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    Robinder G. Khemani, MD

    TitleAssociate Professor of Clinical Pediatrics
    SchoolKeck School of Medicine of USC
    DepartmentPediatrics
    AddressCHL Mail Stop 12
    Off Campus
    Los Angeles California 90089
    Phone+1 323 361 2557
    vCardDownload vCard

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      Dr. Khemani is a Pediatric Intensive Care Physician and Clinical Researcher at the Children's Hospital Los Angeles. His major area of research interest involves using observational data to answer important clinical questions in the realm of pediatric critical care. This includes but is not limited to the creation and validation of quality indicators and severity of illness scores to develop objective criteria for comparing pediatric intensive care unit (PICU) outcomes internationally. This work involves both disease specific markers for certain subgroups of PICU patients, or global ICU populations. These findings will help target specific areas for quality improvement, and help evaluate new interventions and treatment modalities.

      He is also interested in pediatric mechanical ventilation, lung injury, and respiratory physiology, both translationally and at the bedside. He has specific interests in acute respiratory distress syndrome and upper airway obstruction: developing and validating minimally invasive pulmonary function techniques. Moreover, he uses his background in statistical modeling to examine the impact of different treatment regimens on cohorts of patients with specific respiratory disease such as upper airway obstruction, obstructive airways, hypoxemic respiratory failure, and acute lung injury.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Newth CJL, Sward KA, Khemani R, Page K, Meert KL, Carcillo JA, Shanley TP, Moler FW, Pollack MM, Dalton HJ, Wessel DL, Berger JT, Berg RA, Harrison RE, Holubkov R, Doctor A, Dean JM, Jenkins TL, Nicholson CE. Variability in Usual Care Mechanical Ventilation for Pediatric Acute Respiratory Distress Syndrome: Time for a Decision Support Protocol? Pediatr Crit Care Med. 2017 Sep 19. PMID: 28930815.
        View in: PubMed
      2. Sward KA, Newth CJL, Khemani R, Page K, Meert KL, Carcillo JA, Shanley TP, Moler FW, Pollack MM, Dalton HJ, Wessel DL, Berger JT, Berg RA, Harrison RE, Doctor A, Dean JM, Holobkov R, Jenkins TL, Nicholson CE. Potential Acceptability of a Pediatric Ventilator Management Computer Protocol. Pediatr Crit Care Med. 2017 Sep 16. PMID: 28926488.
        View in: PubMed
      3. Newth CJL, Khemani R, Jouvet PA, Sward KA. Mechanical Ventilation and Decision Support in Pediatric Intensive Care. Pediatr Clin North Am. 2017 Oct; 64(5):1057-1070. PMID: 28941535.
        View in: PubMed
      4. Khemani R, Sekayan T, Hotz J, Flink RC, Rafferty GF, Iyer N, Newth CJL. Risk Factors for Pediatric Extubation Failure: The Importance of Respiratory Muscle Strength. Crit Care Med. 2017 Aug; 45(8):e798-e805. PMID: 28437378.
        View in: PubMed
      5. Weiler T, Kamerkar A, Hotz J, Ross PA, Newth CJL, Khemani R. The Relationship between High Flow Nasal Cannula Flow Rate and Effort of Breathing in Children. J Pediatr. 2017 Jun 29. PMID: 28669609.
        View in: PubMed
      6. Wong R, Deakers T, Hotz J, Khemani R, Ross PA, Newth CJ. Volume and Pressure Delivery During Pediatric High-Frequency Oscillatory Ventilation. Pediatr Crit Care Med. 2017 Apr; 18(4):e189-e194. PMID: 28212162.
        View in: PubMed
      7. Kamerkar A, Hotz J, Morzov R, Newth CJL, Ross PA, Khemani R. Comparison of Effort of Breathing for Infants on Nasal Modes of Respiratory Support. J Pediatr. 2017 Jun; 185:26-32.e3. PMID: 28366356.
        View in: PubMed
      8. Virk MK, Hotz J, Khemani R, Newth CJ, Ross PA. Change in Oxygen Consumption Following Inhalation of Albuterol in Comparison with Levalbuterol in Healthy Adult Volunteers. Lung. 2017 Apr; 195(2):233-239. PMID: 28210808.
        View in: PubMed
      9. Che Z, Purushotham S, Khemani R, Liu Y. Interpretable Deep Models for ICU Outcome Prediction. AMIA Annu Symp Proc. 2016; 2016:371-380. PMID: 28269832.
        View in: PubMed
      10. Modesto I Alapont V, Khemani R, Medina A, Del Villar Guerra P, Molina Cambra A. Bayes to the Rescue: Continuous Positive Airway Pressure Has Less Mortality Than High-Flow Oxygen. Pediatr Crit Care Med. 2017 Feb; 18(2):e92-e99. PMID: 28157810.
        View in: PubMed
      11. Yehya N, Bhalla AK, Thomas NJ, Khemani R. The authors reply. Pediatr Crit Care Med. 2017 Feb; 18(2):204-205. PMID: 28157806.
        View in: PubMed
      12. Willson DF, Hoot M, Khemani R, Carrol C, Kirby A, Schwarz A, Gedeit R, Nett ST, Erickson S, Flori H, Hays S, Hall M. Pediatric Ventilator-Associated Infections: The Ventilator-Associated INfection Study. Pediatr Crit Care Med. 2017 Jan; 18(1):e24-e34. PMID: 27828898.
        View in: PubMed
      13. Parvathaneni K, Belani S, Leung D, Newth CJ, Khemani R. Evaluating the Performance of the Pediatric Acute Lung Injury Consensus Conference Definition of Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2017 Jan; 18(1):17-25. PMID: 27673384.
        View in: PubMed
      14. Razavi A, Newth CJL, Khemani R, Beltramo F, Ross PA. Cardiac output and systemic vascular resistance: Clinical assessment compared with a noninvasive objective measurement in children with shock. J Crit Care. 2017 Jun; 39:6-10. PMID: 28088009.
        View in: PubMed
      15. Khemani R, Newth CJ. CPAP alone best estimates post-extubation effort during spontaneous breathing trials in children. Intensive Care Med. 2017 Jan; 43(1):150-151. PMID: 27742999.
        View in: PubMed
      16. Spicer AC, Calfee CS, Zinter MS, Khemani R, Lo VP, Alkhouli MF, Orwoll BE, Graciano AL, Boriosi JP, Howard JP, Flori HR, Matthay MA, Sapru A. A Simple and Robust Bedside Model for Mortality Risk in Pediatric Patients With Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Oct; 17(10):907-916. PMID: 27487912.
        View in: PubMed
      17. Beltramo F, Menteer J, Razavi A, Khemani R, Szmuszkovicz J, Newth CJ, Ross PA. Letter to Editor: Reliability of the Ultrasound Cardiac Output Monitor for Pediatric Patients. Pediatr Cardiol. 2016 Aug; 37(6):1189-90. PMID: 27350277.
        View in: PubMed
      18. Khemani R, Hotz J, Morzov R, Flink RC, Kamerkar A, LaFortune M, Rafferty GF, Ross PA, Newth CJ. Pediatric extubation readiness tests should not use pressure support. Intensive Care Med. 2016 Aug; 42(8):1214-22. PMID: 27318942.
        View in: PubMed
      19. Sanchez-Pinto LN, Khemani R. Development of a Prediction Model of Early Acute Kidney Injury in Critically Ill Children Using Electronic Health Record Data. Pediatr Crit Care Med. 2016 Jun; 17(6):508-15. PMID: 27124567.
        View in: PubMed
      20. Mandell I, Khemani R. The authors reply. Pediatr Crit Care Med. 2016 Jun; 17(6):582. PMID: 27261658.
        View in: PubMed
      21. Markovitz BP, Kukuyeva I, Soto-Campos G, Khemani R. PICU Volume and Outcome: A Severity-Adjusted Analysis. Pediatr Crit Care Med. 2016 Jun; 17(6):483-9. PMID: 26959348.
        View in: PubMed
      22. Beltramo F, Menteer J, Razavi A, Khemani R, Szmuszkovicz J, Newth CJ, Ross PA. Reply to Letter to the Editor. Pediatr Cardiol. 2016 Mar; 37(3):619-20. PMID: 26987651.
        View in: PubMed
      23. Ross PA, Newth CJ, Leung D, Wetzel RC, Khemani R. Obesity and Mortality Risk in Critically Ill Children. Pediatrics. 2016 Mar; 137(3):e20152035. PMID: 26908670.
        View in: PubMed
      24. Bhalla AK, Khemani R. Recruitment Maneuvers to the Extreme. Respir Care. 2016 Feb; 61(2):260-1. PMID: 26796618.
        View in: PubMed
      25. Yehya N, Bhalla AK, Thomas NJ, Khemani R. Alveolar Dead Space Fraction Discriminates Mortality in Pediatric Acute Respiratory Distress Syndrome. Pediatr Crit Care Med. 2016 Feb; 17(2):101-9. PMID: 26669646; PMCID: PMC4740261 [Available on 02/01/17].
      26. Khemani R, Hotz J, Morzov R, Flink R, Kamerkar A, Ross PA, Newth CJ. Evaluating Risk Factors for Pediatric Post-extubation Upper Airway Obstruction Using a Physiology-based Tool. Am J Respir Crit Care Med. 2016 Jan 15; 193(2):198-209. PMID: 26389847; PMCID: PMC4731712 [Available on 01/15/17].
      27. Bhalla A, Newth C, Khemani R. The authors reply. Crit Care Med. 2016 Jan; 44(1):e52-3. PMID: 26672944.
        View in: PubMed
      28. Mandell IM, Aghamohammadi S, Deakers T, Khemani R. Procalcitonin to Detect Suspected Bacterial Infections in the PICU. Pediatr Crit Care Med. 2016 Jan; 17(1):e4-12. PMID: 26492060.
        View in: PubMed
      29. Orwoll BE, Spicer AC, Zinter MS, Alkhouli MF, Khemani R, Flori HR, Neuhaus JM, Calfee CS, Matthay MA, Sapru A. Elevated soluble thrombomodulin is associated with organ failure and mortality in children with acute respiratory distress syndrome (ARDS): a prospective observational cohort study. Crit Care. 2015 Dec 14; 19:435. PMID: 26652251; PMCID: PMC4699329.
      30. Bhalla AK, Belani S, Leung D, Newth CJ, Khemani R. Higher Dead Space Is Associated With Increased Mortality in Critically Ill Children. Crit Care Med. 2015 Nov; 43(11):2439-45. PMID: 26200768.
        View in: PubMed
      31. Erickson S, Smith LS, Khemani R, Willson DF, Jouvet P, Thomas NJ. The authors reply. Pediatr Crit Care Med. 2015 Nov; 16(9):899-900. PMID: 26536565.
        View in: PubMed
      32. Kim P, Salazar A, Ross PA, Newth CJ, Khemani R. Comparison of Tidal Volumes at the Endotracheal Tube and at the Ventilator. Pediatr Crit Care Med. 2015 Nov; 16(9):e324-31. PMID: 26226341.
        View in: PubMed
      33. Sanchez-Pinto LN, Goldstein SL, Schneider JB, Khemani R. Association Between Progression and Improvement of Acute Kidney Injury and Mortality in Critically Ill Children. Pediatr Crit Care Med. 2015 Oct; 16(8):703-10. PMID: 26132741.
        View in: PubMed
      34. Beltramo F, Menteer J, Razavi A, Khemani R, Szmuszkovicz J, Newth CJ, Ross PA. Validation of an Ultrasound Cardiac Output Monitor as a Bedside Tool for Pediatric Patients. Pediatr Cardiol. 2016 Jan; 37(1):177-83. PMID: 26364291.
        View in: PubMed
      35. Smith LS, Khemani R, Erickson S, Willson DF, Jouvet P, Thomas NJ. The authors reply. Pediatr Crit Care Med. 2015 Sep; 16(7):689-91. PMID: 26335127.
        View in: PubMed
      36. Bhalla AK, Rubin S, Newth CJ, Ross P, Morzov R, Soto-Campos G, Khemani R. Monitoring Dead Space in Mechanically Ventilated Children: Volumetric Capnography Versus Time-Based Capnography. Respir Care. 2015 Nov; 60(11):1548-55. PMID: 26199451.
        View in: PubMed
      37. Khemani R, Smith LS, Zimmerman JJ, Erickson S. Pediatric acute respiratory distress syndrome: definition, incidence, and epidemiology: proceedings from the Pediatric Acute Lung Injury Consensus Conference. Pediatr Crit Care Med. 2015 Jun; 16(5 Suppl 1):S23-40. PMID: 26035358.
        View in: PubMed
      38. Salazar AM, Newth CC, Khemani R, Jürg H, Ross PA. Pulmonary function testing in infants with tetralogy of Fallot and absent pulmonary valve syndrome. Ann Pediatr Cardiol. 2015 May-Aug; 8(2):108-12. PMID: 26085760; PMCID: PMC4453177.
      39. Khemani R, Smith L. Are we ready to accept the Berlin definition of acute respiratory distress syndrome for use in children? Crit Care Med. 2015 May; 43(5):1132-4. PMID: 25876111; PMCID: PMC4400856.
      40. Frey LJ, Sward KA, Newth CJ, Khemani R, Cryer ME, Thelen JL, Enriquez R, Shaoyu S, Pollack MM, Harrison RE, Meert KL, Berg RA, Wessel DL, Shanley TP, Dalton H, Carcillo J, Jenkins TL, Dean JM. Virtualization of open-source secure web services to support data exchange in a pediatric critical care research network. J Am Med Inform Assoc. 2015 Nov; 22(6):1271-6. PMID: 25796596; PMCID: PMC4639713 [Available on 11/01/16].
      41. Ross PA, Khemani R, Rubin SS, Bhalla AK, Newth CJ. Elevated positive end-expiratory pressure decreases cardiac index in a rhesus monkey model. Front Pediatr. 2014; 2:134. PMID: 25520944; PMCID: PMC4253666.
      42. Khemani R, Flink R, Hotz J, Ross PA, Ghuman A, Newth CJ. Respiratory inductance plethysmography calibration for pediatric upper airway obstruction: an animal model. Pediatr Res. 2015 Jan; 77(1-1):75-83. PMID: 25279987; PMCID: PMC4268304.
      43. Khemani R, Rubin S, Belani S, Leung D, Erickson S, Smith LS, Zimmerman JJ, Newth CJ. Pulse oximetry vs. PaO2 metrics in mechanically ventilated children: Berlin definition of ARDS and mortality risk. Intensive Care Med. 2015 Jan; 41(1):94-102. PMID: 25231293.
        View in: PubMed
      44. Khemani R, Celikkaya EB, Shelton CR, Kale D, Ross PA, Wetzel RC, Newth CJ. Algorithms to estimate PaCO2 and pH using noninvasive parameters for children with hypoxemic respiratory failure. Respir Care. 2014 Aug; 59(8):1248-57. PMID: 24368862.
        View in: PubMed
      45. Bennett TD, Spaeder MC, Matos RI, Watson RS, Typpo KV, Khemani R, Crow S, Benneyworth BD, Thiagarajan RR, Dean JM, Markovitz BP. Existing data analysis in pediatric critical care research. Front Pediatr. 2014; 2:79. PMID: 25121079; PMCID: PMC4114296.
      46. Rubin S, Ghuman A, Deakers T, Khemani R, Ross P, Newth CJ. Effort of breathing in children receiving high-flow nasal cannula. Pediatr Crit Care Med. 2014 Jan; 15(1):1-6. PMID: 24201859.
        View in: PubMed
      47. Ingaramo OA, Ngo T, Khemani R, Newth CJ. Impact of positive end-expiratory pressure on cardiac index measured by ultrasound cardiac output monitor*. Pediatr Crit Care Med. 2014 Jan; 15(1):15-20. PMID: 24389709.
        View in: PubMed
      48. Ross PA, Newth CJ, Khemani R. Accuracy of pulse oximetry in children. Pediatrics. 2014 Jan; 133(1):22-9. PMID: 24344108.
        View in: PubMed
      49. Khemani R, Wilson DF, Esteban A, Ferguson ND. Evaluating the Berlin Definition in pediatric ARDS. Intensive Care Med. 2013 Dec; 39(12):2213-6. PMID: 24100944.
        View in: PubMed
      50. Yasaka Y, Khemani R, Markovitz BP. Is shock index associated with outcome in children with sepsis/septic shock?*. Pediatr Crit Care Med. 2013 Oct; 14(8):e372-9. PMID: 23962830.
        View in: PubMed
      51. Ghuman AK, Newth CJ, Khemani R. Impact of gender on sepsis mortality and severity of illness for prepubertal and postpubertal children. J Pediatr. 2013 Sep; 163(3):835-40.e1. PMID: 23706357.
        View in: PubMed
      52. Shibata S, Khemani R, Markovitz B. Patient origin is associated with duration of endotracheal intubation and PICU length of stay for children with status asthmaticus. J Intensive Care Med. 2014 May-Jun; 29(3):154-9. PMID: 23753230.
        View in: PubMed
      53. Khemani R, Schneider JB, Morzov R, Markovitz B, Newth CJ. Pediatric upper airway obstruction: interobserver variability is the road to perdition. J Crit Care. 2013 Aug; 28(4):490-7. PMID: 23337481; PMCID: PMC3644547.
      54. Radhakrishna SM, Reiff AO, Marzan KA, Azen C, Khemani R, Rubin S, Menteer J, Brown DE, Shaham B. Pediatric rheumatic disease in the intensive care unit: lessons learned from 15 years of experience in a tertiary care pediatric hospital. Pediatr Crit Care Med. 2012 May; 13(3):e181-6. PMID: 22561277.
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      55. Khemani R. Dead space to tidal volume ratio (VD/VT) to explain extubation failure in children: the limitations of current evidence. J Pediatr (Rio J). 2012 May; 88(3):191-4. PMID: 22718284.
        View in: PubMed
      56. Khemani R, Thomas NJ, Venkatachalam V, Scimeme JP, Berutti T, Schneider JB, Ross PA, Willson DF, Hall MW, Newth CJ. Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury. Crit Care Med. 2012 Apr; 40(4):1309-16. PMID: 22202709.
        View in: PubMed
      57. Ingaramo OA, Khemani R, Markovitz BP, Epstein D. Effect of race on the timing of the Glenn and Fontan procedures for single-ventricle congenital heart disease. Pediatr Crit Care Med. 2012 Mar; 13(2):174-7. PMID: 21666532.
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      58. Ghuman AK, Newth CJ, Khemani R. The association between the end tidal alveolar dead space fraction and mortality in pediatric acute hypoxemic respiratory failure. Pediatr Crit Care Med. 2012 Jan; 13(1):11-5. PMID: 21499169.
        View in: PubMed
      59. Khemani R, Sward K, Morris A, Dean JM, Newth CJ. Variability in usual care mechanical ventilation for pediatric acute lung injury: the potential benefit of a lung protective computer protocol. Intensive Care Med. 2011 Nov; 37(11):1840-8. PMID: 21965099; PMCID: PMC3589567.
      60. Ross PA, Smith BM, Tolo VT, Khemani R. Continuous infusion of bupivacaine reduces postoperative morphine use in adolescent idiopathic scoliosis after posterior spine fusion. Spine (Phila Pa 1976). 2011 Aug 15; 36(18):1478-83. PMID: 20881514.
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      61. Epstein D, Wong CF, Khemani R, Moromisato DY, Waters K, Kipke MD, Markovitz BP. Race/Ethnicity is not associated with mortality in the PICU. Pediatrics. 2011 Mar; 127(3):e588-97. PMID: 21357333.
        View in: PubMed
      62. Khemani R, Newth CJ. The design of future pediatric mechanical ventilation trials for acute lung injury. Am J Respir Crit Care Med. 2010 Dec 15; 182(12):1465-74. PMID: 20732987; PMCID: PMC3029934.
      63. Edwards JD, Kun SS, Keens TG, Khemani R, Moromisato DY. Children with corrected or palliated congenital heart disease on home mechanical ventilation. Pediatr Pulmonol. 2010 Jul; 45(7):645-9. PMID: 20575088.
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      64. Ross PA, Hammer J, Khemani R, Klein M, Newth CJ. Pressure-rate product and phase angle as measures of acute inspiratory upper airway obstruction in rhesus monkeys. Pediatr Pulmonol. 2010 Jul; 45(7):639-44. PMID: 20575087.
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      65. del Castillo SL, McCulley ME, Khemani R, Jeffries HE, Thomas DW, Peregrine J, Wells WJ, Starnes VA, Moromisato DY. Reducing the incidence of necrotizing enterocolitis in neonates with hypoplastic left heart syndrome with the introduction of an enteral feed protocol. Pediatr Crit Care Med. 2010 May; 11(3):373-7. PMID: 19838139.
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      66. Khemani R. Post extubation stridor the call for objectivity. Indian Pediatr. 2010 Apr; 47(4):307-8. PMID: 20431158.
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      67. Khemani R, Randolph A, Markovitz B. Steroids for post extubation stridor: pediatric evidence is still inconclusive. Intensive Care Med. 2010 Jul; 36(7):1276-7. PMID: 20237767.
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      68. Schneider J, Khemani R, Grushkin C, Bart R. Serum creatinine as stratified in the RIFLE score for acute kidney injury is associated with mortality and length of stay for children in the pediatric intensive care unit. Crit Care Med. 2010 Mar; 38(3):933-9. PMID: 20124891.
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      69. Guner YS, Khemani R, Qureshi FG, Wee CP, Austin MT, Dorey F, Rycus PT, Ford HR, Friedlich P, Stein JE. Outcome analysis of neonates with congenital diaphragmatic hernia treated with venovenous vs venoarterial extracorporeal membrane oxygenation. J Pediatr Surg. 2009 Sep; 44(9):1691-701. PMID: 19735810.
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      70. Nath DS, Carden AJ, Nussbaum DP, Shin AJ, Khemani R, Starnes VA, Wells WJ. Can the Kawashima procedure be performed in younger patients? Ann Thorac Surg. 2009 Aug; 88(2):581-6; discussion 586-7. PMID: 19632416.
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      71. Khemani R, Randolph A, Markovitz B. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2009 Jul 08; (3):CD001000. PMID: 19588321.
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      72. Nath DS, Savla J, Khemani R, Nussbaum DP, Greene CL, Wells WJ. Thoracic duct ligation for persistent chylothorax after pediatric cardiothoracic surgery. Ann Thorac Surg. 2009 Jul; 88(1):246-51; discussion 251-2. PMID: 19559234.
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      73. Khemani R, Markovitz BP, Curley MAQ. Characteristics of children intubated and mechanically ventilated in 16 PICUs. Chest. 2009 Sep; 136(3):765-771. PMID: 19542258; PMCID: PMC2775993.
      74. Khemani R, Conti D, Alonzo TA, Bart RD, Newth CJ. Effect of tidal volume in children with acute hypoxemic respiratory failure. Intensive Care Med. 2009 Aug; 35(8):1428-37. PMID: 19533092.
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      75. Khemani R, Patel NR, Bart RD, Newth CJL. Comparison of the pulse oximetric saturation/fraction of inspired oxygen ratio and the PaO2/fraction of inspired oxygen ratio in children. Chest. 2009 Mar; 135(3):662-668. PMID: 19029434.
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      76. Khemani R, Bart RD, Alonzo TA, Hatzakis G, Hallam D, Newth CJ. Disseminated intravascular coagulation score is associated with mortality for children with shock. Intensive Care Med. 2009 Feb; 35(2):327-33. PMID: 18802683.
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      77. Markovitz BP, Randolph AG, Khemani R. Corticosteroids for the prevention and treatment of post-extubation stridor in neonates, children and adults. Cochrane Database Syst Rev. 2008 Apr 16; (2):CD001000. PMID: 18425866.
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