Curtis Toshio Okamoto, PhD

TitleAssociate Professor of Pharmacology and Pharmaceutical Sciences
InstitutionUniversity of Southern California
DepartmentPharmacology and Pharmaceutical Sciences
AddressPSC 404A
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 3939
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    Collapse Research 
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    NIH/NIDDK R01DK051588Sep 1, 1997 - Feb 29, 2004
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Li Z, Tyrpak DR, Park M, Okamoto CT, MacKay JA. A new temperature-dependent strategy to modulate the epidermal growth factor receptor. Biomaterials. 2018 Nov; 183:319-330. PMID: 30196151.
      View in: PubMed
    2. Okamoto CT. Regulation of Transporters and Channels by Membrane-Trafficking Complexes in Epithelial Cells. Cold Spring Harb Perspect Biol. 2017 Nov 01; 9(11). PMID: 28246186.
      View in: PubMed
    3. Jia C, Medina V, Liu C, He L, Qian D, Taojian T, Okamoto CT, Stiles BL. Crosstalk of LKB1- and PTEN-regulated signals in liver morphogenesis and tumor development. Hepatol Commun. 2017 Apr; 1(2):153-167. PMID: 29152604.
      View in: PubMed
    4. Zhou L, Wang HY, Tong S, Okamoto CT, Shen WC, Zaro JL. Single chain Fc-dimer-human growth hormone fusion protein for improved drug delivery. Biomaterials. 2017 02; 117:24-31. PMID: 27923197.
      View in: PubMed
    5. Meng Z, Edman MC, Hsueh PY, Chen CY, Klinngam W, Tolmachova T, Okamoto CT, Hamm-Alvarez SF. Imbalanced Rab3D versus Rab27 increases cathepsin S secretion from lacrimal acini in a mouse model of Sjögren's Syndrome. Am J Physiol Cell Physiol. 2016 Jun 01; 310(11):C942-54. PMID: 27076615; PMCID: PMC4935202 [Available on 06/01/17].
    6. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay JA. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
      View in: PubMed
    7. Natarajan P, Crothers JM, Rosen JE, Nakada SL, Rakholia M, Okamoto CT, Forte JG, Machen TE. Myosin IIB and F-actin control apical vacuolar morphology and histamine-induced trafficking of H-K-ATPase-containing tubulovesicles in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2014 Apr 15; 306(8):G699-710. PMID: 24578340; PMCID: PMC3989701.
    8. Okamoto CT. Don't wanna be Obama (all by my) self: Rab11a is involved in sequestration of fluid-phase cargo from membrane cargo. Focus on "Rab11a-positive compartments in proximal tubule cells sort fluid-phase and membrane cargo". Am J Physiol Cell Physiol. 2014 Mar 01; 306(5):C428-30. PMID: 24429065.
      View in: PubMed
    9. Gleason BL, Siracuse MV, Moniri NH, Birnie CR, Okamoto CT, Crouch MA. Evolution of preprofessional pharmacy curricula. Am J Pharm Educ. 2013 Jun 12; 77(5):95. PMID: 23788806; PMCID: PMC3687128.
    10. Xu S, Ma L, Evans E, Okamoto CT, Hamm-Alvarez SF. Polymeric immunoglobulin receptor traffics through two distinct apically targeted pathways in primary lacrimal gland acinar cells. J Cell Sci. 2013 Jun 15; 126(Pt 12):2704-17. PMID: 23606742; PMCID: PMC3687702.
    11. Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto CT, Smith CE, Paine ML. Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res. 2013 Mar; 28(3):672-87. PMID: 23044750; PMCID: PMC3562759.
    12. Machen T, Okamoto C, Chew C, Goldenring JR. John Gaetano Forte, PhD. Gastroenterology. 2013 Mar; 144(3):471-3. PMID: 23352594.
      View in: PubMed
    13. Okamoto CT. Caring about the other 47% of the water channels. Focus on "Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel". Am J Physiol Cell Physiol. 2013 Jan 01; 304(1):C33-5. PMID: 23135701.
      View in: PubMed
    14. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632; PMCID: PMC3500625.
    15. Xu S, Olenyuk BZ, Okamoto CT, Hamm-Alvarez SF. Targeting receptor-mediated endocytotic pathways with nanoparticles: rationale and advances. Adv Drug Deliv Rev. 2013 Jan; 65(1):121-38. PMID: 23026636; PMCID: PMC3565049.
    16. Xu S, Edman M, Kothawala MS, Sun G, Chiang L, Mircheff A, Zhu L, Okamoto C, Hamm-Alvarez S. A Rab11a-enriched subapical membrane compartment regulates a cytoskeleton-dependent transcytotic pathway in secretory epithelial cells of the lacrimal gland. J Cell Sci. 2011 Oct 15; 124(Pt 20):3503-14. PMID: 21984810; PMCID: PMC3196860.
    17. Suda J, Zhu L, Okamoto CT, Karvar S. Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology. 2011 Mar; 140(3):868-78. PMID: 20888820.
      View in: PubMed
    18. Okamoto CT. Duodenal epithelial cells provide a stimulus package for the recovery from an acid load. J Physiol. 2009 Jul 15; 587(Pt 14):3409. PMID: 19602628; PMCID: PMC2742261.
    19. Evans E, Zhang W, Jerdeva G, Chen CY, Chen X, Hamm-Alvarez SF, Okamoto CT. Direct interaction between Rab3D and the polymeric immunoglobulin receptor and trafficking through regulated secretory vesicles in lacrimal gland acinar cells. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C662-74. PMID: 18171724; PMCID: PMC4046641.
    20. Zou Y, Wang H, Shapiro JL, Okamoto CT, Brookes SJ, Lyngstadaas SP, Snead ML, Paine ML. Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J. 2007 Dec 15; 408(3):347-54. PMID: 17708745; PMCID: PMC2267358.
    21. Zaro JL, Rajapaksa TE, Okamoto CT, Shen WC. Membrane transduction of oligoarginine in HeLa cells is not mediated by macropinocytosis. Mol Pharm. 2006 Mar-Apr; 3(2):181-6. PMID: 16579647.
      View in: PubMed
    22. Zhang N, Kannan R, Okamoto CT, Ryan SJ, Lee VH, Hinton DR. Characterization of brimonidine transport in retinal pigment epithelium. Invest Ophthalmol Vis Sci. 2006 Jan; 47(1):287-94. PMID: 16384975.
      View in: PubMed
    23. Jerdeva GV, Yarber FA, Trousdale MD, Rhodes CJ, Okamoto CT, Dartt DA, Hamm-Alvarez SF. Dominant-negative PKC-epsilon impairs apical actin remodeling in parallel with inhibition of carbachol-stimulated secretion in rabbit lacrimal acini. Am J Physiol Cell Physiol. 2005 Oct; 289(4):C1052-68. PMID: 15930141; PMCID: PMC1414898.
    24. Chew CS, Okamoto CT, Chen X, Thomas R. Drebrin E2 is differentially expressed and phosphorylated in parietal cells in the gastric mucosa. Am J Physiol Gastrointest Liver Physiol. 2005 Aug; 289(2):G320-31. PMID: 15790763.
      View in: PubMed
    25. Chu C, Okamoto CT, Hamm-Alvarez SF, Lee VH. Stable transfection of MDCK cells with epitope-tagged human PepT1. Pharm Res. 2004 Nov; 21(11):1970-3. PMID: 15587917.
      View in: PubMed
    26. Chew CS, Okamoto CT, Chen X, Qin HY. IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells. Am J Physiol Gastrointest Liver Physiol. 2005 Feb; 288(2):G376-87. PMID: 15458922.
      View in: PubMed
    27. da Costa SR, Okamoto CT, Hamm-Alvarez SF. Actin microfilaments et al.--the many components, effectors and regulators of epithelial cell endocytosis. Adv Drug Deliv Rev. 2003 Nov 14; 55(11):1359-83. PMID: 14597136.
      View in: PubMed
    28. Da Costa SR, Sou E, Xie J, Yarber FA, Okamoto CT, Pidgeon M, Kessels MM, Mircheff AK, Schechter JE, Qualmann B, Hamm-Alvarez SF. Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells. Mol Biol Cell. 2003 Nov; 14(11):4397-413. PMID: 12937279; PMCID: PMC266760.
    29. Chew CS, Chen X, Parente JA, Tarrer S, Okamoto C, Qin HY. Lasp-1 binds to non-muscle F-actin in vitro and is localized within multiple sites of dynamic actin assembly in vivo. J Cell Sci. 2002 Dec 15; 115(Pt 24):4787-99. PMID: 12432067.
      View in: PubMed
    30. Okamoto CT. From genetics to cellular physiology. Focus on "Regulation of transferrin-induced endocytosis by wild-type and C282Y-mutant HFE in transfected HeLa cells". Am J Physiol Cell Physiol. 2002 May; 282(5):C971-2. PMID: 11940509.
      View in: PubMed
    31. Schechter J, Stevenson D, Chang D, Chang N, Pidgeon M, Nakamura T, Okamoto CT, Trousdale MD, Mircheff AK. Growth of purified lacrimal acinar cells in Matrigel raft cultures. Exp Eye Res. 2002 Mar; 74(3):349-60. PMID: 12014916.
      View in: PubMed
    32. Okamoto CT, Li R, Zhang Z, Jeng YY, Chew CS. Regulation of protein and vesicle trafficking at the apical membrane of epithelial cells. J Control Release. 2002 Jan 17; 78(1-3):35-41. PMID: 11772447.
      View in: PubMed
    33. da Costa SR, Andersson S, Arber F, Okamoto C, Hamm-Alvarez S. Cytoskeletal participation in stimulated secretion and compensatory apical plasma membrane retrieval in lacrimal gland acinar cells. Adv Exp Med Biol. 2002; 506(Pt A):199-205. PMID: 12613908.
      View in: PubMed