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    Takeshi Saito, MD, PhD

    TitleAssistant Professor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressHMR 801A
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 2260
    Emailsaitotak@usc.edu
    vCardDownload vCard

      Collapse Overview 
      Collapse Overview
      My research interest has been centered on hepatitis C virus (HCV) virology, pathogenesis, and virus-host interaction including immune response. For the past 10 years during my PhD and Post-Doctoral training, I have investigated viral-host interactions that regulate HCV viral replication through the activation of intracellular innate immune response. In recent years, I have focused on understanding how host cell innate immune pathways sense HCV infection and initiate the host response which involves type I interferon and proinflammatory cytokine production to regulate hepatic immunity. After recent transition to an independent junior faculty position at the University of Southern California (USC), Keck School of Medicine, my laboratory continues to investigate virus-host interactions that regulates disease outcome and pathogenesis of HCV infection. I have extensive expertise and skills in virology, cell signaling, cytokine biology, and cell biology.

      My role as a physician specializing in the care of viral hepatitis at an academic medical center offers the unique integration of basic science and clinical/translational science into the laboratory research program, allowing us to set our aim as "research for the better healthcare". My chief goal is to become an established physician scientist with the skills and knowledge necessary to pursue a lasting career dedicated to translating discoveries in molecular virology into clinical practice or development of novel therapies. USC is supported by two major centers for the study of liver diseases: 1) USC Research Center for Liver Diseases, and 2) Southern California Research Center for ALPD and Cirrhosis. These center directors serve as consultants for the research program and career development. In summary, I have substantial expertise and a track record in the field of innate immunology against viral infection and am efficiently establishing an independent research program in an environment well suited for the study of liver diseases.


      Collapse Biography 
      Collapse Education and Training
      Showa University, School of Medicine, Tokyo, JapanM.D.1998Medicine
      Graduate School of Medicine, Showa University, Tokyo, JapanPh.D.2002Virology
      Internship/Residency, Showa University Hospital, Tokyo, Japan2001Internal Medicine
      Fellowship-Gastroenterology/Hepatology, Showa University Hospital, Tokyo, Japan2004Gastroenterology&Hepatology
      Post-Doctoral Fellowship, University of Texas Southwestern Medical Center, Dallas, TX2005Virology and Immunology
      Post-Doctoral Fellowship, University of Washington School of Medicine, Seattle, WA2009Virology and Immunology
      Collapse Awards and Honors
      CRDFG2017  - 2018CRDF Global Research Award
      L.K. Whittier Foundation2016  - 2017L.K. Whittier Foundation Award
      American Federation For Medical Research2016Western Region American Federation For Medical Research (WAFMR) Outstanding Investigator Award
      NIH (NIDDK)2015  - 2020R01DK101773
      NIH (NIAAA)2014  - 2017R21AA022751
      ISHSR2013Young Investigator Award International Symposium on Cells of the Hepatic Sinusoid
      International Meeting on Hepatitis C Virus & Related Viruses2011Travel Scholarship for 18th International Meeting on Hepatitis C Virus & Related Viruses
      Baxter Foundation 2011Donald E. and Delia B. Baxter Foundation Faculty Fellow Award
      AASLD and American Liver Foundation2010  - 2012Liver Scholar Award
      AGA2010  - 2012American Gastroenterological Association Foundation’s Research Scholar Award (Declined for LSA)
      Japan Society of Hepatology20102010 Hepatology Research High Citation Award
      Viral Hepatitis Research Foundation of Japan 2009Viral Hepatitis Research Foundation of Japan Research Fellowship
      ISICR2008International Society for Interferon & Cytokine Research Milstein Young Investigator Award

      Collapse Research 
      Collapse Research Activities and Funding
      The balancing act: hepatic innate immune defense and viral evasion
      CRDF Global NIAID CRDF GlobalJul 1, 2017 - Jun 30, 2018
      Role: PI
      Diagnostic investigation of occult HCV infection
      L.K. Whittier Foundation L.K. Whittier Foundation Award 2016Sep 1, 2016 - Aug 31, 2017
      Role: PI
      Innate Defense Program against HCV
      NIH R01DK101773May 1, 2015 - Mar 31, 2020
      Role: Principal Investigator
      Retinoid regulation of hepatic innate immunity.
      NIH R21AA022751Aug 20, 2014 - Jul 31, 2016
      Role: Principal Investigator

      Collapse ORNG Applications 
      Collapse Featured Publications
      Collapse Websites
      Collapse In The News
      Collapse Featured Presentations
      Collapse Required Scholarly Project Mentor

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Kahn J, Saito T. Reply. Gastroenterology. 2017 Jul; 153(1):328-329. PMID: 28579275.
        View in: PubMed
      2. Wadhwa S, Kim TH, Lin L, Kanel G, Saito T. Hepatic angiosarcoma with clinical and histological features of Kasabach-Merritt syndrome. World J Gastroenterol. 2017 Apr 07; 23(13):2443-2447. PMID: 28428724.
        View in: PubMed
      3. Elmasry S, Wadhwa S, Bang BR, Cook L, Chopra S, Kanel G, Kim B, Harper T, Feng Z, Jerome KR, Kahn JA, Saito T. Detection of Occult Hepatitis C Virus Infection in Patients Who Achieved a Sustained Virologic Response to Direct-Acting Antiviral Agents for Recurrent Infection After Liver Transplantation. Gastroenterology. 2017 Feb; 152(3):550-553.e8. PMID: 27838287.
        View in: PubMed
      4. Zhu J, Khemichian S, Nghiem D, Zhang SR, Limurti J, Saito T, Fong TL. Comparison of Demographic and Clinical Characteristics of Hispanic and Asian Chronic Hepatitis B Patients in Southern California. J Clin Gastroenterol. 2016 Aug; 50(7):602-7. PMID: 26890328.
        View in: PubMed
      5. Bang BR, Elmasry S, Saito T. Organ system view of the hepatic innate immunity in HCV infection. J Med Virol. 2016 Dec; 88(12):2025-2037. PMID: 27153233.
        View in: PubMed
      6. Cho NE, Bang BR, Gurung P, Li M, Clemens DL, Underhill TM, James LP, Chase JR, Saito T. Retinoid regulation of antiviral innate immunity in hepatocytes. Hepatology. 2016 Jun; 63(6):1783-95. PMID: 26638120; PMCID: PMC4874888 [Available on 06/01/17].
      7. Minassian A, Zhang J, He S, Zhao J, Zandi E, Saito T, Liang C, Feng P. An Internally Translated MAVS Variant Exposes Its Amino-terminal TRAF-Binding Motifs to Deregulate Interferon Induction. PLoS Pathog. 2015 Jul; 11(7):e1005060. PMID: 26221961; PMCID: PMC4519330.
      8. Koyama M, Murata A, Sakamoto Y, Morohashi H, Hasebe T, Saito T, Hakamada K. Risk Factors for Anastomotic Leakage After Intersphincteric Resection Without a Protective Defunctioning Stoma for Lower Rectal Cancer. Ann Surg Oncol. 2016 Feb; 23 Suppl 2:S249-56. PMID: 25743332.
        View in: PubMed
      9. Ooi EL, Chan ST, Cho NE, Wilkins C, Woodward J, Li M, Kikkawa U, Tellinghuisen T, Gale M, Saito T. Novel antiviral host factor, TNK1, regulates IFN signaling through serine phosphorylation of STAT1. Proc Natl Acad Sci U S A. 2014 Feb 04; 111(5):1909-14. PMID: 24449862; PMCID: PMC3918791.
      10. Nookala A, Saberi B, Ter-Oganesyan R, Kanel G, Duong P, Saito T. Isolated arterioportal fistula presenting with variceal hemorrhage. World J Gastroenterol. 2013 May 07; 19(17):2714-7. PMID: 23674881; PMCID: PMC3645392.
      11. Lau DT, Negash A, Chen J, Crochet N, Sinha M, Zhang Y, Guedj J, Holder S, Saito T, Lemon SM, Luxon BA, Perelson AS, Gale M. Innate immune tolerance and the role of kupffer cells in differential responses to interferon therapy among patients with HCV genotype 1 infection. Gastroenterology. 2013 Feb; 144(2):402-413.e12. PMID: 23123437; PMCID: PMC3822610.
      12. Sanada Y, Aida J, Kawano Y, Nakamura K, Shimomura N, Ishikawa N, Arai T, Poon SS, Yamada N, Okada N, Wakiya T, Hayashida M, Saito T, Egami S, Hishikawa S, Ihara Y, Urahashi T, Mizuta K, Yasuda Y, Kawarasaki H, Takubo K. Hepatocellular telomere length in biliary atresia measured by Q-FISH. World J Surg. 2012 Apr; 36(4):908-16. PMID: 22311140.
        View in: PubMed
      13. Munk R, Ghosh P, Ghosh MC, Saito T, Xu M, Carter A, Indig F, Taub DD, Longo DL. Involvement of mTOR in CXCL12 mediated T cell signaling and migration. PLoS One. 2011; 6(9):e24667. PMID: 21931802; PMCID: PMC3171460.
      14. Tada E, Toyomura K, Nakamura H, Sasaki H, Saito T, Kaneko M, Okuma Y, Murayama T. Activation of ceramidase and ceramide kinase by vanadate via a tyrosine kinase-mediated pathway. J Pharmacol Sci. 2010; 114(4):420-32. PMID: 21127389.
        View in: PubMed
      15. Malathi K, Saito T, Crochet N, Barton DJ, Gale M, Silverman RH. RNase L releases a small RNA from HCV RNA that refolds into a potent PAMP. RNA. 2010 Nov; 16(11):2108-19. PMID: 20833746; PMCID: PMC2957051.
      16. Saito T, Gale M. Differential recognition of double-stranded RNA by RIG-I-like receptors in antiviral immunity. J Exp Med. 2008 Jul 07; 205(7):1523-7. PMID: 18591413; PMCID: PMC2442628.
      17. Saito T, Owen DM, Jiang F, Marcotrigiano J, Gale M. Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA. Nature. 2008 Jul 24; 454(7203):523-7. PMID: 18548002; PMCID: PMC2856441.
      18. Saito T, Gale M. Regulation of innate immunity against hepatitis C virus infection. Hepatol Res. 2008; 38(2):115-22. PMID: 18021225.
        View in: PubMed
      19. Saito T, Hirai R, Loo YM, Owen D, Johnson CL, Sinha SC, Akira S, Fujita T, Gale M. Regulation of innate antiviral defenses through a shared repressor domain in RIG-I and LGP2. Proc Natl Acad Sci U S A. 2007 Jan 09; 104(2):582-7. PMID: 17190814; PMCID: PMC1766428.
      20. Saito T, Gale M. Principles of intracellular viral recognition. Curr Opin Immunol. 2007 Feb; 19(1):17-23. PMID: 17118636.
        View in: PubMed
      21. Loo YM, Owen DM, Li K, Erickson AK, Johnson CL, Fish PM, Carney DS, Wang T, Ishida H, Yoneyama M, Fujita T, Saito T, Lee WM, Hagedorn CH, Lau DT, Weinman SA, Lemon SM, Gale M. Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A. 2006 Apr 11; 103(15):6001-6. PMID: 16585524; PMCID: PMC1458687.
      22. Morikawa K, Ito T, Nozawa H, Inokuchi M, Uchikoshi M, Saito T, Mitamura K, Imawari M. Translational enhancement of HCV RNA genotype 1b by 3'-untranslated and envelope 2 protein-coding sequences. Virology. 2006 Feb 20; 345(2):404-15. PMID: 16289655.
        View in: PubMed
      23. Saito T, Ito T, Ishiko H, Yonaha M, Morikawa K, Miyokawa A, Mitamura K. Sequence analysis of PePHD within HCV E2 region and correlation with resistance of interferon therapy in Japanese patients infected with HCV genotypes 2a and 2b. Am J Gastroenterol. 2003 Jun; 98(6):1377-83. PMID: 12818284.
        View in: PubMed
      24. Ohnishi M, Kanda Y, Takeuchi T, Won Kim S, Hori A, Niiya H, Chizuka A, Nakai K, Saito T, Makimoto A, Tanosaki R, Watanabe T, Kobayashi Y, Tobinai K, Takaue Y, Mineishi S. Limited efficacy of lamivudine against hepatitis B virus infection in allogeneic hematopoietic stem cell transplant recipients. Transplantation. 2002 Mar 15; 73(5):812-5. PMID: 11907433.
        View in: PubMed
      25. Saito T, Tanaka S, Yoshida H, Imamura T, Ukegawa J, Seki T, Ikegami A, Yamamura F, Mikami T, Aoyagi Y, Niikawa J, Mitamura K. A case of autoimmune pancreatitis responding to steroid therapy. Evidence of histologic recovery. Pancreatology. 2002; 2(6):550-6. PMID: 12435868.
        View in: PubMed
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