Ian S Haworth, PhD

Title(s)Associate Professor and Co-Director of International Summer Programs
SchoolUSC School of Pharmacy
AddressPSC 304bb
Health Sciences Campus
Los Angeles CA 90089-9121
Phone+1 323 442 3310
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    Ph.D., University of Liverpool, U.K. (advisor: Prof. Raymond J. Abraham), 1986-1989, Physical Organic Chemistry. Postdoc. Oxford University, U.K. (advisor: Prof. W. Graham Richards), 1989-1992. Joined USC in 1992. Dr. Haworth's research interests lie at the interface between chemistry, biology and the computational sciences, with the goal being an improved understanding of the dynamics of molecular association of nucleic acids and proteins. Dr. Haworth has published over 60 papers in this area, and the work has attracted funding from federal and non-federal sources.

    Dr. Haworth's laboratory has developed algorithms for nucleic acid structure building, nucleic acid aptamer design, transporter protein structure and analysis, and MHC-peptide-TCR association. The basis of these algorithms is accurate reproduction of molecular association, through proper molecular and theoretical descriptions of biological interfaces.

    In the teaching area, Dr. Haworth has been active in moving part of the basic science Pharm.D. curriculum from the 'traditional' 'lecture/examination' approach to a more learner-centered, 'case study-based' approach, and has published a number of articles in this area. Dr. Haworth is a former chair of the Drug Design & Discovery section of the American Association of Pharmaceutical Scientists and is an editorial advisory board member for Pharmaceutical Research and AAPS PharmSci.

    Collapse Research 
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    PEPT1: STRUCTURE-FUNCTION, SORTING AND MODULATION
    NIH R01GM059297Mar 1, 2000 - Feb 28, 2006
    Role: Principal Investigator
    POLYAMINES--COMPLEXES WITH ANTITUMOR MECHANISMS
    NIH R29CA064299Jul 1, 1994 - Jun 30, 2000
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    1. An Artificial Intelligence-Supported Medicinal Chemistry Project: An Example for Incorporating AI within the Pharmacy Curriculum. Am J Pharm Educ. 2024 Apr 02; 100696. Culp ML, Mahmoud S, Liu D, Haworth IS. PMID: 38574998.
      View in: PubMed   Mentions:    Fields:    
    2. Pharmacokinetic model of human exposure to ciprofloxacin through consumption of fish. Environ Toxicol Pharmacol. 2024 Mar; 106:104359. Kum OK, Chan KM, Morningstar-Kywi N, MacKay JA, Haworth IS. PMID: 38163528.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    3. Teaching of drug disposition using physiologically based pharmacokinetic modeling software: GastroPlus as an educational tool. Adv Physiol Educ. 2023 Dec 01; 47(4):718-725. Morningstar-Kywi N, Morris DN, Romero RM, Haworth IS. PMID: 37471218.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Prediction of Peptide and TCR CDR3 Loops in Formation of Class I MHC-Peptide-TCR Complexes Using Molecular Models with Solvation. Methods Mol Biol. 2023; 2673:273-287. Mehta NM, Li Y, Patel V, Li W, Morningstar-Kywi N, Pospiech M, Alachkar H, Haworth IS. PMID: 37258921.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    5. Prediction of Water Distributions and Displacement at Protein-Ligand Interfaces. J Chem Inf Model. 2022 03 28; 62(6):1489-1497. Morningstar-Kywi N, Wang K, Asbell TR, Wang Z, Giles JB, Lai J, Brill D, Sutch BT, Haworth IS. PMID: 35261241.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    6. Assessment of the impact of co-curricular activities on achievement of Doctor of Pharmacy program outcomes. Curr Pharm Teach Learn. 2022 04; 14(4):440-448. Matthews ME, Avoundjian A, Ameripour D, Fakolade W, Wu M, Haworth IS. PMID: 35483809.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. Lysine acetylation regulates the interaction between proteins and membranes. Nat Commun. 2021 11 09; 12(1):6466. Okada AK, Teranishi K, Ambroso MR, Isas JM, Vazquez-Sarandeses E, Lee JY, Melo AA, Pandey P, Merken D, Berndt L, Lammers M, Daumke O, Chang K, Haworth IS, Langen R. PMID: 34753925; PMCID: PMC8578602.
      View in: PubMed   Mentions: 18     Fields:    Translation:AnimalsCells
    8. Integration of Clinical and Scientific Principles in the Teaching of Drug-Drug Interactions. Med Sci Educ. 2021 Dec; 31(6):2169-2176. Kim RE, Morningstar-Kywi N, Haworth IS. PMID: 34956730; PMCID: PMC8651912.
      View in: PubMed   Mentions:
    9. Ligand-specific pharmacogenetic effects of nonsynonymous mutations. Pharmacogenet Genomics. 2021 06 01; 31(4):75-82. Morningstar-Kywi N, Haworth IS, Mosley SA. PMID: 33395026.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    10. Corrigendum to "Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression" [Heliyon 5 (3) (March 2019) e01366]. Heliyon. 2019 04; 5(4):e01513. Perri F, Frattaruolo L, Haworth I, Brindisi M, El-Magboub A, Ferrario A, Gomer C, Aiello F, Adams JD. PMID: 31049429; PMCID: PMC6482316.
      View in: PubMed   Mentions:
    11. Experimental Validation of the ALLNOX Program for Studying Protein-Nucleic Acid Complexes. J Phys Chem A. 2019 Apr 25; 123(16):3592-3598. Ding Y, Kathiresan V, Zhang X, Haworth IS, Qin PZ. PMID: 30978022; PMCID: PMC6486822.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    12. Naturally occurring sesquiterpene lactones and their semi-synthetic derivatives modulate PGE2 levels by decreasing COX2 activity and expression. Heliyon. 2019 03; 5(3):e01366. Perri F, Frattaruolo L, Haworth I, Brindisi M, El-magboub A, Ferrario A, Gomer C, Aiello F, Adams JD. PMID: 30976671; PMCID: PMC6441754.
      View in: PubMed   Mentions: 10  
    13. A curcumin-diglutaric acid conjugated prodrug with improved water solubility and antinociceptive properties compared to curcumin. Biosci Biotechnol Biochem. 2018 Aug; 82(8):1301-1308. Muangnoi C, Jithavech P, Ratnatilaka Na Bhuket P, Supasena W, Wichitnithad W, Towiwat P, Niwattisaiwong N, Haworth IS, Rojsitthisak P. PMID: 29678124.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansAnimals
    14. Rational drug design and synthesis of new α-Santonin derivatives as potential COX-2 inhibitors. Bioorg Med Chem Lett. 2018 04 01; 28(6):993-996. Coricello A, El-Magboub A, Luna M, Ferrario A, Haworth IS, Gomer CJ, Aiello F, Adams JD. PMID: 29501395.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    15. Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 2. Rational Bioavailability Design by Global Sensitivity Analysis To Identify Properties Affecting Bioavailability. Mol Pharm. 2018 03 05; 15(3):831-839. Daga PR, Bolger MB, Haworth IS, Clark RD, Martin EJ. PMID: 29337562.
      View in: PubMed   Mentions: 8     Fields:    
    16. Physiologically Based Pharmacokinetic Modeling in Lead Optimization. 1. Evaluation and Adaptation of GastroPlus To Predict Bioavailability of Medchem Series. Mol Pharm. 2018 03 05; 15(3):821-830. Daga PR, Bolger MB, Haworth IS, Clark RD, Martin EJ. PMID: 29337578.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansAnimalsCells
    17. Enhancement of Curcumin Bioavailability Via the Prodrug Approach: Challenges and Prospects. Eur J Drug Metab Pharmacokinet. 2017 Jun; 42(3):341-353. Ratnatilaka Na Bhuket P, El-Magboub A, Haworth IS, Rojsitthisak P. PMID: 27683187.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
    18. Structural Characterization of Membrane-Curving Proteins: Site-Directed Spin Labeling, EPR, and Computational Refinement. Methods Enzymol. 2015; 564:259-88. Ambroso MR, Haworth IS, Langen R. PMID: 26477254.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    19. Computer Modeling of Spin Labels: NASNOX, PRONOX, and ALLNOX. Methods Enzymol. 2015; 563:569-93. Beasley KN, Sutch BT, Hatmal MM, Langen R, Qin PZ, Haworth IS. PMID: 26478499.
      View in: PubMed   Mentions: 10     Fields:    
    20. An Integrated Spin-Labeling/Computational-Modeling Approach for Mapping Global Structures of Nucleic Acids. Methods Enzymol. 2015; 564:427-53. Tangprasertchai NS, Zhang X, Ding Y, Tham K, Rohs R, Haworth IS, Qin PZ. PMID: 26477260; PMCID: PMC4641853.
      View in: PubMed   Mentions: 9     Fields:    Translation:Cells
    21. The role of the C-terminal helix of U1A protein in the interaction with U1hpII RNA. Nucleic Acids Res. 2013 Aug; 41(14):7092-100. Law MJ, Lee DS, Lee CS, Anglim PP, Haworth IS, Laird-Offringa IA. PMID: 23703211; PMCID: PMC3737524.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    22. Electrophoretic mobility of duplex DNA cross-linked by mechlorethamine at a cytosine-cytosine mismatch pair. Electrophoresis. 2013 Mar; 34(6):917-24. Romero RM, Rojsittisak P, Haworth IS. PMID: 23334930.
      View in: PubMed   Mentions: 2     Fields:    Translation:Cells
    23. Idealized models of protofilaments of human islet amyloid polypeptide. J Chem Inf Model. 2012 Nov 26; 52(11):2983-91. Li Y, Hatmal MM, Langen R, Haworth IS. PMID: 23116372; PMCID: PMC3522432.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    24. Nitroxide sensing of a DNA microenvironment: mechanistic insights from EPR spectroscopy and molecular dynamics simulations. J Phys Chem B. 2012 Jun 07; 116(22):6387-96. Popova AM, Hatmal MM, Frushicheva MP, Price EA, Qin PZ, Haworth IS. PMID: 22574834; PMCID: PMC3382087.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    25. Global structure of a three-way junction in a phi29 packaging RNA dimer determined using site-directed spin labeling. J Am Chem Soc. 2012 Feb 08; 134(5):2644-52. Zhang X, Tung CS, Sowa GZ, Hatmal MM, Haworth IS, Qin PZ. PMID: 22229766; PMCID: PMC3279945.
      View in: PubMed   Mentions: 25     Fields:    Translation:Cells
    26. Information intervention in the pharmaceutical sciences. Med Ref Serv Q. 2012; 31(2):188-201. Chatfield AJ, Romero RM, Haworth IS. PMID: 22559181.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Fibril structure of human islet amyloid polypeptide. J Biol Chem. 2012 Feb 17; 287(8):5235-41. Bedrood S, Li Y, Isas JM, Hegde BG, Baxa U, Haworth IS, Langen R. PMID: 22187437; PMCID: PMC3285303.
      View in: PubMed   Mentions: 66     Fields:    Translation:HumansCells
    28. Computer modeling of nitroxide spin labels on proteins. Biopolymers. 2012 Jan; 97(1):35-44. Hatmal MM, Li Y, Hegde BG, Hegde PB, Jao CC, Langen R, Haworth IS. PMID: 21792846; PMCID: PMC3422567.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimalsCells
    29. Modeling of the water network at protein-RNA interfaces. J Chem Inf Model. 2011 Jun 27; 51(6):1347-52. Li Y, Sutch BT, Bui HH, Gallaher TK, Haworth IS. PMID: 21612274.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    30. HPLC-UV, MALDI-TOF-MS and ESI-MS/MS analysis of the mechlorethamine DNA crosslink at a cytosine-cytosine mismatch pair. PLoS One. 2011; 6(6):e20745. Rojsitthisak P, Jongaroonngamsang N, Romero RM, Haworth IS. PMID: 21673963; PMCID: PMC3108972.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    31. Functional role of the intracellular loop linking transmembrane domains 6 and 7 of the human dipeptide transporter hPEPT1. J Membr Biol. 2010 Dec; 238(1-3):43-9. Xu L, Li Y, Haworth IS, Davies DL. PMID: 21104182; PMCID: PMC3032433.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    32. Quantitative assessment of assisted problem-based learning in a pharmaceutics course. Am J Pharm Educ. 2010 May 12; 74(4):66. Romero RM, Eriksen SP, Haworth IS. PMID: 20585427; PMCID: PMC2879117.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    33. Roles of amphipathic helices and the bin/amphiphysin/rvs (BAR) domain of endophilin in membrane curvature generation. J Biol Chem. 2010 Jun 25; 285(26):20164-70. Jao CC, Hegde BG, Gallop JL, Hegde PB, McMahon HT, Haworth IS, Langen R. PMID: 20418375; PMCID: PMC2888429.
      View in: PubMed   Mentions: 46     Fields:    Translation:AnimalsCells
    34. Similarity of protein-RNA interfaces based on motif analysis. J Chem Inf Model. 2009 Sep; 49(9):2139-46. Sutch BT, Chambers EJ, Bayramyan MZ, Gallaher TK, Haworth IS. PMID: 19731952.
      View in: PubMed   Mentions: 1     Fields:    Translation:Cells
    35. Mutagenesis and cysteine scanning of transmembrane domain 10 of the human dipeptide transporter. Pharm Res. 2009 Oct; 26(10):2358-66. Xu L, Haworth IS, Kulkarni AA, Bolger MB, Davies DL. PMID: 19685173; PMCID: PMC2861424.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    36. Conformational variants of duplex DNA correlated with cytosine-rich chromosomal fragile sites. J Biol Chem. 2009 Mar 13; 284(11):7157-64. Tsai AG, Engelhart AE, Hatmal MM, Houston SI, Hud NV, Haworth IS, Lieber MR. PMID: 19106104; PMCID: PMC2652318.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansCells
    37. Structure of membrane-bound alpha-synuclein from site-directed spin labeling and computational refinement. Proc Natl Acad Sci U S A. 2008 Dec 16; 105(50):19666-71. Jao CC, Hegde BG, Chen J, Haworth IS, Langen R. PMID: 19066219; PMCID: PMC2605001.
      View in: PubMed   Mentions: 253     Fields:    Translation:HumansCells
    38. Ethanol inhibits functional activity of the human intestinal dipeptide transporter hPepT1 expressed in Xenopus oocytes. Alcohol Clin Exp Res. 2008 May; 32(5):777-84. Li K, Xu L, Kulkarni AA, Perkins DI, Haworth IS, Davies DL. PMID: 18336632; PMCID: PMC2861421.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansAnimalsCells
    39. Incorporation of zebularine from its 2'-deoxyribonucleoside triphosphate derivative and activity as a template-coding nucleobase. Nucleosides Nucleotides Nucleic Acids. 2008 Feb; 27(2):131-45. Dowd CL, Sutch BT, Haworth IS, Eritja R, Marquez VE, Yang AS. PMID: 18205068.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    40. WATGEN: an algorithm for modeling water networks at protein-protein interfaces. J Comput Chem. 2007 Nov 15; 28(14):2241-51. Bui HH, Schiewe AJ, Haworth IS. PMID: 17471455.
      View in: PubMed   Mentions: 10     Fields:    Translation:Cells
    41. Computation of nitroxide-nitroxide distances in spin-labeled DNA duplexes. Biopolymers. 2007 Sep; 87(1):40-50. Price EA, Sutch BT, Cai Q, Qin PZ, Haworth IS. PMID: 17538992; PMCID: PMC2430107.
      View in: PubMed   Mentions: 17     Fields:    Translation:Cells
    42. Nanometer distance measurements in RNA using site-directed spin labeling. Biophys J. 2007 Sep 15; 93(6):2110-7. Cai Q, Kusnetzow AK, Hideg K, Price EA, Haworth IS, Qin PZ. PMID: 17526583; PMCID: PMC1959523.
      View in: PubMed   Mentions: 28     Fields:    Translation:Cells
    43. Structure-based prediction of MHC-peptide association: algorithm comparison and application to cancer vaccine design. J Mol Graph Model. 2007 Oct; 26(3):667-75. Schiewe AJ, Haworth IS. PMID: 17493854.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    44. Cysteine scanning of transmembrane domain three of the human dipeptide transporter: implications for substrate transport. J Drug Target. 2007 Apr; 15(3):218-25. Links JL, Kulkarni AA, Davies DL, Lee VH, Haworth IS. PMID: 17454359.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    45. Measuring nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nat Protoc. 2007; 2(10):2354-65. Qin PZ, Haworth IS, Cai Q, Kusnetzow AK, Grant GP, Price EA, Sowa GZ, Popova A, Herreros B, He H. PMID: 17947978; PMCID: PMC2430106.
      View in: PubMed   Mentions: 38     Fields:    
    46. A charge pair interaction between Arg282 in transmembrane segment 7 and Asp341 in transmembrane segment 8 of hPepT1. Pharm Res. 2007 Jan; 24(1):66-72. Kulkarni AA, Davies DL, Links JS, Patel LN, Lee VH, Haworth IS. PMID: 17009102.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    47. Computational drug delivery. Adv Drug Deliv Rev. 2006 Nov 30; 58(12-13):1271-3. Haworth IS. PMID: 17069930.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    48. Site-directed spin labeling measurements of nanometer distances in nucleic acids using a sequence-independent nitroxide probe. Nucleic Acids Res. 2006; 34(17):4722-30. Cai Q, Kusnetzow AK, Hubbell WL, Haworth IS, Gacho GP, Van Eps N, Hideg K, Chambers EJ, Qin PZ. PMID: 16966338; PMCID: PMC1635252.
      View in: PubMed   Mentions: 52     Fields:    Translation:Cells
    49. Structural prediction of peptides binding to MHC class I molecules. Proteins. 2006 Apr 01; 63(1):43-52. Bui HH, Schiewe AJ, von Grafenstein H, Haworth IS. PMID: 16447245.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansCells
    50. The role of positively charged amino acids and electrostatic interactions in the complex of U1A protein and U1 hairpin II RNA. Nucleic Acids Res. 2006; 34(1):275-85. Law MJ, Linde ME, Chambers EJ, Oubridge C, Katsamba PS, Nilsson L, Haworth IS, Laird-Offringa IA. PMID: 16407334; PMCID: PMC1326249.
      View in: PubMed   Mentions: 41     Fields:    Translation:Cells
    51. Kinetic analysis of the role of the tyrosine 13, phenylalanine 56 and glutamine 54 network in the U1A/U1 hairpin II interaction. Nucleic Acids Res. 2005; 33(9):2917-28. Law MJ, Chambers EJ, Katsamba PS, Haworth IS, Laird-Offringa IA. PMID: 15914668; PMCID: PMC1140079.
      View in: PubMed   Mentions: 23     Fields:    Translation:HumansCells
    52. Physicochemical and structural characterization of quercetin-beta-cyclodextrin complexes. J Pharm Sci. 2005 May; 94(5):1079-89. Zheng Y, Haworth IS, Zuo Z, Chow MS, Chow AH. PMID: 15793810.
      View in: PubMed   Mentions: 18     Fields:    
    53. Evidence for a triplex DNA conformation at the bcl-2 major breakpoint region of the t(14;18) translocation. J Biol Chem. 2005 Jun 17; 280(24):22749-60. Raghavan SC, Chastain P, Lee JS, Hegde BG, Houston S, Langen R, Hsieh CL, Haworth IS, Lieber MR. PMID: 15840562.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    54. Fine-structure analysis of activation-induced deaminase accessibility to class switch region R-loops. Mol Cell Biol. 2005 Mar; 25(5):1730-6. Yu K, Roy D, Bayramyan M, Haworth IS, Lieber MR. PMID: 15713630; PMCID: PMC549380.
      View in: PubMed   Mentions: 36     Fields:    Translation:AnimalsCells
    55. Stability and strand asymmetry in the non-B DNA structure at the bcl-2 major breakpoint region. J Biol Chem. 2004 Oct 29; 279(44):46213-25. Raghavan SC, Houston S, Hegde BG, Langen R, Haworth IS, Lieber MR. PMID: 15328356.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    56. Analysis of transmembrane segment 7 of the dipeptide transporter hPepT1 by cysteine-scanning mutagenesis. J Biol Chem. 2003 Dec 19; 278(51):51833-40. Kulkarni AA, Haworth IS, Uchiyama T, Lee VH. PMID: 14532279.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansCells
    57. Computation of DNA backbone conformations. J Biomol Struct Dyn. 2003 Aug; 21(1):111-25. Chambers EJ, Price EA, Bayramyan MC, Haworth IS. PMID: 12854963.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    58. Transmembrane segment 5 of the dipeptide transporter hPepT1 forms a part of the substrate translocation pathway. Biochem Biophys Res Commun. 2003 Jun 20; 306(1):177-85. Kulkarni AA, Haworth IS, Lee VH. PMID: 12788085.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    59. Complex role of the beta 2-beta 3 loop in the interaction of U1A with U1 hairpin II RNA. J Biol Chem. 2002 Sep 06; 277(36):33267-74. Katsamba PS, Bayramyan M, Haworth IS, Myszka DG, Laird-Offringa IA. PMID: 12082087.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    60. Extrahelical cytosine bases in DNA duplexes containing d[GCC](n).d[GCC](n) repeats: detection by a mechlorethamine crosslinking reaction. Nucleic Acids Res. 2001 Nov 15; 29(22):4716-23. Rojsitthisak P, Romero RM, Haworth IS. PMID: 11713322; PMCID: PMC92524.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    61. DNA interstrand crosslink formation by mechlorethamine at a cytosine-cytosine mismatch pair: kinetics and sequence dependence. Arch Biochem Biophys. 2001 Feb 15; 386(2):143-53. Romero RM, Rojsitthisak P, Haworth IS. PMID: 11368336.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    62. Water dynamics at the binding interface of four different HLA-A2-peptide complexes. Int Immunol. 2000 Jul; 12(7):949-57. Meng WS, von Grafenstein H, Haworth IS. PMID: 10882406.
      View in: PubMed   Mentions: 5     Fields:    Translation:Cells
    63. DNA structure control by polycationic species: polyamine, cobalt ammines, and di-metallo transition metal chelates. Chirality. 2000 May; 12(4):221-36. Rodger A, Sanders KJ, Hannon MJ, Meistermann I, Parkinson A, Vidler DS, Haworth IS. PMID: 10790193.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    64. Experimental evidence for the presence of a water network at the peptide-MHC interface. Immunol Lett. 1999 Dec 01; 70(3):139-41. Gurlo T, Meng WS, Bui HH, Haworth IS, von Grafenstein H. PMID: 10656665.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    65. Biopharmaceutics of transmucosal peptide and protein drug administration: role of transport mechanisms with a focus on the involvement of PepT1. J Control Release. 1999 Nov 01; 62(1-2):129-40. Lee VH, Chu C, Mahlin ED, Basu SK, Ann DK, Bolger MB, Haworth IS, Yeung AK, Wu SK, Hamm-Alvarez S, Okamoto CT. PMID: 10518644.
      View in: PubMed   Mentions: 10     Fields:    
    66. Spermine inhibition of the 2,5-diaziridinyl-1,4-benzoquinone (DZQ) crosslinking reaction with DNA duplexes containing poly(purine). poly(pyrimidine) tracts. Nucleic Acids Res. 1999 Jul 01; 27(13):2601-9. Shamma T, Haworth IS. PMID: 10373575; PMCID: PMC148467.
      View in: PubMed   Mentions: 3     Fields:    
    67. Anomalous cross-linking by mechlorethamine of DNA duplexes containing C-C mismatch pairs. Biochemistry. 1999 Mar 23; 38(12):3641-8. Romero RM, Mitas M, Haworth IS. PMID: 10090751.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    68. Proton-driven dipeptide uptake in primary cultured rabbit conjunctival epithelial cells. Invest Ophthalmol Vis Sci. 1998 Nov; 39(12):2365-73. Basu SK, Haworth IS, Bolger MB, Lee VH. PMID: 9804145.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    69. Structure, function, and molecular modeling approaches to the study of the intestinal dipeptide transporter PepT1. J Pharm Sci. 1998 Nov; 87(11):1286-91. Bolger MB, Haworth IS, Yeung AK, Ann D, von Grafenstein H, Hamm-Alvarez S, Okamoto CT, Kim KJ, Basu SK, Wu S, Lee VH. PMID: 9811478.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansCells
    70. Molecular identification of a role for tyrosine 167 in the function of the human intestinal proton- coupled dipeptide transporter (hPepT1). Biochem Biophys Res Commun. 1998 Sep 08; 250(1):103-7. Yeung AK, Basu SK, Wu SK, Chu C, Okamoto CT, Hamm-Alvarez SF, von Grafenstein H, Shen WC, Kim KJ, Bolger MB, Haworth IS, Ann DK, Lee VH. PMID: 9735340.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    71. A model of water structure inside the HLA-A2 peptide binding groove. Int Immunol. 1997 Sep; 9(9):1339-46. Meng WS, von Grafenstein H, Haworth IS. PMID: 9310837.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    72. At physiological pH, d(CCG)15 forms a hairpin containing protonated cytosines and a distorted helix. Biochemistry. 1997 Mar 25; 36(12):3687-99. Yu A, Barron MD, Romero RM, Christy M, Gold B, Dai J, Gray DM, Haworth IS, Mitas M. PMID: 9132022.
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    73. Spermine binding to GC-rich DNA: experimental and theoretical studies. Arch Biochem Biophys. 1996 Jan 01; 325(1):39-46. Yuki M, Grukhin V, Lee CS, Haworth IS. PMID: 8554341.
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    74. The trinucleotide repeat sequence d(CGG)15 forms a heat-stable hairpin containing Gsyn. Ganti base pairs. Biochemistry. 1995 Oct 03; 34(39):12803-11. Mitas M, Yu A, Dill J, Haworth IS. PMID: 7548035.
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    75. Molecular cloning, characterization, and mapping of a full-length cDNA encoding human UDP-galactose 4'-epimerase. Biochem Mol Med. 1995 Oct; 56(1):1-7. Daude N, Gallaher TK, Zeschnigk M, Starzinski-Powitz A, Petry KG, Haworth IS, Reichardt JK. PMID: 8593531.
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    76. The trinucleotide repeat sequence d(GTC)15 adopts a hairpin conformation. Nucleic Acids Res. 1995 Jul 25; 23(14):2706-14. Yu A, Dill J, Wirth SS, Huang G, Lee VH, Haworth IS, Mitas M. PMID: 7651831; PMCID: PMC307095.
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    77. Multiple DNA binding modes of anthracene-9-carbonyl-N1-spermine. Bioorg Med Chem. 1995 Jun; 3(6):861-72. Rodger A, Taylor S, Adlam G, Blagbrough IS, Haworth IS. PMID: 7582962.
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    78. Hairpin properties of single-stranded DNA containing a GC-rich triplet repeat: (CTG)15. Nucleic Acids Res. 1995 Mar 25; 23(6):1050-9. Mitas M, Yu A, Dill J, Kamp TJ, Chambers EJ, Haworth IS. PMID: 7731793; PMCID: PMC306804.
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    79. Molecular dynamics simulations of chlorambucil/DNA adducts. A structural basis for the 5'-GNC interstrand DNA crosslink formed by nitrogen mustards. J Biomol Struct Dyn. 1995 Feb; 12(4):911-36. Remias MG, Lee CS, Haworth IS. PMID: 7779307.
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    80. Molecular dynamics simulations provide a structural basis for the experimentally observed nucleotide preferences for DNA interstrand cross-links induced by aziridinylbenzoquinones. Biochemistry. 1993 Nov 30; 32(47):12857-63. Haworth IS, Lee CS, Yuki M, Gibson NW. PMID: 8251508.
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    81. A mutation in the homeodomain of the human MSX2 gene in a family affected with autosomal dominant craniosynostosis. Cell. 1993 Nov 05; 75(3):443-50. Jabs EW, Müller U, Li X, Ma L, Luo W, Haworth IS, Klisak I, Sparkes R, Warman ML, Mulliken JB, et al. PMID: 8106171.
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    82. A molecular basis for human hypersensitivity to aminoglycoside antibiotics. Nucleic Acids Res. 1993 Sep 11; 21(18):4174-9. Hutchin T, Haworth I, Higashi K, Fischel-Ghodsian N, Stoneking M, Saha N, Arnos C, Cortopassi G. PMID: 8414970; PMCID: PMC310046.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansCells
    83. SUBCUR: visualization of structural differences between DNA duplexes. J Mol Graph. 1993 Sep; 11(3):211-3. Sanghani SR, Elcock AH, Haworth IS. PMID: 8110667.
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    84. The DNA complexes of 2,5-diaziridinylbenzoquinone and 3,6-dimethyl-2,5-diaziridinylbenzoquinone. A molecular mechanics study. Anticancer Drug Des. 1993 Aug; 8(4):269-87. Yuki M, Haworth IS. PMID: 8240656.
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    85. A molecular dynamics simulation of a polyamine-induced conformational change of DNA. A possible mechanism for the B to Z transition. J Biomol Struct Dyn. 1992 Aug; 10(1):195-211. Haworth IS, Rodger A, Richards WG. PMID: 1418741.
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    86. A binding mode of lambda-[tris(1,10-phenanthroline)ruthenium(II)]2+ exhibiting preference for purine-3',5'-pyrimidine sites of DNA. J Biomol Struct Dyn. 1991 Dec; 9(3):553-69. Haworth IS, Elcock AH, Rodger A, Richards WG. PMID: 1815643.
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    87. COSMIC(90): an improved molecular mechanics treatment of hydrocarbons and conjugated systems. J Comput Aided Mol Des. 1991 Oct; 5(5):475-504. Morley SD, Abraham RJ, Haworth IS, Jackson DE, Saunders MR, Vinter JG. PMID: 1770382.
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    88. Sequence selective binding to the DNA major groove: tris(1,10-phenanthroline) metal complexes binding to poly(dG-dC) and poly(dA-dT). J Biomol Struct Dyn. 1991 Aug; 9(1):23-44. Haworth IS, Elcock AH, Freeman J, Rodger A, Richards WG. PMID: 1781946.
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    89. A molecular mechanics study of spermine complexation to DNA: a new model for spermine-poly(dG-dC) binding. Proc Biol Sci. 1991 May 22; 244(1310):107-16. Haworth IS, Rodger A, Richards WG. PMID: 1679544.
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    90. Charge calculations in molecular mechanics. Part 8. Partial atomic charges from classical calculations. J Comput Aided Mol Des. 1991 Feb; 5(1):21-39. Abraham RJ, Grant GH, Haworth IS, Smith PE. PMID: 2072123.
      View in: PubMed   Mentions: 6     Fields:    Translation:Cells
    91. A prototype bioreductive DNA groove binding ligand. Anticancer Drug Des. 1991 Feb; 6(1):59-70. Haworth IS, Burt C, Gago F, Reynolds CA, Richards WG. PMID: 1707627.
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    92. Molecular modelling of poly(aryl ether ketones). I. Aryl..aryl interactions in crystal structures. J Comput Aided Mol Des. 1990 Sep; 4(3):283-94. Abraham RJ, Haworth IS. PMID: 2280265.
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    93. A modification to the COSMIC parameterisation using ab initio constrained potential functions. J Comput Aided Mol Des. 1988 Jul; 2(2):125-35. Abraham RJ, Haworth IS. PMID: 3199153.
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