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    Jobin Varkey, PhD

    TitleAssistant Professor of Research Physiology and Neuroscience
    SchoolKeck School of Medicine of USC
    DepartmentZilkha Neurogenetic Institute
    AddressZNI 121, 1501 San Pablo Street
    Health Sciences Campus
    Los Angeles California 90033
    Phone+1 323 442 0106
    vCardDownload vCard

      Collapse Biography 
      Collapse Education and Training
      University of Southern California, Los Angeles. USAPostdoctoral training07/2013Biochemistry/Molecular biology
      Centre for Cellular and Molecular Biology, Hyderabad, IndiaPhD05/2008Biochemistry/Life Sciences
      University of Allahabad, Allahabad, IndiaMS01/2002Biotechnology
      University of Rajasthan, Jaipur, IndiaBS05/1999Biotechnology
      Collapse Awards and Honors
      Department of Biotechnology, Government of India2013  - 2016DBT Ramalingaswami Fellowship
      Council of Scientific and Industrial Research, Government of India2004  - 2007Senior Research Fellowship
      Council of Scientific and Industrial Research, Government of India2002  - 2004Junior Research Fellowship
      Department of Biotechnology, Government of India1999  - 2001MS Scholarship

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. Montagne A, Nikolakopoulou AM, Zhao Z, Sagare AP, Si G, Lazic D, Barnes SR, Daianu M, Ramanathan A, Go A, Lawson EJ, Wang Y, Mack WJ, Thompson PM, Schneider JA, Varkey J, Langen R, Mullins E, Jacobs RE, Zlokovic BV. Pericyte degeneration causes white matter dysfunction in the mouse central nervous system. Nat Med. 2018 Feb 05. PMID: 29400711.
        View in: PubMed
      2. Varkey J, Langen R. Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR. J Magn Reson. 2017 Jul; 280:127-139. PMID: 28579098.
        View in: PubMed
      3. Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC. a-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils. J Biol Chem. 2016 Jan 29; 291(5):2310-8. PMID: 26644467; PMCID: PMC4732214 [Available on 01/29/17].
      4. Basak S, Prasad GV, Varkey J, Chattopadhyay K. Early sodium dodecyl sulfate induced collapse of a-synuclein correlates with its amyloid formation. ACS Chem Neurosci. 2015 Feb 18; 6(2):239-46. PMID: 25369246.
        View in: PubMed
      5. Lai Y, Kim S, Varkey J, Lou X, Song JK, Diao J, Langen R, Shin YK. Nonaggregated a-synuclein influences SNARE-dependent vesicle docking via membrane binding. Biochemistry. 2014 Jun 24; 53(24):3889-96. PMID: 24884175; PMCID: PMC4075992.
      6. Cheng CY, Varkey J, Ambroso MR, Langen R, Han S. Hydration dynamics as an intrinsic ruler for refining protein structure at lipid membrane interfaces. Proc Natl Acad Sci U S A. 2013 Oct 15; 110(42):16838-43. PMID: 24082088; PMCID: PMC3800990.
      7. Varkey J, Mizuno N, Hegde BG, Cheng N, Steven AC, Langen R. a-Synuclein oligomers with broken helical conformation form lipoprotein nanoparticles. J Biol Chem. 2013 Jun 14; 288(24):17620-30. PMID: 23609437; PMCID: PMC3682563.
      8. Ladiwala AR, Bhattacharya M, Perchiacca JM, Cao P, Raleigh DP, Abedini A, Schmidt AM, Varkey J, Langen R, Tessier PM. Rational design of potent domain antibody inhibitors of amyloid fibril assembly. Proc Natl Acad Sci U S A. 2012 Dec 04; 109(49):19965-70. PMID: 23161913; PMCID: PMC3523860.
      9. Mizuno N, Varkey J, Kegulian NC, Hegde BG, Cheng N, Langen R, Steven AC. Remodeling of lipid vesicles into cylindrical micelles by a-synuclein in an extended a-helical conformation. J Biol Chem. 2012 Aug 24; 287(35):29301-11. PMID: 22767608; PMCID: PMC3436199.
      10. Meier F, Abeywardana T, Dhall A, Marotta NP, Varkey J, Langen R, Chatterjee C, Pratt MR. Semisynthetic, site-specific ubiquitin modification of a-synuclein reveals differential effects on aggregation. J Am Chem Soc. 2012 Mar 28; 134(12):5468-71. PMID: 22404520; PMCID: PMC3315850.
      11. Varkey J, Isas JM, Mizuno N, Jensen MB, Bhatia VK, Jao CC, Petrlova J, Voss JC, Stamou DG, Steven AC, Langen R. Membrane curvature induction and tubulation are common features of synucleins and apolipoproteins. J Biol Chem. 2010 Oct 15; 285(42):32486-93. PMID: 20693280; PMCID: PMC2952250.
      12. Varkey J, Singh S, Nagaraj R. Antibacterial activity of linear peptides spanning the carboxy-terminal beta-sheet domain of arthropod defensins. Peptides. 2006 Nov; 27(11):2614-23. PMID: 16914230.
        View in: PubMed
      13. Varkey J, Nagaraj R. Antibacterial activity of human neutrophil defensin HNP-1 analogs without cysteines. Antimicrob Agents Chemother. 2005 Nov; 49(11):4561-6. PMID: 16251296; PMCID: PMC1280114.