Zhipeng Lu

Title(s)Assistant Professor of Pharmacology and Pharmaceutical Sciences
SchoolUSC School of Pharmacy
Address1985 Zonal Ave.
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 0093
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    Collapse Biography 
    Collapse Education and Training
    Fudan University, Shanghai, ChinaBS07/2008Biology
    UNC Chapel Hill, Chapel Hill, NC, USAPhD08/2014Biology
    Stanford University, Stanford, CA, USAPostdoc06/2018Biology
    Collapse Awards and Honors
    Fudan University2005  - 2008People's Scholarship
    Siyuan Foundation, HK, China2006  - 2007Siyuan Scholarship
    UNC Chapel Hill2013  - 2013Graduate Student Transportation Grant
    Damon Runyon Foundation, Sohn Foundation2015  - 2017Damon Runyon-Sohn Fellowship
    RNA Society2017  - 2017RNA Society Scaringe Award
    Stanford University2016  - 2017Jump Start Award for Excellence in Research
    NHGRI2017  - 2022K99/R00 NIH Pathway to Independence Award

    Collapse Overview 
    Collapse Overview
    RNA molecules fold into structures and intermolecular interactions to execute a second layer of genetic instructions beyond encoding proteins. Functions of RNA structures are pervasive and diverse, including many levels of gene regulation, guiding, scaffolding and catalysis. RNA molecules are directly involved in a variety of human diseases, such as genetic disorders resulting from mutations in noncoding RNAs, RNA binding proteins, and infections caused by RNA viruses (like HIV, HCV, Ebola, etc.). My research combines computational, chemical and biological approaches, and aims to elucidate the fundamental mechanisms of "RNA machines". These studies will lead to new understanding and therapies targeting human diseases.

    Collapse Research 
    Collapse Research Activities and Funding
    High Throughput Determination of RNA 3D Structures and Dynamics in Vivo
    NIH R35GM143068Aug 15, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Decoding the RNA Structurome: Method Development and Function Analysis.
    NIH R00HG009662Dec 17, 2018 - Nov 30, 2021
    Role: Principal Investigator
    Decoding the RNA structurome: method development and function analysis
    NIH K99HG009662Aug 15, 2017 - May 31, 2019
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Faculty Mentoring

    Collapse Featured Content 
    Collapse Twitter
    Collapse Featured Videos

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Structural modularity of the XIST ribonucleoprotein complex. Nat Commun. 2020 12 02; 11(1):6163. Lu Z, Guo JK, Wei Y, Dou DR, Zarnegar B, Ma Q, Li R, Zhao Y, Liu F, Choudhry H, Khavari PA, Chang HY. PMID: 33268787; PMCID: PMC7710737.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansAnimalsCells
    2. RISE: a database of RNA interactome from sequencing experiments. Nucleic Acids Res. 2018 01 04; 46(D1):D194-D201. Gong J, Shao D, Xu K, Lu Z, Lu ZJ, Yang YT, Zhang QC. PMID: 29040625; PMCID: PMC5753368.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimalsCells
    3. PARIS: Psoralen Analysis of RNA Interactions and Structures with High Throughput and Resolution. Methods Mol Biol. 2018; 1649:59-84. Lu Z, Gong J, Zhang QC. PMID: 29130190; PMCID: PMC5821472.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    4. Mechanistic insights in X-chromosome inactivation. Philos Trans R Soc Lond B Biol Sci. 2017 Nov 05; 372(1733). Lu Z, Carter AC, Chang HY. PMID: 28947655; PMCID: PMC5627158.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    5. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. 2016 May 19; 165(5):1267-1279. Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. PMID: 27180905; PMCID: PMC5029792.
      View in: PubMed   Mentions: 184     Fields:    Translation:HumansAnimalsCells
    6. Decoding the RNA structurome. Curr Opin Struct Biol. 2016 Feb; 36:142-8. Lu Z, Chang HY. PMID: 26923056; PMCID: PMC4785074.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    7. Metazoan tRNA introns generate stable circular RNAs in vivo. RNA. 2015 Sep; 21(9):1554-65. Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR, Matera AG. PMID: 26194134; PMCID: PMC4536317.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    8. Developmental analysis of spliceosomal snRNA isoform expression. G3 (Bethesda). 2014 Nov 21; 5(1):103-10. Lu Z, Matera AG. PMID: 25416704; PMCID: PMC4291461.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCells
    9. Vicinal: a method for the determination of ncRNA ends using chimeric reads from RNA-seq experiments. Nucleic Acids Res. 2014 May; 42(9):e79. Lu Z, Matera AG. PMID: 24623808; PMCID: PMC4027162.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    10. RIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins. Genome Biol. 2014 Jan 07; 15(1):R7. Lu Z, Guan X, Schmidt CA, Matera AG. PMID: 24393626; PMCID: PMC4053861.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansAnimalsCells
    11. Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes. RNA. 2013 Nov; 19(11):1510-6. Garcia EL, Lu Z, Meers MP, Praveen K, Matera AG. PMID: 24006466; PMCID: PMC3851718.
      View in: PubMed   Mentions: 28     Fields:    Translation:AnimalsCells
    12. REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapy. Neuro Oncol. 2009 Dec; 11(6):790-802. Wang H, Zhang SY, Wang S, Lu J, Wu W, Weng L, Chen D, Zhang Y, Lu Z, Yang J, Chen Y, Zhang X, Chen X, Xi C, Lu D, Zhao S. PMID: 19289490; PMCID: PMC2802399.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansCells
    13. Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential. Diabetologia. 2008 Aug; 51(8):1525-33. Jiang MH, Fei J, Lan MS, Lu ZP, Liu M, Fan WW, Gao X, Lu DR. PMID: 18496667.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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