Steven Grossman

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)The Ronald H. Bloom Family Chair in Cancer Research

    Title(s)Cancer Physician in Chief

    Title(s)Vice Chair for Cancer Programs in the Department for Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study. Cell Rep Med. 2024 Feb 20; 5(2):101391. Yamazaki H, Streicher SA, Wu L, Fukuhara S, Wagner R, Heni M, Grossman SR, Lenz HJ, Setiawan VW, Le Marchand L, Huang BZ. PMID: 38280379; PMCID: PMC10897551.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    2. Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma. Oncogenesis. 2023 Nov 10; 12(1):53. Chougoni KK, Park H, Damle PK, Mason T, Cheng B, Dcona MM, Szomju B, Dozmorov MG, Idowu MO, Grossman SR. PMID: 37949862; PMCID: PMC10638350.
      View in: PubMed   Mentions:
    3. Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer. Cancer Res Commun. 2023 10 04; 3(10):2003-2013. Dcona MM, Chougoni KK, Dcona DT, West JL, Singh SJ, Ellis KC, Grossman SR. PMID: 37707363; PMCID: PMC10549224.
      View in: PubMed   Mentions: Translation:HumansAnimals
    4. Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis. bioRxiv. 2023 Apr 28. Zhang T, Li S, Tan YA, Na JH, Chen Z, Damle P, Chen X, Choi S, Mishra B, Wang D, Grossman SR, Jiang X, Li Y, Chen YT, Xiang JZ, Du YN. PMID: 37163116; PMCID: PMC10168309.
      View in: PubMed   Mentions:
    5. Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study. medRxiv. 2023 Apr 26. Yamazaki H, Streicher SA, Wu L, Fukuhara S, Wagner R, Heni M, Grossman SR, Lenz HJ, Setiawan VW, Marchand LL, Huang BZ. PMID: 37163062; PMCID: PMC10168411.
      View in: PubMed   Mentions:
    6. Rising Incidence and Racial Disparities of Early-Onset Pancreatic Cancer in the United States, 1995-2018. Gastroenterology. 2022 07; 163(1):310-312.e1. Huang BZ, Liu L, Zhang J, USC Pancreas Research Team, Pandol SJ, Grossman SR, Setiawan VW. PMID: 35288111; PMCID: PMC9232973.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    7. Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. Oncologist. 2021 07; 26(7):e1104-e1109. Kim JW, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer PM, Shyr Y, Ivy SP, LoRusso PM. PMID: 33742489; PMCID: PMC8265343.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    8. Cryo-EM structure of CtBP2 confirms tetrameric architecture. Structure. 2021 04 01; 29(4):310-319.e5. Jecrois AM, Dcona MM, Deng X, Bandyopadhyay D, Grossman SR, Schiffer CA, Royer WE. PMID: 33264605; PMCID: PMC9159756.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    9. Extraction of high-quality RNA from mouse pancreatic tumors. MethodsX. 2020; 7:101163. Chougoni KK, Grossman SR. PMID: 33665149; PMCID: PMC7897710.
      View in: PubMed   Mentions: 2  
    10. CtBP determines ovarian cancer cell fate through repression of death receptors. Cell Death Dis. 2020 04 24; 11(4):286. Ding B, Yuan F, Damle PK, Litovchick L, Drapkin R, Grossman SR. PMID: 32332713; PMCID: PMC7181866.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansCells
    11. CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma. Oncogenesis. 2019 Oct 04; 8(10):55. Chawla AT, Chougoni KK, Joshi PJ, Cororaton AD, Memari P, Stansfield JC, Park H, Seth R, Szomju B, Sima AP, Idowu MO, Ellis KC, Grossman SR. PMID: 31586042; PMCID: PMC6778071.
      View in: PubMed   Mentions: 10  
    12. Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities. Mol Pharmacol. 2019 07; 96(1):99-108. Dcona MM, Damle PK, Zarate-Perez F, Morris BL, Nawaz Z, Dennis MJ, Deng X, Korwar S, Singh SJ, Ellis KC, Royer WE, Bandyopadhyay D, Escalante C, Grossman SR. PMID: 31036695; PMCID: PMC6560337.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimalsCells
    13. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell Rep. 2019 03 19; 26(12):3323-3335.e4. Akande OE, Damle PK, Pop M, Sherman NE, Szomju BB, Litovchick LV, Grossman SR. PMID: 30893604; PMCID: PMC6478392.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    14. An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition. Oncotarget. 2018 Aug 21; 9(65):32408-32418. Chawla AT, Cororaton AD, Idowu MO, Damle PK, Szomju B, Ellis KC, Patel BB, Grossman SR. PMID: 30197752; PMCID: PMC6126694.
      View in: PubMed   Mentions: 6     Fields:    
    15. CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors. Cancer Biol Ther. 2017 06 03; 18(6):379-391. Dcona MM, Morris BL, Ellis KC, Grossman SR. PMID: 28532298; PMCID: PMC5536941.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    16. Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia. Oncogene. 2017 08 17; 36(33):4810-4816. Sumner ET, Chawla AT, Cororaton AD, Koblinski JE, Kovi RC, Love IM, Szomju BB, Korwar S, Ellis KC, Grossman SR. PMID: 28414304; PMCID: PMC5561459.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimalsCells
    17. Clinic Blood Pressure Underestimates Ambulatory Blood Pressure in an Untreated Employer-Based US Population: Results From the Masked Hypertension Study. Circulation. 2016 Dec 06; 134(23):1794-1807. Schwartz JE, Burg MM, Shimbo D, Broderick JE, Stone AA, Ishikawa J, Sloan R, Yurgel T, Grossman S, Pickering TG. PMID: 27920072; PMCID: PMC5151173.
      View in: PubMed   Mentions: 47     Fields:    Translation:Humans
    18. Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). Bioorg Med Chem. 2016 06 15; 24(12):2707-15. Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE, Kellogg GE, Grossman SR, Ellis KC. PMID: 27156192; PMCID: PMC4993153.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    19. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016 05; 14(5):423-36. Frum RA, Love IM, Damle PK, Mukhopadhyay ND, Palit Deb S, Deb S, Grossman SR. PMID: 26965143; PMCID: PMC5110038.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    20. Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol. 2015 Apr 17; 10(4):1118-27. Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE. PMID: 25636004; PMCID: PMC4844192.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    21. Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells. Cell Cycle. 2014; 13(22):3506-18. Patel J, Baranwal S, Love IM, Patel NJ, Grossman SR, Patel BB. PMID: 25483087; PMCID: PMC4613182.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    22. Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer. Clin Genitourin Cancer. 2012 Mar; 10(1):15-20. Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD. PMID: 22130294.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    23. Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle. 2010 Sep 15; 9(18):3740-50. Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR. PMID: 20930544; PMCID: PMC3047800.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansAnimalsCells
    24. The accuracy of pain and fatigue items across different reporting periods. Pain. 2008 Sep 30; 139(1):146-157. Broderick JE, Schwartz JE, Vikingstad G, Pribbernow M, Grossman S, Stone AA. PMID: 18455312; PMCID: PMC2617790.
      View in: PubMed   Mentions: 119     Fields:    Translation:Humans
    25. p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. Cancer Res. 2008 Jan 15; 68(2):476-82. Chen YW, Paliwal S, Draheim K, Grossman SR, Lewis BC. PMID: 18199542; PMCID: PMC2376045.
      View in: PubMed   Mentions: 39     Fields:    Translation:AnimalsCells
    26. The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. Cancer Res. 2007 Oct 01; 67(19):9322-9. Paliwal S, Kovi RC, Nath B, Chen YW, Lewis BC, Grossman SR. PMID: 17909040.
      View in: PubMed   Mentions: 40     Fields:    Translation:HumansCells
    27. Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Mol Cell Biol. 2006 Mar; 26(6):2360-72. Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR. PMID: 16508011; PMCID: PMC1430274.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansAnimalsCells
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    NIH Funding Acknowledgment: Important - All publications resulting from the utilization of SC CTSI resources are required to credit the SC CTSI grant by including the NIH funding acknowledgment and must comply with the NIH Public Access Policy.

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