Megan Laura McCain, PhD

Title(s)Assistant Professor
SchoolViterbi School of Engineering, BME
Phone+1 213 821 0791
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    McCain Lab Website

    Megan L. McCain earned her bachelor’s degree in biomedical engineering from Washington University in St. Louis in 2006. As an undergraduate, she worked as a summer intern in the Worldwide Safety Sciences Department at Pfizer, Inc., and in the Research Resources Branch at the National Institute on Aging. She completed her doctoral studies in the School of Engineering and Applied Sciences at Harvard University, including one year abroad in the Department of Physiology at the University of Bern, Switzerland. While a graduate student, Megan was the recipient of an American Heart Association Pre-doctoral Fellowship and the Derek Bok Certificate of Distinction in Teaching. She received her PhD in Engineering and Applied Sciences in 2012 and continued at Harvard University as a postdoctoral fellow at the Wyss Institute for Biologically Inspired Engineering. McCain joined the Department of Biomedical Engineering at University of Southern California in January 2014. She has a secondary appointment in the Department of Stem Cell Biology and Regenerative Medicine at the Keck School of Medicine of USC. She is a member of the Biomedical Engineering Society (BMES), American Society for Cell Biology (ASCB) and the American Heart Association (AHA).

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    Establishing Mechanisms of Human Proximal Tubule Regeneration in an Engineered Organ on Chip Platform
    NIH/NIBIB R21EB025534Sep 23, 2017 - Jul 31, 2019
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Ariyasinghe NR, Lyra-Leite DM, McCain ML. Engineering cardiac microphysiological systems to model pathological extracellular matrix remodeling. Am J Physiol Heart Circ Physiol. 2018 Oct 01; 315(4):H771-H789. PMID: 29906229.
      View in: PubMed
    2. Cho N, Razipour SE, McCain ML. Featured Article: TGF-ß1 dominates extracellular matrix rigidity for inducing differentiation of human cardiac fibroblasts to myofibroblasts. Exp Biol Med (Maywood). 2018 04; 243(7):601-612. PMID: 29504479.
      View in: PubMed
    3. Ariyasinghe NR, Reck CH, Viscio AA, Petersen AP, Lyra-Leite DM, Cho N, McCain ML. Engineering micromyocardium to delineate cellular and extracellular regulation of myocardial tissue contractility. Integr Biol (Camb). 2017 09 18; 9(9):730-741. PMID: 28726917.
      View in: PubMed
    4. Lyra-Leite DM, Andres AM, Petersen AP, Ariyasinghe NR, Cho N, Lee JA, Gottlieb RA, McCain ML. Mitochondrial function in engineered cardiac tissues is regulated by extracellular matrix elasticity and tissue alignment. Am J Physiol Heart Circ Physiol. 2017 Oct 01; 313(4):H757-H767. PMID: 28733449.
      View in: PubMed
    5. Sheehy SP, Grosberg A, Qin P, Behm DJ, Ferrier JP, Eagleson MA, Nesmith AP, Krull D, Falls JG, Campbell PH, McCain ML, Willette RN, Hu E, Parker KK. Toward improved myocardial maturity in an organ-on-chip platform with immature cardiac myocytes. Exp Biol Med (Maywood). 2017 11; 242(17):1643-1656. PMID: 28343439.
      View in: PubMed
    6. Suh GC, Bettadapur A, Santoso JW, McCain ML. Fabrication of Micromolded Gelatin Hydrogels for Long-Term Culture of Aligned Skeletal Myotubes. Methods Mol Biol. 2017; 1668:147-163. PMID: 28842908.
      View in: PubMed
    7. Bettadapur A, Suh GC, Geisse NA, Wang ER, Hua C, Huber HA, Viscio AA, Kim JY, Strickland JB, McCain ML. Prolonged Culture of Aligned Skeletal Myotubes on Micromolded Gelatin Hydrogels. Sci Rep. 2016 06 28; 6:28855. PMID: 27350122.
      View in: PubMed
    8. Aratyn-Schaus Y, Pasqualini FS, Yuan H, McCain ML, Ye GJ, Sheehy SP, Campbell PH, Parker KK. Coupling primary and stem cell-derived cardiomyocytes in an in vitro model of cardiac cell therapy. J Cell Biol. 2016 Feb 15; 212(4):389-97. PMID: 26858266; PMCID: PMC4754718.
    9. Horton RE, Yadid M, McCain ML, Sheehy SP, Pasqualini FS, Park SJ, Cho A, Campbell P, Parker KK. Angiotensin II Induced Cardiac Dysfunction on a Chip. PLoS One. 2016; 11(1):e0146415. PMID: 26808388; PMCID: PMC4725954.
    10. Lee H, Adams WJ, Alford PW, McCain ML, Feinberg AW, Sheehy SP, Goss JA, Parker KK. Cytoskeletal prestress regulates nuclear shape and stiffness in cardiac myocytes. Exp Biol Med (Maywood). 2015 Nov; 240(11):1543-54. PMID: 25908635; PMCID: PMC4778402.
    11. Nesmith AP, Agarwal A, McCain ML, Parker KK. Human airway musculature on a chip: an in vitro model of allergic asthmatic bronchoconstriction and bronchodilation. Lab Chip. 2014 Oct 21; 14(20):3925-36. PMID: 25093641; PMCID: PMC4167568.
    12. Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q, Ding J, Chen J, Wang DZ, Li K, Wang J, Wanders RJ, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK, Pu WT. Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies. Nat Med. 2014 Jun; 20(6):616-23. PMID: 24813252.
      View in: PubMed
    13. McCain ML, Desplantez T, Kléber AG. Engineering cardiac cell junctions in vitro to study the intercalated disc. Cell Commun Adhes. 2014 Jun; 21(3):181-91. PMID: 24754499.
      View in: PubMed
    14. McCain ML, Agarwal A, Nesmith HW, Nesmith AP, Parker KK. Micromolded gelatin hydrogels for extended culture of engineered cardiac tissues. Biomaterials. 2014 Jul; 35(21):5462-71. PMID: 24731714.
      View in: PubMed
    15. McCain ML, Yuan H, Pasqualini FS, Campbell PH, Parker KK. Matrix elasticity regulates the optimal cardiac myocyte shape for contractility. Am J Physiol Heart Circ Physiol. 2014 Jun 01; 306(11):H1525-39. PMID: 24682394.
      View in: PubMed
    16. Agarwal A, Goss JA, Cho A, McCain ML, Parker KK. Microfluidic heart on a chip for higher throughput pharmacological studies. Lab Chip. 2013 Sep 21; 13(18):3599-608. PMID: 23807141; PMCID: PMC3786400.
    17. Agarwal A, Farouz Y, Nesmith AP, Deravi LF, McCain ML, Parker KK. Micropatterning Alginate Substrates for in vitro Cardiovascular Muscle on a Chip. Adv Funct Mater. 2013 Aug 12; 23(30):3738-3746. PMID: 26213529.
      View in: PubMed
    18. McCain ML, Sheehy SP, Grosberg A, Goss JA, Parker KK. Recapitulating maladaptive, multiscale remodeling of failing myocardium on a chip. Proc Natl Acad Sci U S A. 2013 Jun 11; 110(24):9770-5. PMID: 23716679.
      View in: PubMed
    19. Nawroth JC, Lee H, Feinberg AW, Ripplinger CM, McCain ML, Grosberg A, Dabiri JO, Parker KK. A tissue-engineered jellyfish with biomimetic propulsion. Nat Biotechnol. 2012 Aug; 30(8):792-7. PMID: 22820316.
      View in: PubMed
    20. McCain ML, Lee H, Aratyn-Schaus Y, Kléber AG, Parker KK. Cooperative coupling of cell-matrix and cell-cell adhesions in cardiac muscle. Proc Natl Acad Sci U S A. 2012 Jun 19; 109(25):9881-6. PMID: 22675119; PMCID: PMC3382528.
    21. Beauchamp P, Desplantez T, McCain ML, Li W, Asimaki A, Rigoli G, Parker KK, Saffitz JE, Kleber AG. Electrical coupling and propagation in engineered ventricular myocardium with heterogeneous expression of connexin43. Circ Res. 2012 May 25; 110(11):1445-53. PMID: 22518032; PMCID: PMC3381798.
    22. Grosberg A, Nesmith AP, Goss JA, Brigham MD, McCain ML, Parker KK. Muscle on a chip: in vitro contractility assays for smooth and striated muscle. J Pharmacol Toxicol Methods. 2012 May-Jun; 65(3):126-35. PMID: 22521339; PMCID: PMC4184427.
    23. Desplantez T, McCain ML, Beauchamp P, Rigoli G, Rothen-Rutishauser B, Parker KK, Kleber AG. Connexin43 ablation in foetal atrial myocytes decreases electrical coupling, partner connexins, and sodium current. Cardiovasc Res. 2012 Apr 01; 94(1):58-65. PMID: 22287588; PMCID: PMC3307380.
    24. McCain ML, Desplantez T, Geisse NA, Rothen-Rutishauser B, Oberer H, Parker KK, Kleber AG. Cell-to-cell coupling in engineered pairs of rat ventricular cardiomyocytes: relation between Cx43 immunofluorescence and intercellular electrical conductance. Am J Physiol Heart Circ Physiol. 2012 Jan; 302(2):H443-50. PMID: 22081700; PMCID: PMC3339855.
    25. Grosberg A, Alford PW, McCain ML, Parker KK. Ensembles of engineered cardiac tissues for physiological and pharmacological study: heart on a chip. Lab Chip. 2011 Dec 21; 11(24):4165-73. PMID: 22072288; PMCID: PMC4038963.
    26. McCain ML, Parker KK. Mechanotransduction: the role of mechanical stress, myocyte shape, and cytoskeletal architecture on cardiac function. Pflugers Arch. 2011 Jul; 462(1):89-104. PMID: 21499986.
      View in: PubMed
    27. Hucker WJ, McCain ML, Laughner JI, Iaizzo PA, Efimov IR. Connexin 43 expression delineates two discrete pathways in the human atrioventricular junction. Anat Rec (Hoboken). 2008 Feb; 291(2):204-15. PMID: 18085635; PMCID: PMC2756604.
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