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Randall C. Wetzel, MD

TitleProfessor of Pediatrics
InstitutionUniversity of Southern California
DepartmentPediatrics
AddressCHL Mail Stop 12
Off Campus
Los Angeles CA 90089
Phone+1 323 361 2557
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    Dr. Randall Wetzel is the Chairman of the Department of Anesthesiology Critical Care Medicine at Children’s Hospital Los Angeles, Professor (Tenured) of Anesthesiology and Pediatrics, Keck School of Medicine, University of Southern California, and the Director of The Laura P. and Leland K. Whittier Virtual Pediatric Intensive Care Unit (VPICU) at Children’s Hospital Los Angeles. Prior to coming to CHLA, Dr. Wetzel held various faculty appointments in Anesthesiology and Critical Care Medicine at Johns Hopkins Hospital and University from 1981-1997.

    After completing his undergraduate studies at Durham University in England, he went on to receive his medical degree from the Medical College of St. Bartholomew’s Hospital, London University, England. He moved stateside for his pediatric residency, then fellowship training in Critical Care and Pediatric Cardiology at Rainbow Babies and Children’s Hospital at University Hospitals in Cleveland, Ohio. He was subsequently a fellow in Pediatric Critical Care and Resident/Chief Resident in Anesthesiology/Critical Care Medicine at Johns Hopkins Hospital in Baltimore. Dr. Wetzel returned to England for a fellowship in Pediatric Anesthesia and Critical Care Medicine at the Hospital for Sick Children and Guy’s Hospital in London. In addition, he earned a Master of Science in Business (Medicine) from Johns Hopkins University (1997). He moved to Los Angeles in 1997.

    His current interests in medical informatics led him to develop the VPICU; a Southern California Critical Care Telemedicine Network; he is CEO and Chair of VPS, LLC a Quality Improvement and Data management company with over 120 hospital clients; and he leads a complex big data research team developing data extraction, management, architecture and advanced analytic techniques for highly granular Pediatric Critical Care Data. He has received over $18 million in federal and private foundation grant funding for these projects. He has served as a board member for The American Board of Pediatrics (2000-2003); Editor-in-Chief, the Society for Pediatric Anesthesia (1988-1995). He has authored 94 peer-reviewed articles and 45 book chapters, he is editor of Roger’s Critical Care Medicine and Critical Heart Disease in Infants and Children; and has presented over 100 abstracts at various symposia.

    Dr. Wetzel and his wife Ann have been married 34 years and currently reside in La Cañada, California. They have four wonderful daughters.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Nagoshi M, Reddy S, Bell M, Cresencia A, Margolis R, Wetzel R, Ross P. Low-dose dexmedetomidine as an adjuvant to propofol infusion for children in MRI: A double-cohort study. Paediatr Anaesth. 2018 Jun 07. PMID: 29882298.
      View in: PubMed
    2. Williams JB, Ghosh D, Wetzel R. Applying Machine Learning to Pediatric Critical Care Data. Pediatr Crit Care Med. 2018 Apr 30. PMID: 29727354.
      View in: PubMed
    3. Ho LV, Ledbetter D, Aczon M, Wetzel R. The Dependence of Machine Learning on Electronic Medical Record Quality. AMIA Annu Symp Proc. 2017; 2017:883-891. PMID: 29854155.
      View in: PubMed
    4. Wetzel R. First Get the Data, Then Do the Science! Pediatr Crit Care Med. 2018 Apr; 19(4):382-383. PMID: 29620713.
      View in: PubMed
    5. Gupta P, Rettiganti M, Gossett JM, Daufeldt J, Rice TB, Wetzel R. Development and Validation of an Empiric Tool to Predict Favorable Neurologic Outcomes Among PICU Patients. Crit Care Med. 2018 Jan; 46(1):108-115. PMID: 28991830.
      View in: PubMed
    6. Gupta P, Rettiganti M, Rice TB, Wetzel R. Impact of 24/7 In-Hospital Intensivist Coverage on Outcomes in Pediatric Intensive Care. A Multicenter Study. Am J Respir Crit Care Med. 2016 Dec 15; 194(12):1506-1513. PMID: 27367580.
      View in: PubMed
    7. Gupta P, Rettiganti M, Fisher PL, Chang AC, Rice TB, Wetzel R. Association of Freestanding Children's Hospitals With Outcomes in Children With Critical Illness. Crit Care Med. 2016 Dec; 44(12):2131-2138. PMID: 27513535.
      View in: PubMed
    8. Gupta P, Richardson T, Hall M, Bertoch D, Hebbar KB, Fortenberry JD, Wetzel R. Effect of Inhaled Nitric Oxide on Outcomes in Children With Acute Lung Injury: Propensity Matched Analysis From a Linked Database. Crit Care Med. 2016 Oct; 44(10):1901-9. PMID: 27163193.
      View in: PubMed
    9. Nagoshi M, Morzov R, Hotz J, Belson P, Matar M, Ross P, Wetzel R. Mainstream capnography system for nonintubated children in the postanesthesia care unit: Performance with changing flow rates, and a comparison to side stream capnography. Paediatr Anaesth. 2016 Dec; 26(12):1179-1187. PMID: 27663694.
      View in: PubMed
    10. Gall C, Wetzel R, Kolker A, Kanter RK, Toltzis P. Pediatric Triage in a Severe Pandemic: Maximizing Survival by Establishing Triage Thresholds. Crit Care Med. 2016 Sep; 44(9):1762-8. PMID: 27071069.
      View in: PubMed
    11. Gupta P, Rettiganti M, Jeffries HE, Scanlon MC, Ghanayem NS, Daufeldt J, Rice TB, Wetzel R. Risk factors and outcomes of in-hospital cardiac arrest following pediatric heart operations of varying complexity. Resuscitation. 2016 08; 105:1-7. PMID: 27185218.
      View in: PubMed
    12. Ross PA, Newth CJ, Leung D, Wetzel R, Khemani RG. Obesity and Mortality Risk in Critically Ill Children. Pediatrics. 2016 Mar; 137(3):e20152035. PMID: 26908670.
      View in: PubMed
    13. Gupta P, Tang X, Rettiganti M, Lauer C, Kacmarek RM, Rice TB, Markovitz BP, Wetzel R. Association of house staff training with mortality in children with critical illness. Acta Paediatr. 2016 Feb; 105(2):e60-6. PMID: 26399703.
      View in: PubMed
    14. Kale DC, Che Z, Bahadori MT, Li W, Liu Y, Wetzel R. Causal Phenotype Discovery via Deep Networks. AMIA Annu Symp Proc. 2015; 2015:677-86. PMID: 26958203; PMCID: PMC4765623.
    15. Jeffries HE, Soto-Campos G, Katch A, Gall C, Rice TB, Wetzel R. Pediatric Index of Cardiac Surgical Intensive Care Mortality Risk Score for Pediatric Cardiac Critical Care. Pediatr Crit Care Med. 2015 Nov; 16(9):846-52. PMID: 26196254.
      View in: PubMed
    16. Gupta P, Rettiganti M, Gossett JM, Yeh JC, Jeffries HE, Rice TB, Wetzel R. Risk factors for mechanical ventilation and reintubation after pediatric heart surgery. J Thorac Cardiovasc Surg. 2016 Feb; 151(2):451-8.e3. PMID: 26507405.
      View in: PubMed
    17. Toltzis P, Soto-Campos G, Shelton C, Kuhn EM, Hahn R, Kanter RK, Wetzel R. Evidence-Based Pediatric Outcome Predictors to Guide the Allocation of Critical Care Resources in a Mass Casualty Event. Pediatr Crit Care Med. 2015 Sep; 16(7):e207-16. PMID: 26121100.
      View in: PubMed
    18. Fackler J, Lehmann HP, Wetzel R. Critical care for rare diseases (and procedures): redux. Pediatr Crit Care Med. 2015 Mar; 16(3):297-9. PMID: 25738931.
      View in: PubMed
    19. Gupta P, Tang X, Gossett JM, Gall CM, Lauer C, Rice TB, Wetzel R. Variation of ventilation practices with center volume after pediatric heart surgery. Clin Cardiol. 2015 Mar; 38(3):178-84. PMID: 25707486.
      View in: PubMed
    20. Gupta P, Kacmarek RM, Wetzel R. It is too early to declare early or late rescue high-frequency oscillatory ventilation dead--reply. JAMA Pediatr. 2014 Sep; 168(9):863. PMID: 25179022.
      View in: PubMed
    21. Gupta P, Tang X, Gall CM, Lauer C, Rice TB, Wetzel R. Epidemiology and outcomes of in-hospital cardiac arrest in critically ill children across hospitals of varied center volume: a multi-center analysis. Resuscitation. 2014 Nov; 85(11):1473-9. PMID: 25110249.
      View in: PubMed
    22. Khemani RG, Celikkaya EB, Shelton CR, Kale D, Ross PA, Wetzel R, Newth CJ. Algorithms to estimate PaCO2 and pH using noninvasive parameters for children with hypoxemic respiratory failure. Respir Care. 2014 Aug; 59(8):1248-57. PMID: 24368862.
      View in: PubMed
    23. Gupta P, Tang X, Gossett JM, Gall CM, Lauer C, Rice TB, Carroll CL, Kacmarek RM, Wetzel R. Association of center volume with outcomes in critically ill children with acute asthma. Ann Allergy Asthma Immunol. 2014 Jul; 113(1):42-7. PMID: 24835583.
      View in: PubMed
    24. Gupta P, Green JW, Tang X, Gall CM, Gossett JM, Rice TB, Kacmarek RM, Wetzel R. Comparison of high-frequency oscillatory ventilation and conventional mechanical ventilation in pediatric respiratory failure. JAMA Pediatr. 2014 Mar; 168(3):243-9. PMID: 24445980.
      View in: PubMed
    25. Marcin JP, Wetzel R. The parsimonious pediatric index of mortality*. Pediatr Crit Care Med. 2013 Sep; 14(7):718-9. PMID: 24162957.
      View in: PubMed
    26. Burke RV, Berg BM, Vee P, Morton I, Nager A, Neches R, Wetzel R, Upperman JS. Using robotic telecommunications to triage pediatric disaster victims. J Pediatr Surg. 2012 Jan; 47(1):221-4. PMID: 22244422.
      View in: PubMed
    27. Wetzel R, Sachedeva R, Rice TB. Are all ICUs the same? Paediatr Anaesth. 2011 Jul; 21(7):787-93. PMID: 21554489.
      View in: PubMed
    28. Wetzel R. Who is doing what to whom: a large prospective study of propofol anesthesia in children. Anesth Analg. 2009 Mar; 108(3):695-8. PMID: 19224769.
      View in: PubMed
    29. Gorman M, Sachdeva R, Rice T, Wetzel R. Support for PICUs and the PRISM scoring algorithms. Pediatr Crit Care Med. 2009 Jan; 10(1):143-4. PMID: 19131881.
      View in: PubMed
    30. LaRovere JM, Jeffries HE, Sachdeva RC, Rice TB, Wetzel R, Cooper DS, Bird GL, Ghanayem NS, Checchia PA, Chang AC, Wessel DL. Databases for assessing the outcomes of the treatment of patients with congenital and paediatric cardiac disease--the perspective of critical care. Cardiol Young. 2008 Dec; 18 Suppl 2:130-6. PMID: 19063783.
      View in: PubMed
    31. Wetzel R. Calcium: a double-edged sword. Pediatr Crit Care Med. 2007 May; 8(3):300-1. PMID: 17496519.
      View in: PubMed
    32. Graham AS, Chandrashekharaiah G, Citak A, Wetzel R, Newth CJ. Positive end-expiratory pressure and pressure support in peripheral airways obstruction : work of breathing in intubated children. Intensive Care Med. 2007 Jan; 33(1):120-7. PMID: 17111110.
      View in: PubMed
    33. Wetzel R. Don't confuse the anesthetic with the anesthesiologist! Anesth Analg. 2006 Oct; 103(4):859-62. PMID: 17000794.
      View in: PubMed
    34. Baden HP, Berger J, Brilli RI, Burns JP, Checchia PA, Dalton HJ, Nadkarni V, Pollack M, Wetzel R, Zimmerman JJ. Pediatric cardiac critical care patients should be cared for by intensivists. J Am Coll Cardiol. 2006 Jul 04; 48(1):221-2; author reply 222-3. PMID: 16814678.
      View in: PubMed
    35. Wetzel R. Precise use of medical terminology. Crit Care Med. 2006 Jun; 34(6):1854; author reply 1854-5. PMID: 16715005.
      View in: PubMed
    36. Baden HP, Zimmerman JJ, Brilli RJ, Wong H, Wetzel R, Burns JP, Nadkarni V, Checchia PA, Dalton HJ, Berger J, Pollack M, Notterman D, Green TP, Blumer J, Dean M. Intensivist-led team approach to critical care of children with heart disease. Pediatrics. 2006 May; 117(5):1854-6; author reply 1856-7. PMID: 16651353.
      View in: PubMed
    37. Jeffries HE, Wells WJ, Starnes VA, Wetzel R, Moromisato DY. Gastrointestinal morbidity after Norwood palliation for hypoplastic left heart syndrome. Ann Thorac Surg. 2006 Mar; 81(3):982-7. PMID: 16488706.
      View in: PubMed
    38. Randolph AG, Forbes PW, Gedeit RG, Arnold JH, Wetzel R, Luckett PM, O'Neil ME, Venkataraman ST, Meert KL, Cheifetz IM, Cox PN, Hanson JH. Cumulative fluid intake minus output is not associated with ventilator weaning duration or extubation outcomes in children. Pediatr Crit Care Med. 2005 Nov; 6(6):642-7. PMID: 16276328.
      View in: PubMed
    39. Willis BC, Graham AS, Yoon E, Wetzel R, Newth CJ. Pressure-rate products and phase angles in children on minimal support ventilation and after extubation. Intensive Care Med. 2005 Dec; 31(12):1700-5. PMID: 16228176.
      View in: PubMed
    40. Baker LC, Wetzel R. Telemedicine: basic technical considerations. J Intensive Care Med. 2004 Sep-Oct; 19(5):297-8. PMID: 15481113.
      View in: PubMed
    41. Willis BC, Graham AS, Wetzel R, L Newth CJ. Respiratory inductance plethysmography used to diagnose bilateral diaphragmatic paralysis: a case report. Pediatr Crit Care Med. 2004 Jul; 5(4):399-402. PMID: 15215015.
      View in: PubMed
    42. Wetzel R. Telemedicine and intensive care: are we ready and willing? J Intensive Care Med. 2004 Mar-Apr; 19(2):117-8. PMID: 15070521.
      View in: PubMed
    43. Randolph AG, Wypij D, Venkataraman ST, Hanson JH, Gedeit RG, Meert KL, Luckett PM, Forbes P, Lilley M, Thompson J, Cheifetz IM, Hibberd P, Wetzel R, Cox PN, Arnold JH. Effect of mechanical ventilator weaning protocols on respiratory outcomes in infants and children: a randomized controlled trial. JAMA. 2002 Nov 27; 288(20):2561-8. PMID: 12444863.
      View in: PubMed
    44. Wetzel R, Burns RC. Multiple trauma in children: critical care overview. Crit Care Med. 2002 Nov; 30(11 Suppl):S468-77. PMID: 12528789.
      View in: PubMed
    45. Fackler JC, Wetzel R. Critical care for rare diseases. Pediatr Crit Care Med. 2002 Jan; 3(1):89-90. PMID: 12813239.
      View in: PubMed
    46. Wetzel R. The virtual pediatric intensive care unit. Practice in the new millennium. Pediatr Clin North Am. 2001 Jun; 48(3):795-814. PMID: 11411306.
      View in: PubMed