Brian Applegate, PhD

Title(s)Professor of Otolaryngology - Head & Neck Surgery
AddressRm 441 Zilkha Neurogenetic Institute
Health Sciences Campus
Los Angeles CA 90033-4508
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    Collapse Research 
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    Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH/NIBIB R01EB027113Apr 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH/NHLBI R01HL111361Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Development of high-resolution molecular imaging of endogenous chromophores with
    NIH/NCRR R21RR025799May 15, 2009 - Apr 30, 2013
    Role: Principal Investigator
    New Technologies for high resolution optical molecular imaging
    NIH/NIBIB R21EB007729Jun 1, 2008 - May 31, 2011
    Role: Principal Investigator
    Bringing Molecular Contrast to OCT
    NIH/NIBIB F32EB004237Sep 1, 2004 - Aug 31, 2006
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Dual-modality optical coherence tomography and frequency-domain fluorescence lifetime imaging microscope system for intravascular imaging. J Biomed Opt. 2020 Sep; 25(9). Chen X, Kim W, Serafino M, Tan Z, Jo J, Applegate B. PMID: 33000570.
      View in: PubMed   Mentions:    Fields:    
    2. Methylene blue-filled biodegradable polymer particles as a contrast agent for optical coherence tomography. Biomed Opt Express. 2020 Aug 01; 11(8):4255-4274. Palma-Chavez JA, Kim W, Serafino M, Jo JA, Charoenphol P, Applegate BE. PMID: 32923040.
      View in: PubMed   Mentions:
    3. Noise and sensitivity in optical coherence tomography based vibrometry. Opt Express. 2019 Nov 11; 27(23):33333-33350. Kim S, Oghalai JS, Applegate BE. PMID: 31878404.
      View in: PubMed   Mentions:    Fields:    
    4. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system. Biomed Opt Express. 2019 Sep 01; 10(9):4395-4410. Kim W, Kim S, Huang S, Oghalai JS, Applegate BE. PMID: 31565497.
      View in: PubMed   Mentions:
    5. Automated detection of superficial macrophages in atherosclerotic plaques using autofluorescence lifetime imaging. Atherosclerosis. 2019 06; 285:120-127. Rico-Jimenez JJ, Serafino MJ, Shrestha S, Chen X, Kim W, Adame J, Buja LM, Vela D, Applegate BE, Jo JA. PMID: 31051415.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    6. Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces. J Neurosci. 2019 03 06; 39(10):1805-1816. Dewey JB, Applegate BE, Oghalai JS. PMID: 30651330.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    7. Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry. J Neurophysiol. 2018 12 01; 120(6):2847-2857. Dong W, Xia A, Raphael PD, Puria S, Applegate B, Oghalai JS. PMID: 30281386.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    8. Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea. Cell Rep. 2018 06 05; 23(10):2915-2927. Dewey JB, Xia A, Müller U, Belyantseva IA, Applegate BE, Oghalai JS. PMID: 29874579.
      View in: PubMed   Mentions: 7     Fields:    Translation:AnimalsCells
    9. Osmotic stabilization prevents cochlear synaptopathy after blast trauma. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):E4853-E4860. Kim J, Xia A, Grillet N, Applegate BE, Oghalai JS. PMID: 29735658.
      View in: PubMed   Mentions: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    10. Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window. Opt Lett. 2018 May 01; 43(9):1966-1969. Kim W, Kim S, Oghalai JS, Applegate BE. PMID: 29714773.
      View in: PubMed   Mentions: 3     Fields:    Translation:Animals
    11. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography. Biomed Opt Express. 2017 Oct 01; 8(10):4579-4594. Liu GS, Zhu MH, Kim J, Raphael P, Applegate BE, Oghalai JS. PMID: 29082086.
      View in: PubMed   Mentions:
    12. Enhanced coupling of light into a turbid medium through microscopic interface engineering. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7941-7946. Thompson JV, Hokr BH, Kim W, Ballmann CW, Applegate BE, Jo J, Yamilov A, Cao H, Scully MO, Yakovlev VV. PMID: 28701381.
      View in: PubMed   Mentions: 1     Fields:    
    13. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography. J Biomed Opt. 2017 07 01; 22(7):76002. Liu GS, Kim J, Applegate BE, Oghalai JS. PMID: 28687821.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    14. Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla. Nat Commun. 2016 10 31; 7:13133. Xia A, Liu X, Raphael PD, Applegate BE, Oghalai JS. PMID: 27796310.
      View in: PubMed   Mentions: 9     Fields:    Translation:AnimalsCells
    15. Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti. J Neurosci. 2016 08 03; 36(31):8160-73. Lee HY, Raphael PD, Xia A, Kim J, Grillet N, Applegate BE, Ellerbee Bowden AK, Oghalai JS. PMID: 27488636.
      View in: PubMed   Mentions: 26     Fields:    Translation:AnimalsCells
    16. Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence. Biomed Opt Express. 2016 Sep 01; 7(9):3184-3197. Shrestha S, Serafino MJ, Rico-Jimenez J, Park J, Chen X, Zhaorigetu S, Walton BL, Jo JA, Applegate BE. PMID: 27699091.
      View in: PubMed   Mentions:
    17. Lensless, ultra-wideband fiber optic rotary joint for biomedical applications. Opt Lett. 2016 May 01; 41(9):1973-6. Kim W, Chen X, Jo JA, Applegate BE. PMID: 27128052.
      View in: PubMed   Mentions: 2     Fields:    
    18. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model. Biomed Opt Express. 2016 May 01; 7(5):2000-15. Pande P, Shrestha S, Park J, Gimenez-Conti I, Brandon J, Applegate BE, Jo JA. PMID: 27231638.
      View in: PubMed   Mentions:
    19. High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography. Biomed Opt Express. 2016 Apr 01; 7(4):1430-44. Kim S, Raphael PD, Oghalai JS, Applegate BE. PMID: 27446666.
      View in: PubMed   Mentions:
    20. Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo. Methods Mol Biol. 2016; 1427:449-62. Jawadi Z, Applegate BE, Oghalai JS. PMID: 27259941.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    21. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear. Biomed Opt Express. 2015 Jun 01; 6(6):2246-57. Pawlowski ME, Shrestha S, Park J, Applegate BE, Oghalai JS, Tkaczyk TS. PMID: 26114043.
      View in: PubMed   Mentions:
    22. In vivo molecular contrast OCT imaging of methylene blue. Opt Lett. 2015 Apr 01; 40(7):1426-9. Kim W, Applegate BE. PMID: 25831349.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    23. Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3128-33. Lee HY, Raphael PD, Park J, Ellerbee AK, Applegate BE, Oghalai JS. PMID: 25737536.
      View in: PubMed   Mentions: 60     Fields:    Translation:Animals
    24. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear. Opt Lett. 2014 Nov 01; 39(21):6233-6. Park J, Carbajal EF, Chen X, Oghalai JS, Applegate BE. PMID: 25361322.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    25. Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch. J Biomed Opt. 2014 Aug; 19(8):086022. Pande P, Shrestha S, Park J, Serafino MJ, Gimenez-Conti I, Brandon J, Cheng YS, Applegate BE, Jo JA. PMID: 25162909.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    26. Molecular Imaging in Optical Coherence Tomography. Curr Mol Imaging. 2014 Jul 01; 3(2):88-105. Mattison SP, Kim W, Park J, Applegate BE. PMID: 25821718.
      View in: PubMed   Mentions:
    27. Vibration of the organ of Corti within the cochlear apex in mice. J Neurophysiol. 2014 Sep 01; 112(5):1192-204. Gao SS, Wang R, Raphael PD, Moayedi Y, Groves AK, Zuo J, Applegate BE, Oghalai JS. PMID: 24920025.
      View in: PubMed   Mentions: 29     Fields:    Translation:AnimalsCells
    28. In vivo pump-probe optical coherence tomography imaging in Xenopus laevis. J Biophotonics. 2015 Jan; 8(1-2):25-35. Carrasco-Zevallos O, Shelton RL, Kim W, Pearson J, Applegate BE. PMID: 24282110.
      View in: PubMed   Mentions: 2     Fields:    Translation:Animals
    29. Continuous real-time photoacoustic demodulation via field programmable gate array for dynamic imaging of zebrafish cardiac cycle. Biomed Opt Express. 2013; 4(8):1451-63. Mattison SP, Shelton RL, Maxson RT, Applegate BE. PMID: 24010007.
      View in: PubMed   Mentions:
    30. Chromatic confocal microscopy for multi-depth imaging of epithelial tissue. Biomed Opt Express. 2013 May 01; 4(5):732-40. Olsovsky C, Shelton R, Carrasco-Zevallos O, Applegate BE, Maitland KC. PMID: 23667789.
      View in: PubMed   Mentions:
    31. In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography. Biomed Opt Express. 2013 Feb 01; 4(2):230-40. Gao SS, Raphael PD, Wang R, Park J, Xia A, Applegate BE, Oghalai JS. PMID: 23411442.
      View in: PubMed   Mentions:
    32. Application of non-negative matrix factorization to multispectral FLIM data analysis. Biomed Opt Express. 2012 Sep 01; 3(9):2244-62. Pande P, Applegate BE, Jo JA. PMID: 23024917.
      View in: PubMed   Mentions:
    33. Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography. Opt Lett. 2011 Dec 01; 36(23):4716-8. Applegate BE, Shelton RL, Gao SS, Oghalai JS. PMID: 22139294.
      View in: PubMed   Mentions: 10     Fields:    Translation:Animals
    34. Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography. Opt Express. 2011 Aug 01; 19(16):15415-28. Gao SS, Xia A, Yuan T, Raphael PD, Shelton RL, Applegate BE, Oghalai JS. PMID: 21934905.
      View in: PubMed   Mentions: 27     Fields:    Translation:Animals
    35. Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses. Biomed Opt Express. 2011 Apr 11; 2(5):1135-46. Wu Q, Applegate BE, Yeh AT. PMID: 21559126.
      View in: PubMed   Mentions:
    36. Ultrahigh resolution photoacoustic microscopy via transient absorption. Biomed Opt Express. 2010 Aug 23; 1(2):676-686. Shelton RL, Applegate BE. PMID: 21258499.
      View in: PubMed   Mentions:
    37. A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization. Biomed Opt Express. 2010 Jul 16; 1(1):186-200. Park J, Jo JA, Shrestha S, Pande P, Wan Q, Applegate BE. PMID: 21258457.
      View in: PubMed   Mentions:
    38. Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin. Opt Express. 2010 Jun 07; 18(12):12399-410. Jacob D, Shelton RL, Applegate BE. PMID: 20588366.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    39. A bioluminescence-based assay for enumeration of lytic bacteriophage. J Microbiol Methods. 2009 Oct; 79(1):18-22. Kim S, Schuler B, Terekhov A, Auer J, Mauer LJ, Perry L, Applegate B. PMID: 19628012.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    40. Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography. Opt Express. 2006 Oct 02; 14(20):9142-55. Applegate BE, Izatt JA. PMID: 19529295.
      View in: PubMed   Mentions: 16     Fields:    
    41. Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography. Opt Lett. 2006 Aug 15; 31(16):2426-8. Sarunic MV, Applegate BE, Izatt JA. PMID: 16880844.
      View in: PubMed   Mentions: 8     Fields:    Translation:Humans
    42. Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques. Opt Express. 2005 Oct 03; 13(20):8146-63. Applegate B, Yang C, Izatt J. PMID: 19498844.
      View in: PubMed   Mentions: 8     Fields:    
    43. Spectral domain second-harmonic optical coherence tomography. Opt Lett. 2005 Sep 15; 30(18):2391-3. Sarunic MV, Applegate BE, Izatt JA. PMID: 16196329.
      View in: PubMed   Mentions: 10     Fields:    
    44. Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. Opt Lett. 2004 Oct 01; 29(19):2252-4. Applegate BE, Yang C, Rollins AM, Izatt JA. PMID: 15524371.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    45. Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Opt Lett. 2004 Sep 01; 29(17):2016-8. Yang C, McGuckin LE, Simon JD, Choma MA, Applegate BE, Izatt JA. PMID: 15455765.
      View in: PubMed   Mentions: 11     Fields:    Translation:Animals
    46. Validity of DSM-IV ADHD. J Am Acad Child Adolesc Psychiatry. 2001 May; 40(5):502-4. Lahey BB, Applegate B. PMID: 11349689.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    47. Relation of age of onset to the type and severity of child and adolescent conduct problems. J Abnorm Child Psychol. 1999 Aug; 27(4):247-60. Lahey BB, Goodman SH, Waldman ID, Bird H, Canino G, Jensen P, Regier D, Leaf PJ, Gordon R, Applegate B. PMID: 10503644.
      View in: PubMed   Mentions: 16     Fields:    Translation:Humans
    48. Validity of DSM-IV subtypes of conduct disorder based on age of onset. J Am Acad Child Adolesc Psychiatry. 1998 Apr; 37(4):435-42. Lahey BB, Loeber R, Quay HC, Applegate B, Shaffer D, Waldman I, Hart EL, McBurnett K, Frick PJ, Jensen PS, Dulcan MK, Canino G, Bird HR. PMID: 9549965.
      View in: PubMed   Mentions: 48     Fields:    Translation:Humans
    49. Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. J Am Acad Child Adolesc Psychiatry. 1997 Sep; 36(9):1211-21. Applegate B, Lahey BB, Hart EL, Biederman J, Hynd GW, Barkley RA, Ollendick T, Frick PJ, Greenhill L, McBurnett K, Newcorn JH, Kerdyk L, Garfinkel B, Waldman I, Shaffer D. PMID: 9291722.
      View in: PubMed   Mentions: 53     Fields:    Translation:HumansCTClinical Trials
    50. Twenty-one-month follow-up study of school-age children exposed to Hurricane Andrew. J Am Acad Child Adolesc Psychiatry. 1996 Mar; 35(3):359-64. Shaw JA, Applegate B, Schorr C. PMID: 8714325.
      View in: PubMed   Mentions: 34     Fields:    Translation:Humans
    51. Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study. J Abnorm Child Psychol. 1995 Dec; 23(6):729-49. Hart EL, Lahey BB, Loeber R, Applegate B, Frick PJ. PMID: 8609310.
      View in: PubMed   Mentions: 112     Fields:    Translation:Humans
    52. Psychological effects of Hurricane Andrew on an elementary school population. J Am Acad Child Adolesc Psychiatry. 1995 Sep; 34(9):1185-92. Shaw JA, Applegate B, Tanner S, Perez D, Rothe E, Campo-Bowen AE, Lahey BL. PMID: 7559313.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    53. DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents. Am J Psychiatry. 1994 Nov; 151(11):1673-85. Lahey BB, Applegate B, McBurnett K, Biederman J, Greenhill L, Hynd GW, Barkley RA, Newcorn J, Jensen P, Richters J. PMID: 7943460.
      View in: PubMed   Mentions: 192     Fields:    Translation:Humans
    54. DSM-IV field trials for oppositional defiant disorder and conduct disorder in children and adolescents. Am J Psychiatry. 1994 Aug; 151(8):1163-71. Lahey BB, Applegate B, Barkley RA, Garfinkel B, McBurnett K, Kerdyk L, Greenhill L, Hynd GW, Frick PJ, Newcorn J. PMID: 8037251.
      View in: PubMed   Mentions: 36     Fields:    Translation:Humans
    55. DSM-IV field trials for the disruptive behavior disorders: symptom utility estimates. J Am Acad Child Adolesc Psychiatry. 1994 May; 33(4):529-39. Frick PJ, Lahey BB, Applegate B, Kerdyck L, Ollendick T, Hynd GW, Garfinkel B, Greenhill L, Biederman J, Barkley RA. PMID: 8005906.
      View in: PubMed   Mentions: 51     Fields:    Translation:Humans
    56. Young boys who commit serious sexual offenses: demographics, psychometrics, and phenomenology. Bull Am Acad Psychiatry Law. 1993; 21(4):399-408. Shaw JA, Campo-Bowen AE, Applegate B, Perez D, Antoine LB, Hart EL, Lahey BB, Testa RJ, Devaney A. PMID: 8054670.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    57. An investigation of somatic anxiety and intelligence in children using the Kaufman-ABC and an Apple IIe program measuring heart rate. Percept Mot Skills. 1990 Apr; 70(2):387-94. Kaufman AS, Eller BF, Applegate B. PMID: 2342838.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    58. Effects of background event rate on sustained attention of mentally retarded and nonretarded adults. Am J Ment Retard. 1990 Mar; 94(5):499-508. Tomporowski PD, Hayden AM, Applegate B. PMID: 2138465.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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