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    Kimberly Gokoffski

    TitleAssistant Professor of Clinical Ophthalmology
    SchoolKeck School of Medicine of USC
    DepartmentOphthalmology
    AddressHC4 4900 1450 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033-6103
    Phone+1 323 442 6768
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      Collapse Overview 
      Collapse Overview
      My research interests are focused on the clinical need for optic nerve regeneration. Optic neuropathies are diseases in which the optic nerve (ON) – the cable that transmits information from the eye to the brain – is damaged. Advanced optic neuropathies, like glaucoma, result in irreversible vision loss because the cells that make up the ON are not capable of self-renewal. To restore vision in patients with optic neuropathies, we need to regenerate the ON. The current rate-limiting step to ON regeneration is directing stem cells that have been implanted in the eye to grow an axon out of the eye to the brain — a distance that spans 5cm in humans.

      The goal of my research is 1.) to elucidate the molecular signals that guide axon growth and 2.) to test whether an applied electrical field can be used to direct the growth of implanted stem cells. The results from this project will be developed into a technology to facilitate ON regeneration and restore vision in patients blinded by optic neuropathies.


      Collapse Biography 
      Collapse Education and Training
      University of California, BerkeleyBS2002
      University of California, IrvinePhD2010
      University of California, IrvineMD2012
      University of California, DavisOphthalmology Residency2016
      USC Roski Eye InstituteNeuro-Ophthalmology2017
      Collapse Awards and Honors
      UC Irvine2001Alpha Omega Alpha Honors Society Community Service Award
      UC Irvine2001Center for Complex Biological Systems Student Project Grant
      UC Irvine2001MSTP 2nd Place Oral Presentation Award
      UC Irvine2001NIH Neurosciences Training Grant
      NIH2001NINDS/AUPN/ANA Medical Students Mentoring Workshop Scholarship
      University of Kansas2001Research Experience for Undergraduates (REU) Fellowship
      University of Pittsburgh2001Summer Undergraduate Research Program (SURP) Fellowship
      UC Irvine2002School of Biological Sciences Travel Award
      UC Irvine2005  - 2007Paul H. Silverman Award for Research in Stem Cells
      International Conference in Systems Biology2006Travel Award
      Center for Complex Biological Systems2007Student Project Grant
      UC Irvine2008Developmental and Systems Biology Training Grant
      UC Irvine2009Graduated with Distinction in Community Service
      UC Irvine2009Graduated with Distinction in Research
      Department of Ophthalmology, UC Davis20121st Place Resident Research Presentation, Alumni Day
      North American Neuro-Ophthalmology Society2017Thomas Carlow Young Investigator Award

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Gokoffski K, Thinda S. Ophthalmic Artery Occlusion after Cocaine Use. J Emerg Med. 2015 Jul; 49(1):61-2. PMID: 25858339.
        View in: PubMed
      2. Gokoffski K, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42. PMID: 21852401; PMCID: PMC3171217.
      3. Chou CS, Lo WC, Gokoffski K, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q. Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17; 99(10):3145-54. PMID: 21081061; PMCID: PMC2980753.
      4. Lander AD, Gokoffski K, Wan FY, Nie Q, Calof AL. Cell lineages and the logic of proliferative control. PLoS Biol. 2009 Jan 20; 7(1):e15. PMID: 19166268; PMCID: PMC2628408.
      5. Lo WC, Chou CS, Gokoffski K, Wan FY, Lander AD, Calof AL, Nie Q. Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009 Jan; 6(1):59-82. PMID: 19292508; PMCID: PMC2756546.