Seiji Shibata, MD, PhD

Title(s)Assistant Professor of Clinical Otolaryngology Head & Neck Surgery
SchoolKeck School of Medicine of Usc
Address1537 Norfolk Street Street
Health Sciences Campus
Los Angeles CA 90033
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    Kansai Medical University, JapanMD/PhD03/2007Medicine
    University of Michigan, MI06/2011Neuroscience
    University of Iowa Hospitals and Clinics, IA06/2018Otolaryngology Residency
    University of Iowa Hospitals and Clinics, IA06/2020Neurotology fellowship

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    Seiji B. Shibata, MD, PhD, specializes in chronic ear disease, otosclerosis, cochlear implantation, vestibular disorders, facial nerve disorders, and skull base tumors including acoustic neuromas, meningiomas, and glomus tumors.

    Dr. Shibata graduated from Kansai Medical University in Osaka Japan, where he earned both his medical doctorate and PhD. He completed his residency in Otolaryngology – Head and Neck Surgery at Kansai Medical University Hospitals in Osaka Japan. Dr. Shibata then pursued further training in the United States and completed his residency in Otolaryngology – Head and Neck Surgery and his surgical fellowship in Neurotology at the world-renowned University of Iowa Hospitals and Clinics.

    Dr. Shibata has conducted cutting-edge inner ear research at both the University of Michigan and the University of Iowa. He has authored numerous peer-reviewed publications and textbook chapters in his field. He is a board-certified member of both the American Academy of Otolaryngology – Head and Neck Surgery and the Oto-Rhino-Laryngological Society of Japan. Dr. Shibata is a physician-scientist who strives to offer high quality, compassionate care to patients in his clinic while pursuing scientific advancements in his laboratory.
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    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Neomycin-induced deafness in neonatal mice. J Neurosci Methods. 2023 05 01; 391:109852. Cutri RM, Lin J, Nguyen NV, Shakya D, Shibata SB. PMID: 37031766.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    2. Incidence of Postoperative CSF Leaks in Class III Obese Patients Undergoing Middle Cranial Fossa Approach for Spontaneous CSF Leak Repair. Otol Neurotol. 2023 04 01; 44(4):382-387. Cutri RM, Shibata SB, Zhang H, Gantz BJ, Hansen MR. PMID: 36791337.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. Mutation-agnostic RNA interference with engineered replacement rescues Tmc1-related hearing loss. Life Sci Alliance. 2023 03; 6(3). Iwasa Y, Klimara MJ, Yoshimura H, Walls WD, Omichi R, West CA, Shibata SB, Ranum PT, Smith RJ. PMID: 36574989; PMCID: PMC9795038.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    4. Comparative Analysis of Robotics-Assisted and Manual Insertions of Cochlear Implant Electrode Arrays. Otol Neurotol. 2022 12 01; 43(10):1155-1161. Claussen AD, Shibata SB, Kaufmann CR, Henslee A, Hansen MR. PMID: 36201552; PMCID: PMC10962863.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    5. Reduction of sporadic and neurofibromatosis type 2-associated vestibular schwannoma growth in vitro and in vivo after treatment with the c-Jun N-terminal kinase inhibitor AS602801. J Neurosurg. 2023 04 01; 138(4):962-971. Dougherty MC, Shibata SB, Clark JJ, Canady FJ, Yates CW, Hansen MR. PMID: 36087315; PMCID: PMC10193498.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    6. Neuralgia and Atypical Facial, Ear, and Head Pain. Otolaryngol Clin North Am. 2022 Jun; 55(3):595-606. Cutri RM, Shakya D, Shibata SB. PMID: 35680205.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    7. The biological underpinnings of radiation therapy for vestibular schwannomas: Review of the literature. Laryngoscope Investig Otolaryngol. 2021 Jun; 6(3):458-468. Dougherty MC, Shibata SB, Hansen MR. PMID: 34195368; PMCID: PMC8223465.
      View in: PubMed   Mentions: 4  
    8. Transmastoid and Transtemporal Drainage of Petrous Apicitis with Otitis Media. Ann Otol Rhinol Laryngol. 2021 Mar; 130(3):314-318. Isaac H, Liu A, Shibata SB, Hansen MR. PMID: 32772562.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    9. Effects of Neurod1 Expression on Mouse and Human Schwannoma Cells. Laryngoscope. 2021 01; 131(1):E259-E270. Kersigo J, Gu L, Xu L, Pan N, Vijayakuma S, Jones T, Shibata SB, Fritzsch B, Hansen MR. PMID: 32438526; PMCID: PMC7772964.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansAnimalsCells
    10. Hair Cell Transduction Efficiency of Single- and Dual-AAV Serotypes in Adult Murine Cochleae. Mol Ther Methods Clin Dev. 2020 Jun 12; 17:1167-1177. Omichi R, Yoshimura H, Shibata SB, Vandenberghe LH, Smith RJH. PMID: 32518805; PMCID: PMC7270144.
      View in: PubMed   Mentions: 21  
    11. Gene therapy for hair cell regeneration: Review and new data. Hear Res. 2020 09 01; 394:107981. Shibata SB, West MB, Du X, Iwasa Y, Raphael Y, Kopke RD. PMID: 32563621.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansAnimalsCells
    12. An Osseous Destructive Mass of the Infratemporal Fossa. JAMA Otolaryngol Head Neck Surg. 2020 02 01; 146(2):194-195. Vesole AS, Shibata SB, Hansen MR. PMID: 31774471.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    13. Gene therapy for hearing loss. Hum Mol Genet. 2019 10 01; 28(R1):R65-R79. Omichi R, Shibata SB, Morton CC, Smith RJH. PMID: 31227837; PMCID: PMC6796998.
      View in: PubMed   Mentions: 50     Fields:    Translation:HumansAnimals
    14. Targeted Allele Suppression Prevents Progressive Hearing Loss in the Mature Murine Model of Human TMC1 Deafness. Mol Ther. 2019 03 06; 27(3):681-690. Yoshimura H, Shibata SB, Ranum PT, Moteki H, Smith RJH. PMID: 30686588; PMCID: PMC6403483.
      View in: PubMed   Mentions: 46     Fields:    Translation:HumansAnimalsCells
    15. Enhanced viral-mediated cochlear gene delivery in adult mice by combining canal fenestration with round window membrane inoculation. Sci Rep. 2018 02 14; 8(1):2980. Yoshimura H, Shibata SB, Ranum PT, Smith RJH. PMID: 29445157; PMCID: PMC5812997.
      View in: PubMed   Mentions: 51     Fields:    Translation:HumansAnimalsCells
    16. Intravenous rAAV2/9 injection for murine cochlear gene delivery. Sci Rep. 2017 08 29; 7(1):9609. Shibata SB, Yoshimura H, Ranum PT, Goodwin AT, Smith RJH. PMID: 28852025; PMCID: PMC5575199.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCells
    17. RNA Interference Prevents Autosomal-Dominant Hearing Loss. Am J Hum Genet. 2016 06 02; 98(6):1101-1113. Shibata SB, Ranum PT, Moteki H, Pan B, Goodwin AT, Goodman SS, Abbas PJ, Holt JR, Smith RJH. PMID: 27236922; PMCID: PMC4908151.
      View in: PubMed   Mentions: 67     Fields:    Translation:HumansAnimalsCells
    18. Comprehensive genetic testing in the clinical evaluation of 1119 patients with hearing loss. Hum Genet. 2016 Apr; 135(4):441-450. Sloan-Heggen CM, Bierer AO, Shearer AE, Kolbe DL, Nishimura CJ, Frees KL, Ephraim SS, Shibata SB, Booth KT, Campbell CA, Ranum PT, Weaver AE, Black-Ziegelbein EA, Wang D, Azaiez H, Smith RJH. PMID: 26969326; PMCID: PMC4796320.
      View in: PubMed   Mentions: 219     Fields:    Translation:Humans
    19. HOMER2, a stereociliary scaffolding protein, is essential for normal hearing in humans and mice. PLoS Genet. 2015 Mar; 11(3):e1005137. Azaiez H, Decker AR, Booth KT, Simpson AC, Shearer AE, Huygen PL, Bu F, Hildebrand MS, Ranum PT, Shibata SB, Turner A, Zhang Y, Kimberling WJ, Cornell RA, Smith RJ. PMID: 25816005; PMCID: PMC4376867.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    20. Differential effects of AAV.BDNF and AAV.Ntf3 in the deafened adult guinea pig ear. Sci Rep. 2015 Mar 02; 5:8619. Budenz CL, Wong HT, Swiderski DL, Shibata SB, Pfingst BE, Raphael Y. PMID: 25726967; PMCID: PMC4649680.
      View in: PubMed   Mentions: 33     Fields:    Translation:AnimalsCells
    21. TBC1D24 mutation causes autosomal-dominant nonsyndromic hearing loss. Hum Mutat. 2014 Jul; 35(7):819-23. Azaiez H, Booth KT, Bu F, Huygen P, Shibata SB, Shearer AE, Kolbe D, Meyer N, Black-Ziegelbein EA, Smith RJ. PMID: 24729539; PMCID: PMC4267685.
      View in: PubMed   Mentions: 47     Fields:    Translation:HumansCells
    22. Downregulation of N-methyl-D-aspartate receptor ζ1 subunit (GluN1) gene in inferior colliculus with aging. Brain Res. 2012 May 15; 1454:23-32. Osumi Y, Shibata SB, Kanda S, Yagi M, Ooka H, Shimano T, Asako M, Kawamoto K, Kuriyama H, Inoue T, Nishiyama T, Yamashita T, Tomoda K. PMID: 22483791.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    23. Hyaluronic acid enhances gene delivery into the cochlea. Hum Gene Ther. 2012 Mar; 23(3):302-10. Shibata SB, Cortez SR, Wiler JA, Swiderski DL, Raphael Y. PMID: 22074321; PMCID: PMC3300073.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    24. Cochlear infrastructure for electrical hearing. Hear Res. 2011 Nov; 281(1-2):65-73. Pfingst BE, Bowling SA, Colesa DJ, Garadat SN, Raphael Y, Shibata SB, Strahl SB, Su GL, Zhou N. PMID: 21605648; PMCID: PMC3208788.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimals
    25. Nerve maintenance and regeneration in the damaged cochlea. Hear Res. 2011 Nov; 281(1-2):56-64. Shibata SB, Budenz CL, Bowling SA, Pfingst BE, Raphael Y. PMID: 21596129; PMCID: PMC3196294.
      View in: PubMed   Mentions: 35     Fields:    Translation:HumansAnimalsCells
    26. Future approaches for inner ear protection and repair. J Commun Disord. 2010 Jul-Aug; 43(4):295-310. Shibata SB, Raphael Y. PMID: 20430401; PMCID: PMC2905731.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    27. Transgenic BDNF induces nerve fiber regrowth into the auditory epithelium in deaf cochleae. Exp Neurol. 2010 Jun; 223(2):464-72. Shibata SB, Cortez SR, Beyer LA, Wiler JA, Di Polo A, Pfingst BE, Raphael Y. PMID: 20109446; PMCID: PMC2864331.
      View in: PubMed   Mentions: 61     Fields:    Translation:AnimalsCells
    28. Gene transfer using bovine adeno-associated virus in the guinea pig cochlea. Gene Ther. 2009 Aug; 16(8):990-7. Shibata SB, Di Pasquale G, Cortez SR, Chiorini JA, Raphael Y. PMID: 19458651; PMCID: PMC2726904.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    29. Administration of amitriptyline attenuates noise-induced hearing loss via glial cell line-derived neurotrophic factor (GDNF) induction. Brain Res. 2007 May 04; 1144:74-81. Shibata SB, Osumi Y, Yagi M, Kanda S, Kawamoto K, Kuriyama H, Nishiyama T, Yamashita T. PMID: 17331482.
      View in: PubMed   Mentions: 11     Fields:    Translation:AnimalsCells
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