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Zhipeng Lu

Title(s)Assistant Professor of Pharmacology and Pharmaceutical Sciences
SchoolSchool of Pharmacy
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    Collapse Biography 
    Collapse Education and Training
    Fudan University, Shanghai, ChinaBS07/2008Biology
    UNC Chapel Hill, Chapel Hill, NC, USAPhD08/2014Biology
    Stanford University, Stanford, CA, USAPostdoc06/2018Biology
    Collapse Awards and Honors
    Fudan University2005  - 2008People's Scholarship
    Siyuan Foundation, HK, China2006  - 2007Siyuan Scholarship
    UNC Chapel Hill2013  - 2013Graduate Student Transportation Grant
    Damon Runyon Foundation, Sohn Foundation2015  - 2017Damon Runyon-Sohn Fellowship
    RNA Society2017  - 2017RNA Society Scaringe Award
    Stanford University2016  - 2017Jump Start Award for Excellence in Research
    NHGRI2017  - 2022K99/R00 NIH Pathway to Independence Award

    Collapse Overview 
    Collapse Overview
    RNA molecules fold into structures and intermolecular interactions to execute a second layer of genetic instructions beyond encoding proteins. Functions of RNA structures are pervasive and diverse, including many levels of gene regulation, guiding, scaffolding and catalysis. RNA molecules are directly involved in a variety of human diseases, such as genetic disorders resulting from mutations in noncoding RNAs, RNA binding proteins, and infections caused by RNA viruses (like HIV, HCV, Ebola, etc.). My research combines computational, chemical and biological approaches, and aims to elucidate the fundamental mechanisms of "RNA machines". These studies will lead to new understanding and therapies targeting human diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    Decoding the RNA Structurome: Method Development and Function Analysis.
    NIH/NHGRI R00HG009662Dec 17, 2018 - Nov 30, 2021
    Role: Principal Investigator
    Decoding the RNA structurome: method development and function analysis
    NIH/NHGRI K99HG009662Aug 15, 2017 - May 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
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    Collapse In The News
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    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Gong J, Shao D, Xu K, Lu Z, Lu ZJ, Yang YT, Zhang QC. RISE: a database of RNA interactome from sequencing experiments. Nucleic Acids Res. 2018 Jan 04; 46(D1):D194-D201. PMID: 29040625.
      View in: PubMed
    2. Lu Z, Gong J, Zhang QC. PARIS: Psoralen Analysis of RNA Interactions and Structures with High Throughput and Resolution. Methods Mol Biol. 2018; 1649:59-84. PMID: 29130190.
      View in: PubMed
    3. Lu Z, Carter AC, Chang HY. Mechanistic insights in X-chromosome inactivation. Philos Trans R Soc Lond B Biol Sci. 2017 Nov 05; 372(1733). PMID: 28947655.
      View in: PubMed
    4. Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. 2016 May 19; 165(5):1267-1279. PMID: 27180905.
      View in: PubMed
    5. Lu Z, Chang HY. Decoding the RNA structurome. Curr Opin Struct Biol. 2016 Feb; 36:142-8. PMID: 26923056; PMCID: PMC4785074 [Available on 02/26/17].
      View in: PubMed, PubMed Central
    6. Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR, Matera AG. Metazoan tRNA introns generate stable circular RNAs in vivo. RNA. 2015 Sep; 21(9):1554-65. PMID: 26194134; PMCID: PMC4536317.
      View in: PubMed, PubMed Central
    7. Lu Z, Matera AG. Developmental analysis of spliceosomal snRNA isoform expression. G3 (Bethesda). 2014 Nov 21; 5(1):103-10. PMID: 25416704; PMCID: PMC4291461.
      View in: PubMed, PubMed Central
    8. Lu Z, Matera AG. Vicinal: a method for the determination of ncRNA ends using chimeric reads from RNA-seq experiments. Nucleic Acids Res. 2014 May; 42(9):e79. PMID: 24623808; PMCID: PMC4027162.
      View in: PubMed, PubMed Central
    9. Lu Z, Guan X, Schmidt CA, Matera AG. RIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins. Genome Biol. 2014 Jan 07; 15(1):R7. PMID: 24393626; PMCID: PMC4053861.
      View in: PubMed, PubMed Central
    10. Garcia EL, Lu Z, Meers MP, Praveen K, Matera AG. Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes. RNA. 2013 Nov; 19(11):1510-6. PMID: 24006466; PMCID: PMC3851718.
      View in: PubMed, PubMed Central
    11. Wang H, Zhang SY, Wang S, Lu J, Wu W, Weng L, Chen D, Zhang Y, Lu Z, Yang J, Chen Y, Zhang X, Chen X, Xi C, Lu D, Zhao S. REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapy. Neuro Oncol. 2009 Dec; 11(6):790-802. PMID: 19289490; PMCID: PMC2802399.
      View in: PubMed, PubMed Central
    12. Jiang MH, Fei J, Lan MS, Lu ZP, Liu M, Fan WW, Gao X, Lu DR. Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential. Diabetologia. 2008 Aug; 51(8):1525-33. PMID: 18496667.
      View in: PubMed
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