Fumito Ito, MD, PhD

Title(s)Associate Professor of Surgery and Molecular Microbiology and Immunology
SchoolKeck School of Medicine of Usc
Address1520 San Pablo St.
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0002-6866-671X Additional info
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    Other Positions
    Title(s)Co-Leader of the Translational and Clinical Sciences Research (TACS) Program


    Collapse Biography 
    Collapse Education and Training
    University of Michigan, Ann Arbor, MIResearch Fellowship06/2003Tumor Immunology
    University of Wisconsin, Madison, WIResidency06/2008Surgery
    Roswell Park Comprehensive Cancer Center, Buffalo, NYClinical Fellowship06/2010Surgical Oncology
    Collapse Awards and Honors
    Society of Thermal Medicine2010New Investigator Award
    American College of Surgeons2014Faculty Research Fellowship Award
    Central Surgical Association Foundation2014Turcotte Enrichment Award
    Melanoma Research Alliance2015Young Investigator Award
    Department of Defense2019Investigator Initiated Translational Research Award
    Cancer Research Institute2019Technology Impact Award
    METAvivor2021Translational Research Award

    Collapse Overview 
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Early on-treatment blood-based biomarkers for prediction of response to immunotherapy in melanoma
    NIH/NCATS Apr 1, 2023 - Mar 31, 2024
    Role: PI
    Description: The objective of this project is to assess the utility of IL-6 as a marker to predict response to immunotherapy in melanoma patients
    In situ radioimmunotherapy to maximize the engagement of cross-presenting dendritic cells to treat metastatic breast cancer
    METAvivor Translational Research AwardOct 1, 2022 - Sep 30, 2024
    Role: Principal Investigator
    Lung Cancer Early Detection and Immunotherapy Response Prediction and Monitoring with an Exo-PROS Liquid Biopsy
    NIH R01CA272827Sep 1, 2022 - Aug 31, 2027
    Role: Co-PI
    In situ radioimmunotherapy to maximize the engagement of conventional type 1 dendritic cells against non-T cell-inflamed tumors
    NIH R01CA255240Aug 1, 2021 - Jul 31, 2026
    Role: Principal Investigator
    Adoptive Cell Therapy with Rejuvenated Antigen-Specific T Cells
    NIH K08CA197966Aug 25, 2015 - Jul 31, 2020
    Role: Principal Investigator

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases. NPJ Precis Oncol. 2023 Nov 14; 7(1):120. In GK, Ribeiro JR, Yin J, Xiu J, Bustos MA, Ito F, Chow F, Zada G, Hwang L, Salama AKS, Park SJ, Moser JC, Darabi S, Domingo-Musibay E, Ascierto ML, Margolin K, Lutzky J, Gibney GT, Atkins MB, Izar B, Hoon DSB, VanderWalde AM. PMID: 37964004; PMCID: PMC10646102.
      View in: PubMed   Mentions: 2  
    2. Fluctuations in Gut Microbiome Composition During Immune Checkpoint Inhibitor Therapy. World J Oncol. 2023 Jun; 14(3):178-187. Sarkar J, Cortes Gomez E, Oba T, Chen H, Dy GK, Segal BH, Ernstoff MS, Ito F. PMID: 37350807; PMCID: PMC10284636.
      View in: PubMed   Mentions: 1  
    3. Predictive and Prognostic Implications of Circulating CX3CR1+ CD8+ T Cells in Non-Small Cell Lung Cancer Patients Treated with Chemo-Immunotherapy. Cancer Res Commun. 2023 03; 3(3):510-520. Abdelfatah E, Long MD, Kajihara R, Oba T, Yamauchi T, Chen H, Sarkar J, Attwood K, Matsuzaki J, Segal BH, Dy GK, Ito F. PMID: 37009132; PMCID: PMC10060186.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    4. Axillary lymph node recurrence following wire-directed sentinel lymph node dissection for breast cancer patients with biopsy-proven axillary metastases prior to neoadjuvant chemotherapy at a safety net medical center. J Surg Oncol. 2023 Jul; 128(1):9-15. Sargent RE, Siegel E, Ito F, Kramme K, Kraft E, Hendrix V, Carr AA, Nelson ME, Bian SX, Jayachandran P, Sener SF. PMID: 36933187.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    5. Tcf-1 protects anti-tumor TCR-engineered CD8+ T-cells from GzmB mediated self-destruction. Cancer Immunol Immunother. 2022 Dec; 71(12):2881-2898. Zangari B, Tsuji T, Matsuzaki J, Mohammadpour H, Eppolito C, Battaglia S, Ito F, Chodon T, Koya R, Robert McGray AJ, Odunsi K. PMID: 35460379; PMCID: PMC9588092.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    6. Generation of cDC-like cells from human induced pluripotent stem cells via Notch signaling. J Immunother Cancer. 2022 01; 10(1). Makino K, Long MD, Kajihara R, Matsueda S, Oba T, Kanehira K, Liu S, Ito F. PMID: 35101945; PMCID: PMC8804689.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    7. Immunization with short peptide particles reveals a functional CD8+ T-cell neoepitope in a murine renal carcinoma model. J Immunother Cancer. 2021 12; 9(12). He X, Zhou S, Dolan M, Shi Y, Wang J, Quinn B, Jahagirdar D, Huang WC, Tsuji M, Pili R, Ito F, Ortega J, Abrams SI, Ebos JML, Lovell JF. PMID: 34862254; PMCID: PMC8647534.
      View in: PubMed   Mentions: 8     Fields:    Translation:AnimalsCells
    8. Local, multimodal intralesional therapy renders distant brain metastases susceptible to PD-L1 blockade in a preclinical model of triple-negative breast cancer. Sci Rep. 2021 11 09; 11(1):21992. Yokoi T, Oba T, Kajihara R, Abrams SI, Ito F. PMID: 34754037; PMCID: PMC8578367.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    9. Position-Scanning Peptide Libraries as Particle Immunogens for Improving CD8+ T-Cell Responses. Adv Sci (Weinh). 2021 12; 8(24):e2103023. He X, Zhou S, Quinn B, Huang WC, Jahagirdar D, Vega M, Ortega J, Long MD, Ito F, Abrams SI, Lovell JF. PMID: 34716694; PMCID: PMC8693074.
      View in: PubMed   Mentions: 5     Fields:    Translation:AnimalsCells
    10. Neoadjuvant In Situ Immunomodulation Enhances Systemic Antitumor Immunity against Highly Metastatic Tumors. Cancer Res. 2021 12 15; 81(24):6183-6195. Oba T, Kajihara R, Yokoi T, Repasky EA, Ito F. PMID: 34666993; PMCID: PMC8678344.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    11. Multimodal Intralesional Therapy for Reshaping the Myeloid Compartment of Tumors Resistant to Anti-PD-L1 Therapy via IRF8 Expression. J Immunol. 2021 09 01; 207(5):1298-1309. Patel A, Oba T, Kajihara R, Yokoi T, Abrams SI, Ito F. PMID: 34362833; PMCID: PMC8387427.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimalsCells
    12. Clinical characteristics, time course, treatment and outcomes of patients with immune checkpoint inhibitor-associated myocarditis. J Immunother Cancer. 2021 06; 9(6). Puzanov I, Subramanian P, Yatsynovich YV, Jacobs DM, Chilbert MR, Sharma UC, Ito F, Feuerstein SG, Stefanovic F, Switzer B, Hicar MD, Curtis AB, Spangenthal EJ, Dy GK, Ernstoff MS, Vachhani P, Page BJ, Agrawal N, Khunger A, Kapoor A, Hattoum A, Schentag JJ. PMID: 34162715; PMCID: PMC8231054.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    13. CD40 and CD80/86 signaling in cDC1s mediate effective neoantigen vaccination and generation of antigen-specific CX3CR1+ CD8+ T cells. Cancer Immunol Immunother. 2022 Jan; 71(1):137-151. Yamauchi T, Hoki T, Oba T, Kajihara R, Attwood K, Cao X, Ito F. PMID: 34037810; PMCID: PMC8715856.
      View in: PubMed   Mentions: 10     Fields:    Translation:AnimalsCellsPHPublic Health
    14. In situ delivery of iPSC-derived dendritic cells with local radiotherapy generates systemic antitumor immunity and potentiates PD-L1 blockade in preclinical poorly immunogenic tumor models. J Immunother Cancer. 2021 05; 9(5). Oba T, Makino K, Kajihara R, Yokoi T, Araki R, Abe M, Minderman H, Chang AE, Odunsi K, Ito F. PMID: 34049930; PMCID: PMC8166607.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    15. T-cell CX3CR1 expression as a dynamic blood-based biomarker of response to immune checkpoint inhibitors. Nat Commun. 2021 03 03; 12(1):1402. Yamauchi T, Hoki T, Oba T, Jain V, Chen H, Attwood K, Battaglia S, George S, Chatta G, Puzanov I, Morrison C, Odunsi K, Segal BH, Dy GK, Ernstoff MS, Ito F. PMID: 33658501; PMCID: PMC7930182.
      View in: PubMed   Mentions: 68     Fields:    Translation:HumansAnimalsCells
    16. Defining best practices for tissue procurement in immuno-oncology clinical trials: consensus statement from the Society for Immunotherapy of Cancer Surgery Committee. J Immunother Cancer. 2020 11; 8(2). Gastman B, Agarwal PK, Berger A, Boland G, Broderick S, Butterfield LH, Byrd D, Fecci PE, Ferris RL, Fong Y, Goff SL, Grabowski MM, Ito F, Lim M, Lotze MT, Mahdi H, Malafa M, Morris CD, Murthy P, Neves RI, Odunsi A, Pai SI, Prabhakaran S, Rosenberg SA, Saoud R, Sethuraman J, Skitzki J, Slingluff CL, Sondak VK, Sunwoo JB, Turcotte S, Yeung CC, Kaufman HL. PMID: 33199512; PMCID: PMC7670953.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    17. Overcoming primary and acquired resistance to anti-PD-L1 therapy by induction and activation of tumor-residing cDC1s. Nat Commun. 2020 10 27; 11(1):5415. Oba T, Long MD, Keler T, Marsh HC, Minderman H, Abrams SI, Liu S, Ito F. PMID: 33110069; PMCID: PMC7592056.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansAnimalsCells
    18. A Critical Role of CD40 and CD70 Signaling in Conventional Type 1 Dendritic Cells in Expansion and Antitumor Efficacy of Adoptively Transferred Tumor-Specific T Cells. J Immunol. 2020 10 01; 205(7):1867-1877. Oba T, Hoki T, Yamauchi T, Keler T, Marsh HC, Cao X, Ito F. PMID: 32848036; PMCID: PMC7511447.
      View in: PubMed   Mentions: 20     Fields:    Translation:AnimalsCells
    19. CX3CR1-CD8+ T cells are critical in antitumor efficacy but functionally suppressed in the tumor microenvironment. JCI Insight. 2020 04 23; 5(8). Yamauchi T, Hoki T, Oba T, Saito H, Attwood K, Sabel MS, Chang AE, Odunsi K, Ito F. PMID: 32255766; PMCID: PMC7205436.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    20. In situ thermal ablation augments antitumor efficacy of adoptive T cell therapy. Int J Hyperthermia. 2019 11; 36(sup1):22-36. Ito F, Vardam TD, Appenheimer MM, Eng KH, Gollnick SO, Muhitch JB, Evans SS. PMID: 31795828; PMCID: PMC6897324.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    21. Induced Pluripotent Stem Cell-Derived T Cells for Cancer Immunotherapy. Surg Oncol Clin N Am. 2019 07; 28(3):489-504. Patel SJ, Yamauchi T, Ito F. PMID: 31079802; PMCID: PMC6516087.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    22. Low DMT1 Expression Associates With Increased Oxidative Phosphorylation and Early Recurrence in Hepatocellular Carcinoma. J Surg Res. 2019 02; 234:343-352. Hoki T, Katsuta E, Yan L, Takabe K, Ito F. PMID: 30527495; PMCID: PMC6291835.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    23. Generation of Tumor Antigen-Specific iPSC-Derived Thymic Emigrants Using a 3D Thymic Culture System. Cell Rep. 2018 03 20; 22(12):3175-3190. Vizcardo R, Klemen ND, Islam SMR, Gurusamy D, Tamaoki N, Yamada D, Koseki H, Kidder BL, Yu Z, Jia L, Henning AN, Good ML, Bosch-Marce M, Maeda T, Liu C, Abdullaev Z, Pack S, Palmer DC, Stroncek DF, Ito F, Flomerfelt FA, Kruhlak MJ, Restifo NP. PMID: 29562175; PMCID: PMC5930030.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    24. Emerging role of RNA binding protein UNR/CSDE1 in melanoma. J Xiangya Med. 2017 May; 2. Gandhi S, Ito F, Ernstoff MS. PMID: 30135958; PMCID: PMC6100785.
      View in: PubMed   Mentions:
    25. Generation of Induced Pluripotent Stem Cells from Human Melanoma Tumor-infiltrating Lymphocytes. J Vis Exp. 2016 11 11; (117). Saito H, Iwabuchi K, Fusaki N, Ito F. PMID: 27911363; PMCID: PMC5226217.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    26. Adoptive Transfer of CD8+ T Cells Generated from Induced Pluripotent Stem Cells Triggers Regressions of Large Tumors Along with Immunological Memory. Cancer Res. 2016 06 15; 76(12):3473-83. Saito H, Okita K, Chang AE, Ito F. PMID: 27197199; PMCID: PMC4911287.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    27. Pre-resectional Radiofrequency Ablation as a Neoadjuvant in situ Tumor Vaccine. J Vaccines Vaccin. 2016 Apr; 7(2). Ito F, Evans SS. PMID: 28944091; PMCID: PMC5606234.
      View in: PubMed   Mentions: 1  
    28. Reprogramming of Melanoma Tumor-Infiltrating Lymphocytes to Induced Pluripotent Stem Cells. Stem Cells Int. 2016; 2016:8394960. Saito H, Okita K, Fusaki N, Sabel MS, Chang AE, Ito F. PMID: 27057178; PMCID: PMC4707343.
      View in: PubMed   Mentions: 13  
    29. Immune Adjuvant Activity of Pre-Resectional Radiofrequency Ablation Protects against Local and Systemic Recurrence in Aggressive Murine Colorectal Cancer. PLoS One. 2015; 10(11):e0143370. Ito F, Ku AW, Bucsek MJ, Muhitch JB, Vardam-Kaur T, Kim M, Fisher DT, Camoriano M, Khoury T, Skitzki JJ, Gollnick SO, Evans SS. PMID: 26599402; PMCID: PMC4657935.
      View in: PubMed   Mentions: 19     Fields:    Translation:AnimalsCells
    30. Antitumor effector B cells directly kill tumor cells via the Fas/FasL pathway and are regulated by IL-10. Eur J Immunol. 2015 Apr; 45(4):999-1009. Tao H, Lu L, Xia Y, Dai F, Wang Y, Bao Y, Lundy SK, Ito F, Pan Q, Zhang X, Zheng F, Shu G, Fang B, Jiang J, Xia J, Huang S, Li Q, Chang AE. PMID: 25545618; PMCID: PMC4414939.
      View in: PubMed   Mentions: 54     Fields:    Translation:AnimalsCells
    31. Cancer immunotherapy: current status and future directions. Surg Oncol Clin N Am. 2013 Oct; 22(4):765-83. Ito F, Chang AE. PMID: 24012398.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    32. Water: a simple solution for tumor spillage. Ann Surg Oncol. 2011 Aug; 18(8):2357-63. Ito F, Camoriano M, Seshadri M, Evans SS, Kane JM, Skitzki JJ. PMID: 21301970; PMCID: PMC5778406.
      View in: PubMed   Mentions: 13     Fields:    Translation:AnimalsCells
    33. Hilar cholangiocarcinoma: current management. Ann Surg. 2009 Aug; 250(2):210-8. Ito F, Cho CS, Rikkers LF, Weber SM. PMID: 19638920.
      View in: PubMed   Mentions: 88     Fields:    Translation:Humans
    34. Resection of hilar cholangiocarcinoma: concomitant liver resection decreases hepatic recurrence. Ann Surg. 2008 Aug; 248(2):273-9. Ito F, Agni R, Rettammel RJ, Been MJ, Cho CS, Mahvi DM, Rikkers LF, Weber SM. PMID: 18650638.
      View in: PubMed   Mentions: 80     Fields:    Translation:Humans
    35. Transabdominal preperitoneal robotic inguinal hernia repair. J Laparoendosc Adv Surg Tech A. 2008 Jun; 18(3):397-9. Ito F, Jarrard D, Gould JC. PMID: 18503373.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    36. The utility of intraoperative bilateral internal jugular venous sampling with rapid parathyroid hormone testing. Ann Surg. 2007 Jun; 245(6):959-63. Ito F, Sippel R, Lederman J, Chen H. PMID: 17522522; PMCID: PMC1876969.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    37. Robotic foregut surgery. Int J Med Robot. 2006 Dec; 2(4):287-92. Ito F, Gould JC. PMID: 17520645.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    38. Anti-CD137 monoclonal antibody administration augments the antitumor efficacy of dendritic cell-based vaccines. Cancer Res. 2004 Nov 15; 64(22):8411-9. Ito F, Li Q, Shreiner AB, Okuyama R, Jure-Kunkel MN, Teitz-Tennenbaum S, Chang AE. PMID: 15548712.
      View in: PubMed   Mentions: 43     Fields:    Translation:AnimalsCells
    39. Phenotypic stability of mature dendritic cells tuned by TLR or CD40 to control the efficiency of cytotoxic T cell priming. Microbiol Immunol. 2004; 48(3):211-9. Nakamura I, Kajino K, Bamba H, Itoh F, Takikita M, Ogasawara K. PMID: 15031535.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    40. Radiotherapy potentiates the therapeutic efficacy of intratumoral dendritic cell administration. Cancer Res. 2003 Dec 01; 63(23):8466-75. Teitz-Tennenbaum S, Li Q, Rynkiewicz S, Ito F, Davis MA, McGinn CJ, Chang AE. PMID: 14679011.
      View in: PubMed   Mentions: 66     Fields:    Translation:AnimalsCells
    41. Polarization effects of 4-1BB during CD28 costimulation in generating tumor-reactive T cells for cancer immunotherapy. Cancer Res. 2003 May 15; 63(10):2546-52. Li Q, Carr A, Ito F, Teitz-Tennenbaum S, Chang AE. PMID: 12750278.
      View in: PubMed   Mentions: 23     Fields:    Translation:AnimalsCells
    42. Antitumor reactivity of anti-CD3/anti-CD28 bead-activated lymphoid cells: implications for cell therapy in a murine model. J Immunother. 2003 May-Jun; 26(3):222-33. Ito F, Carr A, Svensson H, Yu J, Chang AE, Li Q. PMID: 12806276.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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