Kimberly Gokoffski, MD, PhD
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| Title(s) | Associate Professor of Clinical Ophthalmology |
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| School | Keck School of Medicine of Usc |
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| Address | HC4 4900 1450 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-6103
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| Phone | +1 323 442 6335 |
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| vCard | Download vCard |
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| Title(s) | Associate Director of Research, Institute for Technology and Medical Systems (ITEMS) |
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Biography
| University of California, Berkeley | BS | 2002 | |
| University of California, Irvine | PhD | 2010 | |
| University of California, Irvine | MD | 2012 | |
| University of California, Davis | Ophthalmology Residency | 2016 | |
| USC Roski Eye Institute | Neuro-Ophthalmology | 2017 | |
| UC Irvine | 2001 | | Alpha Omega Alpha Honors Society Community Service Award |
| UC Irvine | 2001 | | Center for Complex Biological Systems Student Project Grant |
| UC Irvine | 2001 | | MSTP 2nd Place Oral Presentation Award |
| UC Irvine | 2001 | | NIH Neurosciences Training Grant |
| NIH | 2001 | | NINDS/AUPN/ANA Medical Students Mentoring Workshop Scholarship |
| University of Kansas | 2001 | | Research Experience for Undergraduates (REU) Fellowship |
| University of Pittsburgh | 2001 | | Summer Undergraduate Research Program (SURP) Fellowship |
| UC Irvine | 2002 | | School of Biological Sciences Travel Award |
| UC Irvine | 2005
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| 2007 | Paul H. Silverman Award for Research in Stem Cells |
| International Conference in Systems Biology | 2006 | | Travel Award |
| Center for Complex Biological Systems | 2007 | | Student Project Grant |
| UC Irvine | 2008 | | Developmental and Systems Biology Training Grant |
| UC Irvine | 2009 | | Graduated with Distinction in Community Service |
| UC Irvine | 2009 | | Graduated with Distinction in Research |
| Department of Ophthalmology, UC Davis | 2012 | | 1st Place Resident Research Presentation, Alumni Day |
| North American Neuro-Ophthalmology Society | 2017 | | Thomas Carlow Young Investigator Award |
Overview
My research interests are focused on the clinical need for optic nerve regeneration. Optic neuropathies are diseases in which the optic nerve (ON) – the cable that transmits information from the eye to the brain – is damaged. Advanced optic neuropathies, like glaucoma, result in irreversible vision loss because the cells that make up the ON are not capable of self-renewal. To restore vision in patients with optic neuropathies, we need to regenerate the ON. The current rate-limiting step to ON regeneration is directing stem cells that have been implanted in the eye to grow an axon out of the eye to the brain — a distance that spans 5cm in humans.
The goal of my research is 1.) to elucidate the molecular signals that guide axon growth and 2.) to test whether an applied electrical field can be used to direct the growth of implanted stem cells. The results from this project will be developed into a technology to facilitate ON regeneration and restore vision in patients blinded by optic neuropathies.
ORNG Applications
Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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Advances and Challenges in Wearable Glaucoma Diagnostics and Therapeutics. Bioengineering (Basel). 2024 Jan 30; 11(2).
Shean R, Yu N, Guntipally S, Nguyen V, He X, Duan S, Gokoffski K, Zhu Y, Xu B. PMID: 38391624; PMCID: PMC10886103.
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PubMed Mentions:
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Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Mol Neurodegener. 2023 09 21; 18(1):64.
Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, RReSTORe Consortium, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV. PMID: 37735444; PMCID: PMC10514988.
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2 Fields:
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HumansAnimalsCells
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The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium. Ophthalmol Sci. 2023 Dec; 3(4):100390.
Johnson TV, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Zack DJ. PMID: 38025164; PMCID: PMC10630665.
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Asymmetric charge balanced waveforms direct retinal ganglion cell axon growth. Sci Rep. 2023 08 14; 13(1):13233.
Peng MG, Iseri E, Simonyan A, Lam P, Kim T, Medvidovic S, Paknahad J, Machnoor M, Lazzi G, Gokoffski KK. PMID: 37580344; PMCID: PMC10425404.
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HumansCells
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AxonQuantifier: A semi-automated program for quantifying axonal density from whole-mounted optic nerves. J Neurosci Methods. 2023 07 01; 394:109895.
Peng MG, Lee J, Ho W, Kim T, Yao P, Medvidovic S, Alas B, Wu V, Runner MM, Gokoffski KK. PMID: 37315846; PMCID: PMC10330882.
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AnimalsCells
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Re: "Correlation of Automated Computed Tomography Volumetric Analysis Metrics With Motility Disturbances in Thyroid Eye Disease". Ophthalmic Plast Reconstr Surg. 2023 Mar-Apr 01; 39(2):194.
Li J, Li S, Park KE, Wen J, Lee J, Ayala FA, Lerner A, Gokoffski KK, Zhang-Nunes S, Patel V, Chang JR. PMID: 36867765.
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Humans
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The Influence of Electrode Properties on Induced Voltage Gradient Along the Rat Optic Nerve. IEEE J Electromagn RF Microw Med Biol. 2022 Sep; 6(3):321-330.
Paknahad J, Machnoor M, Lazzi G, Gokoffski KK. PMID: 36910030; PMCID: PMC10004096.
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Internuclear Ophthalmoplegia Characterizes Multiple Sclerosis Rather Than Neuromyelitis Optica Spectrum Disease. J Neuroophthalmol. 2022 06 01; 42(2):239-245.
Hamza MM, Alas BF, Huang C, Quon JC, Amezcua L, Robers MV, Gokoffski KK. PMID: 35427281.
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1 Fields:
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Humans
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Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis. Am J Ophthalmol Case Rep. 2022 Jun; 26:101485.
OuYang WL, Long C, Azam S, Jia C, Gokoffski K, Wong B, Patel V. PMID: 35300402; PMCID: PMC8921343.
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Miller Fisher Syndrome With Acetylcholine Receptor Antibody: A Case Series. J Neuroophthalmol. 2023 Dec 01; 43(4):e311-e312.
Situ BA, Koulisis N, Gokoffski KK, Greer CE. PMID: 35234686.
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Humans
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Metastatic neuroendocrine tumors mimicking as primary ocular disease. Am J Ophthalmol Case Rep. 2022 Jun; 26:101425.
Shen A, Haghighi A, Liang T, Lee OT, Gange W, DeBoer C, Akhter M, Saber MS, Patel VR, Berry JL, Gokoffski KK. PMID: 35243162; PMCID: PMC8858882.
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2
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Surgical Outcomes of Transposition Surgery for the Correction of Large-Angle Strabismus. J Neuroophthalmol. 2021 Dec 01; 41(4):e806-e814.
Gokoffski KK, Lifton J, Xu BY, Patel VR. PMID: 34788250.
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Humans
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Electrical devices for visual restoration. Surv Ophthalmol. 2022 May-Jun; 67(3):793-800.
Sharf T, Kalakuntla T, J Lee D, Gokoffski KK. PMID: 34487742; PMCID: PMC9241872.
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3 Fields:
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Humans
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Glaucoma Expert-Level Detection of Angle Closure in Goniophotographs With Convolutional Neural Networks: The Chinese American Eye Study. Am J Ophthalmol. 2021 06; 226:100-107.
Chiang M, Guth D, Pardeshi AA, Randhawa J, Shen A, Shan M, Dredge J, Nguyen A, Gokoffski K, Wong BJ, Song B, Lin S, Varma R, Xu BY. PMID: 33577791; PMCID: PMC8286291.
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6 Fields:
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Humans
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A case of reversible toxic optic neuropathy from tacrolimus (FK506). Am J Ophthalmol Case Rep. 2020 Dec; 20:100932.
Gokoffski KK, Patel VR. PMID: 33005819; PMCID: PMC7509794.
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PubMed Mentions:
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Optic Nerve Regeneration: How Will We Get There? J Neuroophthalmol. 2020 06; 40(2):234-242.
Gokoffski KK, Lam P, Alas BF, Peng MG, Ansorge HRR. PMID: 32282513; PMCID: PMC7211134.
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8 Fields:
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HumansCells
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Clinical correlation recommended: accuracy of clinician versus radiologic interpretation of the imaging of orbital lesions. Orbit. 2021 Apr; 40(2):133-137.
Bacorn C, Gokoffski KK, Lin LK. PMID: 32279603.
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5 Fields:
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Humans
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Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions. Curr Opin Neurol. 2020 02; 33(1):93-105.
Gokoffski KK, Peng M, Alas B, Lam P. PMID: 31809331; PMCID: PMC8153234.
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21 Fields:
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HumansAnimalsCells
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Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro. Invest Ophthalmol Vis Sci. 2019 08 01; 60(10):3659-3668.
Gokoffski KK, Jia X, Shvarts D, Xia G, Zhao M. PMID: 31469406; PMCID: PMC6716951.
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22 Fields:
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AnimalsCells
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Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System. Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):90-97.
Gokoffski KK, Chatterjee A, Khaderi SK. PMID: 30620274.
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6 Fields:
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Humans
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Ophthalmic Artery Occlusion after Cocaine Use. J Emerg Med. 2015 Jul; 49(1):61-2.
Gokoffski KK, Thinda S. PMID: 25858339.
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Humans
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Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42.
Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. PMID: 21852401; PMCID: PMC3171217.
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63 Fields:
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AnimalsCells
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Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17; 99(10):3145-54.
Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q. PMID: 21081061; PMCID: PMC2980753.
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PubMed Mentions:
23 Fields:
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AnimalsCells
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Cell lineages and the logic of proliferative control. PLoS Biol. 2009 Jan 20; 7(1):e15.
Lander AD, Gokoffski KK, Wan FY, Nie Q, Calof AL. PMID: 19166268; PMCID: PMC2628408.
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PubMed Mentions:
143 Fields:
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AnimalsCells
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Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009 Jan; 6(1):59-82.
Lo WC, Chou CS, Gokoffski KK, Wan FY, Lander AD, Calof AL, Nie Q. PMID: 19292508; PMCID: PMC2756546.
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PubMed Mentions:
57 Fields:
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HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
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| 2009 | 2 |
| 2010 | 1 |
| 2011 | 1 |
| 2015 | 1 |
| 2019 | 2 |
| 2020 | 4 |
| 2021 | 3 |
| 2022 | 5 |
| 2023 | 5 |
| 2024 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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