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    Qifa Zhou, PhD

    TitleProfessor of Ophthalmology and Biomedical Engineering
    SchoolKeck School of Medicine of USC
    AddressMMR 312 1333 San Pablo Street
    University Park Campus
    Los Angeles California 90033-6103
    Phone+1 213 740 9475
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      Dr. Zhou’s research focuses on the design and fabrication of high frequency ultrasonic transducers using new piezoelectric single crystal and thin film technologies for medical imaging applications. He has integrated ultrasonic technology with advanced optical technology for intravascular imaging application. His current work is to develop miniaturized photoacoustic imaging (PA) probes using high frequency ultrasound transducers for endoscopic application. The primary motivations are to overcome the depth limitation of existing endoscopic imaging technologies and to provide functional information for disease states via photoacoustic imaging.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Weitz AC, Lee NS, Yoon CW, Bonyad A, Goo KS, Kim S, Moon S, Jung H, Zhou Q, Chow RH, Shung KK. Functional Assay of Cancer Cell Invasion Potential Based on Mechanotransduction of Focused Ultrasound. Front Oncol. 2017; 7:161. PMID: 28824873.
        View in: PubMed
      2. Chen Z, Zheng L, Cao W, Chen X, Chen R, Li R, Shung K, Zhou Q. High-Frequency Ultrasonic Imaging with Lead-free (Na,K)(Nb,Ta)O3 Single Crystal. Ultrason Imaging. 2017 Apr 01; 161734617701069. PMID: 28395599.
        View in: PubMed
      3. Yang Y, Chen Z, Song X, Zhang Z, Zhang J, Shung KK, Zhou Q, Chen Y. Biomimetic Anisotropic Reinforcement Architectures by Electrically Assisted Nanocomposite 3D Printing. Adv Mater. 2017 Mar; 29(11). PMID: 28185341.
        View in: PubMed
      4. Ma T, Qian X, Chiu CT, Yu M, Jung H, Tung YS, Shung KK, Zhou Q. High-resolution harmonic motion imaging (HR-HMI) for tissue biomechanical property characterization. Quant Imaging Med Surg. 2015 Feb; 5(1):108-17. PMID: 25694960; PMCID: PMC4312300.
      5. Li Y, Lee C, Chen R, Zhou Q, Shung KK. A feasibility study of in vivo applications of single beam acoustic tweezers. Appl Phys Lett. 2014 Oct 27; 105(17):173701. PMID: 25422525.
        View in: PubMed
      6. Zhou Q, Lam KH, Zheng H, Qiu W, Shung KK. Piezoelectric single crystals for ultrasonic transducers in biomedical applications. Prog Mater Sci. 2014 Oct 01; 66:87-111. PMID: 25386032.
        View in: PubMed
      7. Li X, Li J, Jing J, Ma T, Liang S, Zhang J, Mohar D, Raney A, Mahon S, Brenner M, Patel P, Shung KK, Zhou Q, Chen Z. Integrated IVUS-OCT Imaging for Atherosclerotic Plaque Characterization. IEEE J Sel Top Quantum Electron. 2014 Mar; 20(2):7100108. PMID: 24771992.
        View in: PubMed
      8. Ma T, Zhang X, Chiu CT, Chen R, Kirk Shung K, Zhou Q, Jiao S. Systematic study of high-frequency ultrasonic transducer design for laser-scanning photoacoustic ophthalmoscopy. J Biomed Opt. 2014 Jan; 19(1):16015. PMID: 24441942; PMCID: PMC3895818.
      9. Park J, Cummins TM, Harrison M, Lee J, Zhou Q, Lien CL, Shung KK. High frequency photoacoustic imaging for in vivo visualizing blood flow of zebrafish heart. Opt Express. 2013 Jun 17; 21(12):14636-42. PMID: 23787651; PMCID: PMC3726247.
      10. Hsu HS, Benjauthrit V, Wei Q, Huang Y, Zhou Q, Shung KK. Silver Doped 0.9PMN-PT-0.1PZT Composite Films for very High Frequency Ultrasonic Transducer Applications. Appl Phys A Mater Sci Process. 2013 May 01; 111(2):459-463. PMID: 23814408.
        View in: PubMed
      11. Hwang JY, Lee NS, Lee C, Lam KH, Kim HH, Woo J, Lin MY, Kisler K, Choi H, Zhou Q, Chow RH, Shung KK. Investigating contactless high frequency ultrasound microbeam stimulation for determination of invasion potential of breast cancer cells. Biotechnol Bioeng. 2013 Oct; 110(10):2697-705. PMID: 23568761; PMCID: PMC3839413.
      12. Lam KH, Ji HF, Zheng F, Ren W, Zhou Q, Shung KK. Development of lead-free single-element ultrahigh frequency (170-320MHz) ultrasonic transducers. Ultrasonics. 2013 Jul; 53(5):1033-8. PMID: 23485349; PMCID: PMC3624055.
      13. Chen R, Paeng DG, Lam KH, Zhou Q, Shung KK, Matsuoka N, Humayun MS. In vivo Sonothrombolysis of Ear Marginal Vein of Rabbits Monitored with High-frequency Ultrasound Needle Transducer. J Med Biol Eng. 2013; 33(1):103-110. PMID: 25356073.
        View in: PubMed
      14. Yu F, Lee J, Jen N, Li X, Zhang Q, Tang R, Zhou Q, Kim ES, Hsiai TK. Elevated electrochemical impedance in the endoluminal regions with high shear stress: implication for assessing lipid-rich atherosclerotic lesions. Biosens Bioelectron. 2013 May 15; 43:237-44. PMID: 23318546; PMCID: PMC3594425.
      15. Chen R, Wu J, Ho Lam K, Yao L, Zhou Q, Tian J, Han P, Shung KK. Thermal-independent properties of PIN-PMN-PT single-crystal linear-array ultrasonic transducers. IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Dec; 59(12):2777-84. PMID: 23221227; PMCID: PMC3740094.
      16. Lam KH, Hsu HS, Li Y, Lee C, Lin A, Zhou Q, Kim ES, Shung KK. Ultrahigh frequency lensless ultrasonic transducers for acoustic tweezers application. Biotechnol Bioeng. 2013 Mar; 110(3):881-6. PMID: 23042219; PMCID: PMC4090028.
      17. Raphael DT, Li X, Park J, Chen R, Chabok H, Barukh A, Zhou Q, Elgazery M, Shung KK. 20 MHz forward-imaging single-element beam steering with an internal rotating variable-angle reflecting surface: Wire phantom and ex vivo pilot study. Ultrasonics. 2013 Feb; 53(2):561-9. PMID: 23122968; PMCID: PMC3510328.
      18. Li X, Wei W, Zhou Q, Shung KK, Chen Z. Intravascular photoacoustic imaging at 35 and 80 MHz. J Biomed Opt. 2012 Oct; 17(10):106005. PMID: 23224004; PMCID: PMC3461096.
      19. Park J, Huang Y, Chen R, Lee J, Cummins TM, Zhou Q, Lien CL, Shung KK. Pulse inversion chirp coded tissue harmonic imaging (PI-CTHI) of Zebrafish heart using high frame rate ultrasound biomicroscopy. Ann Biomed Eng. 2013 Jan; 41(1):41-52. PMID: 22930467; PMCID: PMC3524374.
      20. Park J, Li X, Zhou Q, Shung KK. Combined chirp coded tissue harmonic and fundamental ultrasound imaging for intravascular ultrasound: 20-60 MHz phantom and ex vivo results. Ultrasonics. 2013 Feb; 53(2):369-76. PMID: 22871273; PMCID: PMC3860271.
      21. Hsu HS, Benjauthrit V, Zheng F, Chen R, Huang Y, Zhou Q, Shung KK. PMN-PT-PZT composite films for high frequency ultrasonic transducer applications. Sens Actuators A Phys. 2012 Jun; 179:121-124. PMID: 23750072.
        View in: PubMed
      22. Choi H, Li X, Lau ST, Hu C, Zhou Q, Shung KK. Development of integrated preamplifier for high-frequency ultrasonic transducers and low-power handheld receiver. IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Dec; 58(12):2646-58. PMID: 23443700; PMCID: PMC3589742.
      23. Li X, Wu W, Chung Y, Shih WY, Shih WH, Zhou Q, Shung KK. 80-MHz intravascular ultrasound transducer using PMN-PT free-standing film. IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Nov; 58(11):2281-8. PMID: 22083761; PMCID: PMC3304502.
      24. Zhu BP, Guo WK, Shen GZ, Zhou Q, Shung KK. Structure and electrical properties of (111)-oriented Pb(Mg1/3Nb2/3)O3-PbZrO3-PbTiO3 thin film for ultra-high-frequency transducer applications. IEEE Trans Ultrason Ferroelectr Freq Control. 2011 Sep; 58(9):1962-7. PMID: 21937332; PMCID: PMC3181068.
      25. Zhou Q, Lau S, Wu D, Shung KK. Piezoelectric films for high frequency ultrasonic transducers in biomedical applications. Prog Mater Sci. 2011 Feb; 56(2):139-174. PMID: 21720451.
        View in: PubMed
      26. Chabok HR, Zhou Q, Alagha S, Tian J, Han P, Shung KK. Thickness Dependent Characteristics of High Permittivity PMN-0.32PT Single Crystal for High Frequency Medical Imaging Applications. Ferroelectrics. 2011; 422(1):70-76. PMID: 22162876.
        View in: PubMed
      27. Zhou Q, Wu D, Liu C, Zhu B, Djuth F, Shung K. Micro-machined high-frequency (80 MHz) PZT thick film linear arrays. IEEE Trans Ultrason Ferroelectr Freq Control. 2010 Oct; 57(10):2213-20. PMID: 20889407; PMCID: PMC2966894.
      28. Jiao S, Jiang M, Hu J, Fawzi A, Zhou Q, Shung KK, Puliafito CA, Zhang HF. Photoacoustic ophthalmoscopy for in vivo retinal imaging. Opt Express. 2010 Feb 15; 18(4):3967-72. PMID: 20389409; PMCID: PMC2864517.
      29. Wu DW, Zhou Q, Geng X, Liu CG, Djuth F, Shung KK. Very high frequency (beyond 100 MHz) PZT kerfless linear arrays. IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Oct; 56(10):2304-10. PMID: 19942516; PMCID: PMC2850572.
      30. Wu D, Zhou Q, Shung KK, Bharadwaja SN, Zhang D, Zheng H. Dielectric and Piezoelectric Properties of PZT Composite Thick Films with Variable Solution to Powder Ratios. J Am Ceram Soc. 2009 May 08; 92(6):1276-1279. PMID: 20376196.
        View in: PubMed
      31. Sun P, Zhang Y, Yu F, Parks E, Lyman A, Wu Q, Ai L, Hu CH, Zhou Q, Shung K, Lien CL, Hsiai TK. Micro-electrocardiograms to study post-ventricular amputation of zebrafish heart. Ann Biomed Eng. 2009 May; 37(5):890-901. PMID: 19280341.
        View in: PubMed
      32. Zhou Q, Cha JH, Huang Y, Zhang R, Cao W, Shung KK. Alumina/epoxy nanocomposite matching layers for high-frequency ultrasound transducer application. IEEE Trans Ultrason Ferroelectr Freq Control. 2009 Jan; 56(1):213-9. PMID: 19213648; PMCID: PMC2729565.
      33. Huang CC, Zhou Q, Ameri H, Wu DW, Sun L, Wang SH, Humayun MS, Shung KK. Determining the acoustic properties of the lens using a high-frequency ultrasonic needle transducer. Ultrasound Med Biol. 2007 Dec; 33(12):1971-7. PMID: 17673358.
        View in: PubMed
      34. Zhou Q, Xu X, Gottlieb EJ, Sun L, Cannata JM, Ameri H, Humayun MS, Han P, Shung KK. PMN-PT single crystal, high-frequency ultrasonic needle transducers for pulsed-wave Doppler application. IEEE Trans Ultrason Ferroelectr Freq Control. 2007 Mar; 54(3):668-75. PMID: 17375836.
        View in: PubMed
      35. Hu CH, Liu R, Zhou Q, Yen J, Kirk Shung K. Coded excitation using biphase-coded pulse with mismatched filters for high-frequency ultrasound imaging. Ultrasonics. 2006 Jul; 44(3):330-6. PMID: 16714042.
        View in: PubMed
      36. Cannata JM, Williams JA, Zhou Q, Ritter TA, Shung KK. Development of a 35-MHz piezo-composite ultrasound array for medical imaging. IEEE Trans Ultrason Ferroelectr Freq Control. 2006 Jan; 53(1):224-36. PMID: 16471449.
        View in: PubMed
      37. Guo H, Cannata JM, Zhou Q, Shung KK. Design and fabrication of broadband graded ultrasonic transducers with rectangular kerfs. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Nov; 52(11):2096-102. PMID: 16422423; PMCID: PMC2410098.
      38. Huang C, Marmarelis VZ, Zhou Q, Shung KK. An analytical model of multilayer ultrasonic transducers with an inversion layer. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):469-79. PMID: 15857055.
        View in: PubMed
      39. Zhou Q, Cannata JM, Meyer RJ, van Tol DJ, Tadigadapa S, Hughes WJ, Shung KK, Trolier-McKinstry S. Fabrication and characterization of micromachined high-frequency tonpilz transducers derived by PZT thick films. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Mar; 52(3):350-7. PMID: 15857042.
        View in: PubMed
      40. Zhou Q, Cannata JM, Guo H, Huang C, Marmarelis VZ, Shung KK. Half-thickness inversion layer high-frequency ultrasonic transducers using LiNbO3 single crystal. IEEE Trans Ultrason Ferroelectr Freq Control. 2005 Jan; 52(1):127-33. PMID: 15742569.
        View in: PubMed
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