Cheng Yu, PhD

Title(s)Professor of Clinical Neurological Surgery
SchoolKeck School of Medicine of Usc
AddressUNH Gamma Unit
Health Sciences Campus
Los Angeles CA 90089
Phone+1 323 442 8735
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    Other Positions
    Title(s)Radiation Safety Officer, Keck Medical Center of USC


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    Dr. Yu joined the USC School of Medicine in March 1994 as an assistant professor of clinical radiation oncology and then promoted to an associate professor in 2000 and full professor in 2003. He also served as Director of Division of Radiation Oncology Physics at USC from 2003 to 2006. He briefly joined the Stanford University School of Medicine in 2006 as a Clinical Professor and Chief of Robotic Radiosurgery Physics. Dr. Yu completed his undergraduate studies in physics in China before coming to the United States in 1986. He earned his doctorate in solid state physics at Michigan Technological University in 1991 and did a post-doctorate fellowship in radiation oncology at the University of Chicago in 1994.

    Dr. Yu plays an integral role in treatment planning, machine calibrations and quality assurance. His extensive experience in stereotactic radiosurgery includes thousands of cases in involving tumors, vascular malformations, pain syndromes and epilepsy.

    Dr. Yu's research interests at USC primarily focus on comparative dosimetry of radiosurgery modalities, such as linac based, Gamma Knife and CyberKnife radiosurgery systems. He is the author or co-author of over 100 peer-reviewed scientific papers, scientific abstracts and meeting presentations, as well as 10 chapters in technical books. Dr. Yu served as a member of AAPM Task Group 135, Quality Assurance for Robotic Radiosurgery, from 2006 to 2010.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Mitochondrial permeability transition regulator, cyclophilin D, is transcriptionally activated by C/EBP during adipogenesis. J Biol Chem. 2023 Dec; 299(12):105458. Yu C, Sautchuk R, Martinez J, Eliseev RA. PMID: 37949231; PMCID: PMC10716586.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    2. Role of the Mitochondrial Permeability Transition in Bone Metabolism and Aging. J Bone Miner Res. 2023 04; 38(4):522-540. Sautchuk R, Yu C, McArthur M, Massie C, Brookes PS, Porter GA, Awad H, Eliseev RA. PMID: 36779737; PMCID: PMC10101909.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    3. Optimized photochemistry enables efficient analysis of dynamic RNA structuromes and interactomes in genetic and infectious diseases. Nat Commun. 2021 04 20; 12(1):2344. Zhang M, Li K, Bai J, Velema WA, Yu C, van Damme R, Lee WH, Corpuz ML, Chen JF, Lu Z. PMID: 33879794; PMCID: PMC8058046.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansCells
    4. Paradoxical androgen receptor regulation by small molecule enantiomers. Proc Natl Acad Sci U S A. 2021 03 23; 118(12). Patsch K, Liu C, Zapotoczny G, Sun Y, Sura H, Ung N, Sun RX, Haliday B, Yu C, Aljehani M, Lee JSH, Kashemirov BA, Agus DB, McKenna CE, Ruderman D. PMID: 33741738; PMCID: PMC8000581.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    5. Automatic detection and segmentation of multiple brain metastases on magnetic resonance image using asymmetric UNet architecture. Phys Med Biol. 2021 01 13; 66(1):015003. Cao Y, Vassantachart A, Ye JC, Yu C, Ruan D, Sheng K, Lao Y, Shen ZL, Balik S, Bian S, Zada G, Shiu A, Chang EL, Yang W. PMID: 33186927.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    6. Stereotactic Radiosurgery for Residual and Recurrent Nonfunctioning Pituitary Adenomas: A Contemporary Case Series of GammaKnife and CyberKnife Radiosurgery. World Neurosurg. 2020 11; 143:e60-e69. Tucker D, Penn M, Brunswick A, Uttarwar V, Gogia A, Marietta M, Yu C, Carmichael J, Chang E, Zada G. PMID: 32603864.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Effectiveness of Gamma Knife Radiosurgery in the Treatment of Refractory Trigeminal Neuralgia: A Case Series. Oper Neurosurg (Hagerstown). 2020 06 01; 18(6):571-576. Tavakol S, Jackanich A, Strickland BA, Marietta M, Ravina K, Yu C, Chang EL, Giannotta S, Zada G. PMID: 31620790.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. A Phantom Study of the Spatial Precision and Accuracy of Stereotactic Localization Using Computed Tomography Imaging with the Leksell Stereotactic System. World Neurosurg. 2020 07; 139:e297-e307. Tafreshi AR, Peng T, Yu C, Kramer DR, Gogia AS, Lee MB, Barbaro MF, Sebastian R, Del Campo-Vera RM, Chen KH, Kellis SS, Lee B. PMID: 32298832.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. Use of Salvage Surgery or Stereotactic Radiosurgery for Multiply Recurrent Skull Base Chordomas: A Single-Institution Experience and Review of the Literature. J Neurol Surg B Skull Base. 2021 Apr; 82(2):161-174. Yoo SK, Strickland BA, Zada G, Bian SX, Garsa A, Ye JC, Yu C, Weiss MH, Wrobel BB, Giannotta S, Chang EL. PMID: 33777630; PMCID: PMC7987397.
      View in: PubMed   Mentions:
    10. Long-Term Tumor Control Rates Following Gamma Knife Radiosurgery for Acoustic Neuroma. World Neurosurg. 2019 Feb; 122:366-371. Tucker DW, Gogia AS, Donoho DA, Yim B, Yu C, Fredrickson VL, Chang EL, Freidman RA, Zada G, Giannotta SL. PMID: 30447465.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    11. Stereotactic radiosurgery to the resection cavity for brain metastases: prognostic factors and outcomes. J Radiosurg SBRT. 2015; 3(3):179-186. Abel RJ, Ji L, Yu C, Lederman A, Chen T, Liu C, Zada G, Kim PE, Apuzzo M, Chang EL. PMID: 29296400; PMCID: PMC5746332.
      View in: PubMed   Mentions: 7  
    12. Evolving societal risks and necessary precautions in the age of nuclear power and therapeutic radiation: an American perspective. World Neurosurg. 2014 Dec; 82(6):1060-1070.e1. Pham MH, Yu C, Rusch M, Holloway C, Chang E, Apuzzo ML. PMID: 25218709.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Radiosurgery for metastatic disease at the craniocervical junction. World Neurosurg. 2014 Dec; 82(6):1331-6. Tuchman A, Yu C, Chang EL, Kim PE, Rusch MC, Apuzzo ML. PMID: 25195109.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    14. Focused ultrasound: relevant history and prospects for the addition of mechanical energy to the neurosurgical armamentarium. World Neurosurg. 2014 Sep-Oct; 82(3-4):354-65. Christian E, Yu C, Apuzzo ML. PMID: 24952224.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    15. Supplementing the neurosurgical virtuoso: evolution of automation from mythology to operating room adjunct. World Neurosurg. 2014 May-Jun; 81(5-6):719-29. Attenello FJ, Lee B, Yu C, Liu CY, Apuzzo ML. PMID: 24631913.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Cerebral arteriovenous malformations: issues of the interplay between stereotactic radiosurgery and endovascular surgical therapy. World Neurosurg. 2011 May-Jun; 75(5-6):638-47. Yashar P, Amar AP, Giannotta SL, Yu C, Pagnini PG, Liu CY, Apuzzo ML. PMID: 21704930.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    17. Long-term outcomes and patterns of tumor progression after gamma knife radiosurgery for benign meningiomas. Neurosurgery. 2010 Aug; 67(2):322-8; discussion 328-9. Zada G, Pagnini PG, Yu C, Erickson KT, Hirschbein J, Zelman V, Apuzzo ML. PMID: 20644417.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    18. Early decreased tumor volume following fractionated Gamma Knife Radiosurgery for metastatic melanoma and the role of "adaptive radiosurgery": case report. Neurosurgery. 2010 Aug; 67(2):E512-3. Zada G, Yu C, Pagnini PG, Khalessi AA, Zelman V, Apuzzo ML. PMID: 20644382.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    19. Delayed toxicity from gamma knife radiosurgery to lesions in and adjacent to the brainstem. J Clin Neurosci. 2009 Sep; 16(9):1139-47. Davidson L, Zada G, Yu C, Petrovich Z, Pagnini PG, Zee CS, Giannotta SL, Zelman V, Apuzzo ML. PMID: 19576781.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    20. Infrared thermal imaging: a review of the literature and case report. Neuroimage. 2009 Aug; 47 Suppl 2:T154-62. Kateb B, Yamamoto V, Yu C, Grundfest W, Gruen JP. PMID: 19332140.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    21. The CyberKnife stereotactic radiosurgery system: description, installation, and an initial evaluation of use and functionality. Neurosurgery. 2008 Feb; 62 Suppl 2:785-9. Kuo JS, Yu C, Petrovich Z, Apuzzo ML. PMID: 18596427.
      View in: PubMed   Mentions: 4     Fields:    
    22. Chained lightning: part III--Emerging technology, novel therapeutic strategies, and new energy modalities for radiosurgery. Neurosurgery. 2007 Dec; 61(6):1111-29; discussion 1129-30. Hoh DJ, Liu CY, Chen JC, Pagnini PG, Yu C, Wang MY, Apuzzo ML. PMID: 18162890.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    23. Chained lightning, part II: neurosurgical principles, radiosurgical technology, and the manipulation of energy beam delivery. Neurosurgery. 2007 Sep; 61(3):433-46; discussion 446. Hoh DJ, Liu CY, Chen JC, Pagnini PG, Yu C, Wang MY, Apuzzo ML. PMID: 17881954.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    24. Chained lightning, part I: Exploitation of energy and radiobiological principles for therapeutic purposes. Neurosurgery. 2007 Jul; 61(1):14-27; discussion 27-8. Hoh DJ, Liu CY, Pagnini PG, Yu C, Wang MY, Apuzzo ML. PMID: 17621015.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    25. Stereotactic radiosurgery: adjacent tissue injury and response after high-dose single fraction radiation: Part I--Histology, imaging, and molecular events. Neurosurgery. 2007 Jan; 60(1):31-44; discussion 44-5. Oh BC, Pagnini PG, Wang MY, Liu CY, Kim PE, Yu C, Apuzzo ML. PMID: 17228251.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    26. Postoperative Gamma Knife surgery for benign meningiomas of the cranial base. Neurosurg Focus. 2007; 23(4):E6. Davidson L, Fishback D, Russin JJ, Weiss MH, Yu C, Pagnini PG, Zelman V, Apuzzo ML, Giannotta SL. PMID: 17961043.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    27. Toward the emergence of nanoneurosurgery: part I--progress in nanoscience, nanotechnology, and the comprehension of events in the mesoscale realm. Neurosurgery. 2005 Oct; 57(4):606-34; discussion 606-34. Leary SP, Liu CY, Yu C, Apuzzo ML. PMID: 16239874.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    28. Gamma knife radiosurgery for trigeminal neuralgia. Neurosurgery. 2005 Jun; 56(6):1295-301; discussion 1301-3. McNatt SA, Yu C, Giannotta SL, Zee CS, Apuzzo ML, Petrovich Z. PMID: 15918946.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCTClinical Trials
    29. An anthropomorphic phantom study of the accuracy of Cyberknife spinal radiosurgery. Neurosurgery. 2004 Nov; 55(5):1138-49. Yu C, Main W, Taylor D, Kuduvalli G, Apuzzo ML, Adler JR. PMID: 15509320.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    30. The Leksell gamma knife Model U versus Model C: a quantitative comparison of radiosurgical treatment parameters. Neurosurgery. 2004 Jul; 55(1):168-72; discussion 172-3. Kuo JS, Yu C, Giannotta SL, Petrovich Z, Apuzzo ML. PMID: 15214986.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    31. Gamma knife radiosurgery for benign cavernous sinus tumors: quantitative analysis of treatment outcomes. Neurosurgery. 2004 Jun; 54(6):1385-93; discussion 1393-4. Kuo JS, Chen JC, Yu C, Zelman V, Giannotta SL, Petrovich Z, MacPherson D, Apuzzo ML. PMID: 15157295.
      View in: PubMed   Mentions: 27     Fields:    Translation:Humans
    32. Study of magnetic resonance imaging-based arteriovenous malformation delineation without conventional angiography. Neurosurgery. 2004 May; 54(5):1104-; discussion 1108-10. Yu C, Petrovich Z, Apuzzo ML, Zelman V, Giannotta SL. PMID: 15113464.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    33. Measurements of the relative output factors for CyberKnife collimators. Neurosurgery. 2004 Jan; 54(1):157-61; discussion 161-2. Yu C, Jozsef G, Apuzzo ML, Petrovich Z. PMID: 14683553.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    34. The CyberKnife stereotactic radiosurgery system: description, installation, and an initial evaluation of use and functionality. Neurosurgery. 2003 Nov; 53(5):1235-9; discussion 1239. Kuo JS, Yu C, Petrovich Z, Apuzzo ML. PMID: 14580294.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    35. Dosimetric comparison of CyberKnife with other radiosurgical modalities for an ellipsoidal target. Neurosurgery. 2003 Nov; 53(5):1155-62; discussion 1162-3. Yu C, Jozsef G, Apuzzo ML, Petrovich Z. PMID: 14580283.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    36. Gamma knife radiosurgery for pituitary adenoma: early results. Neurosurgery. 2003 Jul; 53(1):51-9; discussion 59-61. Petrovich Z, Yu C, Giannotta SL, Zee CS, Apuzzo ML. PMID: 12823873.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    37. Fetal radiation doses for model C gamma knife radiosurgery. Neurosurgery. 2003 Mar; 52(3):687-93; discussion 693. Yu C, Jozsef G, Apuzzo ML, MacPherson DM, Petrovich Z. PMID: 12590695.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    38. Radiotherapy and stereotactic radiosurgery for pituitary tumors. Neurosurg Clin N Am. 2003 Jan; 14(1):147-66. Petrovich Z, Jozsef G, Yu C, Apuzzo ML. PMID: 12690986.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    39. Survival and pattern of failure in brain metastasis treated with stereotactic gamma knife radiosurgery. J Neurosurg. 2002 Dec; 97(5 Suppl):499-506. Petrovich Z, Yu C, Giannotta SL, O'Day S, Apuzzo ML. PMID: 12507085.
      View in: PubMed   Mentions: 52     Fields:    Translation:Humans
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