Jess Holguin works extensively with individuals who have experienced head injury, spinal cord injury, stroke, multitrauma, orthodepic conditions and other medically complex conditions. His clinical expertise derives from many years of experience, including his time as senior clinician for neurorehabilitation at St. Jude's regional brain injury rehabilitation center.

Dr. Holguin has been an invited lecturer on topics such as neurorehabilitation, cognition and visual perception at the University of Southern California and the Braille Institute/Center for the Partially Sighted. As an assistant professor of clinical occupational therapy, Dr. Holguin treats patients at Keck Hospital of USC, serves as mentor to faculty, residents and students, and develops programs targeting enhanced participation in meaningful activities for patients experiencing neurological dysfunction.

As a former member of the USC Well Elderly 2 randomized controlled trial team, Dr. Holguin contributed to the analysis and interpretation of research findings. His research interests include neurological rehabilitation, successful aging and the interrelated nature of well-being and participation in meaningful activity.