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    Michael E. Selsted, MD, PhD

    TitleChair and Professor of Pathology
    SchoolKeck School of Medicine of USC
    AddressHMR 2011 Zonal Ave
    Health Sciences Campus
    Los Angeles California 90089-9092
    Phone+1 323 442 1180
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      Dr. Selsted is an internationally renowned scholar in the field of innate immunity and pathogenesis whose research discoveries have resulted in more than 20 U.S. patents. In addition to his pioneering research and clinical science, Dr. Selsted is a prolific author and experienced administrator. Under his leadership, National Institutes of Health and total research funding at the University of California, Irvine Department of Pathology and Laboratory Medicine increased more than four-fold to $6.6 million.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Jayne JG, Bensman TJ, Schaal JB, Park AYJ, Kimura E, Tran D, Selsted M, Beringer PM. Rhesus Theta (?)-Defensin-1 Attenuates Endotoxin-Induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. Am J Respir Cell Mol Biol. 2017 Sep 27. PMID: 28954201.
        View in: PubMed
      2. Beringer PM, Bensman TJ, Ho H, Agnello M, Denovel N, Nguyen A, Wong-Beringer A, She R, Tran DQ, Moskowitz SM, Selsted M. Rhesus ?-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa. J Antimicrob Chemother. 2016 Jan; 71(1):181-8. PMID: 26433781; PMCID: PMC5007590 [Available on 01/01/17].
      3. Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted M. Rhesus macaque ?-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-?B and MAPK pathways. J Leukoc Biol. 2015 Dec; 98(6):1061-70. PMID: 26269197.
        View in: PubMed
      4. Oh YT, Tran D, Buchanan TA, Selsted M, Youn JH. ?-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats. Am J Physiol Endocrinol Metab. 2015 Jul 15; 309(2):E154-60. PMID: 25991648; PMCID: PMC4504933.
      5. Tai KP, Le VV, Selsted M, Ouellette AJ. Hydrophobic determinants of a-defensin bactericidal activity. Infect Immun. 2014 Jun; 82(6):2195-202. PMID: 24614658; PMCID: PMC4019156.
      6. Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted M, Sahl HG. Killing of staphylococci by ?-defensins involves membrane impairment and activation of autolytic enzymes. Antibiotics (Basel). 2014; 3(4):617-31. PMID: 25632351; PMCID: PMC4306331.
      7. Mastroianni JR, Lu W, Selsted M, Ouellette AJ. Differential Susceptibility of Bacteria to Mouse Paneth Cell a-Defensins under Anaerobic Conditions. Antibiotics (Basel). 2014; 3(4):493-508. PMID: 25383215.
        View in: PubMed
      8. Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted M, Ouellette AJ, Wong-Beringer A. Microbicidal effects of a- and ?-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa. Innate Immun. 2015 Jan; 21(1):17-29. PMID: 24345876; PMCID: PMC4062604.
      9. Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted M, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Nat Prod Rep. 2013 Jan; 30(1):108-60. PMID: 23165928; PMCID: PMC3954855.
      10. Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted M. Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis. PLoS One. 2012; 7(12):e51337. PMID: 23236475; PMCID: PMC3516535.
      11. Ouellette AJ, Selsted M. Immunology. HD6 defensin nanonets. Science. 2012 Jul 27; 337(6093):420-1. PMID: 22837514.
        View in: PubMed
      12. Lehrer RI, Cole AM, Selsted M. ?-Defensins: cyclic peptides with endless potential. J Biol Chem. 2012 Aug 03; 287(32):27014-9. PMID: 22700960; PMCID: PMC3411038.
      13. Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted M. High fidelity processing and activation of the human a-defensin HNP1 precursor by neutrophil elastase and proteinase 3. PLoS One. 2012; 7(3):e32469. PMID: 22448222; PMCID: PMC3308943.
      14. Rapireddy S, Nhon L, Meehan RE, Franks J, Stolz DB, Tran D, Selsted M, Ly DH. RTD-1mimic containing ?PNA scaffold exhibits broad-spectrum antibacterial activities. J Am Chem Soc. 2012 Mar 07; 134(9):4041-4. PMID: 22332599; PMCID: PMC4848027.
      15. Mastroianni JR, Costales JK, Zaksheske J, Selsted M, Salzman NH, Ouellette AJ. Alternative luminal activation mechanisms for paneth cell a-defensins. J Biol Chem. 2012 Mar 30; 287(14):11205-12. PMID: 22334698; PMCID: PMC3322892.
      16. Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted M, Dorrestein PC, Pevzner PA. Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases. J Proteome Res. 2011 Oct 07; 10(10):4505-12. PMID: 21851130; PMCID: PMC3242011.
      17. Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted M, Wong GC. Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization. J Am Chem Soc. 2011 May 04; 133(17):6720-7. PMID: 21473577; PMCID: PMC3090259.
      18. Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted M. Rhesus macaque ?-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities. J Leukoc Biol. 2011 Feb; 89(2):283-90. PMID: 21084627; PMCID: PMC3024902.
      19. Seidel A, Ye Y, de Armas LR, Soto M, Yarosh W, Marcsisin RA, Tran D, Selsted M, Camerini D. Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms. PLoS One. 2010 Mar 17; 5(3):e9737. PMID: 20305815; PMCID: PMC2840026.
      20. Wohlford-Lenane CL, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted M, McCray PB. Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease. J Virol. 2009 Nov; 83(21):11385-90. PMID: 19710146; PMCID: PMC2772759.
      21. Tongaonkar P, Selsted M. SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides. J Biol Chem. 2009 Feb 27; 284(9):5602-9. PMID: 19109254; PMCID: PMC2645818.
      22. Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted M, Tan M. The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis. J Antimicrob Chemother. 2009 Jan; 63(1):115-23. PMID: 18957395; PMCID: PMC2721699.
      23. Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted M, Cocco MJ. Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque. J Biol Chem. 2008 Dec 19; 283(51):35869-77. PMID: 18930922; PMCID: PMC2602889.
      24. Garcia AE, Osapay G, Tran PA, Yuan J, Selsted M. Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes. Infect Immun. 2008 Dec; 76(12):5883-91. PMID: 18852242; PMCID: PMC2583559.
      25. Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted M. Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins. Antimicrob Agents Chemother. 2008 Mar; 52(3):944-53. PMID: 18160518; PMCID: PMC2258523.
      26. Selsted M. A pocket guide to explorations of the defensin field. Curr Pharm Des. 2007; 13(30):3061-4. PMID: 17979748.
        View in: PubMed
      27. Tydell CC, Yuan J, Tran P, Selsted M. Bovine peptidoglycan recognition protein-S: antimicrobial activity, localization, secretion, and binding properties. J Immunol. 2006 Jan 15; 176(2):1154-62. PMID: 16394004.
        View in: PubMed
      28. Selsted M, Ouellette AJ. Mammalian defensins in the antimicrobial immune response. Nat Immunol. 2005 Jun; 6(6):551-7. PMID: 15908936.
        View in: PubMed
      29. Selsted M. Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins. Curr Protein Pept Sci. 2004 Oct; 5(5):365-71. PMID: 15544531.
        View in: PubMed
      30. Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted M, Ouellette AJ. Paneth cell alpha-defensins from rhesus macaque small intestine. Infect Immun. 2004 Mar; 72(3):1470-8. PMID: 14977952; PMCID: PMC356057.
      31. Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted M, Ouellette AJ. Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions. J Biol Chem. 2004 Mar 19; 279(12):11976-83. PMID: 14702345.
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      32. Yamamoto CM, Banaiee N, Yount NY, Patel B, Selsted M. Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes. J Leukoc Biol. 2004 Feb; 75(2):332-41. PMID: 14634060.
        View in: PubMed
      33. Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted M, Ouellette AJ. Quantitative interactions between cryptdin-4 amino terminal variants and membranes. Peptides. 2003 Nov; 24(11):1795-805. PMID: 15019212.
        View in: PubMed
      34. Mackewicz CE, Yuan J, Tran P, Diaz L, Mack E, Selsted M, Levy JA. alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors. AIDS. 2003 Sep 26; 17(14):F23-32. PMID: 14502030.
        View in: PubMed
      35. Pecota DC, Osapay G, Selsted M, Wood TK. Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide. J Biotechnol. 2003 Jan 09; 100(1):1-12. PMID: 12413781.
        View in: PubMed
      36. Tang YQ, Yeaman MR, Selsted M. Antimicrobial peptides from human platelets. Infect Immun. 2002 Dec; 70(12):6524-33. PMID: 12438321; PMCID: PMC132966.
      37. Yue G, Merlin D, Selsted M, Lencer WI, Madara JL, Eaton DC. Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells. Am J Physiol Gastrointest Liver Physiol. 2002 May; 282(5):G757-65. PMID: 11960772.
        View in: PubMed
      38. Tydell CC, Yount N, Tran D, Yuan J, Selsted M. Isolation, characterization, and antimicrobial properties of bovine oligosaccharide-binding protein. A microbicidal granule protein of eosinophils and neutrophils. J Biol Chem. 2002 May 31; 277(22):19658-64. PMID: 11880375.
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      39. Tran D, Tran PA, Tang YQ, Yuan J, Cole T, Selsted M. Homodimeric theta-defensins from rhesus macaque leukocytes: isolation, synthesis, antimicrobial activities, and bacterial binding properties of the cyclic peptides. J Biol Chem. 2002 Feb 01; 277(5):3079-84. PMID: 11675394.
        View in: PubMed
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