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    Laurie D. De Leve, MD, PhD

    TitleProfessor of Medicine
    SchoolKeck School of Medicine of USC
    DepartmentMedicine
    AddressHMR 603
    Health Sciences Campus
    Los Angeles California 90089-9091
    Phone+1 323 442 3248
    vCardDownload vCard
      Other Positions
      TitleSenior Associate Chair For Scientific Affairs, Department of Medicine


      Collapse Overview 
      Collapse Overview
      Dr. DeLeve's clinical interests include general gastroenterology, colon cancer screening, irritable bowel syndrome, drug-induced liver disease. Her research interests include the role of liver sinusoidal endothelial cell in liver injury recovery and liver fibrosis and drug-induced liver injury.

      Born in New York City and raised in the Netherlands, Dr. DeLeve obtained a PhD in Pharmacology from the University of Toronto after receiving her medical degree from the Erasmus University of Rotterdam. Following her residency at the University of Michigan and fellowship at UCLA, Dr. DeLeve joined the Keck School of Medicine as an Assistant Professor in 1990.


      Collapse Biography 
      Collapse Awards and Honors
      Alpha Omega Alpha2005Teaching Award
      Western Society for Clinical Investigation2008Outstanding Investigator Award
      USC2015Mellon Mentoring Award for Faculty Mentoring Faculty

      Collapse Bibliographic 
      Collapse Publications
      Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
      List All   |   Timeline
      1. DeLeve LD, Wang X, Wang L. VEGF-sdf1 recruitment of CXCR7+ bone marrow progenitors of liver sinusoidal endothelial cells promotes rat liver regeneration. Am J Physiol Gastrointest Liver Physiol. 2016 May 01; 310(9):G739-46. PMID: 26939868; PMCID: PMC4867332 [Available on 05/01/17].
      2. DeLeve LD. Liver sinusoidal endothelial cells in hepatic fibrosis. Hepatology. 2015 May; 61(5):1740-6. PMID: 25131509; PMCID: PMC4333127.
      3. Pastuszka MK, Wang X, Lock LL, Janib SM, Cui H, DeLeve LD, MacKay JA. An amphipathic alpha-helical peptide from apolipoprotein A1 stabilizes protein polymer vesicles. J Control Release. 2014 Oct 10; 191:15-23. PMID: 25016969; PMCID: PMC4327866.
      4. DeLeve LD. Liver sinusoidal endothelial cells and liver regeneration. J Clin Invest. 2013 May; 123(5):1861-6. PMID: 23635783; PMCID: PMC3635729.
      5. Tallman MS, McDonald GB, DeLeve LD, Baer MR, Cook MN, Graepel GJ, Kollmer C. Incidence of sinusoidal obstruction syndrome following Mylotarg (gemtuzumab ozogamicin): a prospective observational study of 482 patients in routine clinical practice. Int J Hematol. 2013 Apr; 97(4):456-64. PMID: 23460018.
        View in: PubMed
      6. Wang L, Wang X, Wang L, Chiu JD, van de Ven G, Gaarde WA, Deleve L. Hepatic vascular endothelial growth factor regulates recruitment of rat liver sinusoidal endothelial cell progenitor cells. Gastroenterology. 2012 Dec; 143(6):1555-1563.e2. PMID: 22902870; PMCID: PMC3505224.
      7. Wang L, Wang X, Xie G, Wang L, Hill CK, DeLeve LD. Liver sinusoidal endothelial cell progenitor cells promote liver regeneration in rats. J Clin Invest. 2012 Apr; 122(4):1567-73. PMID: 22406533; PMCID: PMC3314456.
      8. Xie G, Wang X, Wang L, Wang L, Atkinson RD, Kanel GC, Gaarde WA, Deleve L. Role of differentiation of liver sinusoidal endothelial cells in progression and regression of hepatic fibrosis in rats. Gastroenterology. 2012 Apr; 142(4):918-927.e6. PMID: 22178212; PMCID: PMC3618963.
      9. Warren A, Cogger VC, Fraser R, Deleve L, McCuskey RS, Le Couteur DG. The effects of old age on hepatic stellate cells. Curr Gerontol Geriatr Res. 2011; 2011:439835. PMID: 21687587; PMCID: PMC3114409.
      10. DeLeve LD, Jaeschke H, Kalra VK, Asahina K, Brenner DA, Tsukamoto H. 15th International Symposium on Cells of the Hepatic Sinusoid, 2010. Liver Int. 2011 Jul; 31(6):762-72. PMID: 21645207; PMCID: PMC4388239.
      11. Xie G, Wang L, Wang X, Wang L, DeLeve LD. Isolation of periportal, midlobular, and centrilobular rat liver sinusoidal endothelial cells enables study of zonated drug toxicity. Am J Physiol Gastrointest Liver Physiol. 2010 Nov; 299(5):G1204-10. PMID: 20813915; PMCID: PMC2993174.
      12. Cogger VC, McNerney GP, Nyunt T, DeLeve LD, McCourt P, Smedsrød B, Le Couteur DG, Huser TR. Three-dimensional structured illumination microscopy of liver sinusoidal endothelial cell fenestrations. J Struct Biol. 2010 Sep; 171(3):382-8. PMID: 20570732; PMCID: PMC3043550.
      13. Harb R, Xie G, Lutzko C, Guo Y, Wang X, Hill CK, Kanel GC, DeLeve LD. Bone marrow progenitor cells repair rat hepatic sinusoidal endothelial cells after liver injury. Gastroenterology. 2009 Aug; 137(2):704-12. PMID: 19447108; PMCID: PMC2747805.
      14. DeLeve LD, Valla DC, Garcia-Tsao G. Vascular disorders of the liver. Hepatology. 2009 May; 49(5):1729-64. PMID: 19399912.
        View in: PubMed
      15. DeLeve LD, Wang X, Kanel GC, Atkinson RD, McCuskey RS. Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. Am J Pathol. 2008 Oct; 173(4):993-1001. PMID: 18772330; PMCID: PMC2543068.
      16. Deleve L, Wang X, Guo Y. Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology. 2008 Sep; 48(3):920-30. PMID: 18613151; PMCID: PMC2695448.
      17. Deleve L. Sinusoidal obstruction syndrome. Gastroenterol Hepatol (N Y). 2008 Feb; 4(2):101-3. PMID: 21904484; PMCID: PMC3088834.
      18. DeLeve LD. Hepatic microvasculature in liver injury. Semin Liver Dis. 2007 Nov; 27(4):390-400. PMID: 17979075.
        View in: PubMed
      19. DeLeve LD, Wang X, McCuskey MK, McCuskey RS. Rat liver endothelial cells isolated by anti-CD31 immunomagnetic separation lack fenestrae and sieve plates. Am J Physiol Gastrointest Liver Physiol. 2006 Dec; 291(6):G1187-9. PMID: 16782698.
        View in: PubMed
      20. McCuskey RS, Bethea NW, Wong J, McCuskey MK, Abril ER, Wang X, Ito Y, DeLeve LD. Ethanol binging exacerbates sinusoidal endothelial and parenchymal injury elicited by acetaminophen. J Hepatol. 2005 Mar; 42(3):371-7. PMID: 15710220.
        View in: PubMed
      21. DeLeve LD, Wang X, Hu L, McCuskey MK, McCuskey RS. Rat liver sinusoidal endothelial cell phenotype is maintained by paracrine and autocrine regulation. Am J Physiol Gastrointest Liver Physiol. 2004 Oct; 287(4):G757-63. PMID: 15191879.
        View in: PubMed
      22. Adams PC, Arthur MJ, Boyer TD, DeLeve LD, Di Bisceglie AM, Hall M, Levin TR, Provenzale D, Seeff L. Screening in liver disease: report of an AASLD clinical workshop. Hepatology. 2004 May; 39(5):1204-12. PMID: 15122748.
        View in: PubMed
      23. DeLeve LD, Wang X, Kanel GC, Ito Y, Bethea NW, McCuskey MK, Tokes ZA, Tsai J, McCuskey RS. Decreased hepatic nitric oxide production contributes to the development of rat sinusoidal obstruction syndrome. Hepatology. 2003 Oct; 38(4):900-8. PMID: 14512877.
        View in: PubMed
      24. Deleve L, Wang X, Tsai J, Kanel G, Strasberg S, Tokes ZA. Sinusoidal obstruction syndrome (veno-occlusive disease) in the rat is prevented by matrix metalloproteinase inhibition. Gastroenterology. 2003 Sep; 125(3):882-90. PMID: 12949732.
        View in: PubMed
      25. Kumar S, DeLeve LD, Kamath PS, Tefferi A. Hepatic veno-occlusive disease (sinusoidal obstruction syndrome) after hematopoietic stem cell transplantation. Mayo Clin Proc. 2003 May; 78(5):589-98. PMID: 12744547.
        View in: PubMed
      26. DeLeve LD, Ito Y, Bethea NW, McCuskey MK, Wang X, McCuskey RS. Embolization by sinusoidal lining cells obstructs the microcirculation in rat sinusoidal obstruction syndrome. Am J Physiol Gastrointest Liver Physiol. 2003 Jun; 284(6):G1045-52. PMID: 12584111.
        View in: PubMed
      27. DeLeve LD. Vascular liver diseases. Curr Gastroenterol Rep. 2003 Feb; 5(1):63-70. PMID: 12530950.
        View in: PubMed
      28. Poreddy V, DeLeve LD. Hepatic circulatory diseases associated with chronic myeloid disorders. Clin Liver Dis. 2002 Nov; 6(4):909-31. PMID: 12516199.
        View in: PubMed
      29. DeLeve LD, Shulman HM, McDonald GB. Toxic injury to hepatic sinusoids: sinusoidal obstruction syndrome (veno-occlusive disease). Semin Liver Dis. 2002 Feb; 22(1):27-42. PMID: 11928077.
        View in: PubMed
      30. DeLeve LD. Hepatic venoocclusive disease: a major complication of hematopoietic stem cell transplantation in cancer patients. Tumori. 2001 Mar-Apr; 87(2):S27-9. PMID: 11401220.
        View in: PubMed
      31. DeLeve LD, Wang X. Role of oxidative stress and glutathione in busulfan toxicity in cultured murine hepatocytes. Pharmacology. 2000 Apr; 60(3):143-54. PMID: 10754451.
        View in: PubMed
      32. Wang X, Kanel GC, DeLeve LD. Support of sinusoidal endothelial cell glutathione prevents hepatic veno-occlusive disease in the rat. Hepatology. 2000 Feb; 31(2):428-34. PMID: 10655267.
        View in: PubMed
      33. DeLeve LD, McCuskey RS, Wang X, Hu L, McCuskey MK, Epstein RB, Kanel GC. Characterization of a reproducible rat model of hepatic veno-occlusive disease. Hepatology. 1999 Jun; 29(6):1779-91. PMID: 10347121.
        View in: PubMed
      34. DeLeve LD. Glutathione defense in non-parenchymal cells. Semin Liver Dis. 1998; 18(4):403-13. PMID: 9875557.
        View in: PubMed
      35. DeLeve LD, Wang X, Kaplowitz N, Shulman HM, Bart JA, van der Hoek A. Sinusoidal endothelial cells as a target for acetaminophen toxicity. Direct action versus requirement for hepatocyte activation in different mouse strains. Biochem Pharmacol. 1997 May 09; 53(9):1339-45. PMID: 9214695.
        View in: PubMed
      36. DeLeve LD. Effect of decreased glutathione levels in hereditary glutathione synthetase deficiency on dibromoethane-induced genotoxicity in human fibroblasts. Mutat Res. 1997 Mar 17; 389(2-3):291-7. PMID: 9093395.
        View in: PubMed
      37. DeLeve LD. Dinitrochlorobenzene is genotoxic by sister chromatid exchange in human skin fibroblasts. Mutat Res. 1996 Nov 04; 371(1-2):105-8. PMID: 8950355.
        View in: PubMed
      38. DeLeve LD. Cellular target of cyclophosphamide toxicity in the murine liver: role of glutathione and site of metabolic activation. Hepatology. 1996 Oct; 24(4):830-7. PMID: 8855185.
        View in: PubMed
      39. DeLeve LD, Wang X, Kuhlenkamp JF, Kaplowitz N. Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive disease. Hepatology. 1996 Mar; 23(3):589-99. PMID: 8617441.
        View in: PubMed
      40. DeLeve LD, Kaplowitz N. Mechanisms of drug-induced liver disease. Gastroenterol Clin North Am. 1995 Dec; 24(4):787-810. PMID: 8749899.
        View in: PubMed
      41. Runnegar MT, Maddatu T, Deleve L, Berndt N, Govindarajan S. Differential toxicity of the protein phosphatase inhibitors microcystin and calyculin A. J Pharmacol Exp Ther. 1995 Apr; 273(1):545-53. PMID: 7714810.
        View in: PubMed
      42. Deleve L. Dacarbazine toxicity in murine liver cells: a model of hepatic endothelial injury and glutathione defense. J Pharmacol Exp Ther. 1994 Mar; 268(3):1261-70. PMID: 8138939.
        View in: PubMed
      43. DeLeve LD, Kaplowitz N. Glutathione metabolism and its role in hepatotoxicity. Pharmacol Ther. 1991 Dec; 52(3):287-305. PMID: 1820580.
        View in: PubMed
      44. DeLeve LD, Kaplowitz N. Importance and regulation of hepatic glutathione. Semin Liver Dis. 1990 Nov; 10(4):251-66. PMID: 2281333.
        View in: PubMed
      45. Reeves RA, Boer WH, DeLeve L, Leenen FH. Beta-blockade disappearance rate predicts beta-adrenergic hypersensitivity. Clin Pharmacol Ther. 1989 Sep; 46(3):279-90. PMID: 2550167.
        View in: PubMed
      46. DeLeve LD, Endrenyi L, Leenen FH. Plasma concentration-response relationships of two formulations of propranolol. J Clin Pharmacol. 1985 Apr; 25(3):182-6. PMID: 3998198.
        View in: PubMed
      47. Reeves RA, Boer WH, DeLeve L, Leenen FH. Nonselective beta-blockade enhances pressor responsiveness to epinephrine, norepinephrine, and angiotensin II in normal man. Clin Pharmacol Ther. 1984 Apr; 35(4):461-6. PMID: 6705443.
        View in: PubMed
      48. Leenen FH, Smith DL, DeLeve L. Nonselective beta-receptor stimulation and blockade and left ventricular function. Clin Pharmacol Ther. 1983 Nov; 34(5):570-5. PMID: 6138177.
        View in: PubMed