Olivier Pernet

Title(s)Assistant Professor of Research Pediatrics
SchoolKeck School of Medicine of Usc
Address1333 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Awards and Honors
    University, Rennes, France2005Academic Excellence Award - Rennes
    Paris VII University, Paris, France2006Master Degree with honors
    École Normale Supérieure de Lyon, Lyon, France2009Doctorate Degree with highest distinction
    Clinical and Translational Science Institute (CTSI)2017Core Voucher Award
    The 2017 Palm Springs Symposium on HIV/AIDS2017HIV Disease from Resistance to Cure” Award
    Nature Microbiology2018NSV-2018 Nature Microbiology Poster Award

    Collapse Overview 
    Collapse Overview
    Dr. Olivier Pernet is a virologist with over 15 years of research experience in the field of emerging zoonotic viruses, with a special attention on bat related diseases (Nipah Virus, Ebola Virus, SARS-CoV-1, SARS-CoV-2,...). Dr. Pernet work focuses on host-virus interactions and how to use them for biomedical applications (outbreak preparedness, surveillance, high-throughput serology, drug discovery, gene therapy,...).
    After a brief period at bioMérieux where he worked on SARS-CoV-1 detection assay, Dr. Pernet moved to Paris and completed a Master Degree in Medical Virology at the Paris Diderot University and the Institut Pasteur. He then joined the École Normale Supérieure de Lyon for his PhD under the mentorship of Dr. Robin Buckland. There he studied Henipaviruses cellular entry in the Bio-Safety Level 4 Jean Mérieux "P4" laboratory. During his time in Lyon, he unraveled a new entry model for Paramyxoviruses and identify drugs with the potential to treat the dreaded Nipah Virus. He also worked on antivirals targeting Ebola Virus and Crimean-Congo Hemorrhagic Fever Virus. Additionally, while in France Dr. Pernet worked on outbreak prevention and mitigation by studying viral shedding in bats from France and Mali.
    Dr. Pernet then moved to the US on a joint position at UCLA and UTMB/Galveston National Laboratory. Under the supervision of Dr. Benhur Lee and Dr. Alexander Freiberg, he continued his work on viral entry, using the Henipavirus glycoproteins to design new vectors for gene therapy. While at UCLA, Dr. Pernet also documented the first human cases of Henipavirus on the African continent and identified risk factors for zoonotic transmission in Cameroon.
    He has since moved on to become a faculty at Keck Medicine of USC, in the department of Pediatrics where he works on immune response toward viral (co)infections in LA's highly diverse population. During the ongoing COVID-19 outbreak, Dr. Pernet has continued his work at Keck Medicine of USC, where he developed a highly sensitive saliva-based assays against SARS-CoV-2 in order to increase hospitals testing capacities in the early days of the pandemic, and then worked the immune system interaction with COVID-19, vaccine response, and mother to child transmission of SARS-CoV-2.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. In vivo selection of anti-HIV-1 gene-modified human hematopoietic stem/progenitor cells to enhance engraftment and HIV-1 inhibition. Mol Ther. 2024 Feb 07; 32(2):384-394. Guo Q, Zhang J, Parikh K, Brinkley A, Lin S, Zakarian C, Pernet O, Shimizu S, Khamaikawin W, Hacke K, Kasahara N, An DS. PMID: 38087779; PMCID: PMC10862071.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Association between levels of receptor binding domain antibodies of SARS-CoV-2, receipt of booster and risk of breakthrough infections: LA pandemic surveillance cohort study. Sci Rep. 2023 11 25; 13(1):20761. Sood N, Lam CN, Kawaguchi E, Pernet O, Kovacs A, Unger JB, Hu H. PMID: 38007568; PMCID: PMC10676434.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCellsPHPublic Health
    3. SARS-CoV-2 viral variants can rapidly be identified for clinical decision making and population surveillance using a high-throughput digital droplet PCR assay. Sci Rep. 2023 05 10; 13(1):7612. Pernet O, Weisenhaus M, Stafylis C, Williams C, Campan M, Pettersson J, Green N, Lee DM, Thomas PD, Ward P, Hu H, Klausner JD, Kovacs AAZ, U. S. C. Variant Study Group. PMID: 37165019; PMCID: PMC10170421.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCellsPHPublic Health
    4. Surveillance of Severe Acute Respiratory Syndrome Coronavirus 2 and Variants Using Digital Droplet Polymerase Chain Reaction at a Large University and Healthcare System in California. Open Forum Infect Dis. 2023 Apr; 10(4):ofad147. Stafylis C, Pernet O, Hernandez-Tamayo C, Kovacs A, Emerson J, Ward PM, Van Orman S, Gilliland F, Conti D, Weisenhaus M, Ghanem-Uzqueda A, Yepez D, Stellar S, Tadanki AP, Max J, Fottrell H, Ong E, Navarro S, Moses K, Akaolisa M, Hosseini B, Sunesara S, Wang Y, Strum E, Casagrande Y, Arenas N, Williams C, Thomas P, Chu T, Hu H, Klausner JD. PMID: 37089777; PMCID: PMC10117372.
      View in: PubMed   Mentions: 1  
    5. Quantification of Severe Acute Respiratory Syndrome Coronavirus 2 Binding Antibody Levels To Assess Infection and Vaccine-Induced Immunity Using WHO Standards. Microbiol Spectr. 2023 02 14; 11(1):e0370922. Pernet O, Balog S, Kawaguchi ES, Lam CN, Anthony P, Simon P, Kotha R, Sood N, Hu H, Kovacs A. PMID: 36688648; PMCID: PMC9927585.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCellsPHPublic Health
    6. The Evolutionary Dance between Innate Host Antiviral Pathways and SARS-CoV-2. Pathogens. 2022 May 03; 11(5). Aliyari SR, Quanquin N, Pernet O, Zhang S, Wang L, Cheng G. PMID: 35631059; PMCID: PMC9147806.
      View in: PubMed   Mentions: 3  
    7. Suppressing fatty acid synthase by type I interferon and chemical inhibitors as a broad spectrum anti-viral strategy against SARS-CoV-2. Acta Pharm Sin B. 2022 Apr; 12(4):1624-1635. Aliyari SR, Ghaffari AA, Pernet O, Parvatiyar K, Wang Y, Gerami H, Tong AJ, Vergnes L, Takallou A, Zhang A, Wei X, Chilin LD, Wu Y, Semenkovich CF, Reue K, Smale ST, Lee B, Cheng G. PMID: 35251918; PMCID: PMC8883762.
      View in: PubMed   Mentions: 7  
    8. Seroprevalence of Antibodies Specific to Receptor Binding Domain of SARS-CoV-2 and Vaccination Coverage Among Adults in Los Angeles County, April 2021: The LA Pandemic Surveillance Cohort Study. JAMA Netw Open. 2022 01 04; 5(1):e2144258. Sood N, Pernet O, Lam CN, Klipp A, Kotha R, Kovacs A, Hu H. PMID: 35050360; PMCID: PMC8777558.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCellsPHPublic Health
    9. Nipah Virus C Protein Recruits Tsg101 to Promote the Efficient Release of Virus in an ESCRT-Dependent Pathway. PLoS Pathog. 2016 05; 12(5):e1005659. Park A, Yun T, Vigant F, Pernet O, Won ST, Dawes BE, Bartkowski W, Freiberg AN, Lee B. PMID: 27203423; PMCID: PMC4874542.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    10. Stem cell-based therapies for HIV/AIDS. Adv Drug Deliv Rev. 2016 08 01; 103:187-201. Pernet O, Yadav SS, An DS. PMID: 27151309; PMCID: PMC4935568.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    11. Molecular recognition of human ephrinB2 cell surface receptor by an emergent African henipavirus. Proc Natl Acad Sci U S A. 2015 Apr 28; 112(17):E2156-65. Lee B, Pernet O, Ahmed AA, Zeltina A, Beaty SM, Bowden TA. PMID: 25825759; PMCID: PMC4418902.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    12. Timing of galectin-1 exposure differentially modulates Nipah virus entry and syncytium formation in endothelial cells. J Virol. 2015 Mar; 89(5):2520-9. Garner OB, Yun T, Pernet O, Aguilar HC, Park A, Bowden TA, Freiberg AN, Lee B, Baum LG. PMID: 25505064; PMCID: PMC4325760.
      View in: PubMed   Mentions: 24     Fields:    Translation:HumansCells
    13. Evidence for henipavirus spillover into human populations in Africa. Nat Commun. 2014 Nov 18; 5:5342. Pernet O, Schneider BS, Beaty SM, LeBreton M, Yun TE, Park A, Zachariah TT, Bowden TA, Hitchens P, Ramirez CM, Daszak P, Mazet J, Mazet J, Freiberg AN, Wolfe ND, Lee B. PMID: 25405640; PMCID: PMC4237230.
      View in: PubMed   Mentions: 94     Fields:    Translation:HumansAnimalsCells
    14. Efficient reverse genetics reveals genetic determinants of budding and fusogenic differences between Nipah and Hendra viruses and enables real-time monitoring of viral spread in small animal models of henipavirus infection. J Virol. 2015 Jan 15; 89(2):1242-53. Yun T, Park A, Hill TE, Pernet O, Beaty SM, Juelich TL, Smith JK, Zhang L, Wang YE, Vigant F, Gao J, Wu P, Lee B, Freiberg AN. PMID: 25392218; PMCID: PMC4300668.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    15. Functional rectification of the newly described African henipavirus fusion glycoprotein (Gh-M74a). J Virol. 2014 May; 88(9):5171-6. Pernet O, Beaty S, Lee B. PMID: 24522929; PMCID: PMC3993810.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    16. Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol. Immunity. 2013 Jan 24; 38(1):92-105. Liu SY, Aliyari R, Chikere K, Li G, Marsden MD, Smith JK, Pernet O, Guo H, Nusbaum R, Zack JA, Freiberg AN, Su L, Lee B, Cheng G. PMID: 23273844; PMCID: PMC3698975.
      View in: PubMed   Mentions: 332     Fields:    Translation:HumansAnimalsCells
    17. Nipah virus envelope-pseudotyped lentiviruses efficiently target ephrinB2-positive stem cell populations in vitro and bypass the liver sink when administered in vivo. J Virol. 2013 Feb; 87(4):2094-108. Palomares K, Vigant F, Van Handel B, Pernet O, Chikere K, Hong P, Sherman SP, Patterson M, An DS, Lowry WE, Mikkola HK, Morizono K, Pyle AD, Lee B. PMID: 23192877; PMCID: PMC3571488.
      View in: PubMed   Mentions: 22     Fields:    Translation:HumansAnimalsCells
    18. Henipavirus receptor usage and tropism. Curr Top Microbiol Immunol. 2012; 359:59-78. Pernet O, Wang YE, Lee B. PMID: 22695915; PMCID: PMC3587688.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansAnimalsCells
    19. Regulation of the nucleocytoplasmic trafficking of viral and cellular proteins by ubiquitin and small ubiquitin-related modifiers. Biol Cell. 2012 Mar; 104(3):121-38. Wang YE, Pernet O, Lee B. PMID: 22188262; PMCID: PMC3625690.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    20. Nipah virus entry can occur by macropinocytosis. Virology. 2009 Dec 20; 395(2):298-311. Pernet O, Pohl C, Ainouze M, Kweder H, Buckland R. PMID: 19854459.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
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