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    Andrew Mackay, PhD

    TitleAssociate Professor
    SchoolSchool of Pharmacy
    DepartmentPharmacology and Pharmaceutical Sciences
    AddressPSC 306A
    Health Sciences Campus
    Los Angeles California 90089-9121
    Phone+1 323 442 4118
    vCardDownload vCard

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Shah M, Edman MC, Reddy Janga S, Yarber F, Meng Z, Klinngam W, Bushman J, Ma T, Liu S, Louie S, Mehta A, Ding C, MacKay J, Hamm-Alvarez SF. Rapamycin Eye Drops Suppress Lacrimal Gland Inflammation In a Murine Model of Sjögren's Syndrome. Invest Ophthalmol Vis Sci. 2017 Jan 01; 58(1):372-385. PMID: 28122086.
        View in: PubMed
      2. Despanie J, Dhandhukia JP, Hamm-Alvarez SF, MacKay J. Elastin-like polypeptides: Therapeutic applications for an emerging class of nanomedicines. J Control Release. 2016 Oct 28; 240:93-108. PMID: 26578439.
        View in: PubMed
      3. Brill DA, MacKay J. Image-driven pharmacokinetics: nanomedicine concentration across space and time. Nanomedicine (Lond). 2015 Sep; 10(18):2861-79. PMID: 26370694.
        View in: PubMed
      4. Pastuszka MK, MacKay J. Engineering structure and function using thermoresponsive biopolymers. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2016 Jan; 8(1):123-38. PMID: 26112277.
        View in: PubMed
      5. Hsueh PY, Edman MC, Sun G, Shi P, Xu S, Lin YA, Cui H, Hamm-Alvarez SF, MacKay J. Tear-mediated delivery of nanoparticles through transcytosis of the lacrimal gland. J Control Release. 2015 Jun 28; 208:2-13. PMID: 25523518.
        View in: PubMed
      6. Wang W, Despanie J, Shi P, Edman-Woolcott MC, Lin YA, Cui H, Heur JM, Fini ME, Hamm-Alvarez SF, MacKay J. Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles. J Mater Chem B Mater Biol Med. 2014 Dec 14; 2(46):8131-8141. PMID: 25530855.
        View in: PubMed
      7. Wang W, Jashnani A, Aluri SR, Gustafson JA, Hsueh PY, Yarber F, McKown RL, Laurie GW, Hamm-Alvarez SF, MacKay J. A thermo-responsive protein treatment for dry eyes. J Control Release. 2015 Feb 10; 199:156-67. PMID: 25481446.
        View in: PubMed
      8. Pastuszka MK, Okamoto CT, Hamm-Alvarez SF, MacKay J. Flipping the Switch on Clathrin-Mediated Endocytosis using Thermally Responsive Protein Microdomains. Adv Funct Mater. 2014 Sep 10; 24(34):5340-5347. PMID: 25419208.
        View in: PubMed
      9. Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay J. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. PMID: 25016969.
        View in: PubMed
      10. Janib SM, Gustafson JA, Minea RO, Swenson SD, Liu S, Pastuszka MK, Lock LL, Cui H, Markland FS, Conti PS, Li Z, MacKay J. Multimeric disintegrin protein polymer fusions that target tumor vasculature. Biomacromolecules. 2014 Jul 14; 15(7):2347-58. PMID: 24871936.
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      11. Wang W, Sreekumar PG, Valluripalli V, Shi P, Wang J, Lin YA, Cui H, Kannan R, Hinton DR, MacKay J. Protein polymer nanoparticles engineered as chaperones protect against apoptosis in human retinal pigment epithelial cells. J Control Release. 2014 Oct 10; 191:4-14. PMID: 24780268.
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      12. Shi P, Gustafson JA, MacKay J. Genetically engineered nanocarriers for drug delivery. Int J Nanomedicine. 2014; 9:1617-26. PMID: 24741309.
        View in: PubMed
      13. Aluri SR, Shi P, Gustafson JA, Wang W, Lin YA, Cui H, Liu S, Conti PS, Li Z, Hu P, Epstein AL, Mackay JA. A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody. ACS Nano. 2014 Mar 25; 8(3):2064-76. PMID: 24484356.
        View in: PubMed
      14. Shi P, Lin YA, Pastuszka M, Cui H, Mackay JA. Triggered sorting and co-assembly of genetically engineered protein microdomains in the cytoplasm. Adv Mater. 2014 Jan; 26(3):449-54. PMID: 24136711.
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      15. Shah M, Edman MC, Janga SR, Shi P, Dhandhukia J, Liu S, Louie SG, Rodgers K, Mackay JA, Hamm-Alvarez SF. A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome. J Control Release. 2013 Nov 10; 171(3):269-79. PMID: 23892265.
        View in: PubMed
      16. Shi P, Aluri S, Lin YA, Shah M, Edman M, Dhandhukia J, Cui H, MacKay J. Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo. J Control Release. 2013 Nov 10; 171(3):330-8. PMID: 23714121.
        View in: PubMed
      17. Dhandhukia J, Weitzhandler I, Wang W, MacKay J. Switchable elastin-like polypeptides that respond to chemical inducers of dimerization. Biomacromolecules. 2013 Apr 8; 14(4):976-85. PMID: 23406497.
        View in: PubMed
      18. Janib SM, Liu S, Park R, Pastuszka MK, Shi P, Moses AS, Orosco MM, Lin YA, Cui H, Conti PS, Li Z, MacKay J. Kinetic quantification of protein polymer nanoparticles using non-invasive imaging. Integr Biol (Camb). 2013 Jan; 5(1):183-94. PMID: 23093022.
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      19. Pastuszka MK, Janib SM, Weitzhandler I, Okamoto CT, Hamm-Alvarez S, Mackay JA. A tunable and reversible platform for the intracellular formation of genetically engineered protein microdomains. Biomacromolecules. 2012 Nov 12; 13(11):3439-44. PMID: 23088632.
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      20. Aluri S, Pastuszka MK, Moses AS, Mackay JA. Elastin-like Peptide amphiphiles form nanofibers with tunable length. Biomacromolecules. 2012 Sep 10; 13(9):2645-54. PMID: 22849577.
        View in: PubMed
      21. Shah M, Hsueh PY, Sun G, Chang HY, Janib SM, Mackay JA. Biodegradation of elastin-like polypeptide nanoparticles. Protein Sci. 2012 Jun; 21(6):743-50. PMID: 22434766.
        View in: PubMed
      22. Sun G, Hsueh PY, Janib SM, Hamm-Alvarez S, Andrew MacKay J. Design and cellular internalization of genetically engineered polypeptide nanoparticles displaying adenovirus knob domain. J Control Release. 2011 Oct 30; 155(2):218-26. PMID: 21699930.
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      23. Chen M, McDaniel JR, MacKay J, Chilkoti, A. . Proceedings of the National Academy of Inventors. Nanoscale Self-Assembly for Delivery of Therapeutics and Imaging Agents. 2011; 1(13):5-25.
      24. Mackay JA, Callahan DJ, Fitzgerald KN, Chilkoti A. Quantitative Model of the Phase Behavior of Recombinant pH-Responsive Elastin-Like Polypeptides. Biomacromolecules. 2010 Oct 6. PMID: 20925333.
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      25. MacKay J, Li Z. Theranostic agents that co-deliver therapeutic and imaging agents? Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1003-4. PMID: 20937334.
        View in: PubMed
      26. Janib SM, Moses AS, MacKay J. Imaging and drug delivery using theranostic nanoparticles. Adv Drug Deliv Rev. 2010 Aug 30; 62(11):1052-63. PMID: 20709124.
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      27. Pastuszka MK, Mackay JA. Biomolecular engineering of intracellular switches in eukaryotes. J Drug Deliv Sci Technol. 2010 May; 20(3):163-169. PMID: 21209849.
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      28. McDaniel JR, Mackay JA, Quiroz FG, Chilkoti A. Recursive directional ligation by plasmid reconstruction allows rapid and seamless cloning of oligomeric genes. Biomacromolecules. 2010 Apr 12; 11(4):944-52. PMID: 20184309.
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      29. Liu W, MacKay J, Dreher MR, Chen M, McDaniel JR, Simnick AJ, Callahan DJ, Zalutsky MR, Chilkoti A. Injectable intratumoral depot of thermally responsive polypeptide-radionuclide conjugates delays tumor progression in a mouse model. J Control Release. 2010 May 21; 144(1):2-9. PMID: 20117157.
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      30. MacKay J, Chen M, McDaniel JR, Liu W, Simnick AJ, Chilkoti A. Self-assembling chimeric polypeptide-doxorubicin conjugate nanoparticles that abolish tumours after a single injection. Nat Mater. 2009 Dec; 8(12):993-9. PMID: 19898461.
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      31. Gao W, Liu W, Mackay JA, Zalutsky MR, Toone EJ, Chilkoti A. In situ growth of a stoichiometric PEG-like conjugate at a protein's N-terminus with significantly improved pharmacokinetics. Proc Natl Acad Sci U S A. 2009 Sep 8; 106(36):15231-6. PMID: 19706892.
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      32. Aluri S, Janib SM, Mackay JA. Environmentally responsive peptides as anticancer drug carriers. Adv Drug Deliv Rev. 2009 Sep 30; 61(11):940-52. PMID: 19628014.
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      33. Wu Y, MacKay J, McDaniel JR, Chilkoti A, Clark RL. Fabrication of elastin-like polypeptide nanoparticles for drug delivery by electrospraying. Biomacromolecules. 2009 Jan 12; 10(1):19-24. PMID: 19072041.
        View in: PubMed
      34. Mackay JA, Chilkoti A. Temperature sensitive peptides: engineering hyperthermia-directed therapeutics. Int J Hyperthermia. 2008 Sep; 24(6):483-95. PMID: 18608590.
        View in: PubMed
      35. MacKay J, Li W, Huang Z, Dy EE, Huynh G, Tihan T, Collins R, Deen DF, Szoka FC. HIV TAT peptide modifies the distribution of DNA nanolipoparticles following convection-enhanced delivery. Mol Ther. 2008 May; 16(5):893-900. PMID: 18388927.
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      36. Lim DW, Trabbic-Carlson K, Mackay JA, Chilkoti A. Improved non-chromatographic purification of a recombinant protein by cationic elastin-like polypeptides. Biomacromolecules. 2007 May; 8(5):1417-24. PMID: 17407348.
        View in: PubMed
      37. Chilkoti A, Christensen T, MacKay J. Stimulus responsive elastin biopolymers: Applications in medicine and biotechnology. Curr Opin Chem Biol. 2006 Dec; 10(6):652-7. PMID: 17055770.
        View in: PubMed
      38. Huang Z, Guo X, Li W, MacKay J, Szoka FC. Acid-triggered transformation of diortho ester phosphocholine liposome. J Am Chem Soc. 2006 Jan 11; 128(1):60-1. PMID: 16390121.
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      39. Lee CC, MacKay J, Fréchet JM, Szoka FC. Designing dendrimers for biological applications. Nat Biotechnol. 2005 Dec; 23(12):1517-26. PMID: 16333296.
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      40. Huang Z, Li W, MacKay J, Szoka FC. Thiocholesterol-based lipids for ordered assembly of bioresponsive gene carriers. Mol Ther. 2005 Mar; 11(3):409-17. PMID: 15727937.
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      41. Krylova IN, Sablin EP, Moore J, Xu RX, Waitt GM, MacKay J, Juzumiene D, Bynum JM, Madauss K, Montana V, Lebedeva L, Suzawa M, Williams JD, Williams SP, Guy RK, Thornton JW, Fletterick RJ, Willson TM, Ingraham HA. Structural analyses reveal phosphatidyl inositols as ligands for the NR5 orphan receptors SF-1 and LRH-1. Cell. 2005 Feb 11; 120(3):343-55. PMID: 15707893.
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      42. MacKay J, Deen DF, Szoka FC. Distribution in brain of liposomes after convection enhanced delivery; modulation by particle charge, particle diameter, and presence of steric coating. Brain Res. 2005 Feb 28; 1035(2):139-53. PMID: 15722054.
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      43. Li W, Huang Z, MacKay J, Grube S, Szoka FC. Low-pH-sensitive poly(ethylene glycol) (PEG)-stabilized plasmid nanolipoparticles: effects of PEG chain length, lipid composition and assembly conditions on gene delivery. J Gene Med. 2005 Jan; 7(1):67-79. PMID: 15515149.
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      44. Guo X, MacKay J, Szoka FC. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys J. 2003 Mar; 84(3):1784-95. PMID: 12609880.
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      45. Choi JS, MacKay J, Szoka FC. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem. 2003 Mar-Apr; 14(2):420-9. PMID: 12643753.
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      46. Mackay JA, Szoka FC. HIV TAT Protein Transduction Domain Mediated Cell Binding and Intracellular Delivery of Nanoparticles. J Dispers Sci Technol. 2003; 24(3):465-473. PMID: 20808712.
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      47. Martin I, Shastri VP, Padera RF, Yang J, Mackay AJ, Langer R, Vunjak-Novakovic G, Freed LE. Selective differentiation of mammalian bone marrow stromal cells cultured on three-dimensional polymer foams. J Biomed Mater Res. 2001 May; 55(2):229-35. PMID: 11255174.
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