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    Pin Wang, PhD

    SchoolViterbi School of Engineering, BME
    AddressRTH 506
    University Park Campus
    Los Angeles California 90089-1211
    Phone+1 213 740 0780
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      Engineered Viral Vectors for Targeted Gene Delivery
      In the targeted gene delivery area, we are interested in engineering viral vectors capable of targeting specific cell types. Our long-term goal is to design and optimize lentiviral vectors that can selectively deliver appropriate genes to target cells, tissues and organs after direct administration in vivo. We have demonstrated a flexible and general targeting strategy by separating the functions of specific binding and fusion onto two distinct molecules and co-incorporating them into the lentiviral vectors. We are evaluating the utility of these engineered vectors for treating genetic diseases and cancer.

      Dendritic Cell-Directed Vaccine
      In the vectored vaccine area, we are developing lentiviral vectors as a novel vaccine carrier. We have identified a dendritic cell-directed lenitviral vector system and demonstrated the potential of this system to induce high magnitude and quality of immune responses. In collaboration with various labs, we are currently testing this dendritic cell-targeted system for cancer and HIV/AIDS vaccines.

      In the bionanotechnology area, we are interested in developing novel nanoscale tools for visualizing virus trafficking and interrogating molecular mechanism of viral infection. In addition, we are designing new viral vector tools for achieving site-specific manipulation of stem cell genomes for the future of regenerative medicines. We are also applying polymeric biomaterials for modulating the immune responses. Recently, we have been collaborating with various labs to design and study a nanocapsule-based protein delivery system for bioengineering applications such as delivering therapeutic proteins for cancer treatment and delivering immunogens for vaccine applications. We are also a member of the Join Center for Translational Medicine, where we work with a team of basic scientists and clinical investigators to translate our laboratory discovery into human therapies.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Tai A, Froelich S, Joo KI, Wang P. Production of lentiviral vectors with enhanced efficiency to target dendritic cells by attenuating mannosidase activity of mammalian cells. J Biol Eng. 2011; 5(1):1. PMID: 21276219.
        View in: PubMed