Linda J. Hovanessian Larsen, MD

Title(s)Professor of Clinical Radiology
SchoolKeck School of Medicine of Usc
Address1500 San Pablo Street, 2nd Floor
Health Sciences Campus
Los Angeles CA 90033
Phone+1 323 442 8541
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    Other Positions
    Title(s)Section Chief of Breast Imaging

    Title(s)Vice Chair of Professional Development

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    University of California, Los Angeles (UCLA), Los Angeles, CaliforniaBS
    Keck School of Medicine of USC, Los Angeles, CaliforniaMD
    University of California, Los Angeles (UCLA), Los Angeles, CaliforniaDiagnostic Radiology Residency Program
    Mount Sinai Medical Center, Miami Beach, FloridaBreast Imaging Fellowship

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    Dr. Linda Hovanessian Larsen was born and raised in Los Angeles, California. After graduating from USC Keck School of Medicine, Dr. Larsen completed her residency training in Diagnostic Radiology at the University of California, Los Angeles (UCLA) and her fellowship training at Mount Sinai Medical Center in Miami, Florida.
    She began working as an Assistant Professor in Radiology at the University of Miami Medical Center, specializing in breast imaging. In 1998, she and her family moved back to Los Angeles, and she joined the faculty of the USC Keck School of Medicine, Department of Radiology (DOR).
    Dr. Larsen soon became the Director of Mammography for the LAC+USC Medical Center. She has always advocated the multidisciplinary team approach to patient care and has worked closely with the breast surgeons, oncologists, and pathologists to provide high-quality, equitable healthcare for the community.
    In 2003, Dr. Larsen became the Chief of Women’s Imaging (now Breast Imaging). She currently oversees the Norris Breast Center, Verdugo Hills Breast Center, and LAC+USC County Mammography.
    Dr. Larsen has served on administrative and clinical committees for the DOR, and has spearheaded many of the Breast Imaging research projects. She incorporated the USC DOR into the American College of Radiology Imaging Network (ACRIN), which is a national multicenter organization supported in part by the National Cancer Institute.
    Dr. Larsen’s main area of research concentrates on innovative breast imaging techniques, including digital breast tomosynthesis, automated whole breast ultrasound, and contrast enhanced breast ultrasound. She has received grant awards from the Susan G Komen Breast Cancer Foundation, the Whittier Foundation, and participates in NCI-ACRIN, I-SPY 2, and SWOG multicenter trials. Her most rewarding project was an NIH funded grant for the Susan Love foundation, which evaluated a low-cost ultrasound device used to triage palpable breast lumps in women living in low income countries that do not readily have access to healthcare.
    Dr. Larsen is a recognized leader in the field of breast imaging, lecturing locally and nationally on breast cancer screening, diagnosis, and advanced imaging techniques. She enjoys reaching out to women in the community and educating them about the best tools available for early detection of breast cancer. However, by far, her most favorite teaching involves medical students, residents, and fellows on the clinical service. She believes the diverse patient populations and clinical experiences at LAC+USC Mammography and the Norris Breast Center together provide an unparalleled foundation for an outstanding education in breast imaging.

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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Addressing ethnic disparities in imaging utilization and clinical outcomes for COVID-19. Clin Imaging. 2021 Sep; 77:276-282. Larsen LH, Desai B, Cen SY, Stahl D, Lei X, Gholamrezanezhad A, Yamashita M. PMID: 34167069; PMCID: PMC8214936.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    2. Factors associated with MRI detection of occult lesions in newly diagnosed breast cancers. J Surg Oncol. 2020 Mar; 121(4):589-598. Wecsler J, Jeong YJ, Raghavendra AS, Mack WJ, Tripathy D, Yamashita MW, Sheth PA, Hovanessian Larsen L, Russell CA, MacDonald H, Sener SF, Lang JE. PMID: 31984517; PMCID: PMC7032991.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    3. Contrast-Enhanced Ultrasound Imaging of Breast Masses: Adjunct Tool to Decrease the Number of False-Positive Biopsy Results. J Ultrasound Med. 2019 Sep; 38(9):2259-2273. Lee SC, Tchelepi H, Grant E, Desai B, Luo C, Groshen S, Hovanessian-Larsen L. PMID: 30597640; PMCID: PMC7735954.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    4. Clinical findings and outcomes of MRI staging of breast cancer in a diverse population. Breast Cancer Res Treat. 2019 Apr; 174(2):315-324. Raghavendra A, Wecsler J, Ji L, Sheth P, Ricker C, Church T, Sposto R, Lang J, Sener S, Larsen L, Tripathy D. PMID: 30542816; PMCID: PMC7494176.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Accuracy of Contrast-Enhanced Ultrasound Compared With Magnetic Resonance Imaging in Assessing the Tumor Response After Neoadjuvant Chemotherapy for Breast Cancer. J Ultrasound Med. 2017 May; 36(5):901-911. Lee SC, Grant E, Sheth P, Garcia AA, Desai B, Ji L, Groshen S, Hwang D, Yamashita M, Hovanessian-Larsen L. PMID: 28150325; PMCID: PMC7710668.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    6. High-frequency ultrasound imaging for breast cancer biopsy guidance. J Med Imaging (Bellingham). 2015 Oct; 2(4):047001. Cummins T, Yoon C, Choi H, Eliahoo P, Kim HH, Yamashita MW, Hovanessian-Larsen LJ, Lang JE, Sener SF, Vallone J, Martin SE, Kirk Shung K. PMID: 26693167; PMCID: PMC4675170.
      View in: PubMed   Mentions: 2  
    7. ED breast cases and other breast emergencies. Emerg Radiol. 2016 Feb; 23(1):67-77. Khadem N, Reddy S, Lee S, Larsen L, Walker D. PMID: 26541875.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    8. Modified Bi-Rads Scoring of Breast Imaging Findings Improves Clinical Judgment. Breast J. 2015 Nov-Dec; 21(6):642-50. Silberman H, Sheth PA, Parisky YR, Hovanessian-Larsen LJ, Sheth S, Tripathy D. PMID: 26411901.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. A Phase II Study of 3'-Deoxy-3'-18F-Fluorothymidine PET in the Assessment of Early Response of Breast Cancer to Neoadjuvant Chemotherapy: Results from ACRIN 6688. J Nucl Med. 2015 Nov; 56(11):1681-9. Kostakoglu L, Duan F, Idowu MO, Jolles PR, Bear HD, Muzi M, Cormack J, Muzi JP, Pryma DA, Specht JM, Hovanessian-Larsen L, Miliziano J, Mallett S, Shields AF, Mankoff DA, ACRIN 668 Investigative Team. PMID: 26359256; PMCID: PMC4737647.
      View in: PubMed   Mentions: 36     Fields:    Translation:HumansCTClinical Trials
    10. Double-Blind Randomized 12-Month Soy Intervention Had No Effects on Breast MRI Fibroglandular Tissue Density or Mammographic Density. Cancer Prev Res (Phila). 2015 Oct; 8(10):942-51. Wu AH, Spicer D, Garcia A, Tseng CC, Hovanessian-Larsen L, Sheth P, Martin SE, Hawes D, Russell C, MacDonald H, Tripathy D, Su MY, Ursin G, Pike MC. PMID: 26276750; PMCID: PMC4596769.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    11. Malignancy rates after surgical excision of discordant breast biopsies. J Surg Res. 2015 May 01; 195(1):152-7. Poole BB, Wecsler JS, Sheth P, Sener SF, Wang L, Larsen L, Tripathy D, Lang JE. PMID: 25519987.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. The role of axillary ultrasound in the detection of metastases from primary breast cancers. Am J Surg. 2013 Mar; 205(3):242-4; discussion 244-5. Yamashita M, Hovanessian-Larsen L, Sener SF. PMID: 23369307.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    13. Detection of breast cancer with addition of annual screening ultrasound or a single screening MRI to mammography in women with elevated breast cancer risk. JAMA. 2012 Apr 04; 307(13):1394-404. Berg WA, Zhang Z, Lehrer D, Jong RA, Pisano ED, Barr RG, Böhm-Vélez M, Mahoney MC, Evans WP, Larsen LH, Morton MJ, Mendelson EB, Farria DM, Cormack JB, Marques HS, Adams A, Yeh NM, Gabrielli G, ACRIN 6666 Investigators. PMID: 22474203; PMCID: PMC3891886.
      View in: PubMed   Mentions: 301     Fields:    Translation:Humans
    14. Lowering oral contraceptive norethindrone dose increases estrogen and progesterone receptor levels with no reduction in proliferation of breast epithelium: a randomized trial. Contraception. 2012 Sep; 86(3):238-43. Hovanessian-Larsen L, Taylor D, Hawes D, Spicer DV, Press MF, Wu AH, Pike MC, Pearce CL. PMID: 22325110; PMCID: PMC3355208.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Shear-wave elastography improves the specificity of breast US: the BE1 multinational study of 939 masses. Radiology. 2012 Feb; 262(2):435-49. Berg WA, Cosgrove DO, Doré CJ, Schäfer FK, Svensson WE, Hooley RJ, Ohlinger R, Mendelson EB, Balu-Maestro C, Locatelli M, Tourasse C, Cavanaugh BC, Juhan V, Stavros AT, Tardivon A, Gay J, Henry JP, Cohen-Bacrie C, BE1 Investigators. PMID: 22282182.
      View in: PubMed   Mentions: 227     Fields:    Translation:HumansCTClinical Trials
    16. Breast epithelial cell proliferation is markedly increased with short-term high levels of endogenous estrogen secondary to controlled ovarian hyperstimulation. Breast Cancer Res Treat. 2012 Apr; 132(2):653-60. Chung K, Hovanessian-Larsen LJ, Hawes D, Taylor D, Downey S, Spicer DV, Stanczyk FZ, Patel S, Anderson AR, Pike MC, Wu AH, Pearce CL. PMID: 22083231; PMCID: PMC3303045.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    17. Breast cancer: comparative effectiveness of positron emission mammography and MR imaging in presurgical planning for the ipsilateral breast. Radiology. 2011 Jan; 258(1):59-72. Berg WA, Madsen KS, Schilling K, Tartar M, Pisano ED, Larsen LH, Narayanan D, Ozonoff A, Miller JP, Kalinyak JE. PMID: 21076089; PMCID: PMC3009380.
      View in: PubMed   Mentions: 56     Fields:    Translation:Humans
    18. Reasons women at elevated risk of breast cancer refuse breast MR imaging screening: ACRIN 6666. Radiology. 2010 Jan; 254(1):79-87. Berg WA, Blume JD, Adams AM, Jong RA, Barr RG, Lehrer DE, Pisano ED, Evans WP, Mahoney MC, Hovanessian Larsen L, Gabrielli GJ, Mendelson EB. PMID: 20032143; PMCID: PMC2811274.
      View in: PubMed   Mentions: 57     Fields:    Translation:HumansPHPublic Health
    19. Granulomatous lobular mastitis: imaging, diagnosis, and treatment. AJR Am J Roentgenol. 2009 Aug; 193(2):574-81. Hovanessian Larsen LJ, Peyvandi B, Klipfel N, Grant E, Iyengar G. PMID: 19620458.
      View in: PubMed   Mentions: 74     Fields:    Translation:Humans
    20. Progesterone and estrogen receptors in pregnant and premenopausal non-pregnant normal human breast. Breast Cancer Res Treat. 2009 Nov; 118(1):161-8. Taylor D, Pearce CL, Hovanessian-Larsen L, Downey S, Spicer DV, Bartow S, Pike MC, Wu AH, Hawes D. PMID: 19205874.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    21. Combined screening with ultrasound and mammography vs mammography alone in women at elevated risk of breast cancer. JAMA. 2008 May 14; 299(18):2151-63. Berg WA, Blume JD, Cormack JB, Mendelson EB, Lehrer D, Böhm-Vélez M, Pisano ED, Jong RA, Evans WP, Morton MJ, Mahoney MC, Larsen LH, Barr RG, Farria DM, Marques HS, Boparai K, ACRIN 6666 Investigators. PMID: 18477782; PMCID: PMC2718688.
      View in: PubMed   Mentions: 397     Fields:    Translation:HumansPHPublic Health
    22. Differentiation of cancerous lesions in excised human breast specimens using multiband attenuation profiles from ultrasonic transmission tomography. J Ultrasound Med. 2008 Mar; 27(3):435-51. Jeong JW, Shin DC, Do SH, Blanco C, Klipfel NE, Holmes DR, Hovanessian-Larsen LJ, Marmarelis VZ. PMID: 18314522.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    23. Imaging characteristics of malignant lesions of the male breast. Radiographics. 2006 Jul-Aug; 26(4):993-1006. Chen L, Chantra PK, Larsen LH, Barton P, Rohitopakarn M, Zhu EQ, Bassett LW. PMID: 16844928.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    24. Greatly increased occurrence of breast cancers in areas of mammographically dense tissue. Breast Cancer Res. 2005; 7(5):R605-8. Ursin G, Hovanessian-Larsen L, Parisky YR, Pike MC, Wu AH. PMID: 16168104; PMCID: PMC1242126.
      View in: PubMed   Mentions: 73     Fields:    Translation:Humans
    25. Retroperitoneal cystic lymphangioma: MR findings. Magn Reson Imaging. 1990; 8(1):91-3. Hovanessian LJ, Larsen DW, Raval JK, Colletti PM. PMID: 2325521.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    26. Central and renal hemodynamic effects of a new agonist at peripheral dopamine- and beta-2 adrenoreceptors (dopexamine) in patients with heart failure. Am Heart J. 1989 Mar; 117(3):607-14. Jamison M, Widerhorn J, Weber L, Campese V, Vasquez J, Hovanessian L, Rahimtoola SH, Elkayam U. PMID: 2537556.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
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