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Curtis T. Okamoto, PhD

Title(s)Associate Professor of Pharmacology and Pharmaceutical Sciences
Phone+1 323 442 3939
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    ASSEMBLY AND TARGETING OF EPITHELIAL P-TYPE ATPASES
    NIH/NIDDK R01DK051588Sep 1, 1997 - Feb 29, 2004
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Hamm-Alvarez SF, Janga SR, Edman MC, Feigenbaum D, Freire D, Mack WJ, Okamoto CT, Lew MF. Levels of oligomeric a-Synuclein in reflex tears distinguish Parkinson's disease patients from healthy controls. Biomark Med. 2019 Sep 25. PMID: 31552762.
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    2. Hamm-Alvarez SF, Okamoto CT, Janga SR, Feigenbaum D, Edman MC, Freire D, Shah M, Ghanshani R, Mack WJ, Lew MF. Oligomeric a-synuclein is increased in basal tears of Parkinson's patients. Biomark Med. 2019 Aug; 13(11):941-952. PMID: 31262201.
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    3. Li Z, Tyrpak DR, Park M, Okamoto CT, MacKay JA. A new temperature-dependent strategy to modulate the epidermal growth factor receptor. Biomaterials. 2018 11; 183:319-330. PMID: 30196151.
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    4. Okamoto CT. Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells. Cold Spring Harb Perspect Biol. 2017 Nov 01; 9(11). PMID: 28246186.
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    5. Jia C, Medina V, Liu C, He L, Qian D, Taojian T, Okamoto CT, Stiles BL. Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. Hepatol Commun. 2017 Apr; 1(2):153-167. PMID: 29152604.
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    6. Zhou L, Wang HY, Tong S, Okamoto CT, Shen WC, Zaro JL. Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery. Biomaterials. 2017 02; 117:24-31. PMID: 27923197.
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    7. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 06 01; 310(11):C942-54. PMID: 27076615.
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    8. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
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    9. Natarajan P, Crothers JM, Rosen JE, Nakada SL, Rakholia M, Okamoto CT, Forte JG, Machen TE. Myosin IIB and F-actin control apical vacuolar morphology and histamine-induced trafficking of H-K-ATPase-containing tubulovesicles in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 306(8):G699-710. PMID: 24578340.
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    10. Okamoto CT. Don't wanna be Obama (all by my) self: Rab11a is involved in sequestration of fluid-phase cargo from membrane cargo. Focus on "Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo". Am J Physiol Cell Physiol. 2014 Mar 01; 306(5):C428-30. PMID: 24429065.
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    11. Gleason BL, Siracuse MV, Moniri NH, Birnie CR, Okamoto CT, Crouch MA. Evolution of preprofessional pharmacy curricula. Am J Pharm Educ. 2013 Jun 12; 77(5):95. PMID: 23788806.
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    12. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez SF. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. PMID: 23606742.
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    13. Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto CT, Smith CE, Paine ML. Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res. 2013 Mar; 28(3):672-87. PMID: 23044750.
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    14. Machen T, Okamoto C, Chew C, Goldenring JR. John Gaetano Forte, PhD. Gastroenterology. 2013 Mar; 144(3):471-3. PMID: 23352594.
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    15. Okamoto CT. Caring about the other 47% of the water channels. Focus on "Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel". Am J Physiol Cell Physiol. 2013 Jan 01; 304(1):C33-5. PMID: 23135701.
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    16. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632.
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    17. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. PMID: 23026636.
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    18. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. PMID: 21984810.
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    19. Suda J, Zhu L, Okamoto CT, Karvar S. Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology. 2011 Mar; 140(3):868-78. PMID: 20888820.
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    20. Okamoto CT. Duodenal epithelial cells provide a stimulus package for the recovery from an acid load. J Physiol. 2009 Jul 15; 587(Pt 14):3409. PMID: 19602628.
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    21. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. PMID: 18171724.
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    22. Zou Y, Wang H, Shapiro JL, Okamoto CT, Brookes SJ, Lyngstadaas SP, Snead ML, Paine ML. Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15; 408(3):347-54. PMID: 17708745.
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    23. Shapiro JL, Wen X, Okamoto CT, Wang HJ, Lyngstadaas SP, Goldberg M, Snead ML, Paine ML. Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci. 2007 Jan; 64(2):244-56. PMID: 17187173.
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    24. Zaro JL, Rajapaksa TE, Okamoto CT, Shen WC. Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis. Mol Pharm. 2006 Mar-Apr; 3(2):181-6. PMID: 16579647.
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    25. Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton DR. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. PMID: 16384975.
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    26. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141.
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    27. Wen X, Lei YP, Zhou YL, Okamoto CT, Snead ML, Paine ML. Structural organization and cellular localization of tuftelin-interacting protein 11 (TFIP11). Cell Mol Life Sci. 2005 May; 62(9):1038-46. PMID: 15868102.
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    28. Chew CS, Okamoto CT, Chen X, Thomas R. Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G320-31. PMID: 15790763.
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    29. Chu C, Okamoto CT, Hamm-Alvarez SF, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. PMID: 15587917.
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    30. Chew CS, Okamoto CT, Chen X, Qin HY. IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Feb; 288(2):G376-87. PMID: 15458922.
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    31. da Costa SR, Okamoto CT, Hamm-Alvarez SF. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. PMID: 14597136.
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    32. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. PMID: 12937279.
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    33. Chew CS, Chen X, Parente JA, Tarrer S, Okamoto C, Qin HY. Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo. J Cell Sci. 2002 Dec 15; 115(Pt 24):4787-99. PMID: 12432067.
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    34. Okamoto CT. From genetics to cellular physiology. Focus on "Regulation of transferrin-induced endocytosis by wild-type and C282Y-mutant HFE in transfected HeLa cells". Am J Physiol Cell Physiol. 2002 May; 282(5):C971-2. PMID: 11940509.
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    35. Schechter J, Stevenson D, Chang D, Chang N, Pidgeon M, Nakamura T, Okamoto CT, Trousdale MD, Mircheff AK. Growth of purified lacrimal acinar cells in Matrigel raft cultures. Exp Eye Res. 2002 Mar; 74(3):349-60. PMID: 12014916.
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    36. Okamoto CT, Li R, Zhang Z, Jeng YY, Chew CS. Regulation of protein and vesicle trafficking at the apical membrane of epithelial cells. J Control Release. 2002 Jan 17; 78(1-3):35-41. PMID: 11772447.
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    37. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. PMID: 12613908.
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    38. Okamoto CT, Forte JG. Vesicular trafficking machinery, the actin cytoskeleton, and H+-K+-ATPase recycling in the gastric parietal cell. J Physiol. 2001 Apr 15; 532(Pt 2):287-96. PMID: 11306650.
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    39. Okamoto CT, Duman JG, Tyagarajan K, McDonald KL, Jeng YY, McKinney J, Forte TM, Forte JG. Clathrin in gastric acid secretory (parietal) cells: biochemical characterization and subcellular localization. Am J Physiol Cell Physiol. 2000 Sep; 279(3):C833-51. PMID: 10942733.
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    40. Okamoto CT, McKinney J, Jeng YY. Clathrin in mitotic spindles. Am J Physiol Cell Physiol. 2000 Aug; 279(2):C369-74. PMID: 10913003.
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    41. Paine CT, Paine ML, Luo W, Okamoto CT, Lyngstadaas SP, Snead ML. A tuftelin-interacting protein (TIP39) localizes to the apical secretory pole of mouse ameloblasts. J Biol Chem. 2000 Jul 21; 275(29):22284-92. PMID: 10806191.
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    42. Okamoto CT, Chow DC, Forte AJ. Interaction of alpha- and beta-subunits in native H-K-ATPase and cultured cells transfected with H-K-ATPase beta-subunit. Am J Physiol Cell Physiol. 2000 Apr; 278(4):C727-38. PMID: 10751322.
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    43. Yang T, Zeng H, Zhang J, Okamoto CT, Warren DW, Wood RL, Bachmann M, Mircheff AK. Stimulation with carbachol alters endomembrane distribution and plasma membrane expression of intracellular proteins in lacrimal acinar cells. Exp Eye Res. 1999 Dec; 69(6):651-61. PMID: 10620394.
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    44. Okamoto CT. HSP27 and signaling to the actin cytoskeleton focus on "HSP27 expression regulates CCK-induced changes of the actin cytoskeleton in CHO-CCK-A cells". Am J Physiol. 1999 12; 277(6):C1029-31. PMID: 10600753.
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    45. Yang T, Zeng H, Zhang J, Okamoto CT, Warren DW, Wood RL, Bachmann M, Mircheff AK. MHC class II molecules, cathepsins, and La/SSB proteins in lacrimal acinar cell endomembranes. Am J Physiol. 1999 11; 277(5):C994-C1007. PMID: 10564093.
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    46. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release. 1999 Nov 01; 62(1-2):129-40. PMID: 10518644.
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    47. Orzech E, Schlessinger K, Weiss A, Okamoto CT, Aroeti B. Interactions of the AP-1 Golgi adaptor with the polymeric immunoglobulin receptor and their possible role in mediating brefeldin A-sensitive basolateral targeting from the trans-Golgi network. J Biol Chem. 1999 Jan 22; 274(4):2201-15. PMID: 9890983.
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    48. Okamoto CT, Jeng YY. An immunologically distinct beta-adaptin on tubulovesicles of gastric oxyntic cells. Am J Physiol. 1998 11; 275(5):C1323-9. PMID: 9814981.
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    49. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez S, Okamoto CT, Kim KJ, Basu SK, Wu S, Lee VH. Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci. 1998 Nov; 87(11):1286-91. PMID: 9811478.
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    50. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. PMID: 9735340.
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    51. Okamoto CT, Karam SM, Jeng YY, Forte JG, Goldenring JR. Identification of clathrin and clathrin adaptors on tubulovesicles of gastric acid secretory (oxyntic) cells. Am J Physiol. 1998 04; 274(4):C1017-29. PMID: 9575799.
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    52. Basu SK, Shen J, Elbert KJ, Okamoto CT, Lee VH, von Grafenstein H. Development and utility of anti-PepT1 anti-peptide polyclonal antibodies. Pharm Res. 1998 Feb; 15(2):338-42. PMID: 9523324.
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    53. Mircheff AK, Gierow JP, Yang T, Zhang J, Wood RL, Azzarolo AM, Warren DW, Zeng H, Guo Z, Kaslow HR, Hamm-Alvarez SF, Okamoto CT, Bachmann M. Sjögren's autoimmunity: how perturbation of recognition in endomembrane traffic may provoke pathological recognition at the cell surface. J Mol Recognit. 1998; 11(1-6):40-8. PMID: 10076804.
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    54. Gierow JP, Yang T, Bekmezian A, Liu N, Norian JM, Kim SA, Rafisolyman S, Zeng H, Okamoto CT, Wood RL, Mircheff AK. Na-K-ATPase in lacrimal gland acinar cell endosomal system: correcting a case of mistaken identity. Am J Physiol. 1996 Nov; 271(5 Pt 1):C1685-98. PMID: 8944653.
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    55. Okamoto CT, Song W, Bomsel M, Mostov KE. Rapid internalization of the polymeric immunoglobulin receptor requires phosphorylated serine 726. J Biol Chem. 1994 Jun 03; 269(22):15676-82. PMID: 8195218.
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    56. Okamoto CT, Shia SP, Bird C, Mostov KE, Roth MG. The cytoplasmic domain of the polymeric immunoglobulin receptor contains two internalization signals that are distinct from its basolateral sorting signal. J Biol Chem. 1992 May 15; 267(14):9925-32. PMID: 1577823.
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    57. Mostov K, Apodaca G, Aroeti B, Okamoto C. Plasma membrane protein sorting in polarized epithelial cells. J Cell Biol. 1992 Feb; 116(3):577-83. PMID: 1730769.
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    58. Aroeti B, Casanova J, Okamoto C, Cardone M, Pollack A, Tang K, Mostov K. Polymeric immunoglobulin receptor. Int Rev Cytol. 1992; 137B:157-68. PMID: 1478818.
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    59. Canfield VA, Okamoto CT, Chow D, Dorfman J, Gros P, Forte JG, Levenson R. Cloning of the H,K-ATPase beta subunit. Tissue-specific expression, chromosomal assignment, and relationship to Na,K-ATPase beta subunits. J Biol Chem. 1990 Nov 15; 265(32):19878-84. PMID: 1978834.
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    60. Okamoto CT, Karpilow JM, Smolka A, Forte JG. Isolation and characterization of gastric microsomal glycoproteins. Evidence for a glycosylated beta-subunit of the H+/K(+)-ATPase. Biochim Biophys Acta. 1990 Mar 01; 1037(3):360-72. PMID: 1690026.
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    61. Forte JG, Hanzel DK, Okamoto C, Chow D, Urushidani T. Membrane and protein recycling associated with gastric HCl secretion. J Intern Med Suppl. 1990; 732:17-26. PMID: 2166524.
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    62. Okamoto CT, Forte JG. Distribution of lectin-binding sites in oxyntic and chief cells of isolated rabbit gastric glands. Gastroenterology. 1988 Aug; 95(2):334-42. PMID: 3134267.
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    63. Reichstein BJ, Okamoto C, Forte JG. Effect of ethanol on acid secretion by isolated gastric glands from rabbit. Gastroenterology. 1986 Aug; 91(2):439-47. PMID: 3013711.
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    64. Nagle BW, Okamoto C, Taggart B, Burnside B. The teleost cone cytoskeleton. Localization of actin, microtubules, and intermediate filaments. Invest Ophthalmol Vis Sci. 1986 May; 27(5):689-701. PMID: 3700018.
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    65. Wolosin JM, Okamoto C, Forte TM, Forte JG. Actin and associated proteins in gastric epithelial cells. Biochim Biophys Acta. 1983 Dec 13; 761(2):171-82. PMID: 6228258.
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    66. Forte JG, Forte TM, Black JA, Okamoto C, Wolosin JM. Correlation of parietal cell structure and function. J Clin Gastroenterol. 1983; 5 Suppl 1:17-27. PMID: 6228573.
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