Steven Grossman

Title(s)Professor of Medicine
SchoolKeck School of Medicine of Usc
Address1450 Biggy Street
Health Sciences Campus
Los Angeles CA 90033
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    Other Positions
    Title(s)The Ronald H. Bloom Family Chair in Cancer Research

    Title(s)Cancer Physician in Chief

    Title(s)Vice Chair for Cancer Programs in the Department for Medicine


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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ovarian tumor cells gain competitive advantage by actively reducing the cellular fitness of microenvironment cells. Nat Biotechnol. 2024 Dec 09. Madan E, Palma AM, Vudatha V, Kumar A, Bhoopathi P, Wilhelm J, Bernas T, Martin PC, Bilolikar G, Gogna A, Peixoto ML, Dreier I, Araujo TF, Garre E, Gustafsson A, Dorayappan KDP, Mamidi N, Sun Z, Yekelchyk M, Accardi D, Olsen AL, Lin L, Titelman AA, Bianchi M, Jessmon P, Farid EA, Pradhan AK, Neufeld L, Yeini E, Maji S, Pelham CJ, Kim H, Oh D, Rolfsnes HO, Marques RC, Lu A, Nagane M, Chaudhary S, Gupta K, Gogna KC, Bigio A, Bhoopathi K, Mannangatti P, Achary KG, Akhtar J, Belião S, Das S, Correia I, da Silva CL, Fialho AM, Poellmann MJ, Javius-Jones K, Hawkridge AM, Pal S, Shree KS, Rakha EA, Khurana S, Xiao G, Zhang D, Rijal A, Lyons C, Grossman SR, Turner DP, Pillappa R, Prakash K, Gupta G, Robinson GLWG, Koblinski J, Wang H, Singh G, Singh S, Rayamajhi S, Bacolod MD, Richards H, Sayeed S, Klein KP, Chelmow D, Satchi-Fainaro R, Selvendiran K, Connolly D, Thorsen FA, Bjerkvig R, Nephew KP, Idowu MO, Kühnel MP, Moskaluk C, Hong S, Redmond WL, Landberg G, Lopez-Beltran A, Poklepovic AS, Sanyal A, Fisher PB, Church GM, Menon U, Drapkin R, Godwin AK, Luo Y, Ackermann M, Tzankov A, Mertz KD, Jonigk D, Tsung A, Sidransky D, Trevino J, Saavedra AP, Winn R, Won KJ, Moreno E, Gogna R. PMID: 39653752.
      View in: PubMed   Mentions:
    2. Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study. Cell Rep Med. 2024 Dec 03; 101842. Yamazaki H, Streicher SA, Wu L, Fukuhara S, Wagner R, Heni M, Grossman SR, Lenz HJ, Setiawan VW, Le Marchand L, Huang BZ. PMID: 39631403.
      View in: PubMed   Mentions:    Fields:    
    3. Oncogenic Mutant p53 Sensitizes Non-Small Cell Lung Cancer Cells to Proteasome Inhibition via Oxidative Stress-Dependent Induction of Mitochondrial Apoptosis. Cancer Res Commun. 2024 Oct 01; 4(10):2685-2698. Chougoni KK, Neely V, Ding B, Oduah E, Lam VT, Hu B, Koblinski JE, Windle BE, Palit Deb S, Deb S, Nieva JJ, Radhakrishnan SK, Harada H, Grossman SR. PMID: 39302104; PMCID: PMC11474859.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    4. Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis. Cancer Lett. 2024 Nov 01; 604:217240. Zhang T, Li S, Tan YA, Chen X, Zhang C, Chen Z, Mishra B, Na JH, Choi S, Shin SJ, Damle P, Chougoni KK, Grossman SR, Wang D, Jiang X, Li Y, Hissong E, Chen YT, Xiang JZ, Du YN. PMID: 39265800; PMCID: PMC11471366.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    5. The Causal Effect of Intrapancreatic Fat Deposition on Acute and Chronic Pancreatitis: A Mendelian Randomization Study. Am J Gastroenterol. 2024 Aug 20. Yamazaki H, Heni M, Wagner R, Fukuhara S, Grossman SR, Han S, Wu L, Streicher SA, Huang BZ. PMID: 39162745.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Genetic Evidence for a Causal Link between Intra-Pancreatic Fat Deposition and Pancreatitis: a Mendelian Randomization Study. medRxiv. 2024 Jun 04. Yamazaki H, Heni M, Wagner R, Fukuhara S, Grossman SR, Han S, Wu L, Streicher SA, Huang BZ. PMID: 38883800; PMCID: PMC11177924.
      View in: PubMed   Mentions:
    7. Proteasome inhibition paradoxically degrades gain-of-function mutant p53 R273H in NSCLC and could have therapeutic implications. Front Oncol. 2024; 14:1363543. Oduah EI, Sharfstein ST, Seetharamu N, Grossman SR, Litovchick L. PMID: 38660140; PMCID: PMC11039826.
      View in: PubMed   Mentions:
    8. Evidence for a causal link between intra-pancreatic fat deposition and pancreatic cancer: A prospective cohort and Mendelian randomization study. Cell Rep Med. 2024 Feb 20; 5(2):101391. Yamazaki H, Streicher SA, Wu L, Fukuhara S, Wagner R, Heni M, Grossman SR, Lenz HJ, Setiawan VW, Le Marchand L, Huang BZ. PMID: 38280379; PMCID: PMC10897551.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Coordinate transcriptional regulation of ErbB2/3 by C-terminal binding protein 2 signals sensitivity to ErbB2 inhibition in pancreatic adenocarcinoma. Oncogenesis. 2023 Nov 10; 12(1):53. Chougoni KK, Park H, Damle PK, Mason T, Cheng B, Dcona MM, Szomju B, Dozmorov MG, Idowu MO, Grossman SR. PMID: 37949862; PMCID: PMC10638350.
      View in: PubMed   Mentions: 1  
    10. Combined Targeting of NAD Biosynthesis and the NAD-dependent Transcription Factor C-terminal Binding Protein as a Promising Novel Therapy for Pancreatic Cancer. Cancer Res Commun. 2023 10 04; 3(10):2003-2013. Dcona MM, Chougoni KK, Dcona DT, West JL, Singh SJ, Ellis KC, Grossman SR. PMID: 37707363; PMCID: PMC10549224.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    11. Bcl-xL is translocated to the nucleus via CtBP2 to epigenetically promote metastasis. bioRxiv. 2023 Apr 28. Zhang T, Li S, Tan YA, Na JH, Chen Z, Damle P, Chen X, Choi S, Mishra B, Wang D, Grossman SR, Jiang X, Li Y, Chen YT, Xiang JZ, Du YN. PMID: 37163116; PMCID: PMC10168309.
      View in: PubMed   Mentions:
    12. Genetic Evidence Causally Linking Pancreas Fat to Pancreatic Cancer: A Mendelian Randomization Study. medRxiv. 2023 Apr 26. Yamazaki H, Streicher SA, Wu L, Fukuhara S, Wagner R, Heni M, Grossman SR, Lenz HJ, Setiawan VW, Marchand LL, Huang BZ. PMID: 37163062; PMCID: PMC10168411.
      View in: PubMed   Mentions:
    13. Rising Incidence and Racial Disparities of Early-Onset Pancreatic Cancer in the United States, 1995-2018. Gastroenterology. 2022 07; 163(1):310-312.e1. Huang BZ, Liu L, Zhang J, USC Pancreas Research Team, Pandol SJ, Grossman SR, Setiawan VW. PMID: 35288111; PMCID: PMC9232973.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    14. Clinical Activity and Safety of Cediranib and Olaparib Combination in Patients with Metastatic Pancreatic Ductal Adenocarcinoma without BRCA Mutation. Oncologist. 2021 07; 26(7):e1104-e1109. Kim JW, Cardin DB, Vaishampayan UN, Kato S, Grossman SR, Glazer PM, Shyr Y, Ivy SP, LoRusso PM. PMID: 33742489; PMCID: PMC8265343.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    15. The oncogenicity of tumor-derived mutant p53 is enhanced by the recruitment of PLK3. Nat Commun. 2021 01 29; 12(1):704. Vaughan CA, Singh S, Subler MA, Windle JJ, Inoue K, Fry EA, Pillappa R, Grossman SR, Windle B, Andrew Yeudall W, Deb SP, Deb S. PMID: 33514736; PMCID: PMC7846773.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    16. Cryo-EM structure of CtBP2 confirms tetrameric architecture. Structure. 2021 04 01; 29(4):310-319.e5. Jecrois AM, Dcona MM, Deng X, Bandyopadhyay D, Grossman SR, Schiffer CA, Royer WE. PMID: 33264605; PMCID: PMC9159756.
      View in: PubMed   Mentions: 12     Fields:    Translation:HumansCells
    17. Extraction of high-quality RNA from mouse pancreatic tumors. MethodsX. 2020; 7:101163. Chougoni KK, Grossman SR. PMID: 33665149; PMCID: PMC7897710.
      View in: PubMed   Mentions: 3  
    18. CtBP determines ovarian cancer cell fate through repression of death receptors. Cell Death Dis. 2020 04 24; 11(4):286. Ding B, Yuan F, Damle PK, Litovchick L, Drapkin R, Grossman SR. PMID: 32332713; PMCID: PMC7181866.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    19. Harnessing the vulnerabilities of p53 mutants in lung cancer - Focusing on the proteasome: a new trick for an old foe? Cancer Biol Ther. 2020 04 02; 21(4):293-302. Oduah EI, Grossman SR. PMID: 32041464; PMCID: PMC7515531.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansAnimals
    20. p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis. Oncotarget. 2019 Dec 10; 10(65):6997-7009. Ding B, Haidurov A, Chawla A, Parmigiani A, van de Kamp G, Dalina A, Yuan F, Lee JH, Chumakov PM, Grossman SR, Budanov AV. PMID: 31857853; PMCID: PMC6916756.
      View in: PubMed   Mentions: 9     Fields:    
    21. CtBP-a targetable dependency for tumor-initiating cell activity and metastasis in pancreatic adenocarcinoma. Oncogenesis. 2019 Oct 04; 8(10):55. Chawla AT, Chougoni KK, Joshi PJ, Cororaton AD, Memari P, Stansfield JC, Park H, Seth R, Szomju B, Sima AP, Idowu MO, Ellis KC, Grossman SR. PMID: 31586042; PMCID: PMC6778071.
      View in: PubMed   Mentions: 11  
    22. Active-Site Tryptophan, the Target of Antineoplastic C-Terminal Binding Protein Inhibitors, Mediates Inhibitor Disruption of CtBP Oligomerization and Transcription Coregulatory Activities. Mol Pharmacol. 2019 07; 96(1):99-108. Dcona MM, Damle PK, Zarate-Perez F, Morris BL, Nawaz Z, Dennis MJ, Deng X, Korwar S, Singh SJ, Ellis KC, Royer WE, Bandyopadhyay D, Escalante C, Grossman SR. PMID: 31036695; PMCID: PMC6560337.
      View in: PubMed   Mentions: 6     Fields:    Translation:HumansAnimalsCells
    23. DBC1 Regulates p53 Stability via Inhibition of CBP-Dependent p53 Polyubiquitination. Cell Rep. 2019 03 19; 26(12):3323-3335.e4. Akande OE, Damle PK, Pop M, Sherman NE, Szomju BB, Litovchick LV, Grossman SR. PMID: 30893604; PMCID: PMC6478392.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    24. An intestinal stem cell niche in Apc mutated neoplasia targetable by CtBP inhibition. Oncotarget. 2018 Aug 21; 9(65):32408-32418. Chawla AT, Cororaton AD, Idowu MO, Damle PK, Szomju B, Ellis KC, Patel BB, Grossman SR. PMID: 30197752; PMCID: PMC6126694.
      View in: PubMed   Mentions: 9     Fields:    
    25. CtBP- an emerging oncogene and novel small molecule drug target: Advances in the understanding of its oncogenic action and identification of therapeutic inhibitors. Cancer Biol Ther. 2017 06 03; 18(6):379-391. Dcona MM, Morris BL, Ellis KC, Grossman SR. PMID: 28532298; PMCID: PMC5536941.
      View in: PubMed   Mentions: 44     Fields:    Translation:HumansAnimalsCells
    26. Gain-of-function p53 activates multiple signaling pathways to induce oncogenicity in lung cancer cells. Mol Oncol. 2017 06; 11(6):696-711. Vaughan CA, Singh S, Grossman SR, Windle B, Deb SP, Deb S. PMID: 28423230; PMCID: PMC5467493.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimalsCells
    27. Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia. Oncogene. 2017 08 17; 36(33):4810-4816. Sumner ET, Chawla AT, Cororaton AD, Koblinski JE, Kovi RC, Love IM, Szomju BB, Korwar S, Ellis KC, Grossman SR. PMID: 28414304; PMCID: PMC5561459.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansAnimalsCells
    28. Mutant p53 establishes targetable tumor dependency by promoting unscheduled replication. J Clin Invest. 2017 May 01; 127(5):1839-1855. Singh S, Vaughan CA, Frum RA, Grossman SR, Deb S, Palit Deb S. PMID: 28394262; PMCID: PMC5409068.
      View in: PubMed   Mentions: 25     Fields:    Translation:HumansAnimalsCells
    29. Clinic Blood Pressure Underestimates Ambulatory Blood Pressure in an Untreated Employer-Based US Population: Results From the Masked Hypertension Study. Circulation. 2016 Dec 06; 134(23):1794-1807. Schwartz JE, Burg MM, Shimbo D, Broderick JE, Stone AA, Ishikawa J, Sloan R, Yurgel T, Grossman S, Pickering TG. PMID: 27920072; PMCID: PMC5151173.
      View in: PubMed   Mentions: 50     Fields:    Translation:Humans
    30. Design, synthesis, and biological evaluation of substrate-competitive inhibitors of C-terminal Binding Protein (CtBP). Bioorg Med Chem. 2016 06 15; 24(12):2707-15. Korwar S, Morris BL, Parikh HI, Coover RA, Doughty TW, Love IM, Hilbert BJ, Royer WE, Kellogg GE, Grossman SR, Ellis KC. PMID: 27156192; PMCID: PMC4993153.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansCells
    31. Addiction of lung cancer cells to GOF p53 is promoted by up-regulation of epidermal growth factor receptor through multiple contacts with p53 transactivation domain and promoter. Oncotarget. 2016 Mar 15; 7(11):12426-46. Vaughan CA, Pearsall I, Singh S, Windle B, Deb SP, Grossman SR, Yeudall WA, Deb S. PMID: 26820293; PMCID: PMC4914296.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimalsCells
    32. Constitutive Activation of DNA Damage Checkpoint Signaling Contributes to Mutant p53 Accumulation via Modulation of p53 Ubiquitination. Mol Cancer Res. 2016 05; 14(5):423-36. Frum RA, Love IM, Damle PK, Mukhopadhyay ND, Palit Deb S, Deb S, Grossman SR. PMID: 26965143; PMCID: PMC5110038.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansCells
    33. Structure-guided design of a high affinity inhibitor to human CtBP. ACS Chem Biol. 2015 Apr 17; 10(4):1118-27. Hilbert BJ, Morris BL, Ellis KC, Paulsen JL, Schiffer CA, Grossman SR, Royer WE. PMID: 25636004; PMCID: PMC4844192.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansCells
    34. Inhibition of C-terminal binding protein attenuates transcription factor 4 signaling to selectively target colon cancer stem cells. Cell Cycle. 2014; 13(22):3506-18. Patel J, Baranwal S, Love IM, Patel NJ, Grossman SR, Patel BB. PMID: 25483087; PMCID: PMC4613182.
      View in: PubMed   Mentions: 18     Fields:    Translation:HumansCells
    35. The human oncoprotein MDM2 induces replication stress eliciting early intra-S-phase checkpoint response and inhibition of DNA replication origin firing. Nucleic Acids Res. 2014 Jan; 42(2):926-40. Frum RA, Singh S, Vaughan C, Mukhopadhyay ND, Grossman SR, Windle B, Deb S, Deb SP. PMID: 24163099; PMCID: PMC3902934.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    36. Gain-of-Function Activity of Mutant p53 in Lung Cancer through Up-Regulation of Receptor Protein Tyrosine Kinase Axl. Genes Cancer. 2012 Jul; 3(7-8):491-502. Vaughan CA, Singh S, Windle B, Yeudall WA, Frum R, Grossman SR, Deb SP, Deb S. PMID: 23264849; PMCID: PMC3527987.
      View in: PubMed   Mentions: 39  
    37. Impact of the CKD-EPI equation for estimating renal function on eligibility for cisplatin-based chemotherapy in patients with urothelial cancer. Clin Genitourin Cancer. 2012 Mar; 10(1):15-20. Tsao CK, Moshier E, Seng SM, Godbold J, Grossman S, Winston J, Oh WK, Galsky MD. PMID: 22130294.
      View in: PubMed   Mentions: 18     Fields:    Translation:Humans
    38. The ARF tumor suppressor inhibits tumor cell colonization independent of p53 in a novel mouse model of pancreatic ductal adenocarcinoma metastasis. Mol Cancer Res. 2011 Jul; 9(7):867-77. Muniz VP, Barnes JM, Paliwal S, Zhang X, Tang X, Chen S, Zamba KD, Cullen JJ, Meyerholz DK, Meyers S, Davis JN, Grossman SR, Henry MD, Quelle DE. PMID: 21636682; PMCID: PMC3140613.
      View in: PubMed   Mentions: 19     Fields:    Translation:HumansAnimalsCells
    39. Therapeutic targeting of C-terminal binding protein in human cancer. Cell Cycle. 2010 Sep 15; 9(18):3740-50. Straza MW, Paliwal S, Kovi RC, Rajeshkumar B, Trenh P, Parker D, Whalen GF, Lyle S, Schiffer CA, Grossman SR. PMID: 20930544; PMCID: PMC3047800.
      View in: PubMed   Mentions: 39     Fields:    Translation:HumansAnimalsCells
    40. The accuracy of pain and fatigue items across different reporting periods. Pain. 2008 Sep 30; 139(1):146-157. Broderick JE, Schwartz JE, Vikingstad G, Pribbernow M, Grossman S, Stone AA. PMID: 18455312; PMCID: PMC2617790.
      View in: PubMed   Mentions: 116     Fields:    Translation:Humans
    41. p19Arf inhibits the invasion of hepatocellular carcinoma cells by binding to C-terminal binding protein. Cancer Res. 2008 Jan 15; 68(2):476-82. Chen YW, Paliwal S, Draheim K, Grossman SR, Lewis BC. PMID: 18199542; PMCID: PMC2376045.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    42. The alternative reading frame tumor suppressor antagonizes hypoxia-induced cancer cell migration via interaction with the COOH-terminal binding protein corepressor. Cancer Res. 2007 Oct 01; 67(19):9322-9. Paliwal S, Kovi RC, Nath B, Chen YW, Lewis BC, Grossman SR. PMID: 17909040.
      View in: PubMed   Mentions: 41     Fields:    Translation:HumansCells
    43. Targeting of C-terminal binding protein (CtBP) by ARF results in p53-independent apoptosis. Mol Cell Biol. 2006 Mar; 26(6):2360-72. Paliwal S, Pande S, Kovi RC, Sharpless NE, Bardeesy N, Grossman SR. PMID: 16508011; PMCID: PMC1430274.
      View in: PubMed   Mentions: 49     Fields:    Translation:HumansAnimalsCells
    44. ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation. Mol Cell Biol. 2005 Aug; 25(15):6639-48. Pedeux R, Sengupta S, Shen JC, Demidov ON, Saito S, Onogi H, Kumamoto K, Wincovitch S, Garfield SH, McMenamin M, Nagashima M, Grossman SR, Appella E, Harris CC. PMID: 16024799; PMCID: PMC1190357.
      View in: PubMed   Mentions: 58     Fields:    Translation:HumansCells
    45. Yin Yang 1 is a negative regulator of p53. Cell. 2004 Jun 25; 117(7):859-72. Sui G, Affar el B, Shi Y, Brignone C, Wall NR, Yin P, Donohoe M, Luke MP, Calvo D, Grossman SR, Shi Y. PMID: 15210108.
      View in: PubMed   Mentions: 213     Fields:    Translation:HumansAnimalsCells
    46. Physical and functional interactions between PML and MDM2. J Biol Chem. 2003 Aug 01; 278(31):29288-97. Wei X, Yu ZK, Ramalingam A, Grossman SR, Yu JH, Bloch DB, Maki CG. PMID: 12759344.
      View in: PubMed   Mentions: 20     Fields:    Translation:HumansAnimalsCells
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