Christina J. Azevedo, MD

Title(s)Associate Professor of Clinical Neurology
SchoolKeck School of Medicine of Usc
AddressHCT 1520 San Pablo Street
Health Sciences Campus
Los Angeles CA 90033-9405
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    1. Incorporation of the central vein sign into the McDonald criteria. Mult Scler Relat Disord. 2024 Nov 25; 93:106182. Amin M, Nakamura K, Daboul L, O'Donnell C, Cao Q, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BAC, Freeman L, Henry R, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prckovska V, Raza PC, Ramos M, Samudralwar R, Schindler M, Sotirchos ES, Sicotte N, Solomon AJ, Shinohara R, Reich DS, Sati P, Ontaneda D. PMID: 39622133.
      View in: PubMed   Mentions:    Fields:    
    2. Multicenter validation of automated detection of paramagnetic rim lesions on brain MRI in multiple sclerosis. J Neuroimaging. 2024 Nov-Dec; 34(6):750-757. Chen L, Ren Z, Clark KA, Lou C, Liu F, Cao Q, Manning AR, Martin ML, Luskin E, O'Donnell CM, Azevedo CJ, Calabresi PA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Bilello M, Song JW, Kaisey M, Sicotte NL, Reich DS, Solomon AJ, Ontaneda D, Sati P, Absinta M, Schindler MK, Shinohara RT, NAIMS Cooperative. PMID: 39410780.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Multicenter automated central vein sign detection performs as well as manual assessment for the diagnosis of multiple sclerosis. AJNR Am J Neuroradiol. 2024 Sep 27. Manning AR, Letchuman V, Martin ML, Gombos E, Roberts-Fitzgerald T, Cao Q, Raza P, O'Donnell CM, Renner B, Daboul L, Rodrigues P, Ramos M, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Suthiphosuwan S, Schindler MK, Bilello M, Song JW, Sotirchos ES, Sicotte NL, Al-Louzi O, Solomon AJ, Reich DS, Ontaneda D, Sati P, Shinohara RT, NAIMS Cooperative. PMID: 39332906.
      View in: PubMed   Mentions:    Fields:    
    4. Early Disease-Modifying Treatments for Presymptomatic Multiple Sclerosis. CNS Drugs. 2024 Sep 16. Zeydan B, Azevedo CJ, Makhani N, Cohen M, Tutuncu M, Thouvenot E, Siva A, Okuda DT, Kantarci OH, Lebrun-Frenay C. PMID: 39285136.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Choroid plexus enlargement correlates with periventricular pathology but not with disease activity in radiologically isolated syndrome. Mult Scler. 2024 Sep; 30(10):1278-1289. Landes-Château C, Ricigliano VA, Mondot L, Thouvenot E, Labauge P, Louapre C, Zéphir H, Durand-Dubief F, Le Page E, Siva A, Cohen M, Yazdan Panah A, Azevedo CJ, Okuda DT, Stankoff B, Lebrun-Frénay C. PMID: 39246289.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Diagnostic performance of central vein sign versus oligoclonal bands for multiple sclerosis. Mult Scler. 2024 Sep; 30(10):1268-1277. Toljan K, Daboul L, Raza P, Martin ML, Cao Q, O'Donnell CM, Rodrigues P, Derbyshire J, Azevedo CJ, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Sati P, Ontaneda D. PMID: 39234802; PMCID: PMC11421977.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    7. Imaging chronic active lesions in multiple sclerosis: a consensus statement. Brain. 2024 Sep 03; 147(9):2913-2933. Bagnato F, Sati P, Hemond CC, Elliott C, Gauthier SA, Harrison DM, Mainero C, Oh J, Pitt D, Shinohara RT, Smith SA, Trapp B, Azevedo CJ, Calabresi PA, Henry RG, Laule C, Ontaneda D, Rooney WD, Sicotte NL, Reich DS, Absinta M. PMID: 38226694; PMCID: PMC11370808.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    8. Dimethyl fumarate preserves brainstem and cervical spinal cord integrity in radiologically isolated syndrome. J Neurol. 2024 Sep; 271(9):5899-5910. Okuda DT, Azevedo CJ, Pelletier D, Moog TM, Moazami S, Rezvani S, Bovis F, Sormani MP, Siva A, Kantarci O, Lebrun-Frénay C, ARISE Study Investigators. PMID: 38980342.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    9. The diagnostic workup of children with the radiologically isolated syndrome differs by age and by sex. J Neurol. 2024 Jul; 271(7):4019-4027. Makhani N, Lebrun-Frenay C, Siva A, Shabanova V, Wassmer E, Santoro JD, Narula S, Brenton JN, Mar S, Durand-Dubief F, Zephir H, Mathey G, Rojas JI, de Seze J, Tenembaum S, Stone RT, Casez O, Carra-Dallière C, Neuteboom RF, Ahsan N, Arroyo HA, Cabre P, Gombolay G, Inglese M, Louapre C, Margoni M, Palavra F, Pohl D, Reich DS, Ruet A, Thouvenot E, Timby N, Tintore M, Uygunoglu U, Vargas W, Venkateswaran S, Verhelst H, Wickstrom R, Azevedo CJ, Kantarci O, Shapiro ED, Okuda DT, Pelletier D, Observatoire Francophone de la Sclérose en Plaques (OFSEP), Société Francophone de la Sclérose en Pl. PMID: 38564056; PMCID: PMC11323224.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    10. Choroid plexus volume differentiates MS from its mimics. Mult Scler. 2024 Jul; 30(8):1072-1076. Levit E, Ren Z, Gonzenbach V, Azevedo CJ, Calabresi PA, Cree BA, Freeman L, Longbrake EE, Oh J, Schindler MK, Sicotte NL, Reich DS, Ontaneda D, Sati P, Cao Q, Shinohara RT, Solomon AJ. PMID: 38481081; PMCID: PMC11288781.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Author Correction: Toward precision medicine using a "digital twin" approach: modeling the onset of disease-specific brain atrophy in individuals with multiple sclerosis. Sci Rep. 2023 Dec 15; 13(1):22334. Cen S, Gebregziabher M, Moazami S, Azevedo CJ, Pelletier D. PMID: 38102165; PMCID: PMC10724177.
      View in: PubMed   Mentions:    Fields:    
    12. A multicenter pilot study evaluating simplified central vein assessment for the diagnosis of multiple sclerosis. Mult Scler. 2024 Jan; 30(1):25-34. Daboul L, O'Donnell CM, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi PA, Cree BA, Freeman L, Henry RG, Longbrake EE, Oh J, Papinutto N, Pelletier D, Prchkovska V, Raza P, Ramos M, Samudralwar RD, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Sati P, Ontaneda D. PMID: 38088067; PMCID: PMC11037932.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    13. Radiologically isolated syndrome. Lancet Neurol. 2023 11; 22(11):1075-1086. Lebrun-Frenay C, Kantarci O, Siva A, Azevedo CJ, Makhani N, Pelletier D, Okuda DT. PMID: 37839432.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    14. Teriflunomide and Time to Clinical Multiple Sclerosis in Patients With Radiologically Isolated Syndrome: The TERIS Randomized Clinical Trial. JAMA Neurol. 2023 10 01; 80(10):1080-1088. Lebrun-Frénay C, Siva A, Sormani MP, Landes-Chateau C, Mondot L, Bovis F, Vermersch P, Papeix C, Thouvenot E, Labauge P, Durand-Dubief F, Efendi H, Le Page E, Terzi M, Derache N, Bourre B, Hoepner R, Karabudak R, De Seze J, Ciron J, Clavelou P, Wiertlewski S, Turan OF, Yucear N, Cohen M, Azevedo C, Kantarci OH, Okuda DT, Pelletier D, TERIS Study Group. PMID: 37603328; PMCID: PMC10442780.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCTClinical Trials
    15. Toward precision medicine using a "digital twin" approach: modeling the onset of disease-specific brain atrophy in individuals with multiple sclerosis. Sci Rep. 2023 09 28; 13(1):16279. Cen S, Gebregziabher M, Moazami S, Azevedo CJ, Pelletier D. PMID: 37770560; PMCID: PMC10539386.
      View in: PubMed   Mentions: 10     Fields:    Translation:Humans
    16. Recent Advances in Diagnostic, Prognostic, and Disease-Monitoring Biomarkers in Multiple Sclerosis. Neurol Clin. 2024 Feb; 42(1):15-38. Chertcoff A, Schneider R, Azevedo CJ, Sicotte N, Oh J. PMID: 37980112.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    17. The radiologically isolated syndrome: revised diagnostic criteria. Brain. 2023 08 01; 146(8):3431-3443. Lebrun-Frénay C, Okuda DT, Siva A, Landes-Chateau C, Azevedo CJ, Mondot L, Carra-Dallière C, Zephir H, Louapre C, Durand-Dubief F, Le Page E, Bensa C, Ruet A, Ciron J, Laplaud DA, Casez O, Mathey G, de Seze J, Zeydan B, Makhani N, Tutuncu M, Levraut M, Cohen M, Thouvenot E, Pelletier D, Kantarci OH. PMID: 36864688; PMCID: PMC11004931.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Toward Precision Medicine Using a "Digital Twin" Approach: Modeling the Onset of Disease-Specific Brain Atrophy in Individuals with Multiple Sclerosis. Res Sq. 2023 May 02. Cen S, Gebregziabher M, Moazami S, Azevedo C, Pelletier D. PMID: 37205476; PMCID: PMC10187410.
      View in: PubMed   Mentions:
    19. High-dose vitamin D3 supplementation in relapsing-remitting multiple sclerosis: a randomised clinical trial. EClinicalMedicine. 2023 May; 59:101957. Cassard SD, Fitzgerald KC, Qian P, Emrich SA, Azevedo CJ, Goodman AD, Sugar EA, Pelletier D, Waubant E, Mowry EM. PMID: 37125397; PMCID: PMC10130605.
      View in: PubMed   Mentions: 7  
    20. Dimethyl Fumarate Delays Multiple Sclerosis in Radiologically Isolated Syndrome. Ann Neurol. 2023 03; 93(3):604-614. Okuda DT, Kantarci O, Lebrun-Frénay C, Sormani MP, Azevedo CJ, Bovis F, Hua LH, Amezcua L, Mowry EM, Hotermans C, Mendoza J, Walsh JS, von Hehn C, Vargas WS, Donlon S, Naismith RT, Okai A, Pardo G, Repovic P, Stüve O, Siva A, Pelletier D. PMID: 36401339.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    21. Neurofilament Light Chain Levels Are Predictive of Clinical Conversion in Radiologically Isolated Syndrome. Neurol Neuroimmunol Neuroinflamm. 2023 01; 10(1). Rival M, Thouvenot E, Du Trieu de Terdonck L, Laurent-Chabalier S, Demattei C, Uygunoglu U, Castelnovo G, Cohen M, Okuda DT, Kantarci OH, Pelletier D, Azevedo C, Marin P, Lehmann S, Siva A, Mura T, Lebrun-Frenay C, SFSEP and RISC. PMID: 36280258; PMCID: PMC9621336.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    22. Effect of GBCA Use on Detection and Diagnostic Performance of the Central Vein Sign: Evaluation Using a 3-T FLAIR* Sequence in Patients With Suspected Multiple Sclerosis. AJR Am J Roentgenol. 2023 01; 220(1):115-125. Daboul L, O'Donnell CM, Cao Q, Amin M, Rodrigues P, Derbyshire J, Azevedo C, Bar-Or A, Caverzasi E, Calabresi P, Cree BAC, Freeman L, Henry RG, Longbrake EE, Nakamura K, Oh J, Papinutto N, Pelletier D, Samudralwar RD, Suthiphosuwan S, Schindler MK, Sotirchos ES, Sicotte NL, Solomon AJ, Shinohara RT, Reich DS, Ontaneda D, Sati P. PMID: 35975888; PMCID: PMC10016223.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    23. Risk Factors and Time to Clinical Symptoms of Multiple Sclerosis Among Patients With Radiologically Isolated Syndrome. JAMA Netw Open. 2021 10 01; 4(10):e2128271. Lebrun-Frénay C, Rollot F, Mondot L, Zephir H, Louapre C, Le Page E, Durand-Dubief F, Labauge P, Bensa C, Thouvenot E, Laplaud D, de Seze J, Ciron J, Bourre B, Cabre P, Casez O, Ruet A, Mathey G, Berger E, Moreau T, Al Khedr A, Derache N, Clavelou P, Guennoc AM, Créange A, Neau JP, Tourbah A, Camdessanché JP, Maarouf A, Callier C, Vermersch P, Kantarci O, Siva A, Azevedo C, Makhani N, Cohen M, Pelletier D, Okuda D, Vukusic S, RISC, SFSEP, and OFSEP Investigators. PMID: 34633424; PMCID: PMC8506228.
      View in: PubMed   Mentions: 23     Fields:    Translation:Humans
    24. Deep grey matter injury in multiple sclerosis: a NAIMS consensus statement. Brain. 2021 08 17; 144(7):1974-1984. Ontaneda D, Raza PC, Mahajan KR, Arnold DL, Dwyer MG, Gauthier SA, Greve DN, Harrison DM, Henry RG, Li DKB, Mainero C, Moore W, Narayanan S, Oh J, Patel R, Pelletier D, Rauscher A, Rooney WD, Sicotte NL, Tam R, Reich DS, Azevedo CJ, North American Imaging in Multiple Sclerosis Cooperative (NAIMS). PMID: 33757115; PMCID: PMC8370433.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    25. Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis and Myelitis in COVID-19. J Neuroophthalmol. 2020 09; 40(3):398-402. Zhou S, Jones-Lopez EC, Soneji DJ, Azevedo CJ, Patel VR. PMID: 32604245; PMCID: PMC7382408.
      View in: PubMed   Mentions: 92     Fields:    Translation:HumansCellsPHPublic Health
    26. New cases of vasculitis after alemtuzumab. Mult Scler. 2020 10; 26(12):1606-1608. Azevedo CJ, Zamvil SS. PMID: 32081067.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    27. Cerebellar volume loss in radiologically isolated syndrome. Mult Scler. 2021 01; 27(1):130-133. George IC, El Mendili MM, Inglese M, Azevedo CJ, Kantarci O, Lebrun C, Siva A, Okuda DT, Pelletier D. PMID: 31680617; PMCID: PMC7196519.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    28. Contribution of normal aging to brain atrophy in MS. Neurol Neuroimmunol Neuroinflamm. 2019 11; 6(6). Azevedo CJ, Cen SY, Jaberzadeh A, Zheng L, Hauser SL, Pelletier D. PMID: 32330116; PMCID: PMC6807662.
      View in: PubMed   Mentions: 33     Fields:    Translation:Humans
    29. Imaging outcome measures of neuroprotection and repair in MS: A consensus statement from NAIMS. Neurology. 2019 03 12; 92(11):519-533. Oh J, Ontaneda D, Azevedo C, Klawiter EC, Absinta M, Arnold DL, Bakshi R, Calabresi PA, Crainiceanu C, Dewey B, Freeman L, Gauthier S, Henry R, Inglese M, Kolind S, Li DKB, Mainero C, Menon RS, Nair G, Narayanan S, Nelson F, Pelletier D, Rauscher A, Rooney W, Sati P, Schwartz D, Shinohara RT, Tagge I, Traboulsee A, Wang Y, Yoo Y, Yousry T, Zhang Y, Robert Z, Sicotte NL, Reich DS, North American Imaging in Multiple Sclerosis Cooperative. PMID: 30787160; PMCID: PMC6511106.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    30. Intracerebral haemorrhage during alemtuzumab administration. Lancet Neurol. 2019 04; 18(4):329-331. Azevedo CJ, Kutz C, Dix A, Boster A, Sanossian N, Kaplan J. PMID: 30777657.
      View in: PubMed   Mentions: 20     Fields:    Translation:Humans
    31. Body mass index, but not vitamin D status, is associated with brain volume change in MS. Neurology. 2018 12 11; 91(24):e2256-e2264. Mowry EM, Azevedo CJ, McCulloch CE, Okuda DT, Lincoln RR, Waubant E, Hauser SL, Pelletier D. PMID: 30429274; PMCID: PMC6329329.
      View in: PubMed   Mentions: 37     Fields:    Translation:Humans
    32. Thalamic atrophy in multiple sclerosis: A magnetic resonance imaging marker of neurodegeneration throughout disease. Ann Neurol. 2018 02; 83(2):223-234. Azevedo CJ, Cen SY, Khadka S, Liu S, Kornak J, Shi Y, Zheng L, Hauser SL, Pelletier D. PMID: 29328531; PMCID: PMC6317847.
      View in: PubMed   Mentions: 102     Fields:    Translation:Humans
    33. New Concepts Related to Disease Appreciation in Multiple Sclerosis. Neurol Clin. 2018 Feb; 36(1):119-133. Azevedo CJ, Jaberzadeh A, Pelletier D. PMID: 29157393.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Cervical spinal cord atrophy: An early marker of progressive MS onset. Neurol Neuroimmunol Neuroinflamm. 2018 Mar; 5(2):e435. Zeydan B, Gu X, Atkinson EJ, Keegan BM, Weinshenker BG, Tillema JM, Pelletier D, Azevedo CJ, Lebrun-Frenay C, Siva A, Okuda DT, Kantarci K, Kantarci OH. PMID: 29435472; PMCID: PMC5795903.
      View in: PubMed   Mentions: 30     Fields:    
    35. Whole-brain atrophy: ready for implementation into clinical decision-making in multiple sclerosis? Curr Opin Neurol. 2016 06; 29(3):237-42. Azevedo CJ, Pelletier D. PMID: 27070219.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    36. Subcortical grey matter volumes predict subsequent walking function in early multiple sclerosis. J Neurol Sci. 2016 Jul 15; 366:229-233. Nourbakhsh B, Azevedo C, Maghzi AH, Spain R, Pelletier D, Waubant E. PMID: 27288812.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    37. Primary Progressive Multiple Sclerosis Evolving From Radiologically Isolated Syndrome. Ann Neurol. 2016 Feb; 79(2):288-94. Kantarci OH, Lebrun C, Siva A, Keegan MB, Azevedo CJ, Inglese M, Tintoré M, Newton BD, Durand-Dubief F, Amato MP, De Stefano N, Sormani MP, Pelletier D, Okuda DT. PMID: 26599831.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    38. Longitudinal associations between brain structural changes and fatigue in early MS. Mult Scler Relat Disord. 2016 Jan; 5:29-33. Nourbakhsh B, Azevedo C, Nunan-Saah J, Maghzi AH, Spain R, Pelletier D, Waubant E. PMID: 26856940.
      View in: PubMed   Mentions: 21     Fields:    Translation:Humans
    39. Early CNS neurodegeneration in radiologically isolated syndrome. Neurol Neuroimmunol Neuroinflamm. 2015 Jun; 2(3):e102. Azevedo CJ, Overton E, Khadka S, Buckley J, Liu S, Sampat M, Kantarci O, Lebrun Frenay C, Siva A, Okuda DT, Pelletier D. PMID: 25884012; PMCID: PMC4396526.
      View in: PubMed   Mentions: 100     Fields:    
    40. A comparison of continuous video-EEG monitoring and 30-minute EEG in an ICU. Epileptic Disord. 2014 Dec; 16(4):439-48. Khan OI, Azevedo CJ, Hartshorn AL, Montanye JT, Gonzalez JC, Natola MA, Surgenor SD, Morse RP, Nordgren RE, Bujarski KA, Holmes GL, Jobst BC, Scott RC, Thadani VM. PMID: 25498516.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    41. The vitamin D to ameliorate multiple sclerosis (VIDAMS) trial: study design for a multicenter, randomized, double-blind controlled trial of vitamin D in multiple sclerosis. Contemp Clin Trials. 2014 Nov; 39(2):288-93. Bhargava P, Cassard S, Steele SU, Azevedo C, Pelletier D, Sugar EA, Waubant E, Mowry EM. PMID: 25311447.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    42. In vivo evidence of glutamate toxicity in multiple sclerosis. Ann Neurol. 2014 Aug; 76(2):269-78. Azevedo CJ, Kornak J, Chu P, Sampat M, Okuda DT, Cree BA, Nelson SJ, Hauser SL, Pelletier D. PMID: 25043416; PMCID: PMC4142752.
      View in: PubMed   Mentions: 53     Fields:    Translation:Humans
    43. Clinical applications of imaging disease burden in multiple sclerosis: MRI and advanced imaging techniques. Expert Rev Neurother. 2012 Mar; 12(3):323-33. Riley C, Azevedo C, Bailey M, Pelletier D. PMID: 22364331.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
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