PMID: 7931237.
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    185. Structure and function of serotonin 5-HT2 receptors. NIDA Res Monogr. 1994; 146:284-97. Shih JC, Chen K, Gallaher TK. PMID: 8742804.
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    186. The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical. J Neurochem. 1993 Jul; 61(1):187-90. Chen K, Wu HF, Shih JC. PMID: 8515265.
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    187. Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines. Mol Pharmacol. 1993 Jun; 43(6):888-93. Wu HF, Chen K, Shih JC. PMID: 8316221.
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    188. Site-directed mutagenesis of the serotonin 5-hydroxytrypamine2 receptor: identification of amino acids necessary for ligand binding and receptor activation. Mol Pharmacol. 1993 Jun; 43(6):931-40. Wang CD, Gallaher TK, Shih JC. PMID: 8316224.
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    189. Structure and promoter organization of the human monoamine oxidase A and B genes. J Psychiatry Neurosci. 1993 Jan; 18(1):25-32. Shih JC, Grimsby J, Chen K, Zhu QS. PMID: 8461277; PMCID: PMC1188472.
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    190. Promoter organization and activity of human monoamine oxidase (MAO) A and B genes. J Neurosci. 1992 Nov; 12(11):4437-46. Zhu QS, Grimsby J, Chen K, Shih JC. PMID: 1432104; PMCID: PMC6576015.
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    191. Gene structure and expression of the mouse 5-HT2 receptor. J Neurosci Res. 1992 Oct; 33(2):196-204. Yang W, Chen K, Lan NC, Gallaher TK, Shih JC. PMID: 1333538.
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    192. Site-directed mutagenesis of serotonin 5-HT2 receptors. J Chem Neuroanat. 1992 Jul-Aug; 5(4):281-2. Shih JC, Gallaher T, Wang CD, Chen K. PMID: 1524714.
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    193. The human 5-HT2 receptor is encoded by a multiple intron-exon gene. Brain Res Mol Brain Res. 1992 Jun; 14(1-2):20-6. Chen K, Yang W, Grimsby J, Shih JC. PMID: 1323014.
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    194. Dinucleotide repeat (TG)23 polymorphism in the MAOB gene. Nucleic Acids Res. 1992 Feb 25; 20(4):924. Grimsby J, Chen K, Devor EJ, Cloninger CR, Shih JC. PMID: 1542591; PMCID: PMC312052.
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    195. Molecular biology of serotonin (5-HT) receptors. Pharmacol Biochem Behav. 1991 Dec; 40(4):1053-8. Shih JC, Yang W, Chen K, Gallaher T. PMID: 1816559.
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    196. Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Natl Acad Sci U S A. 1991 May 01; 88(9):3637-41. Grimsby J, Chen K, Wang LJ, Lan NC, Shih JC. PMID: 2023912; PMCID: PMC51507.
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    197. Molecular basis of human MAO A and B. Neuropsychopharmacology. 1991 Jan; 4(1):1-7. Shih JC. PMID: 2003865.
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    198. Tissue distribution of human monoamine oxidase A and B mRNA. J Neurochem. 1990 Oct; 55(4):1166-9. Grimsby J, Lan NC, Neve R, Chen K, Shih JC. PMID: 2398352.
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    199. Molecular studies of 5-HT receptors. Ann N Y Acad Sci. 1990; 600:206-11. Shih JC, Chen K. PMID: 2123616.
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    200. The expression of human MAO-A and B genes. J Neural Transm Suppl. 1990; 32:41-7. Shih JC, Grimsby J, Chen K. PMID: 2089104.
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    201. Localization of monoamine oxidase A and B genes on the mouse X chromosome. Nucleic Acids Res. 1989 Oct 25; 17(20):8403. Derry JM, Lan NC, Shih JC, Barnard EA, Barnard PJ. PMID: 2573045; PMCID: PMC335008.
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    202. Expression of functional human monoamine oxidase A and B cDNAs in mammalian cells. J Neurochem. 1989 May; 52(5):1652-4. Lan NC, Chen CH, Shih JC. PMID: 2496202.
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    203. Human monoamine oxidase A and B genes map to Xp 11.23 and are deleted in a patient with Norrie disease. Genomics. 1989 May; 4(4):552-9. Lan NC, Heinzmann C, Gal A, Klisak I, Orth U, Lai E, Grimsby J, Sparkes RS, Mohandas T, Shih JC. PMID: 2744764.
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    204. Identification of 5-hydroxytryptamine1A receptor proteins in bovine frontal cortex. J Neurochem. 1988 Nov; 51(5):1343-9. Takeuchi Y, Yang W, Shih JC. PMID: 3171582.
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    205. Effect of anaerobic digestion on oocysts of the protozoan Eimeria tenella. Appl Environ Microbiol. 1988 Oct; 54(10):2335-41. Lee MR, Shih JC. PMID: 3202626; PMCID: PMC204251.
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    206. cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties. Proc Natl Acad Sci U S A. 1988 Jul; 85(13):4934-8. Bach AW, Lan NC, Johnson DL, Abell CW, Bembenek ME, Kwan SW, Seeburg PH, Shih JC. PMID: 3387449; PMCID: PMC280552.
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    207. Photoaffinity labeling of human placental monoamine oxidase-A by 4-fluoro-3-nitrophenyl azide. Mol Pharmacol. 1988 Feb; 33(2):237-41. Hsu MC, Shih JC. PMID: 3340083.
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    208. Evidence for two conformational states of 5-hydroxytryptamine carrier in rat cortical synaptosomes. Neuropharmacology. 1987 Dec; 26(12):1667-71. Lee JD, Shih JC. PMID: 3501842.
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    209. Photoaffinity labeling of beef liver monoamine oxidase-B by 4-fluoro-3-nitrophenyl azide. Biochem Pharmacol. 1987 Mar 15; 36(6):937-43. Chen SA, Shih JC, Hsu MC, Xu QP. PMID: 3566791.
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    210. 4-Fluoro-3-nitrophenyl azide binding sites on purified beef liver monoamine oxidase B. Neurochem Int. 1987; 10(2):167-72. Hsu MC, Chen S, Shih JC. PMID: 20501066.
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    211. Necessity of ascorbic acid in the radioligand binding assay for [3H]5-hydroxytryptamine. Neuropharmacology. 1986 Aug; 25(8):869-75. Andresen JW, Shih JC. PMID: 3774116.
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    212. [3H]1-[2-(4-aminophenyl)ethyl]-4-(3-trifluoromethylphenyl)piperazine: a selective radioligand for 5-HT1A receptors in rat brain. J Neurochem. 1986 Jan; 46(1):68-75. Ransom RW, Asarch KB, Shih JC. PMID: 2933490.
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    213. Inhibition of monoamine oxidase by phenyl azides. J Neurochem. 1985 Sep; 45(3):940-5. Chen S, Shih JC, Xu QP. PMID: 4031869.
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    214. Photoinactivation of serotonin uptake by an arylazido derivative of 5-hydroxytryptamine. Mol Pharmacol. 1985 Aug; 28(2):185-90. Ransom RW, Lee JD, Bolger MB, Shih JC. PMID: 4022001.
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    215. 5-HT-1a and 5-HT-1b selectivity of two phenylpiperazine derivatives: evidence for 5-HT-1b heterogeneity. Life Sci. 1985 Apr 01; 36(13):1265-73. Asarch KB, Ransom RW, Shih JC. PMID: 3982214.
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    216. 4-Fluoro-3-nitrophenyl azide, a selective photoaffinity label for type B monoamine oxidase. Biochem Pharmacol. 1985 Mar 15; 34(6):781-8. Chen S, Shih JC, Xu QP. PMID: 3977955.
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    217. Interaction of N-(2-nitro-4-azidophenyl)-serotonin with two types of monoamine oxidase in rat brain. J Neurochem. 1984 Dec; 43(6):1680-7. Chen S, Shih JC, Xu QP. PMID: 6491673.
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    218. Differential effect of cholesterol on two types of 5-hydroxytryptamine binding sites. Neurochem Res. 1983 Jun; 8(6):701-10. Shih JC, Ohsawa R. PMID: 6621769.
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    219. Identification of serotonin-binding proteins using a photoaffinity labeling probe. Adv Exp Med Biol. 1981; 133:319-25. Shih JC, Cheng SH. PMID: 6459006.
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    220. Photoaffinity labeling of serotonin-binding proteins. Life Sci. 1979 Dec 24; 25(26):2197-203. Cheng SH, Shih JC. PMID: 542097.
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    221. The alteration of serotonin binding sites in aged human brain. Life Sci. 1978 Oct 09; 23(14):1441-8. Shih JC, Young H. PMID: 713701.
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    222. Determination of monoamine oxidase in rat brain by electron spin resonance techniques. J Neurochem. 1976 Apr; 26(4):799-803. Huang RH, Eiduson S, Shih JC. PMID: 184246.
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    223. Separation of L-phenylalanine: pyruvate transaminase and L-phenylalanine: alpha-ketoglutarate transaminase by sephadex-electrophoresis. Life Sci. 1975 Aug 15; 17(4):627-32. Shih JC. PMID: 1186430.
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