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    Michael Chee-Kuan Khoo, PhD

    SchoolViterbi School of Engineering, BME
    DepartmentBiomedical Engineering
    AddressDRB 140
    University Park Campus
    Los Angeles California 90089-1111
    Phone+1 213 740 0347
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      Michael C.K. Khoo received his BSc(Eng) degree in Mechanical Engineering from the Imperial College of Science and Technology, University of London, in 1976, and the M.S. and Ph.D. degrees in Biomedical Engineering from Harvard University in 1977 and 1981, respectively. Before joining the faculty at USC in 1983, Dr. Khoo worked as a research engineer on a collaborative project involving the Veterans Administration Medical Center (West Roxbury), Brigham and Women's Hospital (Boston) and the Massachusetts Institute of Technology. Dr. Khoo has been the recipient of a Research Career Development Award from the National Institutes of Health and a Career Investigator Award from the American Lung Association. He is principal investigator of one of the Core Projects in the Biomedical Simulations Resource, a national center funded by the NIH National Institute of Biomedical Imaging and Bioengineering, dedicated to advancing the state of the art in biomedical modeling and computer simulation. He is also the co-principal investigator of an NIH training grant in Biomedical Imaging Informatics, and co-Director of Education and Outreach for the NSF-funded Engineering Research Center on Biomimetic Microelectronic Systems. Dr. Khoo is a Fellow of the American Institute of Medical and Biological Engineering (AIMBE) and the Biomedical Engineering Society (BMES). He was BME Department Chair 2003-2010.

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      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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      1. Khaleel M, Puliyel M, Shah P, Sunwoo J, Kato RM, Chalacheva P, Thuptimdang W, Detterich J, Wood JC, Tsao J, Zeltzer L, Sposto R, Khoo M, Coates TD. Individuals with sickle cell disease have a significantly greater vasoconstriction response to thermal pain than controls and have significant vasoconstriction in response to anticipation of pain. Am J Hematol. 2017 Jul 13. PMID: 28707371.
        View in: PubMed
      2. Chalacheva P, Khaleel M, Sunwoo J, Shah P, Detterich JA, Kato RM, Thuptimdang W, Meiselman HJ, Sposto R, Tsao J, Wood JC, Zeltzer L, Coates TD, Khoo M. Biophysical markers of the peripheral vasoconstriction response to pain in sickle cell disease. PLoS One. 2017; 12(5):e0178353. PMID: 28542469.
        View in: PubMed
      3. Khoo M, Pressney I, Hargunani R, Saifuddin A. Small, superficial, indeterminate soft-tissue lesions as suspected sarcomas: is primary excision biopsy suitable? Skeletal Radiol. 2017 Jul; 46(7):919-924. PMID: 28361352.
        View in: PubMed
      4. Chen W, Gillett E, Khoo M, Davidson Ward SL, Nayak KS. Real-time multislice MRI during continuous positive airway pressure reveals upper airway response to pressure change. J Magn Reson Imaging. 2017 Feb 22. PMID: 28225580.
        View in: PubMed
      5. Khoo M, Chalacheva P. Model-Derived Markers of Autonomic Cardiovascular Dysfunction in Sleep-Disordered Breathing. Sleep Med Clin. 2016 Dec; 11(4):489-501. PMID: 28118872.
        View in: PubMed
      6. Hargunani R, Madani H, Khoo M, Fotiadou A, Pressney I, Calleja M, O'Donnell P. Imaging of the Painful Hip Arthroplasty. Can Assoc Radiol J. 2016 Nov; 67(4):345-355. PMID: 27221697.
        View in: PubMed
      7. Wu Z, Chen W, Khoo M, Davidson Ward SL, Nayak KS. Evaluation of upper airway collapsibility using real-time MRI. J Magn Reson Imaging. 2016 Jul; 44(1):158-67. PMID: 26708099.
        View in: PubMed
      8. Khoo M, Pressney I, Hargunani R, Tirabosco R. Melanotic schwannoma: an 11-year case series. Skeletal Radiol. 2016 Jan; 45(1):29-34. PMID: 26386847.
        View in: PubMed
      9. Bhatia R, Lesser DJ, Oliveira FG, Tran WH, Keens TG, Khoo M, Davidson Ward SL. Body Fat Composition: A Predictive Factor for Sleep Related Breathing Disorder in Obese Children. J Clin Sleep Med. 2015 Sep 15; 11(9):1039-45. PMID: 26094935; PMCID: PMC4543248.
      10. Javed A, Kim YC, Khoo M, Ward SL, Nayak KS. Dynamic 3-D MR Visualization and Detection of Upper Airway Obstruction During Sleep Using Region-Growing Segmentation. IEEE Trans Biomed Eng. 2016 Feb; 63(2):431-7. PMID: 26258929; PMCID: PMC4801340 [Available on 02/01/17].
      11. Chalacheva P, Kato RM, Sangkatumvong S, Detterich J, Bush A, Wood JC, Meiselman H, Coates TD, Khoo M. Autonomic responses to cold face stimulation in sickle cell disease: a time-varying model analysis. Physiol Rep. 2015 Jul 14; 3(7). PMID: 26177958; PMCID: PMC4552538.
      12. Berber R, Pappas Y, Khoo M, Miles J, Carrington R, Skinner J, Hart A. A new approach to managing patients with problematic metal hip implants: the use of an Internet-enhanced multidisciplinary team meeting: AAOS exhibit selection. J Bone Joint Surg Am. 2015 Feb 18; 97(4):e20. PMID: 25695991.
        View in: PubMed
      13. Berber R, Khoo M, Cook E, Guppy A, Hua J, Miles J, Carrington R, Skinner J, Hart A. Muscle atrophy and metal-on-metal hip implants: a serial MRI study of 74 hips. Acta Orthop. 2015 Jun; 86(3):351-7. PMID: 25588091; PMCID: PMC4443469.
      14. Chalacheva P, Khoo M. Modeling of deep breath vasoconstriction reflex. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:7792-5. PMID: 26738099; PMCID: PMC4940034.
      15. Soleymani S, Khoo M, Noori S, Seri I. Modeling of neonatal hemodynamics during PDA closure. Conf Proc IEEE Eng Med Biol Soc. 2015; 2015:1886-9. PMID: 26736650.
        View in: PubMed
      16. Berber R, Henckel J, Khoo M, Wan S, Hua J, Skinner J, Hart A. Clinical Usefulness of SPECT-CT in Patients with an Unexplained Pain in Metal on Metal (MOM) Total Hip Arthroplasty. J Arthroplasty. 2015 Apr; 30(4):687-94. PMID: 25583682.
        View in: PubMed
      17. Davidson Ward SL, Amin R, Arens R, Davis S, Gutmark E, Superfine R, Wong B, Zdanski C, Khoo M. Pediatric sleep-related breathing disorders: advances in imaging and computational modeling. IEEE Pulse. 2014 Sep-Oct; 5(5):33-9. PMID: 25437473; PMCID: PMC5025940.
      18. Chalacheva P, Khoo M. Estimating the baroreflex and respiratory modulation of peripheral vascular resistance. Conf Proc IEEE Eng Med Biol Soc. 2014; 2014:2936-9. PMID: 25570606; PMCID: PMC4487769.
      19. Popovic D, Khoo M, Westbrook P. Automatic scoring of sleep stages and cortical arousals using two electrodes on the forehead: validation in healthy adults. J Sleep Res. 2014 Apr; 23(2):211-21. PMID: 24313630; PMCID: PMC4156826.
      20. Kim YC, Lebel RM, Wu Z, Ward SL, Khoo M, Nayak KS. Real-time 3D magnetic resonance imaging of the pharyngeal airway in sleep apnea. Magn Reson Med. 2014 Apr; 71(4):1501-10. PMID: 23788203; PMCID: PMC4159137.
      21. Wu Z, Kim YC, Khoo M, Nayak KS. Evaluation of an independent linear model for acoustic noise on a conventional MRI scanner and implications for acoustic noise reduction. Magn Reson Med. 2014 Apr; 71(4):1613-20. PMID: 23757158; PMCID: PMC3795844.
      22. Khoo M, Blasi A. Sleep-related changes in autonomic control in obstructive sleep apnea: a model-based perspective. Respir Physiol Neurobiol. 2013 Sep 15; 188(3):267-76. PMID: 23707878; PMCID: PMC3778082.
      23. Chalacheva P, Khoo M. An extended model of blood pressure variability: incorporating the respiratory modulation of vascular resistance. Conf Proc IEEE Eng Med Biol Soc. 2013; 2013:3825-8. PMID: 24110565.
        View in: PubMed
      24. Khoo M, Oliveira FM, Cheng L. Understanding the metabolic syndrome: a modeling perspective. IEEE Rev Biomed Eng. 2013; 6:143-55. PMID: 23232440; PMCID: PMC4153831.
      25. Detterich JA, Sangkatumvong S, Kato R, Dongelyan A, Bush A, Khoo M, Meiselman HJ, Coates TD, Wood JC. Patients with sickle cell anemia on simple chronic transfusion protocol show sex differences for hemodynamic and hematologic responses to transfusion. Transfusion. 2013 May; 53(5):1059-68. PMID: 23176402; PMCID: PMC3957479.
      26. Wang W, Redline S, Khoo M. Autonomic markers of impaired glucose metabolism: effects of sleep-disordered breathing. J Diabetes Sci Technol. 2012 Sep 01; 6(5):1159-71. PMID: 23063043; PMCID: PMC3570851.
      27. Berger T, Meng E, George S, Khoo M, Marmarelis V, McCulloch A, Cauwenberghs G, Ohno-Machado L, Schultz J, Johnson JP. Southern California: a hotbed of biomedical engineering: nine bioengineers describe their research and why Southern California has the biotech market cornered. IEEE Pulse. 2012 Jul; 3(4):14-21. PMID: 23008840.
        View in: PubMed
      28. Khoo M. Linking engineering and medicine: fostering collaboration skills in interdisciplinary teams. IEEE Pulse. 2012 Jul; 3(4):27-9. PMID: 22850834.
        View in: PubMed
      29. Lesser DJ, Bhatia R, Tran WH, Oliveira F, Ortega R, Keens TG, Mittelman SD, Khoo M, Davidson Ward SL. Sleep fragmentation and intermittent hypoxemia are associated with decreased insulin sensitivity in obese adolescent Latino males. Pediatr Res. 2012 Sep; 72(3):293-8. PMID: 22669298; PMCID: PMC3427473.
      30. Hoppenbrouwers T, Oliveira F, Sandarupa S, Khoo M, Neuman M, Ramanathan R. The development of the circadian heart rate rhythm (CHR) in Asian infants. Early Hum Dev. 2012 Jul; 88(7):555-61. PMID: 22289413; PMCID: PMC4490788.
      31. Cheng L, Khoo M. Modeling the autonomic and metabolic effects of obstructive sleep apnea: a simulation study. Front Physiol. 2011; 2:111. PMID: 22291654; PMCID: PMC3250672.
      32. Sangkatumvong S, Khoo M, Kato R, Detterich JA, Bush A, Keens TG, Meiselman HJ, Wood JC, Coates TD. Peripheral vasoconstriction and abnormal parasympathetic response to sighs and transient hypoxia in sickle cell disease. Am J Respir Crit Care Med. 2011 Aug 15; 184(4):474-81. PMID: 21616995; PMCID: PMC3175540.
      33. Khoo M, Wang W, Chalacheva P. Monitoring ultradian changes in cardiorespiratory control in obstructive sleep apnea syndrome. Conf Proc IEEE Eng Med Biol Soc. 2011; 2011:1487-90. PMID: 22254601; PMCID: PMC3398741.
      34. Cheng L, Ivanova O, Fan HH, Khoo M. An integrative model of respiratory and cardiovascular control in sleep-disordered breathing. Respir Physiol Neurobiol. 2010 Nov 30; 174(1-2):4-28. PMID: 20542148; PMCID: PMC2965826.
      35. Khoo M. Model-based studies of autonomic and metabolic dysfunction in sleep apnea. Adv Exp Med Biol. 2010; 669:275-9. PMID: 20217365; PMCID: PMC3137921.
      36. Sangkatumvong S, Coates TD, Wood JC, Meiselman HJ, Kato R, Detterich JA, Bush A, Khoo M. Time-varying analysis of autonomic control in response to spontaneous sighs in sickle cell anemia. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1626-9. PMID: 21096136.
        View in: PubMed
      37. Chaicharn J, Lin Z, Chen ML, Ward SL, Keens T, Khoo M. Model-based assessment of cardiovascular autonomic control in children with obstructive sleep apnea. Sleep. 2009 Jul; 32(7):927-38. PMID: 19639756; PMCID: PMC2706908.
      38. Wang W, Tretriluxana S, Redline S, Surovec S, Gottlieb DJ, Khoo M. Association of cardiac autonomic function measures with severity of sleep-disordered breathing in a community-based sample. J Sleep Res. 2008 Sep; 17(3):251-62. PMID: 18547374; PMCID: PMC2774732.
      39. Khoo M. Modeling of autonomic control in sleep-disordered breathing. Cardiovasc Eng. 2008 Mar; 8(1):30-41. PMID: 18060581; PMCID: PMC3339254.
      40. Sangkatumvong S, Khoo M, Coates TD. Abnormal cardiac autonomic control in sickle cell disease following transient hypoxia. Conf Proc IEEE Eng Med Biol Soc. 2008; 2008:1996-9. PMID: 19163084.
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      41. Asyali MH, Berry RB, Khoo M, Altinok A. Determining a continuous marker for sleep depth. Comput Biol Med. 2007 Nov; 37(11):1600-9. PMID: 17434160.
        View in: PubMed
      42. Jo JA, Blasi A, Valladares EM, Juarez R, Baydur A, Khoo M. A nonlinear model of cardiac autonomic control in obstructive sleep apnea syndrome. Ann Biomed Eng. 2007 Aug; 35(8):1425-43. PMID: 17415661.
        View in: PubMed
      43. Blasi A, Jo JA, Valladares E, Juarez R, Baydur A, Khoo M. Autonomic cardiovascular control following transient arousal from sleep: a time-varying closed-loop model. IEEE Trans Biomed Eng. 2006 Jan; 53(1):74-82. PMID: 16402605.
        View in: PubMed
      44. Ivanova OV, Marcu L, Khoo M. A nonparametric method for analysis of fluorescence emission in combined time and wavelength dimensions. Ann Biomed Eng. 2005 Apr; 33(4):531-44. PMID: 15909659; PMCID: PMC2672102.
      45. Blasi A, Jo J, Valladares E, Morgan BJ, Skatrud JB, Khoo M. Cardiovascular variability after arousal from sleep: time-varying spectral analysis. J Appl Physiol (1985). 2003 Oct; 95(4):1394-404. PMID: 12819215.
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      46. Belozeroff V, Berry RB, Khoo M. Model-based assessment of autonomic control in obstructive sleep apnea syndrome. Sleep. 2003 Feb 01; 26(1):65-73. PMID: 12627735.
        View in: PubMed
      47. Jo JA, Blasi A, Valladares E, Juarez R, Baydur A, Khoo M. Model-based assessment of autonomic control in obstructive sleep apnea syndrome during sleep. Am J Respir Crit Care Med. 2003 Jan 15; 167(2):128-36. PMID: 12406844.
        View in: PubMed
      48. Asyali MH, Berry RB, Khoo M. Assessment of closed-loop ventilatory stability in obstructive sleep apnea. IEEE Trans Biomed Eng. 2002 Mar; 49(3):206-16. PMID: 11878312.
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      49. Belozeroff V, Berry RB, Sassoon CS, Khoo M. Effects of CPAP therapy on cardiovascular variability in obstructive sleep apnea: a closed-loop analysis. Am J Physiol Heart Circ Physiol. 2002 Jan; 282(1):H110-21. PMID: 11748054.
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      50. Sternheim CE, Stromeyer CF, Khoo M. Visibility of chromatic flicker upon spectrally mixed adapting fields. Vision Res. 1979; 19(2):175-83. PMID: 425336.
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      51. Stromeyer CF, Khoo M, Muggeridge D. Detection of red and green flashes: evidence for cancellation and facilitation. Sens Processes. 1978 Sep; 2(3):248-71. PMID: 219546.
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