Kimberly Gokoffski, MD, PhD

Title(s)Associate Professor of Clinical Ophthalmology
SchoolKeck School of Medicine of Usc
AddressHC4 4900 1450 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-6103
Phone+1 323 442 6335
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    Other Positions
    Title(s)Associate Director of Research, Institute for Technology and Medical Systems (ITEMS)

    Collapse Biography 
    Collapse Education and Training
    University of California, BerkeleyBS2002
    University of California, IrvinePhD2010
    University of California, IrvineMD2012
    University of California, DavisOphthalmology Residency2016
    USC Roski Eye InstituteNeuro-Ophthalmology2017
    Collapse Awards and Honors
    UC Irvine2001Alpha Omega Alpha Honors Society Community Service Award
    UC Irvine2001Center for Complex Biological Systems Student Project Grant
    UC Irvine2001MSTP 2nd Place Oral Presentation Award
    UC Irvine2001NIH Neurosciences Training Grant
    NIH2001NINDS/AUPN/ANA Medical Students Mentoring Workshop Scholarship
    University of Kansas2001Research Experience for Undergraduates (REU) Fellowship
    University of Pittsburgh2001Summer Undergraduate Research Program (SURP) Fellowship
    UC Irvine2002School of Biological Sciences Travel Award
    UC Irvine2005  - 2007Paul H. Silverman Award for Research in Stem Cells
    International Conference in Systems Biology2006Travel Award
    Center for Complex Biological Systems2007Student Project Grant
    UC Irvine2008Developmental and Systems Biology Training Grant
    UC Irvine2009Graduated with Distinction in Community Service
    UC Irvine2009Graduated with Distinction in Research
    Department of Ophthalmology, UC Davis20121st Place Resident Research Presentation, Alumni Day
    North American Neuro-Ophthalmology Society2017Thomas Carlow Young Investigator Award

    Collapse Overview 
    Collapse Overview
    My research interests are focused on the clinical need for optic nerve regeneration. Optic neuropathies are diseases in which the optic nerve (ON) – the cable that transmits information from the eye to the brain – is damaged. Advanced optic neuropathies, like glaucoma, result in irreversible vision loss because the cells that make up the ON are not capable of self-renewal. To restore vision in patients with optic neuropathies, we need to regenerate the ON. The current rate-limiting step to ON regeneration is directing stem cells that have been implanted in the eye to grow an axon out of the eye to the brain — a distance that spans 5cm in humans.

    The goal of my research is 1.) to elucidate the molecular signals that guide axon growth and 2.) to test whether an applied electrical field can be used to direct the growth of implanted stem cells. The results from this project will be developed into a technology to facilitate ON regeneration and restore vision in patients blinded by optic neuropathies.
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Advances and Challenges in Wearable Glaucoma Diagnostics and Therapeutics. Bioengineering (Basel). 2024 Jan 30; 11(2). Shean R, Yu N, Guntipally S, Nguyen V, He X, Duan S, Gokoffski K, Zhu Y, Xu B. PMID: 38391624; PMCID: PMC10886103.
      View in: PubMed   Mentions:
    2. Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium. Mol Neurodegener. 2023 09 21; 18(1):64. Soucy JR, Aguzzi EA, Cho J, Gilhooley MJ, Keuthan C, Luo Z, Monavarfeshani A, Saleem MA, Wang XW, Wohlschlegel J, RReSTORe Consortium, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Welsbie D, Zack DJ, Johnson TV. PMID: 37735444; PMCID: PMC10514988.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimalsCells
    3. The Retinal Ganglion Cell Repopulation, Stem Cell Transplantation, and Optic Nerve Regeneration Consortium. Ophthalmol Sci. 2023 Dec; 3(4):100390. Johnson TV, Baranov P, Di Polo A, Fortune B, Gokoffski KK, Goldberg JL, Guido W, Kolodkin AL, Mason CA, Ou Y, Reh TA, Ross AG, Samuels BC, Zack DJ. PMID: 38025164; PMCID: PMC10630665.
      View in: PubMed   Mentions:
    4. Asymmetric charge balanced waveforms direct retinal ganglion cell axon growth. Sci Rep. 2023 08 14; 13(1):13233. Peng MG, Iseri E, Simonyan A, Lam P, Kim T, Medvidovic S, Paknahad J, Machnoor M, Lazzi G, Gokoffski KK. PMID: 37580344; PMCID: PMC10425404.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    5. AxonQuantifier: A semi-automated program for quantifying axonal density from whole-mounted optic nerves. J Neurosci Methods. 2023 07 01; 394:109895. Peng MG, Lee J, Ho W, Kim T, Yao P, Medvidovic S, Alas B, Wu V, Runner MM, Gokoffski KK. PMID: 37315846; PMCID: PMC10330882.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCells
    6. Re: "Correlation of Automated Computed Tomography Volumetric Analysis Metrics With Motility Disturbances in Thyroid Eye Disease". Ophthalmic Plast Reconstr Surg. 2023 Mar-Apr 01; 39(2):194. Li J, Li S, Park KE, Wen J, Lee J, Ayala FA, Lerner A, Gokoffski KK, Zhang-Nunes S, Patel V, Chang JR. PMID: 36867765.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. The Influence of Electrode Properties on Induced Voltage Gradient Along the Rat Optic Nerve. IEEE J Electromagn RF Microw Med Biol. 2022 Sep; 6(3):321-330. Paknahad J, Machnoor M, Lazzi G, Gokoffski KK. PMID: 36910030; PMCID: PMC10004096.
      View in: PubMed   Mentions: 1  
    8. Internuclear Ophthalmoplegia Characterizes Multiple Sclerosis Rather Than Neuromyelitis Optica Spectrum Disease. J Neuroophthalmol. 2022 06 01; 42(2):239-245. Hamza MM, Alas BF, Huang C, Quon JC, Amezcua L, Robers MV, Gokoffski KK. PMID: 35427281.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    9. Sphenoethmoidal air cell sinusitis: A rare cause of recurrent optic neuritis. Am J Ophthalmol Case Rep. 2022 Jun; 26:101485. OuYang WL, Long C, Azam S, Jia C, Gokoffski K, Wong B, Patel V. PMID: 35300402; PMCID: PMC8921343.
      View in: PubMed   Mentions:
    10. Miller Fisher Syndrome With Acetylcholine Receptor Antibody: A Case Series. J Neuroophthalmol. 2023 Dec 01; 43(4):e311-e312. Situ BA, Koulisis N, Gokoffski KK, Greer CE. PMID: 35234686.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Metastatic neuroendocrine tumors mimicking as primary ocular disease. Am J Ophthalmol Case Rep. 2022 Jun; 26:101425. Shen A, Haghighi A, Liang T, Lee OT, Gange W, DeBoer C, Akhter M, Saber MS, Patel VR, Berry JL, Gokoffski KK. PMID: 35243162; PMCID: PMC8858882.
      View in: PubMed   Mentions: 2  
    12. Surgical Outcomes of Transposition Surgery for the Correction of Large-Angle Strabismus. J Neuroophthalmol. 2021 Dec 01; 41(4):e806-e814. Gokoffski KK, Lifton J, Xu BY, Patel VR. PMID: 34788250.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Electrical devices for visual restoration. Surv Ophthalmol. 2022 May-Jun; 67(3):793-800. Sharf T, Kalakuntla T, J Lee D, Gokoffski KK. PMID: 34487742; PMCID: PMC9241872.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    14. Glaucoma Expert-Level Detection of Angle Closure in Goniophotographs With Convolutional Neural Networks: The Chinese American Eye Study. Am J Ophthalmol. 2021 06; 226:100-107. Chiang M, Guth D, Pardeshi AA, Randhawa J, Shen A, Shan M, Dredge J, Nguyen A, Gokoffski K, Wong BJ, Song B, Lin S, Varma R, Xu BY. PMID: 33577791; PMCID: PMC8286291.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    15. A case of reversible toxic optic neuropathy from tacrolimus (FK506). Am J Ophthalmol Case Rep. 2020 Dec; 20:100932. Gokoffski KK, Patel VR. PMID: 33005819; PMCID: PMC7509794.
      View in: PubMed   Mentions: 1  
    16. Optic Nerve Regeneration: How Will We Get There? J Neuroophthalmol. 2020 06; 40(2):234-242. Gokoffski KK, Lam P, Alas BF, Peng MG, Ansorge HRR. PMID: 32282513; PMCID: PMC7211134.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    17. Clinical correlation recommended: accuracy of clinician versus radiologic interpretation of the imaging of orbital lesions. Orbit. 2021 Apr; 40(2):133-137. Bacorn C, Gokoffski KK, Lin LK. PMID: 32279603.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    18. Neuro-protection and neuro-regeneration of the optic nerve: recent advances and future directions. Curr Opin Neurol. 2020 02; 33(1):93-105. Gokoffski KK, Peng M, Alas B, Lam P. PMID: 31809331; PMCID: PMC8153234.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    19. Physiologic Electrical Fields Direct Retinal Ganglion Cell Axon Growth In Vitro. Invest Ophthalmol Vis Sci. 2019 08 01; 60(10):3659-3668. Gokoffski KK, Jia X, Shvarts D, Xia G, Zhao M. PMID: 31469406; PMCID: PMC6716951.
      View in: PubMed   Mentions: 22     Fields:    Translation:AnimalsCells
    20. Seasonal incidence of biopsy-proven giant cell arteritis: a 20-year retrospective study of the University of California Davis Medical System. Clin Exp Rheumatol. 2019 Mar-Apr; 37 Suppl 117(2):90-97. Gokoffski KK, Chatterjee A, Khaderi SK. PMID: 30620274.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    21. Ophthalmic Artery Occlusion after Cocaine Use. J Emerg Med. 2015 Jul; 49(1):61-2. Gokoffski KK, Thinda S. PMID: 25858339.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    22. Activin and GDF11 collaborate in feedback control of neuroepithelial stem cell proliferation and fate. Development. 2011 Oct; 138(19):4131-42. Gokoffski KK, Wu HH, Beites CL, Kim J, Kim EJ, Matzuk MM, Johnson JE, Lander AD, Calof AL. PMID: 21852401; PMCID: PMC3171217.
      View in: PubMed   Mentions: 63     Fields:    Translation:AnimalsCells
    23. Spatial dynamics of multistage cell lineages in tissue stratification. Biophys J. 2010 Nov 17; 99(10):3145-54. Chou CS, Lo WC, Gokoffski KK, Zhang YT, Wan FY, Lander AD, Calof AL, Nie Q. PMID: 21081061; PMCID: PMC2980753.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    24. Cell lineages and the logic of proliferative control. PLoS Biol. 2009 Jan 20; 7(1):e15. Lander AD, Gokoffski KK, Wan FY, Nie Q, Calof AL. PMID: 19166268; PMCID: PMC2628408.
      View in: PubMed   Mentions: 143     Fields:    Translation:AnimalsCells
    25. Feedback regulation in multistage cell lineages. Math Biosci Eng. 2009 Jan; 6(1):59-82. Lo WC, Chou CS, Gokoffski KK, Wan FY, Lander AD, Calof AL, Nie Q. PMID: 19292508; PMCID: PMC2756546.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansAnimalsCells
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