Zhipeng Lu
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Title(s) | Assistant Professor of Pharmacology and Pharmaceutical Sciences |
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School | School of Pharmacy |
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vCard | Download vCard |
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Biography Fudan University, Shanghai, China | BS | 07/2008 | Biology | UNC Chapel Hill, Chapel Hill, NC, USA | PhD | 08/2014 | Biology | Stanford University, Stanford, CA, USA | Postdoc | 06/2018 | Biology |
Fudan University | 2005
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| 2008 | People's Scholarship | Siyuan Foundation, HK, China | 2006
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| 2007 | Siyuan Scholarship | UNC Chapel Hill | 2013
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| 2013 | Graduate Student Transportation Grant | Damon Runyon Foundation, Sohn Foundation | 2015
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| 2017 | Damon Runyon-Sohn Fellowship | RNA Society | 2017
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| 2017 | RNA Society Scaringe Award | Stanford University | 2016
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| 2017 | Jump Start Award for Excellence in Research | NHGRI | 2017
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| 2022 | K99/R00 NIH Pathway to Independence Award |
Overview RNA molecules fold into structures and intermolecular interactions to execute a second layer of genetic instructions beyond encoding proteins. Functions of RNA structures are pervasive and diverse, including many levels of gene regulation, guiding, scaffolding and catalysis. RNA molecules are directly involved in a variety of human diseases, such as genetic disorders resulting from mutations in noncoding RNAs, RNA binding proteins, and infections caused by RNA viruses (like HIV, HCV, Ebola, etc.). My research combines computational, chemical and biological approaches, and aims to elucidate the fundamental mechanisms of "RNA machines". These studies will lead to new understanding and therapies targeting human diseases.
Research ORNG Applications Bibliographic
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Gong J, Shao D, Xu K, Lu Z, Lu ZJ, Yang YT, Zhang QC. RISE: a database of RNA interactome from sequencing experiments. Nucleic Acids Res. 2018 Jan 04; 46(D1):D194-D201. PMID: 29040625.
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Lu Z, Gong J, Zhang QC. PARIS: Psoralen Analysis of RNA Interactions and Structures with High Throughput and Resolution. Methods Mol Biol. 2018; 1649:59-84. PMID: 29130190.
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Lu Z, Carter AC, Chang HY. Mechanistic insights in X-chromosome inactivation. Philos Trans R Soc Lond B Biol Sci. 2017 Nov 05; 372(1733). PMID: 28947655.
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Lu Z, Zhang QC, Lee B, Flynn RA, Smith MA, Robinson JT, Davidovich C, Gooding AR, Goodrich KJ, Mattick JS, Mesirov JP, Cech TR, Chang HY. RNA Duplex Map in Living Cells Reveals Higher-Order Transcriptome Structure. Cell. 2016 May 19; 165(5):1267-1279. PMID: 27180905.
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Lu Z, Chang HY. Decoding the RNA structurome. Curr Opin Struct Biol. 2016 Feb; 36:142-8. PMID: 26923056; PMCID: PMC4785074 [Available on 02/26/17].
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Lu Z, Filonov GS, Noto JJ, Schmidt CA, Hatkevich TL, Wen Y, Jaffrey SR, Matera AG. Metazoan tRNA introns generate stable circular RNAs in vivo. RNA. 2015 Sep; 21(9):1554-65. PMID: 26194134; PMCID: PMC4536317.
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Lu Z, Matera AG. Developmental analysis of spliceosomal snRNA isoform expression. G3 (Bethesda). 2014 Nov 21; 5(1):103-10. PMID: 25416704; PMCID: PMC4291461.
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Lu Z, Matera AG. Vicinal: a method for the determination of ncRNA ends using chimeric reads from RNA-seq experiments. Nucleic Acids Res. 2014 May; 42(9):e79. PMID: 24623808; PMCID: PMC4027162.
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Lu Z, Guan X, Schmidt CA, Matera AG. RIP-seq analysis of eukaryotic Sm proteins identifies three major categories of Sm-containing ribonucleoproteins. Genome Biol. 2014 Jan 07; 15(1):R7. PMID: 24393626; PMCID: PMC4053861.
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Garcia EL, Lu Z, Meers MP, Praveen K, Matera AG. Developmental arrest of Drosophila survival motor neuron (Smn) mutants accounts for differences in expression of minor intron-containing genes. RNA. 2013 Nov; 19(11):1510-6. PMID: 24006466; PMCID: PMC3851718.
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Wang H, Zhang SY, Wang S, Lu J, Wu W, Weng L, Chen D, Zhang Y, Lu Z, Yang J, Chen Y, Zhang X, Chen X, Xi C, Lu D, Zhao S. REV3L confers chemoresistance to cisplatin in human gliomas: the potential of its RNAi for synergistic therapy. Neuro Oncol. 2009 Dec; 11(6):790-802. PMID: 19289490; PMCID: PMC2802399.
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Jiang MH, Fei J, Lan MS, Lu ZP, Liu M, Fan WW, Gao X, Lu DR. Hypermethylation of hepatic Gck promoter in ageing rats contributes to diabetogenic potential. Diabetologia. 2008 Aug; 51(8):1525-33. PMID: 18496667.
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