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    Roksana Karim, MD, PhD

    TitleAssistant Professor of Clinical Preventive Medicine
    SchoolKeck School of Medicine of USC
    DepartmentPreventive Medicine
    AddressSSB 2001 N. Soto Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 226 5068
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      Dr. Karim joined the MCA family as an Assistant Professor of Research in 2007; soon after receiving her Doctoral degree in Epidemiology at USC. She received her medical degree from Dhaka Medical College, Bangladesh, in 1996. Her primary research interest is HIV-associated endocrine and cardiovascular complications in women and children and also menopause-related cardiovascular outcomes in women. Dr. Karim has recently received the Zumberge Individual Research Award for her study evaluating the immunopathogenesis of atherosclerosis in HIV-infected children in MCA. She is actively involved in the Women's Interagency HIV Study (WIHS) and has initiated several research projects involving body fat redistribution, sex hormones, and menopause in HIV-infected women. Dr. Karim co-authored a number of publications examining the factors associated with HIV/AIDS disease progression and survival in HIV-infected women. She has authored several research papers looking at hormone therapy, sex hormones and atherosclerosis in postmenopausal women, which are published in well respected peer reviewed journals.


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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Mack WJ, Karim R. Reply To: Higher Intelligence and Later Maternal Age: Which Way Does the Causal Direction Go? J Am Geriatr Soc. 2017 Aug; 65(8):1885-1886. PMID: 28634984.
        View in: PubMed
      2. Enkhmaa B, Anuurad E, Zhang W, Li CS, Kaplan R, Lazar J, Merenstein D, Karim R, Aouizerat B, Cohen M, Butler K, Pahwa S, Ofotokun I, Adimora AA, Golub E, Berglund L. Lipoprotein(a) and HIV: Allele-Specific Apolipoprotein(a) Levels Predict Carotid Intima-Media Thickness in HIV-Infected Young Women in the Women's Interagency HIV Study. Arterioscler Thromb Vasc Biol. 2017 May; 37(5):997-1004. PMID: 28336560.
        View in: PubMed
      3. Karim R, Dang H, Henderson VW, Hodis HN, St John J, Brinton RD, Mack WJ. Effect of Reproductive History and Exogenous Hormone Use on Cognitive Function in Mid- and Late Life. J Am Geriatr Soc. 2016 Dec; 64(12):2448-2456. PMID: 27996108.
        View in: PubMed
      4. Haddad LB, Wall KM, Mehta CC, Golub ET, Rahangdale L, Kempf MC, Karim R, Wright R, Minkoff H, Cohen M, Kassaye S, Cohan D, Ofotokun I, Cohn SE. Trends of and factors associated with live-birth and abortion rates among HIV-positive and HIV-negative women. Am J Obstet Gynecol. 2017 Jan; 216(1):71.e1-71.e16. PMID: 27640942.
        View in: PubMed
      5. Scherzer R, Greenblatt RM, Merhi ZO, Kassaye S, Lambert-Messerlian G, Maki PM, Murphy K, Karim R, Bacchetti P. Use of antimüllerian hormone to predict the menopausal transition in HIV-infected women. Am J Obstet Gynecol. 2017 Jan; 216(1):46.e1-46.e11. PMID: 27473002.
        View in: PubMed
      6. Kuniholm MH, O'Brien TR, Prokunina-Olsson L, Augenbraun M, Plankey M, Karim R, Sarkar M, French AL, Pierce C, Strickler HD, Anastos K. Association of Hepatitis C Virus Infection With CD4/CD8 Ratio in HIV-Positive Women. J Acquir Immune Defic Syndr. 2016 Jun 01; 72(2):162-70. PMID: 27183178; PMCID: PMC4874499.
      7. Kurita K, Henderson VW, Gatz M, St John J, Hodis HN, Karim R, Mack WJ. Association of bilateral oophorectomy with cognitive function in healthy, postmenopausal women. Fertil Steril. 2016 Sep 01; 106(3):749-756.e2. PMID: 27183047.
        View in: PubMed
      8. Peters MG, Bacchetti P, Boylan R, French AL, Tien PC, Plankey MW, Glesby MJ, Augenbraun M, Golub ET, Karim R, Parkes J, Rosenberg W. Enhanced liver fibrosis marker as a noninvasive predictor of mortality in HIV/hepatitis C virus-coinfected women from a multicenter study of women with or at risk for HIV. AIDS. 2016 Mar 13; 30(5):723-9. PMID: 26595542; PMCID: PMC4802865 [Available on 03/13/17].
      9. Spencer LY, Christiansen S, Wang CH, Mack WJ, Young M, Strickler HD, Anastos K, Minkoff H, Cohen M, Geenblatt RM, Karim R, Operskalski E, Frederick T, Homans JD, Landay A, Kovacs A. Systemic Immune Activation and HIV Shedding in the Female Genital Tract. J Acquir Immune Defic Syndr. 2016 Feb 01; 71(2):155-62. PMID: 26334738; PMCID: PMC4712091 [Available on 02/01/17].
      10. Cates JE, Westreich D, Edmonds A, Wright RL, Minkoff H, Colie C, Greenblatt RM, Cejtin HE, Karim R, Haddad LB, Kempf MC, Golub ET, Adimora AA. The Effects of Viral Load Burden on Pregnancy Loss among HIV-Infected Women in the United States. Infect Dis Obstet Gynecol. 2015; 2015:362357. PMID: 26582966; PMCID: PMC4637076.
      11. Hessol NA, Holman S, Minkoff H, Cohen MH, Golub ET, Kassaye S, Karim R, Sosanya O, Shaheen C, Merhi Z. Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV. AIDS Care. 2016; 28(1):11-21. PMID: 26274806; PMCID: PMC4713239 [Available on 01/01/17].
      12. Karim R, Stanczyk FZ, Brinton RD, Rettberg J, Hodis HN, Mack WJ. Association of endogenous sex hormones with adipokines and ghrelin in postmenopausal women. J Clin Endocrinol Metab. 2015 Feb; 100(2):508-15. PMID: 25405497; PMCID: PMC4318897.
      13. Karim R, Mack WJ, Kono N, Tien PC, Anastos K, Lazar J, Young M, Desai S, Golub ET, Kaplan RC, Hodis HN, Kovacs A. T-cell activation, both pre- and post-HAART levels, correlates with carotid artery stiffness over 6.5 years among HIV-infected women in the WIHS. J Acquir Immune Defic Syndr. 2014 Nov 01; 67(3):349-56. PMID: 25314253; PMCID: PMC4197806.
      14. Scherzer R, Bacchetti P, Messerlian G, Goderre J, Maki PM, Seifer DB, Anastos K, Karim R, Greenblatt RM. Impact of CD4+ lymphocytes and HIV infection on Anti-Müllerian Hormone levels in a large cohort of HIV-infected and HIV-uninfected women. Am J Reprod Immunol. 2015 Mar; 73(3):273-84. PMID: 25339186; PMCID: PMC4323676.
      15. Frasco MA, Karim R, Van Den Berg D, Watanabe RM, Anastos K, Cohen M, Gange SJ, Gustafson DR, Liu C, Tien PC, Mack WJ, Pearce CL. Antiretroviral therapy modifies the genetic effect of known type 2 diabetes-associated risk variants in HIV-infected women. AIDS. 2014 Jul 31; 28(12):1815-23. PMID: 24932614; PMCID: PMC4269472.
      16. Shaked I, Hanna DB, Gleißner C, Marsh B, Plants J, Tracy D, Anastos K, Cohen M, Golub ET, Karim R, Lazar J, Prasad V, Tien PC, Young MA, Landay AL, Kaplan RC, Ley K. Macrophage inflammatory markers are associated with subclinical carotid artery disease in women with human immunodeficiency virus or hepatitis C virus infection. Arterioscler Thromb Vasc Biol. 2014 May; 34(5):1085-92. PMID: 24651679; PMCID: PMC4067091.
      17. Shendre A, Irvin MR, Aouizerat BE, Wiener HW, Vazquez AI, Anastos K, Lazar J, Liu C, Karim R, Limdi NA, Cohen MH, Golub ET, Zhi D, Kaplan RC, Shrestha S. RYR3 gene variants in subclinical atherosclerosis among HIV-infected women in the Women's Interagency HIV Study (WIHS). Atherosclerosis. 2014 Apr; 233(2):666-72. PMID: 24561552; PMCID: PMC3965606.
      18. Liu C, Wang C, Glesby MJ, D'souza G, French A, Minkoff H, Maurer T, Karim R, Young M. Effects of highly active antiretroviral therapy and its adherence on herpes zoster incidence: a longitudinal cohort study. AIDS Res Ther. 2013 Dec 27; 10(1):34. PMID: 24373482; PMCID: PMC3904465.
      19. Henderson VW, St John JA, Hodis HN, McCleary CA, Stanczyk FZ, Karim R, Shoupe D, Kono N, Dustin L, Allayee H, Mack WJ. Cognition, mood, and physiological concentrations of sex hormones in the early and late postmenopause. Proc Natl Acad Sci U S A. 2013 Dec 10; 110(50):20290-5. PMID: 24277815; PMCID: PMC3864289.
      20. Mirmirani P, Maurer T, Cohen M, D'Souza G, Karim R, Plankey M, Robison E, Sharma A, Tien PC, Hessol NA. Investigating the effects of metabolic dysregulation on hair follicles: a comparison of HIV-infected women with and without central lipohypertrophy. Int J Dermatol. 2014 Oct; 53(10):e443-8. PMID: 23786579; PMCID: PMC3785560.
      21. Karim R, Mack WJ, Stiller T, Operskalski E, Frederick T, Landay A, Young MA, Tien PC, Augenbraun M, Strickler HD, Kovacs A. Association of HIV clinical disease progression with profiles of early immune activation: results from a cluster analysis approach. AIDS. 2013 Jun 01; 27(9):1473-81. PMID: 23945505; PMCID: PMC3949252.
      22. Plankey M, Bacchetti P, Jin C, Dass-Brailsford P, Gustafson D, Cohen MH, Karim R, Yin M, Tien PC. The association of self-perception of body fat changes and quality of life in the Women's Interagency HIV Study. AIDS Care. 2013; 25(12):1544-50. PMID: 23656440; PMCID: PMC3769511.
      23. Karim R, Mack WJ, Kono N, Tien PC, Anastos K, Lazar J, Young M, Cohen M, Golub E, Greenblatt RM, Kaplan RC, Hodis HN. Gonadotropin and sex steroid levels in HIV-infected premenopausal women and their association with subclinical atherosclerosis in HIV-infected and -uninfected women in the women's interagency HIV study (WIHS). J Clin Endocrinol Metab. 2013 Apr; 98(4):E610-8. PMID: 23418313; PMCID: PMC3615203.
      24. Tien PC, Schneider MF, Cox C, Karim R, Cohen M, Sharma A, Young M, Glesby MJ. Association of HIV infection with incident diabetes mellitus: impact of using hemoglobin A1C as a criterion for diabetes. J Acquir Immune Defic Syndr. 2012 Nov 01; 61(3):334-40. PMID: 22878421; PMCID: PMC3480977.
      25. Homans J, Christensen S, Stiller T, Wang CH, Mack W, Anastos K, Minkoff H, Young M, Greenblatt R, Cohen M, Strickler H, Karim R, Spencer LY, Operskalski E, Frederick T, Kovacs A. Permissive and protective factors associated with presence, level, and longitudinal pattern of cervicovaginal HIV shedding. J Acquir Immune Defic Syndr. 2012 May 01; 60(1):99-110. PMID: 22517416; PMCID: PMC3334315.
      26. Merhi ZO, Seifer DB, Weedon J, Adeyemi O, Holman S, Anastos K, Golub ET, Young M, Karim R, Greenblatt R, Minkoff H. Circulating vitamin D correlates with serum antimüllerian hormone levels in late-reproductive-aged women: Women's Interagency HIV Study. Fertil Steril. 2012 Jul; 98(1):228-34. PMID: 22494925; PMCID: PMC3389125.
      27. Karim R, Dell RM, Greene DF, Mack WJ, Gallagher JC, Hodis HN. Hip fracture in postmenopausal women after cessation of hormone therapy: results from a prospective study in a large health management organization. Menopause. 2011 Nov; 18(11):1172-7. PMID: 21775911; PMCID: PMC3511047.
      28. Linas BS, Minkoff H, Cohen MH, Karim R, Cohan D, Wright RL, Young M, Watts DH, Golub ET. Relative time to pregnancy among HIV-infected and uninfected women in the Women's Interagency HIV Study, 2002-2009. AIDS. 2011 Mar 13; 25(5):707-11. PMID: 21297418; PMCID: PMC3496791.
      29. Kaplan RC, Sinclair E, Landay AL, Lurain N, Sharrett AR, Gange SJ, Xue X, Hunt P, Karim R, Kern DM, Hodis HN, Deeks SG. T cell activation and senescence predict subclinical carotid artery disease in HIV-infected women. J Infect Dis. 2011 Feb 15; 203(4):452-63. PMID: 21220772; PMCID: PMC3071219.
      30. Wyatt CM, Hoover DR, Shi Q, Tien PC, Karim R, Cohen MH, Goderre JL, Seaberg EC, Lazar J, Young MA, Klotman PE, Anastos K. Pre-existing albuminuria predicts AIDS and non-AIDS mortality in women initiating antiretroviral therapy. Antivir Ther. 2011; 16(4):591-6. PMID: 21685547; PMCID: PMC3119869.
      31. Tien PC, Schneider MF, Cox C, Cohen M, Karim R, Lazar J, Young M, Glesby MJ. HIV, HAART, and lipoprotein particle concentrations in the Women's Interagency HIV Study. AIDS. 2010 Nov 27; 24(18):2809-17. PMID: 20871387; PMCID: PMC2992832.
      32. Wyatt CM, Hoover DR, Shi Q, Seaberg E, Wei C, Tien PC, Karim R, Lazar J, Young MA, Cohen MH, Klotman PE, Anastos K. Microalbuminuria is associated with all-cause and AIDS mortality in women with HIV infection. J Acquir Immune Defic Syndr. 2010 Sep; 55(1):73-7. PMID: 20098331; PMCID: PMC2888617.
      33. Karim R, Stanczyk FZ, Hodis HN, Cushman M, Lobo RA, Hwang J, Mack WJ. Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause. 2010 Jul; 17(4):785-90. PMID: 20632462; PMCID: PMC2907167.
      34. Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010 Mar 15; 201(6):823-34. PMID: 20151840; PMCID: PMC3105602.
      35. Fowler EG, Knutson LM, Demuth SK, Siebert KL, Simms VD, Sugi MH, Souza RB, Karim R, Azen SP. Pediatric endurance and limb strengthening (PEDALS) for children with cerebral palsy using stationary cycling: a randomized controlled trial. Phys Ther. 2010 Mar; 90(3):367-81. PMID: 20093327.
        View in: PubMed
      36. Boodram B, Plankey MW, Cox C, Tien PC, Cohen MH, Anastos K, Karim R, Hyman C, Hershow RC. Prevalence and correlates of elevated body mass index among HIV-positive and HIV-negative women in the Women's Interagency HIV Study. AIDS Patient Care STDS. 2009 Dec; 23(12):1009-16. PMID: 19909168; PMCID: PMC2832643.
      37. Karim R, Mack WJ, Hodis HN, Roy S, Stanczyk FZ. Influence of age and obesity on serum estradiol, estrone, and sex hormone binding globulin concentrations following oral estrogen administration in postmenopausal women. J Clin Endocrinol Metab. 2009 Nov; 94(11):4136-43. PMID: 19808850; PMCID: PMC2775642.
      38. Kapetanovic S, Christensen S, Karim R, Lin F, Mack WJ, Operskalski E, Frederick T, Spencer L, Stek A, Kramer F, Kovacs A. Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. PMID: 19196032; PMCID: PMC2856494.
      39. Seifer DB, Golub ET, Lambert-Messerlian G, Benning L, Anastos K, Watts DH, Cohen MH, Karim R, Young MA, Minkoff H, Greenblatt RM. Variations in serum müllerian inhibiting substance between white, black, and Hispanic women. Fertil Steril. 2009 Nov; 92(5):1674-8. PMID: 18930217; PMCID: PMC3037722.
      40. Karim R, Hodis HN, Detrano R, Liu CR, Liu CH, Mack WJ. Relation of Framingham risk score to subclinical atherosclerosis evaluated across three arterial sites. Am J Cardiol. 2008 Oct 01; 102(7):825-30. PMID: 18805105; PMCID: PMC2648859.
      41. Justman JE, Hoover DR, Shi Q, Tan T, Anastos K, Tien PC, Cole SR, Hyman C, Karim R, Weber K, Grinspoon S. Longitudinal anthropometric patterns among HIV-infected and HIV-uninfected women. J Acquir Immune Defic Syndr. 2008 Mar 01; 47(3):312-9. PMID: 18197125; PMCID: PMC4406344.
      42. Khalsa A, Karim R, Mack WJ, Minkoff H, Cohen M, Young M, Anastos K, Tien PC, Seaberg E, Levine AM. Correlates of prevalent hypertension in a large cohort of HIV-infected women: Women's Interagency HIV Study. AIDS. 2007 Nov 30; 21(18):2539-41. PMID: 18025894.
        View in: PubMed
      43. Karim R, Hodis HN, Stanczyk FZ, Lobo RA, Mack WJ. Relationship between serum levels of sex hormones and progression of subclinical atherosclerosis in postmenopausal women. J Clin Endocrinol Metab. 2008 Jan; 93(1):131-8. PMID: 17925335; PMCID: PMC2190735.
      44. Schechter D, Smith AP, Beck J, Roach J, Karim R, Azen S. Outcomes of a mind-body treatment program for chronic back pain with no distinct structural pathology--a case series of patients diagnosed and treated as tension myositis syndrome. Altern Ther Health Med. 2007 Sep-Oct; 13(5):26-35. PMID: 17900039.
        View in: PubMed
      45. Laskus T, Wilkinson J, Karim R, Mack W, Radkowski M, deGiacomo M, Nasseri J, Chen Z, Xu J, Kovacs A. Hepatitis C virus quasispecies in HIV-infected women: role of injecting drug use and highly active antiretroviral therapy (HAART). Hepatology. 2007 Aug; 46(2):359-70. PMID: 17659581; PMCID: PMC3508063.
      46. Nowicki MJ, Karim R, Mack WJ, Minkoff H, Anastos K, Cohen M, Greenblatt RM, Young MA, Gange SJ, Levine AM. Correlates of CD4+ and CD8+ lymphocyte counts in high-risk immunodeficiency virus (HIV)-seronegative women enrolled in the women's interagency HIV study (WIHS). Hum Immunol. 2007 May; 68(5):342-9. PMID: 17462501.
        View in: PubMed
      47. Levine AM, Karim R, Mack W, Gravink DJ, Anastos K, Young M, Cohen M, Newman M, Augenbraun M, Gange S, Watts DH. Neutropenia in human immunodeficiency virus infection: data from the women's interagency HIV study. Arch Intern Med. 2006 Feb 27; 166(4):405-10. PMID: 16505259.
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      48. Lim ST, Karim R, Tulpule A, Nathwani BN, Levine AM. Prognostic factors in HIV-related diffuse large-cell lymphoma: before versus after highly active antiretroviral therapy. J Clin Oncol. 2005 Nov 20; 23(33):8477-82. PMID: 16230675.
        View in: PubMed
      49. Karim R, Mack WJ, Lobo RA, Hwang J, Liu CR, Liu CH, Sevanian A, Hodis HN. Determinants of the effect of estrogen on the progression of subclinical atherosclerosis: Estrogen in the Prevention of Atherosclerosis Trial. Menopause. 2005 Jul-Aug; 12(4):366-73. PMID: 16037751.
        View in: PubMed
      50. Lim ST, Karim R, Nathwani BN, Tulpule A, Espina B, Levine AM. AIDS-related Burkitt's lymphoma versus diffuse large-cell lymphoma in the pre-highly active antiretroviral therapy (HAART) and HAART eras: significant differences in survival with standard chemotherapy. J Clin Oncol. 2005 Jul 01; 23(19):4430-8. PMID: 15883411.
        View in: PubMed
      51. Karim R, Buchanan TA, Hodis HN, Li Y, Mack WJ. The association of smoking and subclinical atherosclerosis in Type 2 diabetes: modification by duration of diabetes. Diabet Med. 2005 Jan; 22(1):81-7. PMID: 15606696.
        View in: PubMed
      52. Berhane K, Karim R, Cohen MH, Masri-Lavine L, Young M, Anastos K, Augenbraun M, Watts DH, Levine AM. Impact of highly active antiretroviral therapy on anemia and relationship between anemia and survival in a large cohort of HIV-infected women: Women's Interagency HIV Study. J Acquir Immune Defic Syndr. 2004 Oct 01; 37(2):1245-52. PMID: 15385731.
        View in: PubMed
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