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Alice Marie Stek, MD

TitleAssistant Professor of Clinical Obstetrics & Gynecology
InstitutionUniversity of Southern California
DepartmentObstetrics & Gynecology
AddressIRD 220 2020 Zonal Ave
Off Campus
Los Angeles CA 90033
Phone+1 323 226 2534
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    Other Positions
    TitleDirector, Hiv Services


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    Collapse Overview
    Dr. Stek completed a residency in Obstetrics and Gynecology and a fellowship in maternal-fetal medicine (MFM). Her research and clinical interests are primarily in the field of HIV in pregnancy and HIV in women. She has been conducting clinical research in these areas since starting her MFM Fellowship. Dr. Stek has been active in the Pediatric AIDS Clinical Trials Group for over 12 years, where she serves on the Perinatal RAC, the Obstetrics Subcommittee and the AACTG Womens Health Committee. She is a member of eight PACTG and AACTG protocol teams and is co-chair and vice-chair of several protocols. She is also a member of the local WIHS team.

    Dr. Steks current research, both in the multicenter research organizations and in the MCA Centers own projects, focuses on the use of antiretroviral medications in pregnancy. Dr. Stek, in collaboration with PACTG pharmacologists in Boston, San Diego, and San Francisco, and locally with Dr. Michael Neely and the USC School of Pharmacy, is studying the pharmacokinetics, and safety and efficacy (collaborating with PACTG, AACTG, and MCA internists and pediatricians) of the medications used to prevent perinatal HIV transmission and for maternal health. Together with a pathologist at Baylor University, she is studying placental pathology in women using antiretrovirals during pregnancy. She collaborated with the USC pathology/lo aboratory medicine department and MCA pediatricians in designing and implementing a rapid HIV testing program for women in labor, and is currently evaluating this program with the USC pathology/laboratory medicine department and an MCA epidemiologist. Other collaborative research projects in the PACTG and AACTG include a comprehensive project to collect data on HIV-infected pregnancies, an evaluation of postpartum virologic and immunologic changes, and a trial of a therapeutic HPV vaccine in HIV-positive adolescents. In addition to these research activities, Dr. Stek provides clinical care for MCAs pregnant patients, and teaches at Womens and Childrens Hospital, USC Keck School of Medicine, and occasionally at USC main campus, as well as outside the university both in the local community and outside of Los Angeles.


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Eke AC, McCormack SA, Best BM, Stek AM, Wang J, Kreitchmann R, Shapiro D, Smith E, Mofenson LM, Capparelli EV, Mirochnick M. Pharmacokinetics of Increased Nelfinavir Plasma Concentrations in Women During Pregnancy and Postpartum. J Clin Pharmacol. 2018 Oct 25. PMID: 30358179.
      View in: PubMed
    2. Momper JD, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Badell ML, Acosta EP, Purswani M, Smith E, Chakhtoura N, Park K, Burchett S, Shapiro DE, Mirochnick M. Elvitegravir/cobicistat pharmacokinetics in pregnant and postpartum women with HIV. AIDS. 2018 Aug 20. PMID: 30134297.
      View in: PubMed
    3. Venkatesh KK, Morrison L, Livingston EG, Stek A, Read JS, Shapiro DE, Tuomala RE. Changing Patterns and Factors Associated With Mode of Delivery Among Pregnant Women With Human Immunodeficiency Virus Infection in the United States. Obstet Gynecol. 2018 May; 131(5):879-890. PMID: 29630021.
      View in: PubMed
    4. Mulligan N, Best BM, Wang J, Capparelli EV, Stek A, Barr E, Buschur SL, Acosta EP, Smith E, Chakhtoura N, Burchett S, Mirochnick M. Dolutegravir pharmacokinetics in pregnant and postpartum women living with HIV. AIDS. 2018 Mar 27; 32(6):729-737. PMID: 29369162.
      View in: PubMed
    5. Eke AC, Chakhtoura N, Kashuba A, Best BM, Sykes C, Wang J, Stek AM, Smith E, Calabrese S, Capparelli EV, Mirochnick M. Rilpivirine Plasma and Cervico-Vaginal Concentrations in Women During Pregnancy and Postpartum. J Acquir Immune Defic Syndr. 2018 Mar 08. PMID: 29528944.
      View in: PubMed
    6. Scott GB, Brogly SB, Muenz D, Stek AM, Read JS. Missed Opportunities for Prevention of Mother-to-Child Transmission of Human Immunodeficiency Virus. Obstet Gynecol. 2017 Apr; 129(4):621-628. PMID: 28277349.
      View in: PubMed
    7. Livingston EG, Huo Y, Patel K, Tuomala RE, Scott GB, Stek A. Complications and Route of Delivery in a Large Cohort Study of HIV-1-Infected Women-IMPAACT P1025. J Acquir Immune Defic Syndr. 2016 09 01; 73(1):74-82. PMID: 27082506.
      View in: PubMed
    8. Mulligan N, Schalkwijk S, Best BM, Colbers A, Wang J, Capparelli EV, Moltó J, Stek AM, Taylor G, Smith E, Hidalgo Tenorio C, Chakhtoura N, van Kasteren M, Fletcher CV, Mirochnick M, Burger D. Etravirine Pharmacokinetics in HIV-Infected Pregnant Women. Front Pharmacol. 2016; 7:239. PMID: 27540363; PMCID: PMC4972814.
    9. Tran AH, Best BM, Stek A, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, George K, Cressey TR, Chakhtoura N, Smith E, Shapiro DE, Mirochnick M. Pharmacokinetics of Rilpivirine in HIV-Infected Pregnant Women. J Acquir Immune Defic Syndr. 2016 07 01; 72(3):289-96. PMID: 26918544.
      View in: PubMed
    10. Stek A, Best BM, Wang J, Capparelli EV, Burchett SK, Kreitchmann R, Rungruengthanakit K, Cressey TR, Mofenson LM, Smith E, Shapiro D, Mirochnick M. Pharmacokinetics of Once Versus Twice Daily Darunavir in Pregnant HIV-Infected Women. J Acquir Immune Defic Syndr. 2015 Sep 01; 70(1):33-41. PMID: 25950206; PMCID: PMC4579345.
    11. Colbers A, Best B, Schalkwijk S, Wang J, Stek A, Hidalgo Tenorio C, Hawkins D, Taylor G, Kreitchmann R, Burchett S, Haberl A, Kabeya K, van Kasteren M, Smith E, Capparelli E, Burger D, Mirochnick M. Maraviroc Pharmacokinetics in HIV-1-Infected Pregnant Women. Clin Infect Dis. 2015 Nov 15; 61(10):1582-9. PMID: 26202768; PMCID: PMC4614410 [Available on 11/15/16].
    12. Sha BE, Tierney C, Sun X, Stek A, Cohn SE, Coombs RW, Bastow B, Aweeka FT. PHARMACOKINETIC EXPOSURE AND VIROLOGIC RESPONSE IN HIV-1 INFECTED PREGNANT WOMEN TREATED WITH LOPINAVIR/RITONAVIR: AIDS CLINICAL TRIALS GROUP PROTOCOL A5153S: A SUBSTUDY TO A5150. Jacobs J AIDS HIV. 2015; 1(1). PMID: 26878071.
      View in: PubMed
    13. Katz IT, Leister E, Kacanek D, Hughes MD, Bardeguez A, Livingston E, Stek A, Shapiro DE, Tuomala R. Factors associated with lack of viral suppression at delivery among highly active antiretroviral therapy-naive women with HIV: a cohort study. Ann Intern Med. 2015 Jan 20; 162(2):90-9. PMID: 25599347; PMCID: PMC4299931.
    14. Watts DH, Stek A, Best BM, Wang J, Capparelli EV, Cressey TR, Aweeka F, Lizak P, Kreitchmann R, Burchett SK, Shapiro DE, Hawkins E, Smith E, Mirochnick M. Raltegravir pharmacokinetics during pregnancy. J Acquir Immune Defic Syndr. 2014 Dec 01; 67(4):375-81. PMID: 25162818.
      View in: PubMed
    15. Atrio J, Stek A, Vora H, Sanchez-Keeland L, Zannat F, Natavio M. The effect of protease inhibitors on the cervical mucus of HIV-positive women taking norethindrone contraception. Eur J Contracept Reprod Health Care. 2015 Apr; 20(2):149-53. PMID: 25285572; PMCID: PMC4655593.
    16. Cressey TR, Urien S, Capparelli EV, Best BM, Buranabanjasatean S, Limtrakul A, Rawangban B, Sabsanong P, Treluyer JM, Jourdain G, Stek A, Lallemant M, Mirochnick M. Impact of body weight and missed doses on lopinavir concentrations with standard and increased lopinavir/ritonavir doses during late pregnancy. J Antimicrob Chemother. 2015 Jan; 70(1):217-24. PMID: 25261418.
      View in: PubMed
    17. Cressey TR, Best BM, Achalapong J, Stek A, Wang J, Chotivanich N, Yuthavisuthi P, Suriyachai P, Prommas S, Shapiro DE, Watts DH, Smith E, Capparelli E, Kreitchmann R, Mirochnick M. Reduced indinavir exposure during pregnancy. Br J Clin Pharmacol. 2013 Sep; 76(3):475-83. PMID: 23305215; PMCID: PMC3769674.
    18. Kreitchmann R, Best BM, Wang J, Stek A, Caparelli E, Watts DH, Smith E, Shapiro DE, Rossi S, Burchett SK, Hawkins E, Byroads M, Cressey TR, Mirochnick M. Pharmacokinetics of an increased atazanavir dose with and without tenofovir during the third trimester of pregnancy. J Acquir Immune Defic Syndr. 2013 May 01; 63(1):59-66. PMID: 23392467; PMCID: PMC3625451.
    19. Frederick T, Homans J, Spencer L, Kramer F, Stek A, Operskalski E, Kovacs A. The effect of prenatal highly active antiretroviral therapy on the transmission of congenital and perinatal/early postnatal cytomegalovirus among HIV-infected and HIV-exposed infants. Clin Infect Dis. 2012 Sep; 55(6):877-84. PMID: 22675157.
      View in: PubMed
    20. Cressey TR, Stek A, Capparelli E, Bowonwatanuwong C, Prommas S, Sirivatanapa P, Yuthavisuthi P, Neungton C, Huo Y, Smith E, Best BM, Mirochnick M. Efavirenz pharmacokinetics during the third trimester of pregnancy and postpartum. J Acquir Immune Defic Syndr. 2012 Mar 01; 59(3):245-52. PMID: 22083071; PMCID: PMC3288559.
    21. Stek AM, Best BM, Luo W, Capparelli E, Burchett S, Hu C, Li H, Read JS, Jennings A, Barr E, Smith E, Rossi SS, Mirochnick M. Effect of pregnancy on emtricitabine pharmacokinetics. HIV Med. 2012 Apr; 13(4):226-35. PMID: 22129166; PMCID: PMC3342997.
    22. Walter J, Fraga L, Orin MJ, Decker WD, Gipps T, Stek A, Aldrovandi GM. Immunomodulatory factors in cervicovaginal secretions from pregnant and non-pregnant women: a cross-sectional study. BMC Infect Dis. 2011 Sep 30; 11:263. PMID: 21961998; PMCID: PMC3190379.
    23. Mirochnick M, Best BM, Stek AM, Capparelli EV, Hu C, Burchett SK, Rossi SS, Hawkins E, Basar M, Smith E, Read JS. Atazanavir pharmacokinetics with and without tenofovir during pregnancy. J Acquir Immune Defic Syndr. 2011 Apr 15; 56(5):412-9. PMID: 21283017; PMCID: PMC3125419.
    24. Sha BE, Tierney C, Cohn SE, Sun X, Coombs RW, Frenkel LM, Kalams SA, Aweeka FT, Bastow B, Bardeguez A, Kmack A, Stek A. Postpartum viral load rebound in HIV-1-infected women treated with highly active antiretroviral therapy: AIDS Clinical Trials Group Protocol A5150. HIV Clin Trials. 2011 Jan-Feb; 12(1):9-23. PMID: 21388937; PMCID: PMC3227722.
    25. Livingston EG, Huo Y, Patel K, Brogly SB, Tuomala R, Scott GB, Bardeguez A, Stek A, Read JS. Mode of delivery and infant respiratory morbidity among infants born to HIV-1-infected women. Obstet Gynecol. 2010 Aug; 116(2 Pt 1):335-43. PMID: 20664394; PMCID: PMC2964131.
    26. Best BM, Stek AM, Mirochnick M, Hu C, Li H, Burchett SK, Rossi SS, Smith E, Read JS, Capparelli EV. Lopinavir tablet pharmacokinetics with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2010 Aug; 54(4):381-8. PMID: 20632458; PMCID: PMC3265163.
    27. Patel K, Shapiro DE, Brogly SB, Livingston EG, Stek AM, Bardeguez AD, Tuomala RE. Prenatal protease inhibitor use and risk of preterm birth among HIV-infected women initiating antiretroviral drugs during pregnancy. J Infect Dis. 2010 Apr 01; 201(7):1035-44. PMID: 20196654; PMCID: PMC2946359.
    28. Stek AM. Antiretroviral medications during pregnancy for therapy or prophylaxis. Curr HIV/AIDS Rep. 2009 May; 6(2):68-76. PMID: 19358777.
      View in: PubMed
    29. Kapetanovic S, Christensen S, Karim R, Lin F, Mack WJ, Operskalski E, Frederick T, Spencer L, Stek A, Kramer F, Kovacs A. Correlates of perinatal depression in HIV-infected women. AIDS Patient Care STDS. 2009 Feb; 23(2):101-8. PMID: 19196032; PMCID: PMC2856494.
    30. Bennetto-Hood C, Bryson YJ, Stek A, King JR, Mirochnick M, Acosta EP. Zidovudine, lamivudine, and nelfinavir concentrations in amniotic fluid and maternal serum. HIV Clin Trials. 2009 Jan-Feb; 10(1):41-7. PMID: 19362995.
      View in: PubMed
    31. Mirochnick M, Best BM, Stek AM, Capparelli E, Hu C, Burchett SK, Holland DT, Smith E, Gaddipati S, Read JS. Lopinavir exposure with an increased dose during pregnancy. J Acquir Immune Defic Syndr. 2008 Dec 15; 49(5):485-91. PMID: 18989231; PMCID: PMC3912695.
    32. Bardeguez AD, Lindsey JC, Shannon M, Tuomala RE, Cohn SE, Smith E, Stek A, Buschur S, Cotter A, Bettica L, Read JS. Adherence to antiretrovirals among US women during and after pregnancy. J Acquir Immune Defic Syndr. 2008 Aug 01; 48(4):408-17. PMID: 18614923; PMCID: PMC2764488.
    33. Stek AM. Antiretroviral treatment in pregnancy. Curr Opin HIV AIDS. 2008 Mar; 3(2):155-60. PMID: 19372959.
      View in: PubMed
    34. Watts DH, Park JG, Cohn SE, Yu S, Hitti J, Stek A, Clax PA, Muderspach L, Lertora JJ. Safety and tolerability of depot medroxyprogesterone acetate among HIV-infected women on antiretroviral therapy: ACTG A5093. Contraception. 2008 Feb; 77(2):84-90. PMID: 18226670.
      View in: PubMed
    35. Sha BE, Gawel SH, Hershow RC, Passaro D, Augenbraun M, Darragh TM, Stek A, Golub ET, Mph LC, Moxley MD, Weber KM, Watts DH. Analysis of standard methods for diagnosing vaginitis: HIV infection does not complicate the diagnosis of vaginitis. J Low Genit Tract Dis. 2007 Oct; 11(4):240-50. PMID: 17917568.
      View in: PubMed
    36. Hitti J, Andersen J, McComsey G, Liu T, Melvin A, Smith L, Stek A, Aberg J, Hull A, Alston-Smith B, Watts DH, Livingston E. Protease inhibitor-based antiretroviral therapy and glucose tolerance in pregnancy: AIDS Clinical Trials Group A5084. Am J Obstet Gynecol. 2007 Apr; 196(4):331.e1-7. PMID: 17403409.
      View in: PubMed
    37. Brogly S, Read JS, Shapiro D, Stek A, Tuomala R. Participation of HIV-infected pregnant women in research in the United States. AIDS Res Hum Retroviruses. 2007 Jan; 23(1):51-3. PMID: 17263632.
      View in: PubMed
    38. Stek AM, Mirochnick M, Capparelli E, Best BM, Hu C, Burchett SK, Elgie C, Holland DT, Smith E, Tuomala R, Cotter A, Read JS. Reduced lopinavir exposure during pregnancy. AIDS. 2006 Oct 03; 20(15):1931-9. PMID: 16988514.
      View in: PubMed
    39. Best BM, Mirochnick M, Capparelli EV, Stek A, Burchett SK, Holland DT, Read JS, Smith E, Hu C, Spector SA, Connor JD. Impact of pregnancy on abacavir pharmacokinetics. AIDS. 2006 Feb 28; 20(4):553-60. PMID: 16470119.
      View in: PubMed
    40. Mirochnick M, Stek A, Acevedo M, Keller M, Holland D, Capparelli E, Connor J, Huang S, Hughes M, Watts H, Mofenson L, Bryson Y. Safety and pharmacokinetics of nelfinavir coadministered with zidovudine and lamivudine in infants during the first 6 weeks of life. J Acquir Immune Defic Syndr. 2005 Jun 01; 39(2):189-94. PMID: 15905735.
      View in: PubMed
    41. Nikolopoulou GB, Nowicki MJ, Du W, Homans J, Stek A, Kramer F, Kovacs A. HCV viremia is associated with drug use in young HIV-1 and HCV coinfected pregnant and non-pregnant women. Addiction. 2005 May; 100(5):626-35. PMID: 15847620; PMCID: PMC3118993.
    42. Gilmore W, Arias M, Stroud N, Stek A, McCarthy KA, Correale J. Preliminary studies of cytokine secretion patterns associated with pregnancy in MS patients. J Neurol Sci. 2004 Sep 15; 224(1-2):69-76. PMID: 15450773.
      View in: PubMed
    43. Hitti J, Frenkel LM, Stek AM, Nachman SA, Baker D, Gonzalez-Garcia A, Provisor A, Thorpe EM, Paul ME, Foca M, Gandia J, Huang S, Wei LJ, Stevens LM, Watts DH, McNamara J. Maternal toxicity with continuous nevirapine in pregnancy: results from PACTG 1022. J Acquir Immune Defic Syndr. 2004 Jul 01; 36(3):772-6. PMID: 15213559.
      View in: PubMed
    44. Acosta EP, Bardeguez A, Zorrilla CD, Van Dyke R, Hughes MD, Huang S, Pompeo L, Stek AM, Pitt J, Watts DH, Smith E, Jiménez E, Mofenson L. Pharmacokinetics of saquinavir plus low-dose ritonavir in human immunodeficiency virus-infected pregnant women. Antimicrob Agents Chemother. 2004 Feb; 48(2):430-6. PMID: 14742191; PMCID: PMC321538.
    45. Massad LS, Springer G, Jacobson L, Watts H, Anastos K, Korn A, Cejtin H, Stek A, Young M, Schmidt J, Minkoff H. Pregnancy rates and predictors of conception, miscarriage and abortion in US women with HIV. AIDS. 2004 Jan 23; 18(2):281-6. PMID: 15075546.
      View in: PubMed
    46. Tuomala RE, Shapiro DE, Mofenson LM, Bryson Y, Culnane M, Hughes MD, O'Sullivan MJ, Scott G, Stek AM, Wara D, Bulterys M. Antiretroviral therapy during pregnancy and the risk of an adverse outcome. N Engl J Med. 2002 Jun 13; 346(24):1863-70. PMID: 12063370.
      View in: PubMed