Brian Applegate, PhD

Title(s)Professor of Otolaryngology - Head & Neck Surgery and Ophthalmology
SchoolKeck School of Medicine of Usc
Address1537 Norfolk Street Street
Health Sciences Campus
Los Angeles CA 90033
ORCID ORCID Icon0000-0003-2795-5678 Additional info
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    Other Positions
    Title(s)Viterbi School of Biomedical Engineering


    Collapse Biography 
    Collapse Education and Training
    The Ohio State University, Columbus, OHPhD12/2000Chemistry

    Collapse Overview 
    Collapse Overview
    Our research interests are broadly to develop novel biophotonic technologies for point-of-care diagnosis and monitoring of human disease as well as the basic scientific understanding of human disease.
    Collapse Websites

    Collapse Research 
    Collapse Research Activities and Funding
    Comb Light Source/Imaging spectrometer for advanced Spectral Domain Optical Coherence Tomography
    NIH R21GM135530Sep 1, 2020 - Aug 31, 2022
    Role: Principal Investigator
    Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH R01EB027113Apr 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH R01HL111361Apr 1, 2012 - Mar 31, 2019
    Role: Principal Investigator
    Development of high-resolution molecular imaging of endogenous chromophores with
    NIH R21RR025799May 15, 2009 - Apr 30, 2013
    Role: Principal Investigator
    New Technologies for high resolution optical molecular imaging
    NIH R21EB007729Jun 1, 2008 - May 31, 2011
    Role: Principal Investigator
    Bringing Molecular Contrast to OCT
    NIH F32EB004237Sep 1, 2004 - Aug 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Endolymphatic hydrops and cochlear synaptopathy after noise exposure are distinct sequelae of hair cell stereociliary bundle trauma. Sci Rep. 2024 10 27; 14(1):25660. Fong ML, Paik CB, Quiñones PM, Walker CB, Serafino MJ, Pan DW, Martinez E, Wang J, Phillips GW, Applegate BE, Gratton MA, Oghalai JS. PMID: 39465341; PMCID: PMC11514180.
      View in: PubMed   Mentions:    Fields:    Translation:AnimalsCellsPHPublic Health
    2. Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2. Dis Model Mech. 2024 Oct 17. Desingu Rajan AR, Huang Y, Stundl J, Chu K, Irodi A, Yang Z, Applegate BE, Bronner ME. PMID: 39415595.
      View in: PubMed   Mentions:    Fields:    
    3. Optical coherence tomography otoscope for imaging of tympanic membrane and middle ear pathology. J Biomed Opt. 2024 Aug; 29(8):086005. Kim W, Long R, Yang Z, Oghalai JS, Applegate BE. PMID: 39165857; PMCID: PMC11334941.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. Generation of a zebrafish neurofibromatosis model via inducible knockout of nf2. bioRxiv. 2024 Apr 27. Rajan ARD, Huang Y, Stundl J, Chu K, Irodi A, Yang Z, Applegate BE, Bronner ME. PMID: 38712289; PMCID: PMC11071375.
      View in: PubMed   Mentions:
    5. Optical Coherence Tomography as a Tool for Imaging the Sinonasal Mucosa in Patients: A Systematic Review. Ear Nose Throat J. 2023 Nov 30; 1455613231214622. Badash I, Raskin J, Applegate B, Wrobel B, Hur K. PMID: 38032064.
      View in: PubMed   Mentions:    Fields:    
    6. Electronic frequency shifting enables long, variable working distance optical coherence tomography. Biomed Opt Express. 2023 Dec 01; 14(12):6579-6591. Wisniowiecki AM, Applegate BE. PMID: 38420318; PMCID: PMC10898551.
      View in: PubMed   Mentions:
    7. Multi-window approach enables two-fold improvement in OCT axial resolution with strong side-lobe suppression and improved phase sensitivity. Biomed Opt Express. 2023 Dec 01; 14(12):6301-6316. Walker CB, Wisniowiecki A, Tang JC, Quiñones PM, Kim W, Oghalai JS, Applegate BE. PMID: 38420305; PMCID: PMC10898564.
      View in: PubMed   Mentions: 1  
    8. High-spatial density snapshot imaging spectrometer enabled by 2-photon fabricated custom fiber bundles. Opt Lett. 2023 Nov 01; 48(21):5587-5590. Cao H, Flynn C, Applegate B, Tkaczyk TS. PMID: 37910709.
      View in: PubMed   Mentions:    Fields:    
    9. Automated Segmentation of Optical Coherence Tomography Images of the Human Tympanic Membrane Using Deep Learning. Algorithms. 2023 Sep; 16(9). Oghalai TP, Long R, Kim W, Applegate BE, Oghalai JS. PMID: 39104565; PMCID: PMC11299891.
      View in: PubMed   Mentions:
    10. COVID-19 in the Clinic: Trial of an Aerosol Containment Mask for Endoscopic Clinic Procedures. Otolaryngol Head Neck Surg. 2024 Jan; 170(1):265-271. Ference EH, Kim W, Oghalai JS, Walker CB, Badash I, Gallagher T, Ma HJ, Applegate BE. PMID: 37622584.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    11. Porcine vocal fold elasticity evaluation using Brillouin spectroscopy. J Biomed Opt. 2023 08; 28(8):087002. Cheburkanov V, Keene E, Pipal J, Johns M, Applegate BE, Yakovlev VV. PMID: 37560326; PMCID: PMC10407566.
      View in: PubMed   Mentions:    Fields:    Translation:Animals
    12. Fabrication of waveguide directional couplers using 2-photon lithography. Opt Express. 2023 Jul 31; 31(16):26323-26334. Flynn C, Cao H, Applegate BE, Tkaczyk TS. PMID: 37710495; PMCID: PMC10544952.
      View in: PubMed   Mentions:    Fields:    
    13. The impact of targeted ablation of one row of outer hair cells and Deiters' cells on cochlear amplification. J Neurophysiol. 2022 11 01; 128(5):1365-1373. Xia A, Udagawa T, Quiñones PM, Atkinson PJ, Applegate BE, Cheng AG, Oghalai JS. PMID: 36259670; PMCID: PMC9678430.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    14. Interplay between traveling wave propagation and amplification at the apex of the mouse cochlea. Biophys J. 2022 08 02; 121(15):2940-2951. Nankali A, Shera CA, Applegate BE, Oghalai JS. PMID: 35778839; PMCID: PMC9388393.
      View in: PubMed   Mentions: 4     Fields:    Translation:AnimalsCells
    15. Vector of motion measurements in the living cochlea using a 3D OCT vibrometry system. Biomed Opt Express. 2022 Apr 01; 13(4):2542-2553. Kim W, Liu D, Kim S, Ratnayake K, Macias-Escriva F, Mattison S, Oghalai JS, Applegate BE. PMID: 35519276; PMCID: PMC9045890.
      View in: PubMed   Mentions: 3  
    16. Unloading outer hair cell bundles in vivo does not yield evidence of spontaneous oscillations in the mouse cochlea. Hear Res. 2022 09 15; 423:108473. Quiñones PM, Meenderink SWF, Applegate BE, Oghalai JS. PMID: 35287989; PMCID: PMC9339463.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    17. Endolymphatic Hydrops is a Marker of Synaptopathy Following Traumatic Noise Exposure. Front Cell Dev Biol. 2021; 9:747870. Badash I, Quiñones PM, Oghalai KJ, Wang J, Lui CG, Macias-Escriva F, Applegate BE, Oghalai JS. PMID: 34805158; PMCID: PMC8602199.
      View in: PubMed   Mentions: 6  
    18. Cochlear outer hair cell electromotility enhances organ of Corti motion on a cycle-by-cycle basis at high frequencies in vivo. Proc Natl Acad Sci U S A. 2021 10 26; 118(43). Dewey JB, Altoè A, Shera CA, Applegate BE, Oghalai JS. PMID: 34686590; PMCID: PMC8639341.
      View in: PubMed   Mentions: 34     Fields:    Translation:AnimalsCells
    19. COVID-19 in the Clinic: Human Testing of an Aerosol Containment Mask for Endoscopic Clinic Procedures. Otolaryngol Head Neck Surg. 2022 04; 166(4):669-675. Ference EH, Kim W, Oghalai JS, Walker CB, Kim JH, Gallagher T, Ma HJ, Applegate BE. PMID: 34311614; PMCID: PMC8978456.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    20. In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device. Biomed Opt Express. 2021 Aug 01; 12(8):5196-5213. Lui CG, Kim W, Dewey JB, Macías-Escrivá FD, Ratnayake K, Oghalai JS, Applegate BE. PMID: 34513251; PMCID: PMC8407818.
      View in: PubMed   Mentions: 7  
    21. COVID-19 in the Clinic: Aerosol Containment Mask for Endoscopic Otolaryngologic Clinic Procedures. Otolaryngol Head Neck Surg. 2022 05; 166(5):850-857. Ference EH, Kim W, Oghalai JS, Kim JH, Applegate BE. PMID: 34154484; PMCID: PMC8262032.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    22. Development and Characterization of PLGA-Based Multistage Delivery System for Enhanced Payload Delivery to Targeted Vascular Endothelium. Macromol Biosci. 2021 03; 21(3):e2000377. Palma-Chavez JA, Fuentes K, Applegate BE, Jo JA, Charoenphol P. PMID: 33393217; PMCID: PMC8203499.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    23. In Vivo Cochlear imaging provides a tool to study endolymphatic hydrops. J Vestib Res. 2021; 31(4):269-276. Badash I, Applegate BE, Oghalai JS. PMID: 33136083.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging. J Biomed Opt. 2020 09; 25(9). Chen X, Kim W, Serafino M, Tan Z, Jo J, Applegate B. PMID: 33000570; PMCID: PMC7525154.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    25. Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography. Biomed Opt Express. 2020 Aug 01; 11(8):4255-4274. Palma-Chavez JA, Kim W, Serafino M, Jo JA, Charoenphol P, Applegate BE. PMID: 32923040; PMCID: PMC7449750.
      View in: PubMed   Mentions: 3  
    26. Direct frequency domain fluorescence lifetime imaging using field programmable gate arrays for real time processing. Rev Sci Instrum. 2020 Mar 01; 91(3):033708. Serafino MJ, Applegate BE, Jo JA. PMID: 32260007; PMCID: PMC7269681.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    27. Noise and sensitivity in optical coherence tomography based vibrometry. Opt Express. 2019 Nov 11; 27(23):33333-33350. Kim S, Oghalai JS, Applegate BE. PMID: 31878404; PMCID: PMC7046037.
      View in: PubMed   Mentions: 6     Fields:    
    28. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system. Biomed Opt Express. 2019 Sep 01; 10(9):4395-4410. Kim W, Kim S, Huang S, Oghalai JS, Applegate BE. PMID: 31565497; PMCID: PMC6757470.
      View in: PubMed   Mentions: 19  
    29. Automated detection of superficial macrophages in atherosclerotic plaques using autofluorescence lifetime imaging. Atherosclerosis. 2019 06; 285:120-127. Rico-Jimenez JJ, Serafino MJ, Shrestha S, Chen X, Kim W, Adame J, Buja LM, Vela D, Applegate BE, Jo JA. PMID: 31051415; PMCID: PMC6536321.
      View in: PubMed   Mentions: 8     Fields:    Translation:HumansCells
    30. Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces. J Neurosci. 2019 03 06; 39(10):1805-1816. Dewey JB, Applegate BE, Oghalai JS. PMID: 30651330; PMCID: PMC6407303.
      View in: PubMed   Mentions: 47     Fields:    Translation:AnimalsCells
    31. Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry. J Neurophysiol. 2018 12 01; 120(6):2847-2857. Dong W, Xia A, Raphael PD, Puria S, Applegate B, Oghalai JS. PMID: 30281386; PMCID: PMC6337041.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    32. Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea. Cell Rep. 2018 06 05; 23(10):2915-2927. Dewey JB, Xia A, Müller U, Belyantseva IA, Applegate BE, Oghalai JS. PMID: 29874579; PMCID: PMC6309882.
      View in: PubMed   Mentions: 25     Fields:    Translation:AnimalsCells
    33. Osmotic stabilization prevents cochlear synaptopathy after blast trauma. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):E4853-E4860. Kim J, Xia A, Grillet N, Applegate BE, Oghalai JS. PMID: 29735658; PMCID: PMC6003510.
      View in: PubMed   Mentions: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    34. Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window. Opt Lett. 2018 May 01; 43(9):1966-1969. Kim W, Kim S, Oghalai JS, Applegate BE. PMID: 29714773; PMCID: PMC6731066.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    35. Hybrid nonlinear photoacoustic and reflectance confocal microscopy for label-free subcellular imaging with a single light source. Opt Lett. 2017 Oct 01; 42(19):4028-4031. Mattison SP, Mondragon E, Kaunas R, Applegate BE. PMID: 28957189.
      View in: PubMed   Mentions: 3     Fields:    Translation:Cells
    36. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography. Biomed Opt Express. 2017 Oct 01; 8(10):4579-4594. Liu GS, Zhu MH, Kim J, Raphael P, Applegate BE, Oghalai JS. PMID: 29082086; PMCID: PMC5654801.
      View in: PubMed   Mentions: 9  
    37. Enhanced coupling of light into a turbid medium through microscopic interface engineering. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7941-7946. Thompson JV, Hokr BH, Kim W, Ballmann CW, Applegate BE, Jo J, Yamilov A, Cao H, Scully MO, Yakovlev VV. PMID: 28701381; PMCID: PMC5544321.
      View in: PubMed   Mentions: 1     Fields:    
    38. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography. J Biomed Opt. 2017 07 01; 22(7):76002. Liu GS, Kim J, Applegate BE, Oghalai JS. PMID: 28687821.
      View in: PubMed   Mentions: 4     Fields:    Translation:Animals
    39. Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla. Nat Commun. 2016 10 31; 7:13133. Xia A, Liu X, Raphael PD, Applegate BE, Oghalai JS. PMID: 27796310; PMCID: PMC5095595.
      View in: PubMed   Mentions: 14     Fields:    Translation:AnimalsCells
    40. Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti. J Neurosci. 2016 08 03; 36(31):8160-73. Lee HY, Raphael PD, Xia A, Kim J, Grillet N, Applegate BE, Ellerbee Bowden AK, Oghalai JS. PMID: 27488636; PMCID: PMC4971363.
      View in: PubMed   Mentions: 77     Fields:    Translation:AnimalsCells
    41. Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence. Biomed Opt Express. 2016 Sep 01; 7(9):3184-3197. Shrestha S, Serafino MJ, Rico-Jimenez J, Park J, Chen X, Zhaorigetu S, Walton BL, Jo JA, Applegate BE. PMID: 27699091; PMCID: PMC5030003.
      View in: PubMed   Mentions: 9  
    42. Lensless, ultra-wideband fiber optic rotary joint for biomedical applications. Opt Lett. 2016 May 01; 41(9):1973-6. Kim W, Chen X, Jo JA, Applegate BE. PMID: 27128052; PMCID: PMC6731063.
      View in: PubMed   Mentions: 4     Fields:    
    43. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model. Biomed Opt Express. 2016 May 01; 7(5):2000-15. Pande P, Shrestha S, Park J, Gimenez-Conti I, Brandon J, Applegate BE, Jo JA. PMID: 27231638; PMCID: PMC4871098.
      View in: PubMed   Mentions: 11  
    44. High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography. Biomed Opt Express. 2016 Apr 01; 7(4):1430-44. Kim S, Raphael PD, Oghalai JS, Applegate BE. PMID: 27446666; PMCID: PMC4929652.
      View in: PubMed   Mentions: 5  
    45. Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo. Methods Mol Biol. 2016; 1427:449-62. Jawadi Z, Applegate BE, Oghalai JS. PMID: 27259941; PMCID: PMC5424701.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    46. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear. Biomed Opt Express. 2015 Jun 01; 6(6):2246-57. Pawlowski ME, Shrestha S, Park J, Applegate BE, Oghalai JS, Tkaczyk TS. PMID: 26114043; PMCID: PMC4473758.
      View in: PubMed   Mentions: 11  
    47. In vivo molecular contrast OCT imaging of methylene blue. Opt Lett. 2015 Apr 01; 40(7):1426-9. Kim W, Applegate BE. PMID: 25831349; PMCID: PMC6731064.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    48. Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3128-33. Lee HY, Raphael PD, Park J, Ellerbee AK, Applegate BE, Oghalai JS. PMID: 25737536; PMCID: PMC4364183.
      View in: PubMed   Mentions: 103     Fields:    Translation:Animals
    49. Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis. Eur Heart J Cardiovasc Imaging. 2015 Aug; 16(8):910-8. Jo JA, Park J, Pande P, Shrestha S, Serafino MJ, Rico Jimenez Jde J, Clubb F, Walton B, Buja LM, Phipps JE, Feldman MD, Adame J, Applegate BE. PMID: 25722204; PMCID: PMC4592321.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    50. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear. Opt Lett. 2014 Nov 01; 39(21):6233-6. Park J, Carbajal EF, Chen X, Oghalai JS, Applegate BE. PMID: 25361322; PMCID: PMC5407367.
      View in: PubMed   Mentions: 12     Fields:    Translation:Animals
    51. Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch. J Biomed Opt. 2014 Aug; 19(8):086022. Pande P, Shrestha S, Park J, Serafino MJ, Gimenez-Conti I, Brandon J, Cheng YS, Applegate BE, Jo JA. PMID: 25162909; PMCID: PMC4145245.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    52. Simplified method for ultra high-resolution photoacoustic microscopy via transient absorption. Opt Lett. 2014 Aug 01; 39(15):4474-7. Mattison SP, Applegate BE. PMID: 25078206.
      View in: PubMed   Mentions: 7     Fields:    Translation:Cells
    53. Molecular Imaging in Optical Coherence Tomography. Curr Mol Imaging. 2014 Jul 01; 3(2):88-105. Mattison SP, Kim W, Park J, Applegate BE. PMID: 25821718; PMCID: PMC4373611.
      View in: PubMed   Mentions: 10  
    54. Vibration of the organ of Corti within the cochlear apex in mice. J Neurophysiol. 2014 Sep 01; 112(5):1192-204. Gao SS, Wang R, Raphael PD, Moayedi Y, Groves AK, Zuo J, Applegate BE, Oghalai JS. PMID: 24920025; PMCID: PMC4122729.
      View in: PubMed   Mentions: 56     Fields:    Translation:AnimalsCells
    55. Molecular specificity in photoacoustic microscopy by time-resolved transient absorption. Opt Lett. 2014 Jun 01; 39(11):3102-5. Shelton RL, Mattison SP, Applegate BE. PMID: 24875987.
      View in: PubMed   Mentions: 6     Fields:    Translation:AnimalsCells
    56. In vivo pump-probe optical coherence tomography imaging in Xenopus laevis. J Biophotonics. 2015 Jan; 8(1-2):25-35. Carrasco-Zevallos O, Shelton RL, Kim W, Pearson J, Applegate BE. PMID: 24282110; PMCID: PMC4955517.
      View in: PubMed   Mentions: 5     Fields:    Translation:Animals
    57. Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy. J Biophotonics. 2014 Oct; 7(10):834-40. Shelton RL, Mattison SP, Applegate BE. PMID: 23963621.
      View in: PubMed   Mentions: 12     Fields:    Translation:AnimalsCells
    58. Continuous real-time photoacoustic demodulation via field programmable gate array for dynamic imaging of zebrafish cardiac cycle. Biomed Opt Express. 2013; 4(8):1451-63. Mattison SP, Shelton RL, Maxson RT, Applegate BE. PMID: 24010007; PMCID: PMC3756580.
      View in: PubMed   Mentions: 5  
    59. Chromatic confocal microscopy for multi-depth imaging of epithelial tissue. Biomed Opt Express. 2013 May 01; 4(5):732-40. Olsovsky C, Shelton R, Carrasco-Zevallos O, Applegate BE, Maitland KC. PMID: 23667789; PMCID: PMC3646600.
      View in: PubMed   Mentions: 15  
    60. In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography. Biomed Opt Express. 2013 Feb 01; 4(2):230-40. Gao SS, Raphael PD, Wang R, Park J, Xia A, Applegate BE, Oghalai JS. PMID: 23411442; PMCID: PMC3567710.
      View in: PubMed   Mentions: 33  
    61. Application of non-negative matrix factorization to multispectral FLIM data analysis. Biomed Opt Express. 2012 Sep 01; 3(9):2244-62. Pande P, Applegate BE, Jo JA. PMID: 23024917; PMCID: PMC3447565.
      View in: PubMed   Mentions: 5  
    62. Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography. Opt Lett. 2011 Dec 01; 36(23):4716-8. Applegate BE, Shelton RL, Gao SS, Oghalai JS. PMID: 22139294; PMCID: PMC3597110.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    63. Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopy. Atherosclerosis. 2012 Feb; 220(2):394-401. Park J, Pande P, Shrestha S, Clubb F, Applegate BE, Jo JA. PMID: 22138141; PMCID: PMC3264694.
      View in: PubMed   Mentions: 22     Fields:    Translation:Humans
    64. Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography. Opt Express. 2011 Aug 01; 19(16):15415-28. Gao SS, Xia A, Yuan T, Raphael PD, Shelton RL, Applegate BE, Oghalai JS. PMID: 21934905; PMCID: PMC3482885.
      View in: PubMed   Mentions: 35     Fields:    Translation:Animals
    65. Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses. Biomed Opt Express. 2011 Apr 11; 2(5):1135-46. Wu Q, Applegate BE, Yeh AT. PMID: 21559126; PMCID: PMC3087571.
      View in: PubMed   Mentions: 13  
    66. Ultrahigh resolution photoacoustic microscopy via transient absorption. Biomed Opt Express. 2010 Aug 23; 1(2):676-686. Shelton RL, Applegate BE. PMID: 21258499; PMCID: PMC3017994.
      View in: PubMed   Mentions: 14  
    67. High-speed multispectral fluorescence lifetime imaging implementation for in vivo applications. Opt Lett. 2010 Aug 01; 35(15):2558-60. Shrestha S, Applegate BE, Park J, Xiao X, Pande P, Jo JA. PMID: 20680057; PMCID: PMC4795163.
      View in: PubMed   Mentions: 32     Fields:    Translation:HumansAnimals
    68. In vivo simultaneous morphological and biochemical optical imaging of oral epithelial cancer. IEEE Trans Biomed Eng. 2010 Oct; 57(10):2596-9. Jo JA, Applegate BE, Park J, Shrestha S, Pande P, Gimenez-Conti IB, Brandon JL. PMID: 20656649; PMCID: PMC4795161.
      View in: PubMed   Mentions: 21     Fields:    Translation:Animals
    69. A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization. Biomed Opt Express. 2010 Jul 16; 1(1):186-200. Park J, Jo JA, Shrestha S, Pande P, Wan Q, Applegate BE. PMID: 21258457; PMCID: PMC3005181.
      View in: PubMed   Mentions: 39  
    70. Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin. Opt Express. 2010 Jun 07; 18(12):12399-410. Jacob D, Shelton RL, Applegate BE. PMID: 20588366; PMCID: PMC3408913.
      View in: PubMed   Mentions: 15     Fields:    Translation:HumansAnimals
    71. Off-axis photoacoustic microscopy. IEEE Trans Biomed Eng. 2010 Aug; 57(8):1835-8. Shelton RL, Applegate BE. PMID: 20176531; PMCID: PMC4787297.
      View in: PubMed   Mentions: 10     Fields:    Translation:HumansAnimals
    72. Multiphoton coherence domain molecular imaging with pump-probe optical coherence microscopy. Opt Lett. 2010 Feb 15; 35(4):532-4. Wan Q, Applegate BE. PMID: 20160808; PMCID: PMC2839887.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    73. Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer. Annu Int Conf IEEE Eng Med Biol Soc. 2010; 2010:1970-3. Shrestha S, Park J, Pande P, Applegate BE, Jo JA. PMID: 21096785.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    74. A bioluminescence-based assay for enumeration of lytic bacteriophage. J Microbiol Methods. 2009 Oct; 79(1):18-22. Kim S, Schuler B, Terekhov A, Auer J, Mauer LJ, Perry L, Applegate B. PMID: 19628012.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    75. Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells. J Biomed Opt. 2007 Jul-Aug; 12(4):044008. McDowell EJ, Ellerbee AK, Choma MA, Applegate BE, Izatt JA. PMID: 17867812.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    76. Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography. Opt Express. 2006 Oct 02; 14(20):9142-55. Applegate BE, Izatt JA. PMID: 19529295.
      View in: PubMed   Mentions: 16     Fields:    
    77. Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography. Opt Lett. 2006 Aug 15; 31(16):2426-8. Sarunic MV, Applegate BE, Izatt JA. PMID: 16880844.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    78. Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques. Opt Express. 2005 Oct 03; 13(20):8146-63. Applegate B, Yang C, Izatt J. PMID: 19498844.
      View in: PubMed   Mentions: 8     Fields:    
    79. Spectral domain second-harmonic optical coherence tomography. Opt Lett. 2005 Sep 15; 30(18):2391-3. Sarunic MV, Applegate BE, Izatt JA. PMID: 16196329.
      View in: PubMed   Mentions: 10     Fields:    
    80. Influence of irrigant needle depth in removing bioluminescent bacteria inoculated into instrumented root canals using real-time imaging in vitro. Int Endod J. 2005 Feb; 38(2):97-104. Sedgley CM, Nagel AC, Hall D, Applegate B. PMID: 15667631.
      View in: PubMed   Mentions: 34     Fields:    Translation:HumansCells
    81. Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. Opt Lett. 2004 Oct 01; 29(19):2252-4. Applegate BE, Yang C, Rollins AM, Izatt JA. PMID: 15524371.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    82. Electron impact ionization in helium nanodroplets: controlling fragmentation by active cooling of molecular ions. J Am Chem Soc. 2004 Sep 15; 126(36):11283-92. Lewis WK, Applegate BE, Sztáray J, Sztáray B, Baer T, Bemish RJ, Miller RE. PMID: 15355110.
      View in: PubMed   Mentions: 6     Fields:    
    83. Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Opt Lett. 2004 Sep 01; 29(17):2016-8. Yang C, McGuckin LE, Simon JD, Choma MA, Applegate BE, Izatt JA. PMID: 15455765; PMCID: PMC1283115.
      View in: PubMed   Mentions: 15     Fields:    Translation:Animals
    84. Explorations of conical intersections and their ramifications for chemistry through the Jahn-Teller effect. Chem Soc Rev. 2003 Jan; 32(1):38-49. Applegate BE, Barckholtz TA, Miller TA. PMID: 12596544.
      View in: PubMed   Mentions: 4     Fields:    
    85. Validity of DSM-IV ADHD. J Am Acad Child Adolesc Psychiatry. 2001 May; 40(5):502-4. Lahey BB, Applegate B. PMID: 11349689.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    86. Relation of age of onset to the type and severity of child and adolescent conduct problems. J Abnorm Child Psychol. 1999 Aug; 27(4):247-60. Lahey BB, Goodman SH, Waldman ID, Bird H, Canino G, Jensen P, Regier D, Leaf PJ, Gordon R, Applegate B. PMID: 10503644.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    87. Validity of DSM-IV subtypes of conduct disorder based on age of onset. J Am Acad Child Adolesc Psychiatry. 1998 Apr; 37(4):435-42. Lahey BB, Loeber R, Quay HC, Applegate B, Shaffer D, Waldman I, Hart EL, McBurnett K, Frick PJ, Jensen PS, Dulcan MK, Canino G, Bird HR. PMID: 9549965.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    88. Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. J Am Acad Child Adolesc Psychiatry. 1997 Sep; 36(9):1211-21. Applegate B, Lahey BB, Hart EL, Biederman J, Hynd GW, Barkley RA, Ollendick T, Frick PJ, Greenhill L, McBurnett K, Newcorn JH, Kerdyk L, Garfinkel B, Waldman I, Shaffer D. PMID: 9291722.
      View in: PubMed   Mentions: 62     Fields:    Translation:HumansCTClinical Trials
    89. Twenty-one-month follow-up study of school-age children exposed to Hurricane Andrew. J Am Acad Child Adolesc Psychiatry. 1996 Mar; 35(3):359-64. Shaw JA, Applegate B, Schorr C. PMID: 8714325.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    90. Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study. J Abnorm Child Psychol. 1995 Dec; 23(6):729-49. Hart EL, Lahey BB, Loeber R, Applegate B, Frick PJ. PMID: 8609310.
      View in: PubMed   Mentions: 136     Fields:    Translation:Humans
    91. Psychological effects of Hurricane Andrew on an elementary school population. J Am Acad Child Adolesc Psychiatry. 1995 Sep; 34(9):1185-92. Shaw JA, Applegate B, Tanner S, Perez D, Rothe E, Campo-Bowen AE, Lahey BL. PMID: 7559313.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    92. DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents. Am J Psychiatry. 1994 Nov; 151(11):1673-85. Lahey BB, Applegate B, McBurnett K, Biederman J, Greenhill L, Hynd GW, Barkley RA, Newcorn J, Jensen P, Richters J, et al. PMID: 7943460.
      View in: PubMed   Mentions: 221     Fields:    Translation:Humans
    93. DSM-IV field trials for oppositional defiant disorder and conduct disorder in children and adolescents. Am J Psychiatry. 1994 Aug; 151(8):1163-71. Lahey BB, Applegate B, Barkley RA, Garfinkel B, McBurnett K, Kerdyk L, Greenhill L, Hynd GW, Frick PJ, Newcorn J, et al. PMID: 8037251.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
    94. DSM-IV field trials for the disruptive behavior disorders: symptom utility estimates. J Am Acad Child Adolesc Psychiatry. 1994 May; 33(4):529-39. Frick PJ, Lahey BB, Applegate B, Kerdyck L, Ollendick T, Hynd GW, Garfinkel B, Greenhill L, Biederman J, Barkley RA, et al. PMID: 8005906.
      View in: PubMed   Mentions: 55     Fields:    Translation:Humans
    95. Young boys who commit serious sexual offenses: demographics, psychometrics, and phenomenology. Bull Am Acad Psychiatry Law. 1993; 21(4):399-408. Shaw JA, Campo-Bowen AE, Applegate B, Perez D, Antoine LB, Hart EL, Lahey BB, Testa RJ, Devaney A. PMID: 8054670.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    96. An investigation of somatic anxiety and intelligence in children using the Kaufman-ABC and an Apple IIe program measuring heart rate. Percept Mot Skills. 1990 Apr; 70(2):387-94. Kaufman AS, Eller BF, Applegate B. PMID: 2342838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    97. Effects of background event rate on sustained attention of mentally retarded and nonretarded adults. Am J Ment Retard. 1990 Mar; 94(5):499-508. Tomporowski PD, Hayden AM, Applegate B. PMID: 2138465.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    98. A modified technique for semen collection by electroejaculation in the domestic cat. Theriogenology. 1986 Sep; 26(3):357-64. Herron MA, Barton CL, Applegate B. PMID: 16726201.
      View in: PubMed   Mentions: 1     Fields:    
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