Amy Merrill-Brugger, BS, PhD
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| Title(s) | Associate Professor and Department Chair, Biomedical Sciences |
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| School | Herman Ostrow School of Dentistry of Usc |
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| Address | CSA 141
Health Sciences Campus
Los Angeles CA 90089-9062
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| Phone | +1 323 442 1147 |
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ORCID
.gif) | 0000-0002-3660-1575  |
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| vCard | Download vCard |
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Biography
| University of California, Santa Barbara, Santa Barbara, CA | BS | | Developmental Biology |
| University of Southern California, Los Angeles, CA | PhD | | Developmental Biology |
| University of California, San Francisco, San Francisco, CA | postdoc | | Developmental Biology |
| University of California, Los Angeles, Los Angeles, CA | postdoc | | Human Genetics |
| The Society for Craniofacial Genetics and Developmental Biology | 2019 | | Marylou Buyse Excellence in Craniofacial Research Award |
| University of Southern California | 2022 | | USC Mentoring Award for Faculty Mentoring Graduate Students |
Overview
Dr. Amy Merrill received her Ph.D. in Biochemistry and Molecular Biology in 2005 from the University of Southern California. During her doctoral studies she used mouse genetics to discover a novel role for cellular boundaries in the pathogenesis of craniosynostosis. From 2005-2007 she did a postdoctoral fellowship at University of California, San Francisco were she uncovered the unique potential of cranial neural crest cells to autonomously control the timing of bone formation in the developing face. Prior to joining the faculty in the Department of Biochemistry and Molecular Biology at USC in 2010, she completed a fellowship in Medical Genetics at University of California, Los Angeles/Cedars Sinai Medical Center. Her studies in human genetics identified the first disease-causing mutations for Short-rib polydactyly syndrome and establish this lethal skeletal disorder as a ciliopathy. Currently Dr. Merrill's laboratory studies the disease mechanism for Bent Bone Dysplasia Syndrome.
Research
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The society for craniofacial genetics and developmental biology 46th annual meeting. Am J Med Genet A. 2024 Apr 02; e63615.
Brugmann SA, Clouthier DE, Fantauzzo KA, Harris MP, Jeong J, Saint-Jeannet JP, Stottmann RW, Merrill AE. PMID: 38563316.
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PubMed Mentions:
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Fibroblast growth factor 2. Differentiation. 2023 Oct 12.
Nickle A, Ko S, Merrill AE. PMID: 37858405.
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PubMed Mentions: Fields:
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The Society for Craniofacial Genetics and Developmental Biology 45th Annual Meeting. Am J Med Genet A. 2023 07; 191(7):1994-2002.
Stottmann RW, Harris MP, Saint-Jeannet JP, Merrill AE, Clouthier DE. PMID: 37040531.
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Humans
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MusMorph, a database of standardized mouse morphology data for morphometric meta-analyses. Sci Data. 2022 05 25; 9(1):230.
Devine J, Vidal-García M, Liu W, Neves A, Lo Vercio LD, Green RM, Richbourg HA, Marchini M, Unger CM, Nickle AC, Radford B, Young NM, Gonzalez PN, Schuler RE, Bugacov A, Rolian C, Percival CJ, Williams T, Niswander L, Calof AL, Lander AD, Visel A, Jirik FR, Cheverud JM, Klein OD, Birnbaum RY, Merrill AE, Ackermann RR, Graf D, Hemberger M, Dean W, Forkert ND, Murray SA, Westerberg H, Marcucio RS, Hallgrímsson B. PMID: 35614082; PMCID: PMC9133120.
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Animals
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The Society for Craniofacial Genetics and Developmental Biology 44th Annual Meeting. Am J Med Genet A. 2022 07; 188(7):2258-2266.
Brugmann SA, Merrill AE, Saint-Jeannet JP, Stottmann RW, Clouthier DE. PMID: 35352468.
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HumansPHPublic Health
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The developing mouse coronal suture at single-cell resolution. Nat Commun. 2021 08 10; 12(1):4797.
Farmer DT, Mlcochova H, Zhou Y, Koelling N, Wang G, Ashley N, Bugacov H, Chen HJ, Parvez R, Tseng KC, Merrill AE, Maxson RE, Wilkie AOM, Crump JG, Twigg SRF. PMID: 34376651; PMCID: PMC8355337.
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PubMed Mentions:
35 Fields:
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AnimalsCells
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Development and maintenance of tendons and ligaments. Development. 2021 04 15; 148(8).
Bobzin L, Roberts RR, Chen HJ, Crump JG, Merrill AE. PMID: 33913478; PMCID: PMC8077520.
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PubMed Mentions:
6 Fields:
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HumansAnimalsCells
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FGF signaling patterns cell fate at the interface between tendon and bone. Development. 2019 08 02; 146(15).
Roberts RR, Bobzin L, Teng CS, Pal D, Tuzon CT, Schweitzer R, Merrill AE. PMID: 31320326; PMCID: PMC6703712.
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PubMed Mentions:
20 Fields:
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AnimalsCells
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Nuclear Fibroblast Growth Factor Receptor Signaling in Skeletal Development and Disease. Curr Osteoporos Rep. 2019 06; 17(3):138-146.
Tuzon CT, Rigueur D, Merrill AE. PMID: 30982184; PMCID: PMC8221190.
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PubMed Mentions:
15 Fields:
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HumansCells
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Nuclear FGFR2 regulates musculoskeletal integration within the developing limb. Dev Dyn. 2019 03; 248(3):233-246.
Salva JE, Roberts RR, Stucky TS, Merrill AE. PMID: 30620790; PMCID: PMC6474847.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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A requirement for Fgfr2 in middle ear development. Genesis. 2019 01; 57(1):e23252.
Rigueur D, Roberts RR, Bobzin L, Merrill AE. PMID: 30253032; PMCID: PMC6349551.
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PubMed Mentions:
3 Fields:
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Animals
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tp53-dependent and independent signaling underlies the pathogenesis and possible prevention of Acrofacial Dysostosis-Cincinnati type. Hum Mol Genet. 2018 08 01; 27(15):2628-2643.
Watt KEN, Neben CL, Hall S, Merrill AE, Trainor PA. PMID: 29750247; PMCID: PMC6927876.
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PubMed Mentions:
14 Fields:
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HumansAnimalsCells
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Prmt1 regulates craniofacial bone formation upstream of Msx1. Mech Dev. 2018 08; 152:13-20.
Gou Y, Li J, Wu J, Gupta R, Cho I, Ho TV, Chai Y, Merrill A, Wang J, Xu J. PMID: 29727702.
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PubMed Mentions:
5 Fields:
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AnimalsCells
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FGFR2 mutations in bent bone dysplasia syndrome activate nucleolar stress and perturb cell fate determination. Hum Mol Genet. 2017 09 01; 26(17):3253-3270.
Neben CL, Tuzon CT, Mao X, Lay FD, Merrill AE. PMID: 28595297; PMCID: PMC5886181.
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PubMed Mentions:
10 Fields:
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HumansCells
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Signaling networks in joint development. Dev Dyn. 2017 04; 246(4):262-274.
Salva JE, Merrill AE. PMID: 27859991; PMCID: PMC5354978.
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PubMed Mentions:
11 Fields:
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HumansAnimalsCells
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Ribosome biogenesis is dynamically regulated during osteoblast differentiation. Gene. 2017 May 15; 612:29-35.
Neben CL, Lay FD, Mao X, Tuzon CT, Merrill AE. PMID: 27847259; PMCID: PMC5382099.
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PubMed Mentions:
8 Fields:
Translation:
AnimalsCells
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The Roles of RNA Polymerase I and III Subunits Polr1c and Polr1d in Craniofacial Development and in Zebrafish Models of Treacher Collins Syndrome. PLoS Genet. 2016 07; 12(7):e1006187.
Noack Watt KE, Achilleos A, Neben CL, Merrill AE, Trainor PA. PMID: 27448281; PMCID: PMC4957770.
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PubMed Mentions:
44 Fields:
Translation:
HumansAnimals
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Modeling craniofacial and skeletal congenital birth defects to advance therapies. Hum Mol Genet. 2016 Oct 01; 25(R2):R86-R93.
Neben CL, Roberts RR, Dipple KM, Merrill AE, Klein OD. PMID: 27346519; PMCID: PMC5036869.
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PubMed Mentions:
6 Fields:
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Clinical and radiographic delineation of Bent Bone Dysplasia-FGFR2 type or Bent Bone Dysplasia with Distinctive Clavicles and Angel-shaped Phalanges. Am J Med Genet A. 2016 10; 170(10):2652-61.
Krakow D, Cohn DH, Wilcox WR, Noh GJ, Raffel LJ, Sarukhanov A, Ivanova MH, Danielpour M, Grange DK, Elliott AM, Bernstein JA, Rimoin DL, Merrill AE, Lachman RS. PMID: 27240702; PMCID: PMC5538138.
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PubMed Mentions:
3 Fields:
Translation:
Humans
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TGFβ and BMP Dependent Cell Fate Changes Due to Loss of Filamin B Produces Disc Degeneration and Progressive Vertebral Fusions. PLoS Genet. 2016 Mar; 12(3):e1005936.
Zieba J, Forlenza KN, Khatra JS, Sarukhanov A, Duran I, Rigueur D, Lyons KM, Cohn DH, Merrill AE, Krakow D. PMID: 27019229; PMCID: PMC4809497.
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PubMed Mentions:
34 Fields:
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HumansAnimalsCells
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Signaling Pathways in Craniofacial Development: Insights from Rare Skeletal Disorders. Curr Top Dev Biol. 2015; 115:493-542.
Neben CL, Merrill AE. PMID: 26589936.
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PubMed Mentions:
13 Fields:
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HumansAnimalsCells
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Bent bone dysplasia syndrome reveals nucleolar activity for FGFR2 in ribosomal DNA transcription. Hum Mol Genet. 2014 Nov 01; 23(21):5659-71.
Neben CL, Idoni B, Salva JE, Tuzon CT, Rice JC, Krakow D, Merrill AE. PMID: 24908667; PMCID: PMC4189901.
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PubMed Mentions:
24 Fields:
Translation:
HumansAnimalsCells
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Ribosome biogenesis in skeletal development and the pathogenesis of skeletal disorders. Biochim Biophys Acta. 2014 Jun; 1842(6):769-78.
Trainor PA, Merrill AE. PMID: 24252615; PMCID: PMC4020712.
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PubMed Mentions:
57 Fields:
Translation:
HumansCells
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Bent bone dysplasia-FGFR2 type, a distinct skeletal disorder, has deficient canonical FGF signaling. Am J Hum Genet. 2012 Mar 09; 90(3):550-7.
Merrill AE, Sarukhanov A, Krejci P, Idoni B, Camacho N, Estrada KD, Lyons KM, Deixler H, Robinson H, Chitayat D, Curry CJ, Lachman RS, Wilcox WR, Krakow D. PMID: 22387015; PMCID: PMC3309195.
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PubMed Mentions:
37 Fields:
Translation:
HumansCells
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Mutations in the gene encoding the RER protein FKBP65 cause autosomal-recessive osteogenesis imperfecta. Am J Hum Genet. 2010 Apr 09; 86(4):551-9.
Alanay Y, Avaygan H, Camacho N, Utine GE, Boduroglu K, Aktas D, Alikasifoglu M, Tuncbilek E, Orhan D, Bakar FT, Zabel B, Superti-Furga A, Bruckner-Tuderman L, Curry CJ, Pyott S, Byers PH, Eyre DR, Baldridge D, Lee B, Merrill AE, Davis EC, Cohn DH, Akarsu N, Krakow D. PMID: 20362275; PMCID: PMC2850430.
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PubMed Mentions:
133 Fields:
Translation:
Humans
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Ciliary abnormalities due to defects in the retrograde transport protein DYNC2H1 in short-rib polydactyly syndrome. Am J Hum Genet. 2009 Apr; 84(4):542-9.
Merrill AE, Merriman B, Farrington-Rock C, Camacho N, Sebald ET, Funari VA, Schibler MJ, Firestein MH, Cohn ZA, Priore MA, Thompson AK, Rimoin DL, Nelson SF, Cohn DH, Krakow D. PMID: 19361615; PMCID: PMC2667993.
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PubMed Mentions:
66 Fields:
Translation:
HumansCells
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Mesenchyme-dependent BMP signaling directs the timing of mandibular osteogenesis. Development. 2008 Apr; 135(7):1223-34.
Merrill AE, Eames BF, Weston SJ, Heath T, Schneider RA. PMID: 18287200; PMCID: PMC2844338.
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PubMed Mentions:
36 Fields:
Translation:
AnimalsCells
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Cell mixing at a neural crest-mesoderm boundary and deficient ephrin-Eph signaling in the pathogenesis of craniosynostosis. Hum Mol Genet. 2006 Apr 15; 15(8):1319-28.
Merrill AE, Bochukova EG, Brugger SM, Ishii M, Pilz DT, Wall SA, Lyons KM, Wilkie AO, Maxson RE. PMID: 16540516.
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PubMed Mentions:
98 Fields:
Translation:
HumansAnimalsCells
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A phylogenetically conserved cis-regulatory module in the Msx2 promoter is sufficient for BMP-dependent transcription in murine and Drosophila embryos. Development. 2004 Oct; 131(20):5153-65.
Brugger SM, Merrill AE, Torres-Vazquez J, Wu N, Ting MC, Cho JY, Dobias SL, Yi SE, Lyons K, Bell JR, Arora K, Warrior R, Maxson R. PMID: 15459107.
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PubMed Mentions:
65 Fields:
Translation:
AnimalsCells
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Msx2 and Twist cooperatively control the development of the neural crest-derived skeletogenic mesenchyme of the murine skull vault. Development. 2003 Dec; 130(24):6131-42.
Ishii M, Merrill AE, Chan YS, Gitelman I, Rice DP, Sucov HM, Maxson RE. PMID: 14597577.
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PubMed Mentions:
83 Fields:
Translation:
HumansAnimals
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Msx2 is an immediate downstream effector of Pax3 in the development of the murine cardiac neural crest. Development. 2002 Jan; 129(2):527-38.
Kwang SJ, Brugger SM, Lazik A, Merrill AE, Wu LY, Liu YH, Ishii M, Sangiorgi FO, Rauchman M, Sucov HM, Maas RL, Maxson RE. PMID: 11807043.
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PubMed Mentions:
38 Fields:
Translation:
HumansAnimalsCells
This graph shows the total number of publications by year. To see the data as text,
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This graph shows the total number of publications by year. To return to the graph,
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| Year | Publications |
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| 2002 | 1 |
| 2003 | 1 |
| 2004 | 1 |
| 2006 | 1 |
| 2008 | 1 |
| 2009 | 1 |
| 2010 | 1 |
| 2012 | 1 |
| 2013 | 1 |
| 2014 | 1 |
| 2015 | 1 |
| 2016 | 6 |
| 2017 | 1 |
| 2018 | 3 |
| 2019 | 3 |
| 2021 | 2 |
| 2022 | 2 |
| 2023 | 2 |
| 2024 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
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This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text,
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