Ararat Chakhoyan

Title(s)Assistant Professor of Research Physiology & Neuroscience
SchoolKeck School of Medicine of Usc
Address1501 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)Assistant Director, MRI/PET Research Unit


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    University Of Caen-Normandy, FranceBachelor Of Science7/2013Image and Sound Processing
    University Of Caen-Normandy, FranceMaster Of Science8/2015Neuroscience
    University Of Caen-Normandy, FrancePhD10/2016Neuroscience and Biomedical Imaging
    University of California Los Angeles, USAPost-Doctoral Fellowship12/2018Brain Tumor Imaging
    University of Southern California, USAPost-Doctoral Fellowship9/2019Amyloid and Tau-PET Imaging

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    Dr. Chakhoyan is the Assistant Professor of Research in the department of Physiology and Neuroscience at the Zilkha Neurogenetic Institute in the Keck School of Medicine at USC. He is involved in different ongoing research projects in the Zlokovic lab. His day-to-day activity includes research design, implementation of innovative methods for human and mouse brain MRI/PET image acquisition, post-processing, analyze and result interpretation. His current research direction and scope of work in Project 1 within the Program Project “Vascular Contribution to Dementia and Genetic Risk Factors for Alzheimer’s Disease (NIH/NIA:1P01AG052350-05)” and the associated sister grant “Vascular Contribution to Dementia and Amyloid and Tau Lesions in APOE4 Carriers (Alzheimer’s Association 008369-00001) led by Drs Zlokovic and Toga is to measure the poorly understood interplay between blood-brain barrier permeability (quantified by MRI), amyloid and tau accumulation (quantified by PET), vascular (small vessel disease, hypertension, diabetes, smoking) and genetic risk factors (Apolipoprotein E4) that is a major risk factor for Alzheimer’s disease. A key technical challenge is the implementation of early MRI/PET biomarkers that can predict disease progression, which helps us to identify potential targets for intervention and improve risk prediction.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Magnetic resonance imaging of white matter response to diesel exhaust particles. Res Sq. 2023 Jul 18. Chakhoyan A, Shkrkova K, Sizdahkhani S, Huuskonen MT, Lamorie-Foote K, Diaz A, Chen S, Liu Q, D'Agostino C, Zhang H, Mack WJ, Sioutas C, Finch CE, Zlokovic B, Mack WJ. PMID: 37503159; PMCID: PMC10371072.
      View in: PubMed   Mentions:
    2. Magnetic resonance imaging of hypoxia in acute stroke compared with fluorine-18 fluoromisonidazole-positron emission tomography: A cross-validation study? NMR Biomed. 2023 03; 36(3):e4858. Valable S, Toutain J, Divoux D, Chazalviel L, Corroyer-Dulmont A, Chakhoyan A, Guillouet S, Bernaudin M, Barbier EL, Touzani O. PMID: 36285719.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Editorial for "MRI-Based Investigation of Association Between Cerebrovascular Structural Alteration and White Matter Hyperintensity Induced by High Blood Pressure". J Magn Reson Imaging. 2021 11; 54(5):1527-1528. Huuskonen MT, Barisano G, Chakhoyan A, Zlokovic BV. PMID: 34331486; PMCID: PMC8976593.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Simultaneous Mapping of Vasculature, Hypoxia, and Proliferation Using Dynamic Susceptibility Contrast MRI, 18F-FMISO PET, and 18F-FLT PET in Relation to Contrast Enhancement in Newly Diagnosed Glioblastoma. J Nucl Med. 2021 10; 62(10):1349-1356. Collet S, Guillamo JS, Berro DH, Chakhoyan A, Constans JM, Lechapt-Zalcman E, Derlon JM, Hatt M, Visvikis D, Guillouet S, Perrio C, Bernaudin M, Valable S. PMID: 34016725; PMCID: PMC8724903.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    5. APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline. Nature. 2020 05; 581(7806):71-76. Montagne A, Nation DA, Sagare AP, Barisano G, Sweeney MD, Chakhoyan A, Pachicano M, Joe E, Nelson AR, D'Orazio LM, Buennagel DP, Harrington MG, Benzinger TLS, Fagan AM, Ringman JM, Schneider LS, Morris JC, Reiman EM, Caselli RJ, Chui HC, Tcw J, Chen Y, Pa J, Conti PS, Law M, Toga AW, Zlokovic BV. PMID: 32376954; PMCID: PMC7250000.
      View in: PubMed   Mentions: 439     Fields:    Translation:HumansCells
    6. Multiparametric MR-PET Imaging Predicts Pharmacokinetics and Clinical Response to GDC-0084 in Patients with Recurrent High-Grade Glioma. Clin Cancer Res. 2020 07 01; 26(13):3135-3144. Ellingson BM, Yao J, Yao J, Raymond C, Nathanson DA, Chakhoyan A, Simpson J, Garner JS, Olivero AG, Mueller LU, Rodon J, Gerstner E, Cloughesy TF, Wen PY. PMID: 32269051; PMCID: PMC8204664.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCTClinical Trials
    7. Metabolic characterization of human IDH mutant and wild type gliomas using simultaneous pH- and oxygen-sensitive molecular MRI. Neuro Oncol. 2019 09 06; 21(9):1184-1196. Yao J, Yao J, Chakhoyan A, Nathanson DA, Yong WH, Salamon N, Raymond C, Mareninov S, Lai A, Nghiemphu PL, Prins RM, Pope WB, Everson RG, Liau LM, Cloughesy TF, Ellingson BM. PMID: 31066901; PMCID: PMC7594567.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    8. Association between Tumor Acidity and Hypervascularity in Human Gliomas Using pH-Weighted Amine Chemical Exchange Saturation Transfer Echo-Planar Imaging and Dynamic Susceptibility Contrast Perfusion MRI at 3T. AJNR Am J Neuroradiol. 2019 06; 40(6):979-986. Wang YL, Yao J, Chakhoyan A, Raymond C, Salamon N, Liau LM, Nghiemphu PL, Lai A, Pope WB, Nguyen N, Ji M, Cloughesy TF, Ellingson BM. PMID: 31097430; PMCID: PMC6527337.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    9. Probabilistic independent component analysis of dynamic susceptibility contrast perfusion MRI in metastatic brain tumors. Cancer Imaging. 2019 Mar 18; 19(1):14. Chakhoyan A, Raymond C, Chen J, Goldman J, Yao J, Yao J, Kaprealian TB, Pouratian N, Ellingson BM. PMID: 30885275; PMCID: PMC6423873.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    10. Validation of vessel size imaging (VSI) in high-grade human gliomas using magnetic resonance imaging, image-guided biopsies, and quantitative immunohistochemistry. Sci Rep. 2019 02 26; 9(1):2846. Chakhoyan A, Yao J, Yao J, Leu K, Pope WB, Salamon N, Yong W, Lai A, Nghiemphu PL, Everson RG, Prins RM, Liau LM, Nathanson DA, Cloughesy TF, Ellingson BM. PMID: 30808879; PMCID: PMC6391482.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    11. pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) as a potential early biomarker for bevacizumab failure in recurrent glioblastoma. J Neurooncol. 2019 May; 142(3):587-595. Yao J, Yao J, Tan CHP, Schlossman J, Chakhoyan A, Raymond C, Pope WB, Salamon N, Lai A, Ji M, Nghiemphu PL, Liau LM, Cloughesy TF, Ellingson BM. PMID: 30806888; PMCID: PMC6482078.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    12. pH-weighted molecular MRI in human traumatic brain injury (TBI) using amine proton chemical exchange saturation transfer echoplanar imaging (CEST EPI). Neuroimage Clin. 2019; 22:101736. Ellingson BM, Yao J, Yao J, Raymond C, Chakhoyan A, Khatibi K, Salamon N, Villablanca JP, Wanner I, Real CR, Laiwalla A, McArthur DL, Monti MM, Hovda DA, Vespa PM. PMID: 30826686; PMCID: PMC6396390.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    13. Post-chemoradiation volumetric response predicts survival in newly diagnosed glioblastoma treated with radiation, temozolomide, and bevacizumab or placebo. Neuro Oncol. 2018 10 09; 20(11):1525-1535. Ellingson BM, Abrey LE, Garcia J, Chinot O, Wick W, Saran F, Nishikawa R, Henriksson R, Mason WP, Harris RJ, Leu K, Woodworth DC, Mehta A, Raymond C, Chakhoyan A, Pope WB, Cloughesy TF. PMID: 29897562; PMCID: PMC6178278.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCTClinical Trials
    14. Volumetric response quantified using T1 subtraction predicts long-term survival benefit from cabozantinib monotherapy in recurrent glioblastoma. Neuro Oncol. 2018 09 03; 20(10):1411-1418. Ellingson BM, Aftab DT, Schwab GM, Hessel C, Harris RJ, Woodworth DC, Leu K, Chakhoyan A, Raymond C, Drappatz J, de Groot J, Prados MD, Reardon DA, Schiff D, Chamberlain M, Mikkelsen T, Desjardins A, Holland J, Ping J, Weitzman R, Wen PY, Cloughesy TF. PMID: 29660005; PMCID: PMC6120362.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCTClinical Trials
    15. Mono-exponential, diffusion kurtosis and stretched exponential diffusion MR imaging response to chemoradiation in newly diagnosed glioblastoma. J Neurooncol. 2018 Sep; 139(3):651-659. Chakhoyan A, Woodworth DC, Harris RJ, Lai A, Nghiemphu PL, Liau LM, Pope WB, Cloughesy TF, Ellingson BM. PMID: 29855771; PMCID: PMC6126989.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    16. 18F-FDOPA PET and MRI characteristics correlate with degree of malignancy and predict survival in treatment-naïve gliomas: a cross-sectional study. J Neurooncol. 2018 Sep; 139(2):399-409. Patel CB, Fazzari E, Chakhoyan A, Yao J, Yao J, Raymond C, Nguyen H, Manoukian J, Nguyen N, Pope W, Cloughesy TF, Nghiemphu PL, Czernin J, Lai A, Ellingson BM. PMID: 29679199; PMCID: PMC6092195.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    17. Simultaneous pH-sensitive and oxygen-sensitive MRI of human gliomas at 3 T using multi-echo amine proton chemical exchange saturation transfer spin-and-gradient echo echo-planar imaging (CEST-SAGE-EPI). Magn Reson Med. 2018 11; 80(5):1962-1978. Harris RJ, Yao J, Yao J, Chakhoyan A, Raymond C, Leu K, Liau LM, Nghiemphu PL, Lai A, Salamon N, Pope WB, Cloughesy TF, Ellingson BM. PMID: 29626359; PMCID: PMC6107417.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    18. Improved Spatiotemporal Resolution of Dynamic Susceptibility Contrast Perfusion MRI in Brain Tumors Using Simultaneous Multi-Slice Echo-Planar Imaging. AJNR Am J Neuroradiol. 2018 01; 39(1):43-45. Chakhoyan A, Leu K, Pope WB, Cloughesy TF, Ellingson BM. PMID: 29074632; PMCID: PMC5766430.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    19. FMISO-PET-derived brain oxygen tension maps: application to glioblastoma and less aggressive gliomas. Sci Rep. 2017 08 31; 7(1):10210. Chakhoyan A, Guillamo JS, Collet S, Kauffmann F, Delcroix N, Lechapt-Zalcman E, Constans JM, Petit E, MacKenzie ET, Barré L, Bernaudin M, Touzani O, Valable S. PMID: 28860608; PMCID: PMC5579277.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    20. Diffusion MRI Phenotypes Predict Overall Survival Benefit from Anti-VEGF Monotherapy in Recurrent Glioblastoma: Converging Evidence from Phase II Trials. Clin Cancer Res. 2017 Oct 01; 23(19):5745-5756. Ellingson BM, Gerstner ER, Smits M, Huang RY, Colen R, Abrey LE, Aftab DT, Schwab GM, Hessel C, Harris RJ, Chakhoyan A, Gahrmann R, Pope WB, Leu K, Raymond C, Woodworth DC, de Groot J, Wen PY, Batchelor TT, van den Bent MJ, Cloughesy TF. PMID: 28655794; PMCID: PMC5626594.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansCTClinical Trials
    21. Carbogen-induced increases in tumor oxygenation depend on the vascular status of the tumor: A multiparametric MRI study in two rat glioblastoma models. J Cereb Blood Flow Metab. 2017 Jun; 37(6):2270-2282. Chakhoyan A, Corroyer-Dulmont A, Leblond MM, Gérault A, Toutain J, Chazaviel L, Divoux D, Petit E, MacKenzie ET, Kauffmann F, Delcroix N, Bernaudin M, Touzani O, Valable S. PMID: 27496553; PMCID: PMC5464716.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimals
    22. Imaging of brain oxygenation with magnetic resonance imaging: A validation with positron emission tomography in the healthy and tumoural brain. J Cereb Blood Flow Metab. 2017 Jul; 37(7):2584-2597. Valable S, Corroyer-Dulmont A, Chakhoyan A, Durand L, Toutain J, Divoux D, Barré L, MacKenzie ET, Petit E, Bernaudin M, Touzani O, Barbier EL. PMID: 27702880; PMCID: PMC5531354.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    23. Imaging Modalities to Assess Oxygen Status in Glioblastoma. Front Med (Lausanne). 2015; 2:57. Corroyer-Dulmont A, Chakhoyan A, Collet S, Durand L, MacKenzie ET, Petit E, Bernaudin M, Touzani O, Valable S. PMID: 26347870; PMCID: PMC4541402.
      View in: PubMed   Mentions: 14  
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