Shuping Zhong, PhD

Title(s)Professor of Research Medicine
SchoolKeck School of Medicine of USC
Phone+1 323 442 1141
vCardDownload vCard

    Collapse Overview 
    Collapse Overview
    Shuping Zhong, Ph.D. received his master degree at Fudan University, Shanghai Medical College (Shanghai Medical University) and his Ph.D. at Hunan Medical University (Xiang-Ya Medical College), and finished his postdoctoral training at University of Minnesota. He joined USC in 2001 and became a faculty member in 2006 in Department of Biochemistry and Molecular Biologyof USC. His studies focus on the molecular mechanism of alcohol-associated breast cancer and hepatocellular carcinoma, which includes signal transduction, histone modifications and regulation of RNA Pol III genes on cancers. His lab discovered for the first time that alcohol-activated JNK1 upregulates Pol III gene transcription to promoted tumor formation in alcohol-fed mice. His studies were the first to demonstrate a role of histone H3 phosophorylation in deregulation of Brf1 and Pol III genes and to establish that alcohol- increased ERa activity enhanced expression of these genes, resulting in cell transformation. His lab is currently exploring the synergistic inhibitory effects of chemicals and kinase inhibitors on alcohol-associated cancers.

    Collapse Research 
    Collapse Research Activities and Funding
    Molecular mechanism of alcohol-associated liver tumor development
    NIH/NIAAA R01AA024169Sep 1, 2017 - Jun 30, 2022
    Role: Principal Investigator
    Function of Runx2 in alcohol-associated breast cancer
    NIH/NIAAA R21AA023247Sep 25, 2014 - Aug 31, 2016
    Role: Principal Investigator
    Role of MSK1, ERa and Brf1 in alcohol-associated breast cancer
    NIH/NIAAA R21AA021114Sep 5, 2012 - Aug 31, 2014
    Role: Principal Investigator
    Mechanism of Alcohol-induced RNA pol III dependent transcription
    NIH/NIAAA R21AA017288Jun 1, 2009 - May 31, 2012
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
    List All   |   Timeline
    1. Zhong Q, Xi S, Liang J, Shi G, Huang Y, Zhang Y, Levy D, Zhong S. The significance of Brf1 overexpression in human hepatocellular carcinoma. Oncotarget. 2016 Feb 02; 7(5):6243-54. PMID: 26701855; PMCID: PMC4868753.
    2. Chen YC, Zhu W, Zhong SP, Zheng FC, Gao FF, Zhang YM, Xu H, Zheng YS, Shi GG. Characterization and bioactivity of novel calcium antagonists - N-methoxy-benzyl haloperidol quaternary ammonium salt. Oncotarget. 2015 Dec 22; 6(41):43759-69. PMID: 26544729; PMCID: PMC4791264.
    3. Wang B, Zhong S, Zheng F, Zhang Y, Gao F, Chen Y, Lu B, Xu H, Shi G. N-n-butyl haloperidol iodide protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Oncotarget. 2015 Sep 22; 6(28):24709-21. PMID: 26359352; PMCID: PMC4694790.
    4. Zhang Y, Liao H, Zhong S, Gao F, Chen Y, Huang Z, Lu S, Sun T, Wang B, Li W, Xu H, Zheng F, Shi G. Effect of N-n-butyl haloperidol iodide on ROS/JNK/Egr-1 signaling in H9c2 cells after hypoxia/reoxygenation. Sci Rep. 2015 Jul 02; 5:11809. PMID: 26134032; PMCID: PMC4488875.
    5. Peng H, Zhu QS, Zhong S, Levy D. Transcription of the Human Microsomal Epoxide Hydrolase Gene (EPHX1) Is Regulated by PARP-1 and Histone H1.2. Association with Sodium-Dependent Bile Acid Transport. PLoS One. 2015; 10(5):e0125318. PMID: 25992604; PMCID: PMC4439041.
    6. Zhong Q, Shi G, Zhang Q, Lu L, Levy D, Zhong S. Tamoxifen represses alcohol-induced transcription of RNA polymerase III-dependent genes in breast cancer cells. Oncotarget. 2014 Dec 15; 5(23):12410-7. PMID: 25400119; PMCID: PMC4322994.
    7. Zhong Q, Shi G, Zhang Y, Lu L, Levy D, Zhong S. Alteration of BRCA1 expression affects alcohol-induced transcription of RNA Pol III-dependent genes. Gene. 2015 Feb 01; 556(1):74-9. PMID: 25447904; PMCID: PMC4272617.
    8. Huang YP, Gao FF, Wang B, Zheng FC, Zhang YM, Chen YC, Huang ZQ, Zheng YS, Zhong SP, Shi GG. N-n-butyl haloperidol iodide inhibits H2O2-induced Na+/Ca2+-exchanger activation via the Na+/H+ exchanger in rat ventricular myocytes. Drug Des Devel Ther. 2014; 8:1257-67. PMID: 25246767; PMCID: PMC4166912.
    9. Yuan R, Zheng F, Zhong S, Tao X, Zhang Y, Gao F, Yao F, Chen J, Chen Y, Shi G. Self-assembled nanoparticles of glycyrrhetic acid-modified pullulan as a novel carrier of curcumin. Molecules. 2014 Aug 28; 19(9):13305-18. PMID: 25170951.
      View in: PubMed
    10. Cai C, Chen Y, Zhong S, Ji B, Wang J, Bai X, Shi G. Anti-inflammatory activity of N-butanol extract from Ipomoea stolonifera in vivo and in vitro. PLoS One. 2014; 9(4):e95931. PMID: 24752203; PMCID: PMC3994116.
    11. Niu Y, Wang Z, Huang H, Zhong S, Cai W, Xie Y, Shi G. Activated pregnane X receptor inhibits cervical cancer cell proliferation and tumorigenicity by inducing G2/M cell-cycle arrest. Cancer Lett. 2014 May 28; 347(1):88-97. PMID: 24486740.
      View in: PubMed
    12. Jiang Z, Chen Y, Yao F, Chen W, Zhong S, Zheng F, Shi G. Antioxidant, antibacterial and antischistosomal activities of extracts from Grateloupia livida (Harv). Yamada. PLoS One. 2013; 8(11):e80413. PMID: 24312216; PMCID: PMC3843663.
    13. Zhang Y, Chen G, Zhong S, Zheng F, Gao F, Chen Y, Huang Z, Cai W, Li W, Liu X, Zheng Y, Xu H, Shi G. N-n-butyl haloperidol iodide ameliorates cardiomyocytes hypoxia/reoxygenation injury by extracellular calcium-dependent and -independent mechanisms. Oxid Med Cell Longev. 2013; 2013:912310. PMID: 24392181; PMCID: PMC3857550.
    14. Zhong Q, Shi G, Zhang Q, Zhang Y, Levy D, Zhong S. Role of phosphorylated histone H3 serine 10 in DEN-induced deregulation of Pol III genes and cell proliferation and transformation. Carcinogenesis. 2013 Nov; 34(11):2460-9. PMID: 23774401; PMCID: PMC3888355.
    15. Peng H, Zhu QS, Zhong S, Levy D. Transcription of the human microsomal epoxide hydrolase gene (EPHX1) is regulated by an HNF-4a/CAR/RXR/PSF complex. Biochim Biophys Acta. 2013 Oct; 1829(10):1000-9. PMID: 23714182.
      View in: PubMed
    16. Zhong Q, Shi G, Zhang Y, Levy D, Zhong S. Elk1 and AP-1 sites in the TBP promoter mediate alcohol-induced deregulation of Pol III-dependent genes. Gene. 2013 Aug 15; 526(1):54-60. PMID: 23454483; PMCID: PMC3715583.
    17. Zhang Q, Jin J, Zhong Q, Yu X, Levy D, Zhong S. ERa mediates alcohol-induced deregulation of Pol III genes in breast cancer cells. Carcinogenesis. 2013 Jan; 34(1):28-37. PMID: 23054611; PMCID: PMC3534194.
    18. Zhong S, Xu J, Li P, Tsukamoto H. Caveosomal oxidative stress causes Src-p21ras activation and lysine 63 TRAF6 protein polyubiquitination in iron-induced M1 hepatic macrophage activation. J Biol Chem. 2012 Sep 14; 287(38):32078-84. PMID: 22829592; PMCID: PMC3442538.
    19. Zhong S, Machida K, Tsukamoto H, Johnson DL. Alcohol induces RNA polymerase III-dependent transcription through c-Jun by co-regulating TATA-binding protein (TBP) and Brf1 expression. J Biol Chem. 2011 Jan 28; 286(4):2393-401. PMID: 21106530; PMCID: PMC3024733.
    20. Zhong S, Johnson DL. The JNKs differentially regulate RNA polymerase III transcription by coordinately modulating the expression of all TFIIIB subunits. Proc Natl Acad Sci U S A. 2009 Aug 04; 106(31):12682-7. PMID: 19620725; PMCID: PMC2722300.
    21. Woiwode A, Johnson SA, Zhong S, Zhang C, Roeder RG, Teichmann M, Johnson DL. PTEN represses RNA polymerase III-dependent transcription by targeting the TFIIIB complex. Mol Cell Biol. 2008 Jun; 28(12):4204-14. PMID: 18391023; PMCID: PMC2423115.
    22. Zhou D, Zhong S, Ye JJ, Quach KM, Johnson DL, Chen S. PNRC is a unique nuclear receptor coactivator that stimulates RNA polymerase III-dependent transcription. J Mol Signal. 2007 Jul 05; 2:5. PMID: 17612402; PMCID: PMC1939705.
    23. Zhong S, Fromm J, Johnson DL. TBP is differentially regulated by c-Jun N-terminal kinase 1 (JNK1) and JNK2 through Elk-1, controlling c-Jun expression and cell proliferation. Mol Cell Biol. 2007 Jan; 27(1):54-64. PMID: 17074809; PMCID: PMC1800663.
    24. Zhong S, Zhang C, Johnson DL. Epidermal growth factor enhances cellular TATA binding protein levels and induces RNA polymerase I- and III-dependent gene activity. Mol Cell Biol. 2004 Jun; 24(12):5119-29. PMID: 15169879; PMCID: PMC419868.
    25. Zhong S, Goto H, Inagaki M, Dong Z. Phosphorylation at serine 28 and acetylation at lysine 9 of histone H3 induced by trichostatin A. Oncogene. 2003 Aug 14; 22(34):5291-7. PMID: 12917630.
      View in: PubMed
    26. Shen ZY, Hu SP, Lu LC, Tang CZ, Kuang ZS, Zhong SP, Zeng Y. Detection of human papillomavirus in esophageal carcinoma. J Med Virol. 2002 Nov; 68(3):412-6. PMID: 12226830.
      View in: PubMed
    27. She QB, Ma WY, Zhong S, Dong Z. Activation of JNK1, RSK2, and MSK1 is involved in serine 112 phosphorylation of Bad by ultraviolet B radiation. J Biol Chem. 2002 Jul 05; 277(27):24039-48. PMID: 11983683.
      View in: PubMed
    28. Zhong S, Jansen C, She QB, Goto H, Inagaki M, Bode AM, Ma WY, Dong Z. Ultraviolet B-induced phosphorylation of histone H3 at serine 28 is mediated by MSK1. J Biol Chem. 2001 Aug 31; 276(35):33213-9. PMID: 11441012.
      View in: PubMed
    29. Zhong S, Quealy JA, Bode AM, Nomura M, Kaji A, Ma WY, Dong Z. Organ-specific activation of activator protein-1 in transgenic mice by 12-o-tetradecanoylphorbol-13-acetate with different administration methods. Cancer Res. 2001 May 15; 61(10):4084-91. PMID: 11358830.
      View in: PubMed
    30. Nomura M, Kaji A, Ma WY, Zhong S, Liu G, Bowden GT, Miyamoto KI, Dong Z. Mitogen- and stress-activated protein kinase 1 mediates activation of Akt by ultraviolet B irradiation. J Biol Chem. 2001 Jul 06; 276(27):25558-67. PMID: 11350959.
      View in: PubMed
    31. Zhang Y, Dong Z, Nomura M, Zhong S, Chen N, Bode AM, Dong Z. Signal transduction pathways involved in phosphorylation and activation of p70S6K following exposure to UVA irradiation. J Biol Chem. 2001 Jun 15; 276(24):20913-23. PMID: 11279232.
      View in: PubMed
    32. Zhong SP, Ma WY, Quealy JA, Zhang Y, Dong Z. Organ-specific distribution of AP-1 in AP-1 luciferase transgenic mice during the maturation process. Am J Physiol Regul Integr Comp Physiol. 2001 Feb; 280(2):R376-81. PMID: 11208564.
      View in: PubMed
    33. Zhang Y, Zhong S, Dong Z, Chen N, Bode AM, Ma W, Dong Z. UVA induces Ser381 phosphorylation of p90RSK/MAPKAP-K1 via ERK and JNK pathways. J Biol Chem. 2001 May 04; 276(18):14572-80. PMID: 11278279.
      View in: PubMed
    34. Zhong S, Zhang Y, Jansen C, Goto H, Inagaki M, Dong Z. MAP kinases mediate UVB-induced phosphorylation of histone H3 at serine 28. J Biol Chem. 2001 Apr 20; 276(16):12932-7. PMID: 11278789.
      View in: PubMed
    35. Zhang Y, Mattjus P, Schmid PC, Dong Z, Zhong S, Ma WY, Brown RE, Bode AM, Schmid HH, Dong Z. Involvement of the acid sphingomyelinase pathway in uva-induced apoptosis. J Biol Chem. 2001 Apr 13; 276(15):11775-82. PMID: 11278294.
      View in: PubMed
    36. Zhong SP, Ma WY, Dong Z. ERKs and p38 kinases mediate ultraviolet B-induced phosphorylation of histone H3 at serine 10. J Biol Chem. 2000 Jul 14; 275(28):20980-4. PMID: 10806218.
      View in: PubMed