Sandy Zhang-Nunes, MD

Title(s)Associate Professor of Clinical Ophthalmology
SchoolKeck School of Medicine of Usc
AddressHC4 4900 1450 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-6103
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    Other Positions
    Title(s)Chief of Oculofacial Plastics Services


    Collapse Biography 
    Collapse Education and Training
    Massachusetts Institute of TechnologyBS2003
    Johns Hopkins University School of MedicineMD2008
    University of California, Los Angeles- Jules Stein Eye InstituteOphthalmology Residency2012
    Ophthalmic Surgeons & Consultants of OHASOPRS Fellowship2014
    Collapse Awards and Honors
    1999National Merit Scholar
    1999Discover Card Scholarship
    1999Zonta Club Scholarship
    1999National Beta Club Scholarship
    1999Olympus Titan Award
    2002MIT Excellent Academic Record
    2003Hans-Lukas Teuber Award for Outstanding Research and Academics in Brain and Cognitive Sciences
    2003Community Connection Award for Leadership in Alternative Spring Break
    2003Sigma Xi Honor Society
    2003Phi Beta Kappa Honor Society
    2003American Neurological Association Travel Award
    2005Howard Hughes Medical Research Fellowship Award
    2005Sarnoff Foundation Research Award
    Los Angeles Magazine, Los Angeles, CA2016  - 2017Rising Stars Top Doctors
    Los Angeles Magazine, Los Angeles, CA2016  - 2017Top Doctors in Pasadena
    Los Angeles Multi-Specialty Cosmetic Academy2019Leadership Award in Aesthetics
    Los Angeles Magazine, Los Angeles, CA2020Top Doctors
    Los Angeles Magazine, Los Angeles, CA2021Top Doctors
    Association of Women Surgeons (AWS) USC2021Women in Medicine Featured Mentors
    Women in Ophthalmology, National Organization2021Educators Award
    Los Angeles Magazine, Los Angeles, CA2022Top Doctors
    Los Angeles Magazine, Los Angeles, CA2023Top Doctors
    Merz2023Winner of Innovation Forum

    Collapse Overview 
    Collapse Overview
    Sandy X. Zhang-Nunes, MD, earned her undergraduate degrees at the Massachusetts Institute of Technology and her medical degree at the Johns Hopkins University School of Medicine. She then completed her ophthalmology residency at Jules Stein Eye Institute UCLA and completed a prestigious two-year American Society of Ophthalmic Plastic Surgery Fellowship based at Ophthalmic Surgeons and Consultants of Ohio in Columbus. Her clinical interests involve eyelid and eyebrow lifting surgeries for both cosmesis and functional reasons (blepharoplasty, ptosis surgery, endoscopic brow lifts), cosmetic lower eyelid, midface and full face surgery, reconstruction after Mohs (tumor) excisions, orbital disease, such as thyroid eye disease, tumors, fractures, eyelid malpositions from aging and congenital anomalies, blepharospasm and hemifacial spasm, cosmetic laser and light therapy, Botox and fillers.

    Dr. Zhang-Nunes treats each patient with care, addressing concerns to achieve the most natural and optimal results as possible. She also enjoys teaching, having published numerous articles in peer-reviewed journals and book chapters, as well as lecturing and presenting research nationally and internationally.

    Dr. Zhang-Nunes’s research focuses on patients with thyroid eye disease. She also conducts studies related to imaging of eyelid and orbital structures, comparison of cosmetic neurotoxins, and dissolution rate of various hyaluronic acid gel fillers. Dr. Zhang-Nunes performs blepharoplasty and brow surgery corrections and studies their clinical outcomes.
    Collapse Websites

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Light Therapy for Facial Rejuvenation and Dry Eyes, Blepharitis, and Styes. Int Ophthalmol Clin. 2024 Jul 01; 64(3):9-12. Zhang-Nunes S. PMID: 38910500.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    2. An Analysis of Surgical Factors Associated with Clinically Significant Eyelid Edema (CSEE) in Patients Undergoing Blepharoplasty: Lid Crease Techniques Associated with CSEE. Ophthalmic Plast Reconstr Surg. 2024 May 09. Park KE, Guo S, Mehta P, Li J, Shen A, Bokman CL, Chang JR, Zhang-Nunes S. PMID: 38722778.
      View in: PubMed   Mentions:    Fields:    
    3. Accuracy and Bias in Artificial Intelligence Chatbot Recommendations for Oculoplastic Surgeons. Cureus. 2024 Apr; 16(4):e57611. Parikh AO, Oca MC, Conger JR, McCoy A, Chang J, Zhang-Nunes S. PMID: 38707042; PMCID: PMC11069401.
      View in: PubMed   Mentions:
    4. Assessing the Utility of ChatGPT in Simplifying Text Complexity of Patient Educational Materials. Cureus. 2024 Mar; 16(3):e55304. Sudharshan R, Shen A, Gupta S, Zhang-Nunes S. PMID: 38559518; PMCID: PMC10981786.
      View in: PubMed   Mentions:
    5. Long-Term Follow-Up of a Case of Severe Hyperglycemia Requiring Hospitalization after Third Dose of Teprotumumab: A Case Report. Case Rep Ophthalmol. 2024 Jan-Dec; 15(1):115-121. Mehta P, Angell T, LeTran V, Lin M, Nguyen A, Zhang-Nunes S. PMID: 38318283; PMCID: PMC10843176.
      View in: PubMed   Mentions:
    6. Response of 21 Hyaluronic Acid Fillers to Recombinant Human Hyaluronidase. Plast Reconstr Surg Glob Open. 2023 Dec; 11(12):e5457. Park KE, Mehta P, Kherani F, Lee WW, Woodward JA, Foster JA, Zhang-Nunes S. PMID: 38145149; PMCID: PMC10745246.
      View in: PubMed   Mentions:
    7. Phthisical eye and orbital ischemia after cosmetic platelet-rich plasma injection to the forehead. Am J Ophthalmol Case Rep. 2024 Jun; 34:101968. Madala S, Bao YK, Lee JH, Gluckstein J, Chang J, Zhang-Nunes S. PMID: 38601194; PMCID: PMC11004058.
      View in: PubMed   Mentions:
    8. Arterial Wall and Tissue Penetration Force With Various Cannulas and Needles. Aesthet Surg J. 2023 11 16; 43(12):1521-1529. Siperstein RD, Broadfield DC, Yerke Hansen P, Conger JR, Zhang-Nunes SX. PMID: 37171834.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Bias and Inaccuracy in AI Chatbot Ophthalmologist Recommendations. Cureus. 2023; 15(9).
    10. Bias and Inaccuracy in AI Chatbot Ophthalmologist Recommendations. Cureus. 2023 Sep; 15(9):e45911. Oca MC, Meller L, Wilson K, Parikh AO, McCoy A, Chang J, Sudharshan R, Gupta S, Zhang-Nunes S. PMID: 37885556; PMCID: PMC10599183.
      View in: PubMed   Mentions: 5  
    11. The Nictavi Tarsus Patch: A New Device for Achieving Temporary Eyelid Closure in Lagophthalmos. Clin Ophthalmol. 2023; 17:1877-1884. Guo S, Borchert MS, Chang M, Nallasamy S, Reid MW, Zhang-Nunes S, Chang JR, Nguyen AM. PMID: 37425025; PMCID: PMC10327908.
      View in: PubMed   Mentions:
    12. A comparison of five point-of-care ultrasound devices for use in ophthalmology and facial aesthetics. Ultrasound. 2024 Feb; 32(1):28-35. Park KE, Mehta P, Tran C, Parikh AO, Zhou Q, Zhang-Nunes S. PMID: 38314019; PMCID: PMC10836224.
      View in: PubMed   Mentions:
    13. Re: "Correlation of Automated Computed Tomography Volumetric Analysis Metrics With Motility Disturbances in Thyroid Eye Disease". Ophthalmic Plast Reconstr Surg. 2023 Mar-Apr 01; 39(2):194. Li J, Li S, Park KE, Wen J, Lee J, Ayala FA, Lerner A, Gokoffski KK, Zhang-Nunes S, Patel V, Chang JR. PMID: 36867765.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    14. Periocular irritation in elderly Asian patient. JAAD Case Rep. 2023 May; 35:19-21. Park KE, Saber MS, Rao NA, Zhang-Nunes S. PMID: 37089758; PMCID: PMC10114504.
      View in: PubMed   Mentions:
    15. Demographic and physiological factors associated with clinically significant eyelid edema in patients following upper eyelid surgery. J Plast Reconstr Aesthet Surg. 2023 03; 78:4-9. Zhang-Nunes S, Guo S, Li J, Mehta P, Yu R, Shen A, Bokman C, Yau A, Chang JR. PMID: 36680851.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Response of five different hyaluronic acid gels to varying doses of recombinant human hyaluronidase. J Plast Reconstr Aesthet Surg. 2022 Oct 20. Mehta P, Ryu C, Park K, Kherani F, Zhang-Nunes S. PMID: 36411234.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Misdiagnosis of Orbital Foreign Body as Glaucoma Drainage Device. J Emerg Med. 2022 07; 63(1):e22-e27. Guo S, Iyengar R, Chudnofsky C, Song B, Zhang-Nunes S. PMID: 35953325.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    18. Ultrahigh field (7T) MRI for assessment of orbitofacial structures. Orbit. 2022 May 23; 1. Zhang-Nunes S, Li J, Foster J, Nabavi C, Straka D, Cahill K, Patel V. PMID: 35603353.
      View in: PubMed   Mentions:    Fields:    
    19. Clinical activity of PD-1 inhibition in the treatment of locally advanced or metastatic basal cell carcinoma. J Immunother Cancer. 2022 05; 10(5). In GK, Nallagangula A, Choi JS, Tachiki L, Blackburn MJ, Capone S, Bollin KB, Reuben DY, Shirai K, Zhang-Nunes S, Ragab O, Terando A, Hu JC, Lee H, Bhatia S, Chandra S, Lutzky J, Gibney GT. PMID: 35545318; PMCID: PMC9096532.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    20. Focused ultrasound stimulation on meibomian glands for the treatment of evaporative dry eye. Exp Biol Med (Maywood). 2022 03; 247(6):519-526. Lu G, Gollapudi S, Li R, Pfeiffer ML, Mehta P, Jiang L, Hamm-Alvarez S, Humayun M, Zhou Q, Zhang-Nunes SX. PMID: 34648358; PMCID: PMC8943330.
      View in: PubMed   Mentions: 1     Fields:    Translation:Animals
    21. Lateral orbital wall anomaly in a patient with thyroid eye disease. Orbit. 2021 Aug 17; 1-4. Mohan S, Koo Lin L, Ho TC, Zhang-Nunes S, Patel V, Chang JR. PMID: 34404314.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Imaging of the post-operative orbit and associated complications. J Clin Neurosci. 2021 Jul; 89:437-447. Anderson RC, Rajagopalan P, Lee J, Li J, Wong B, Zhang-Nunes S, Gupta K, Acharya J, Rajamohan AG, Chang J, Patel V. PMID: 34052071.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    23. Safety and Efficacy of an Augmented Intense Pulse Light Protocol for Dry Eye Syndrome and Blepharitis. Photobiomodul Photomed Laser Surg. 2021 Mar; 39(3):178-184. Zhang-Nunes S, Guo S, Lee D, Chang J, Nguyen A. PMID: 33370543.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    24. Prospective in vivo evaluation of three different hyaluronic acid gels to varying doses of hyaluronidase with long-term follow-up. J Plast Reconstr Aesthet Surg. 2021 Apr; 74(4):874-880. Zhang-Nunes S, Ryu C, Cahill K, Straka D, Nabavi C, Czyz C, Foster J. PMID: 33281083.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    25. Response of twelve different hyaluronic acid gels to varying doses of recombinant human hyaluronidase. J Plast Reconstr Aesthet Surg. 2021 Apr; 74(4):881-889. Ryu C, Lu JE, Zhang-Nunes S. PMID: 33308988.
      View in: PubMed   Mentions: 3     Fields:    
    26. Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study. J Cosmet Sci. 2020 Sep/Oct; 71(5):263-290. Kalasho BD, Minokadeh A, Zhang-Nunes S, Zoumalan RA, Shemirani NL, Waldman AR, Pletzer V, Zoumalan CI. PMID: 33022197.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    27. Organogenesis and distribution of the ocular lymphatic vessels in the anterior eye. JCI Insight. 2020 07 09; 5(13). Wu Y, Seong YJ, Li K, Choi D, Park E, Daghlian GH, Jung E, Bui K, Zhao L, Madhavan S, Daghlian S, Daghlian P, Chin D, Cho IT, Wong AK, Heur M, Zhang-Nunes S, Tan JC, Ema M, Wong TT, Huang AS, Hong YK. PMID: 32641580; PMCID: PMC7406257.
      View in: PubMed   Mentions: 18     Fields:    Translation:Animals
    28. Thyroid eye disease with choroidal folds. Orbit. 2021 Jun; 40(3):206-214. Tran AQ, Zhang-Nunes SX, Cahill K, Alabiad CR, Shriver EM, Ho T, Weinberg DA, Couch SM, Schlachter DM, Nguyen J, Wester ST. PMID: 32326785.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    29. Clinical Update on Checkpoint Inhibitor Therapy for Conjunctival and Eyelid Melanoma. Int Ophthalmol Clin. 2020; 60(2):77-89. Lu JE, Chang JR, Berry JL, In GK, Zhang-Nunes S. PMID: 32205655; PMCID: PMC8059069.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    30. Optic Neuropathy due to an Ethmoid Mucocele: A Case Report and Literature Review. Case Rep Ophthalmol. 2019 May-Aug; 10(2):227-234. Ting MYL, Shan M, Gantz O, Zhang-Nunes S, Wrobel B. PMID: 31692625; PMCID: PMC6760354.
      View in: PubMed   Mentions: 3  
    31. Evolving Minimally Invasive Techniques for Tear Trough Enhancement. Ophthalmic Plast Reconstr Surg. 2015 Jul-Aug; 31(4):306-9. Hill RH, Czyz CN, Kandapalli S, Zhang-Nunes SX, Cahill KV, Wulc AE, Foster JA. PMID: 25299740.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    32. Minimally invasive surgical adjuncts to upper blepharoplasty. Facial Plast Surg Clin North Am. 2015 May; 23(2):137-51. Briceño CA, Zhang-Nunes SX, Massry GG. PMID: 25921565.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Minimally invasive options for the brow and upper lid. Facial Plast Surg Clin North Am. 2015 May; 23(2):153-66. Briceño CA, Zhang-Nunes SX, Massry GG. PMID: 25921566.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    34. Characterization and outcomes of repeat orbital decompression for thyroid-associated orbitopathy. Orbit. 2015 Apr; 34(2):57-65. Zhang-Nunes SX, Dang S, Garneau HC, Hwang C, Isaacs D, Chang SH, Goldberg R. PMID: 25244551.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    35. Late adult onset optic pathway astrocytoma. J Clin Neurosci. 2013 Nov; 20(11):1610-2. Liu Y, Zhang-Nunes S, Zhu X, Xu X, Sun X, Wu Y. PMID: 23790623.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    36. Late central visual recovery after traumatic globe displacement into the maxillary sinus. Ophthalmic Plast Reconstr Surg. 2012 Jan-Feb; 28(1):e17-9. Zhang-Nunes SX, Jarullazada I, Mancini R. PMID: 21490518.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Homeostatic plasticity of GABAergic synaptic transmission in mice lacking GAT1. Biochem Biophys Res Commun. 2007 Sep 21; 361(2):499-504. Xu Y, Cai Y, Gong N, Chen C, Wu Y, Zhang-Nunes S, Wang Z, Xu T, Fei J. PMID: 17655829.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    38. A novel approach to clinical-radiological correlations: Anatomo-Clinical Overlapping Maps (AnaCOM): method and validation. Neuroimage. 2007 Oct 01; 37(4):1237-49. Kinkingnéhun S, Volle E, Pélégrini-Issac M, Golmard JL, Lehéricy S, du Boisguéheneuc F, Zhang-Nunes S, Sosson D, Duffau H, Samson Y, Levy R, Dubois B. PMID: 17702605.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    39. Antibody-mediated clearance of amyloid-beta peptide from cerebral amyloid angiopathy revealed by quantitative in vivo imaging. J Neurosci. 2007 Feb 21; 27(8):1973-80. Prada CM, Garcia-Alloza M, Betensky RA, Zhang-Nunes SX, Greenberg SM, Bacskai BJ, Frosch MP. PMID: 17314293; PMCID: PMC6673561.
      View in: PubMed   Mentions: 26     Fields:    Translation:Animals
    40. AIDS dementia complex in China. J Clin Neurosci. 2007 Jan; 14(1):8-11. Wu YC, Zhao YB, Tang MG, Zhang-Nunes SX, McArthur JC. PMID: 17070055.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    41. Characterization of amyloid deposition in the APPswe/PS1dE9 mouse model of Alzheimer disease. Neurobiol Dis. 2006 Dec; 24(3):516-24. Garcia-Alloza M, Robbins EM, Zhang-Nunes SX, Purcell SM, Betensky RA, Raju S, Prada C, Greenberg SM, Bacskai BJ, Frosch MP. PMID: 17029828.
      View in: PubMed   Mentions: 326     Fields:    Translation:Animals
    42. The cerebral beta-amyloid angiopathies: hereditary and sporadic. Brain Pathol. 2006 Jan; 16(1):30-9. Zhang-Nunes SX, Maat-Schieman ML, van Duinen SG, Roos RA, Frosch MP, Greenberg SM. PMID: 16612980; PMCID: PMC8095991.
      View in: PubMed   Mentions: 81     Fields:    Translation:Humans
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