Kimberly Gokoffski

Title(s)Assistant Professor of Clinical Ophthalmology
Phone+1 323 442 6335
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    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyBS2002
    University of California, IrvinePhD2010
    University of California, IrvineMD2012
    University of California, DavisOphthalmology Residency2016
    USC Roski Eye InstituteNeuro-Ophthalmology2017
    Collapse Awards and Honors
    UC Irvine2001Alpha Omega Alpha Honors Society Community Service Award
    UC Irvine2001Center for Complex Biological Systems Student Project Grant
    UC Irvine2001MSTP 2nd Place Oral Presentation Award
    UC Irvine2001NIH Neurosciences Training Grant
    NIH2001NINDS/AUPN/ANA Medical Students Mentoring Workshop Scholarship
    University of Kansas2001Research Experience for Undergraduates (REU) Fellowship
    University of Pittsburgh2001Summer Undergraduate Research Program (SURP) Fellowship
    UC Irvine2002School of Biological Sciences Travel Award
    UC Irvine2005  - 2007Paul H. Silverman Award for Research in Stem Cells
    International Conference in Systems Biology2006Travel Award
    Center for Complex Biological Systems2007Student Project Grant
    UC Irvine2008Developmental and Systems Biology Training Grant
    UC Irvine2009Graduated with Distinction in Community Service
    UC Irvine2009Graduated with Distinction in Research
    Department of Ophthalmology, UC Davis20121st Place Resident Research Presentation, Alumni Day
    North American Neuro-Ophthalmology Society2017Thomas Carlow Young Investigator Award

    Collapse Overview 
    Collapse Overview
    My research interests are focused on the clinical need for optic nerve regeneration. Optic neuropathies are diseases in which the optic nerve (ON) – the cable that transmits information from the eye to the brain – is damaged. Advanced optic neuropathies, like glaucoma, result in irreversible vision loss because the cells that make up the ON are not capable of self-renewal. To restore vision in patients with optic neuropathies, we need to regenerate the ON. The current rate-limiting step to ON regeneration is directing stem cells that have been implanted in the eye to grow an axon out of the eye to the brain — a distance that spans 5cm in humans.

    The goal of my research is 1.) to elucidate the molecular signals that guide axon growth and 2.) to test whether an applied electrical field can be used to direct the growth of implanted stem cells. The results from this project will be developed into a technology to facilitate ON regeneration and restore vision in patients blinded by optic neuropathies.

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Gokoffski KK, Peng M, Alas B, Lam P. Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions. Curr Opin Neurol. 2020 Feb; 33(1):93-105. PMID: 31809331.
      View in: PubMed
    2. Gokoffski KK, Jia X, Shvarts D, Xia G, Zhao M. Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro. Invest Ophthalmol Vis Sci. 2019 08 01; 60(10):3659-3668. PMID: 31469406.
      View in: PubMed
    3. Gokoffski KK, Chatterjee A, Khaderi SK. Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System. Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):90-97. PMID: 30620274.
      View in: PubMed
    4. Gokoffski KK, Thinda S. Ophthalmic Artery Occlusion after Cocaine Use. J Emerg Med. 2015 Jul; 49(1):61-2. PMID: 25858339.
      View in: PubMed
    5. Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42. PMID: 21852401.
      View in: PubMed
    6. Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q. Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17; 99(10):3145-54. PMID: 21081061.
      View in: PubMed
    7. Lander AD, Gokoffski KK, Wan FY, Nie Q, Calof AL. Cell lineages and the logic of proliferative control. PLoS Biol. 2009 Jan 20; 7(1):e15. PMID: 19166268.
      View in: PubMed
    8. Lo WC, Chou CS, Gokoffski KK, Wan FY, Lander AD, Calof AL, Nie Q. Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009 Jan; 6(1):59-82. PMID: 19292508.
      View in: PubMed