Michael E. Selsted, MD, PhD
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| Title(s) | Professor of Pathology |
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| School | Keck School of Medicine of Usc |
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| Address | HMR 2011 Zonal Ave
Health Sciences Campus
Los Angeles CA 90089-9092
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| Phone | +1 323 442 1180 |
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| vCard | Download vCard |
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| Title(s) | Seth MacFarlane Professor of Immunopathology |
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Overview
Dr. Selsted is a board certified pathologist, physician scientist, and administrator. His academic career includes appointments as Professor (1989-2009) and Chair of Pathology at UC Irvine School of Medicine (2000 - 2009) and Professor and Chair of Pathology in the Keck School of Medicine (2009 - 2024). Dr. Selsted leads a multidisciplinary research program focused on mammalian host defense, innate immunity, and inflammation. This focus led to the discovery and characterization of α-, β-, and θ-defensins, microbicidal and immunomodulatory peptides expressed in myeloid and epithelial cells of vertebrates. These investigations, continuously funded by NIH since 1986, have resulted in more than 50 US and foreign patents, as well as clinical translation of a θ-defensin for treatment of rheumatoid arthritis. Ongoing studies seek to elucidate the immunoregulatory mechanisms of these peptides, design and application of novel analogs, and application of θ-defensin-inspired macrocyclic peptides in models of autoimmune diseases, cancer, and infections caused by MDR bacterial and fungal pathogens.
Research
Bibliographic
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Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
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An ADAM10 Exosite Inhibitor Is Efficacious in an In Vivo Collagen-Induced Arthritis Model. Pharmaceuticals (Basel). 2024 Jan 09; 17(1).
Diez J, Selsted ME, Bannister TD, Minond D. PMID: 38256920; PMCID: PMC10819767.
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PubMed Mentions:
2
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Inhibition of miR-146a Expression and Regulation of Endotoxin Tolerance by Rhesus Theta-Defensin-1. Mediators Inflamm. 2023; 2023:8387330.
Tongaonkar P, Trinh KK, Ouellette AJ, Selsted ME. . PMID: 37101596; PMCID: PMC10125762.
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PubMed Mentions:
3 Fields:
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Preclinical Pharmacokinetics and Safety of Intravenous RTD-1. Antimicrob Agents Chemother. 2022 03 15; 66(3):e0212521.
Park AYJ, Tran DQ, Schaal JB, Wang M, Selsted ME, Beringer PM. PMID: 35041507; PMCID: PMC8923172.
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PubMed Mentions:
4 Fields:
Translation:
Animals
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A host-directed macrocyclic peptide therapeutic for MDR gram negative bacterial infections. Sci Rep. 2021 12 06; 11(1):23447.
Schaal JB, Eriguchi Y, Tran DQ, Tran PA, Hawes C, Cabebe AE, Pike K, Trinh K, Ouellette AJ, Selsted ME. . PMID: 34873199; PMCID: PMC8648872.
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PubMed Mentions:
3 Fields:
Translation:
HumansAnimalsCells
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Anti-Inflammatory Effects of RTD-1 in a Murine Model of Chronic Pseudomonas aeruginosa Lung Infection: Inhibition of NF-κB, Inflammasome Gene Expression, and Pro-IL-1β Biosynthesis. Antibiotics (Basel). 2021 Aug 26; 10(9).
Dughbaj MA, Jayne JG, Park AYJ, Bensman TJ, Algorri M, Ouellette AJ, Selsted ME, Beringer PM. PMID: 34572625; PMCID: PMC8466744.
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PubMed Mentions:
4
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Host Defense Peptides as Templates for Antifungal Drug Development. J Fungi (Basel). 2020 Oct 23; 6(4).
Basso V, Tran DQ, Ouellette AJ, Selsted ME. . PMID: 33113935; PMCID: PMC7711597.
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PubMed Mentions:
8
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RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts. Physiol Genomics. 2019 12 01; 51(12):657-667.
Tongaonkar P, Punj V, Subramanian A, Tran DQ, Trinh KK, Schaal JB, Laragione T, Ouellette AJ, Gulko PS, Selsted ME. PMID: 31762409; PMCID: PMC6962595.
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PubMed Mentions:
7 Fields:
Translation:
HumansAnimalsCells
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Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms. Sci Rep. 2019 11 15; 9(1):16905.
Basso V, Tran DQ, Schaal JB, Tran P, Eriguchi Y, Ngole D, Cabebe AE, Park AY, Beringer PM, Ouellette AJ, Selsted ME. . PMID: 31729441; PMCID: PMC6858451.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Essential role of IFN-γ in T cell-associated intestinal inflammation. JCI Insight. 2018 09 20; 3(18).
Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ. PMID: 30232288; PMCID: PMC6237234.
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PubMed Mentions:
54 Fields:
Translation:
AnimalsCells
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Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species. Antimicrob Agents Chemother. 2018 06; 62(6).
Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME. . PMID: 29610196; PMCID: PMC5971616.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimals
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Rhesus θ-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. Am J Respir Cell Mol Biol. 2018 03; 58(3):310-319.
Jayne JG, Bensman TJ, Schaal JB, Park AYJ, Kimura E, Tran D, Selsted ME, Beringer PM. PMID: 28954201; PMCID: PMC5854954.
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PubMed Mentions:
15 Fields:
Translation:
HumansAnimalsCells
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Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme. J Biol Chem. 2018 02 23; 293(8):2725-2734.
Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME. PMID: 29317500; PMCID: PMC5827436.
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PubMed Mentions:
17 Fields:
Translation:
HumansAnimalsCells
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Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide. PLoS One. 2017; 12(11):e0187868.
Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME. . PMID: 29145473; PMCID: PMC5690597.
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PubMed Mentions:
12 Fields:
Translation:
Animals
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Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation. Antimicrob Agents Chemother. 2017 08; 61(8).
Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM. PMID: 28559270; PMCID: PMC5527632.
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PubMed Mentions:
16 Fields:
Translation:
HumansAnimalsCells
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Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. J Antimicrob Chemother. 2016 Jan; 71(1):181-8.
Beringer PM, Bensman TJ, Ho H, Agnello M, Denovel N, Nguyen A, Wong-Beringer A, She R, Tran DQ, Moskowitz SM, Selsted ME. . PMID: 26433781; PMCID: PMC5007590.
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PubMed Mentions:
19 Fields:
Translation:
HumansAnimalsCells
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Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways. J Leukoc Biol. 2015 Dec; 98(6):1061-70.
Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME. . PMID: 26269197; PMCID: PMC4661038.
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PubMed Mentions:
27 Fields:
Translation:
HumansCells
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θ-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E154-60.
Oh YT, Tran D, Buchanan TA, Selsted ME, Youn JH. PMID: 25991648; PMCID: PMC4504933.
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PubMed Mentions:
5 Fields:
Translation:
Animals
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Hydrophobic determinants of α-defensin bactericidal activity. Infect Immun. 2014 Jun; 82(6):2195-202.
Tai KP, Le VV, Selsted ME, Ouellette AJ. PMID: 24614658; PMCID: PMC4019156.
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PubMed Mentions:
11 Fields:
Translation:
AnimalsCells
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Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel). 2014; 3(4):617-31.
Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG. PMID: 25632351; PMCID: PMC4306331.
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PubMed Mentions:
18
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Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions. Antibiotics (Basel). 2014; 3(4):493-508.
Mastroianni JR, Lu W, Selsted ME, Ouellette AJ. PMID: 25383215; PMCID: PMC4220453.
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PubMed Mentions:
4
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Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun. 2015 Jan; 21(1):17-29.
Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted ME, Ouellette AJ, Wong-Beringer A. PMID: 24345876; PMCID: PMC4062604.
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PubMed Mentions:
20 Fields:
Translation:
Cells
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Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One. 2012; 7(12):e51337.
Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME. PMID: 23236475; PMCID: PMC3516535.
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PubMed Mentions:
40 Fields:
Translation:
Animals
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Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1.
Ouellette AJ, Selsted ME. . PMID: 22837514.
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PubMed Mentions:
5 Fields:
Translation:
HumansAnimals
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High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One. 2012; 7(3):e32469.
Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME. PMID: 22448222; PMCID: PMC3308943.
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PubMed Mentions:
13 Fields:
Translation:
HumansCells
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RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities. J Am Chem Soc. 2012 Mar 07; 134(9):4041-4.
Rapireddy S, Nhon L, Meehan RE, Franks J, Stolz DB, Tran D, Selsted ME, Ly DH. PMID: 22332599; PMCID: PMC4848027.
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PubMed Mentions:
5 Fields:
Translation:
Cells
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Alternative luminal activation mechanisms for paneth cell α-defensins. J Biol Chem. 2012 Mar 30; 287(14):11205-12.
Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ. PMID: 22334698; PMCID: PMC3322892.
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PubMed Mentions:
23 Fields:
Translation:
AnimalsCells
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Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res. 2011 Oct 07; 10(10):4505-12.
Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA. PMID: 21851130; PMCID: PMC3242011.
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PubMed Mentions:
20 Fields:
Translation:
AnimalsCells
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Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc. 2011 May 04; 133(17):6720-7.
Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC. PMID: 21473577; PMCID: PMC3090259.
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PubMed Mentions:
106 Fields:
Translation:
AnimalsCells
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Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. J Leukoc Biol. 2011 Feb; 89(2):283-90.
Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME. . PMID: 21084627; PMCID: PMC3024902.
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PubMed Mentions:
28 Fields:
Translation:
HumansAnimalsCells
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Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. PLoS One. 2010 Mar 17; 5(3):e9737.
Seidel A, Ye Y, de Armas LR, Soto M, Yarosh W, Marcsisin RA, Tran D, Selsted ME, Camerini D. PMID: 20305815; PMCID: PMC2840026.
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PubMed Mentions:
39 Fields:
Translation:
HumansAnimalsCells
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Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol. 2009 Nov; 83(21):11385-90.
Wohlford-Lenane CL, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted ME, McCray PB. PMID: 19710146; PMCID: PMC2772759.
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PubMed Mentions:
72 Fields:
Translation:
HumansAnimalsCells
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SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides. J Biol Chem. 2009 Feb 27; 284(9):5602-9.
Tongaonkar P, Selsted ME. . PMID: 19109254; PMCID: PMC2645818.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother. 2009 Jan; 63(1):115-23.
Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M. PMID: 18957395; PMCID: PMC2721699.
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PubMed Mentions:
13 Fields:
Translation:
AnimalsCells
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Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J Biol Chem. 2008 Dec 19; 283(51):35869-77.
Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted ME, Cocco MJ. PMID: 18930922; PMCID: PMC2602889.
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PubMed Mentions:
4 Fields:
Translation:
AnimalsCells
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Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun. 2008 Dec; 76(12):5883-91.
Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME. . PMID: 18852242; PMCID: PMC2583559.
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PubMed Mentions:
47 Fields:
Translation:
HumansAnimalsCells
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Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53.
Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME. . PMID: 18160518; PMCID: PMC2258523.
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PubMed Mentions:
41 Fields:
Translation:
HumansAnimalsCells
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Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. J Immunol. 2006 Jan 15; 176(2):1154-62.
Tydell CC, Yuan J, Tran P, Selsted ME. . PMID: 16394004.
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PubMed Mentions:
39 Fields:
Translation:
AnimalsCells
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Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8.
Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ. PMID: 14977952; PMCID: PMC356057.
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PubMed Mentions:
19 Fields:
Translation:
AnimalsCells
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alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors. AIDS. 2003 Sep 26; 17(14):F23-32.
Mackewicz CE, Yuan J, Tran P, Diaz L, Mack E, Selsted ME, Levy JA. PMID: 14502030.
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PubMed Mentions:
58 Fields:
Translation:
HumansCells
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Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G757-65.
Yue G, Merlin D, Selsted ME, Lencer WI, Madara JL, Eaton DC. PMID: 11960772.
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PubMed Mentions:
9 Fields:
Translation:
HumansAnimalsCells
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Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils. J Biol Chem. 2002 May 31; 277(22):19658-64.
Tydell CC, Yount N, Tran D, Yuan J, Selsted ME. . PMID: 11880375.
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PubMed Mentions:
31 Fields:
Translation:
AnimalsCells
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Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem. 2002 Feb 01; 277(5):3079-84.
Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted ME. . PMID: 11675394.
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PubMed Mentions:
77 Fields:
Translation:
AnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
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| 2001 | 1 |
| 2002 | 2 |
| 2003 | 1 |
| 2004 | 1 |
| 2006 | 1 |
| 2007 | 1 |
| 2008 | 4 |
| 2009 | 1 |
| 2010 | 2 |
| 2011 | 2 |
| 2012 | 5 |
| 2013 | 1 |
| 2014 | 3 |
| 2015 | 3 |
| 2017 | 2 |
| 2018 | 4 |
| 2019 | 2 |
| 2020 | 1 |
| 2021 | 2 |
| 2022 | 1 |
| 2023 | 1 |
| 2024 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
click here.
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