Jobin Varkey, PhD

Title(s)Assistant Professor of Research Physiology and Neuroscience
SchoolKeck School of Medicine of Usc
Phone+1 323 442 0106
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    Collapse Biography 
    Collapse Education and Training
    University of Southern California, Los Angeles. USAPostdoctoral training07/2013Biochemistry/Molecular biology
    Centre for Cellular and Molecular Biology, Hyderabad, IndiaPhD05/2008Biochemistry/Life Sciences
    University of Allahabad, Allahabad, IndiaMS01/2002Biotechnology
    University of Rajasthan, Jaipur, IndiaBS05/1999Biotechnology
    Collapse Awards and Honors
    Department of Biotechnology, Government of India2013  - 2016DBT Ramalingaswami Fellowship
    Council of Scientific and Industrial Research, Government of India2004  - 2007Senior Research Fellowship
    Council of Scientific and Industrial Research, Government of India2002  - 2004Junior Research Fellowship
    Department of Biotechnology, Government of India1999  - 2001MS Scholarship

    Collapse Research 
    Collapse Research Activities and Funding
    Development of a novel tear-based biomarker assay for diagnosis of Parkinson's disease using RT-QuIC
    NIH/NIA R21AG066070Aug 1, 2020 - Apr 30, 2022
    Role: Co-PI

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Retraction Note: Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2024 Apr 05. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 38580816.
      View in: PubMed   Mentions:    Fields:    
    2. Fluorescent protein tagging promotes phase separation and alters the aggregation pathway of huntingtin exon-1. J Biol Chem. 2024 Jan; 300(1):105585. Pandey NK, Varkey J, Ajayan A, George G, Chen J, Langen R. PMID: 38141760; PMCID: PMC10825056.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    3. Molecular basis of Q-length selectivity for the MW1 antibody-huntingtin interaction. J Biol Chem. 2023 04; 299(4):104616. Bravo-Arredondo JM, Venkataraman R, Varkey J, Isas JM, Situ AJ, Xu H, Chen J, Ulmer TS, Langen R. PMID: 36931390; PMCID: PMC10124945.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    4. An Amphipathic Alpha-Helix Domain from Poliovirus 2C Protein Tubulate Lipid Vesicles. Viruses. 2020 12 18; 12(12). Varkey J, Zhang J, Kim J, George G, He G, Belov G, Langen R, Wang X. PMID: 33353144; PMCID: PMC7766222.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    5. Structural Model of the Proline-Rich Domain of Huntingtin Exon-1 Fibrils. Biophys J. 2020 11 17; 119(10):2019-2028. Falk AS, Bravo-Arredondo JM, Varkey J, Pacheco S, Langen R, Siemer AB. PMID: 33096080; PMCID: PMC7732765.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    6. E46K-like α-synuclein mutants increase lipid interactions and disrupt membrane selectivity. J Biol Chem. 2019 06 21; 294(25):9799-9812. Rovere M, Powers AE, Jiang H, Pitino JC, Fonseca-Ornelas L, Patel DS, Achille A, Langen R, Varkey J, Bartels T. PMID: 31048377; PMCID: PMC6597829.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    7. Construction of Parkinson's disease marker-based weighted protein-protein interaction network for prioritization of co-expressed genes. Gene. 2019 May 20; 697:67-77. George G, Valiya Parambath S, Lokappa SB, Varkey J. PMID: 30776463.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    8. Gene co-expression network analysis for identifying genetic markers in Parkinson's disease - a three-way comparative approach. Genomics. 2019 07; 111(4):819-830. George G, Singh S, Lokappa SB, Varkey J. PMID: 29852216.
      View in: PubMed   Mentions: 16     Fields:    Translation:HumansCells
    9. Membranes as modulators of amyloid protein misfolding and target of toxicity. Biochim Biophys Acta Biomembr. 2018 Sep; 1860(9):1863-1875. Rawat A, Langen R, Varkey J. PMID: 29702073; PMCID: PMC6203680.
      View in: PubMed   Mentions: 14     Fields:    
    10. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 03; 24(3):326-337. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. PMID: 29400711; PMCID: PMC5840035.
      View in: PubMed   Mentions: 183     Fields:    
    11. Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. J Magn Reson. 2017 07; 280:127-139. Varkey J, Langen R. PMID: 28579098; PMCID: PMC5461824.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    12. α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. PMID: 26644467; PMCID: PMC4732214.
      View in: PubMed   Mentions: 26     Fields:    Translation:HumansCells
    13. Early sodium dodecyl sulfate induced collapse of α-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. Basak S, Prasad GV, Varkey J, Chattopadhyay K. PMID: 25369246.
      View in: PubMed   Mentions: 4     Fields:    Translation:Cells
    14. Nonaggregated α-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. PMID: 24884175; PMCID: PMC4075992.
      View in: PubMed   Mentions: 43     Fields:    Translation:Cells
    15. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. PMID: 24082088; PMCID: PMC3800990.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    16. α-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. PMID: 23609437; PMCID: PMC3682563.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    17. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70. Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. PMID: 23161913; PMCID: PMC3523860.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    18. Remodeling of lipid vesicles into cylindrical micelles by α-synuclein in an extended α-helical conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. PMID: 22767608; PMCID: PMC3436199.
      View in: PubMed   Mentions: 55     Fields:    Translation:HumansCells
    19. Semisynthetic, site-specific ubiquitin modification of α-synuclein reveals differential effects on aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. PMID: 22404520; PMCID: PMC3315850.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCells
    20. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93. Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. PMID: 20693280; PMCID: PMC2952250.
      View in: PubMed   Mentions: 164     Fields:    Translation:HumansAnimalsCells
    21. Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. Varkey J, Singh S, Nagaraj R. PMID: 16914230.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    22. Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. Varkey J, Nagaraj R. PMID: 16251296; PMCID: PMC1280114.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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