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Brian Applegate, PhD

Title(s)Visiting Professor of Otolaryngology - Head & Neck Surgery
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    Collapse Research Activities and Funding
    Optical imaging technologies to identify residual cholesteatoma and improve ossiculoplasty outcomes
    NIH/NIBIB R01EB027113Apr 1, 2019 - Dec 31, 2022
    Role: Principal Investigator
    Morphological and Molecular Imaging System for in vivo Atherosclerosis Research
    NIH/NHLBI R01HL111361Apr 1, 2012 - Mar 31, 2017
    Role: Principal Investigator
    Development of high-resolution molecular imaging of endogenous chromophores with
    NIH/NCRR R21RR025799May 15, 2009 - Apr 30, 2013
    Role: Principal Investigator
    New Technologies for high resolution optical molecular imaging
    NIH/NIBIB R21EB007729Jun 1, 2008 - May 31, 2011
    Role: Principal Investigator
    Bringing Molecular Contrast to OCT
    NIH/NIBIB F32EB004237Sep 1, 2004 - Aug 31, 2006
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Kim W, Kim S, Huang S, Oghalai JS, Applegate BE. Picometer scale vibrometry in the human middle ear using a surgical microscope based optical coherence tomography and vibrometry system. Biomed Opt Express. 2019 Sep 01; 10(9):4395-4410. PMID: 31565497.
      View in: PubMed
    2. Rico-Jimenez JJ, Serafino MJ, Shrestha S, Chen X, Kim W, Adame J, Buja LM, Vela D, Applegate BE, Jo JA. Automated detection of superficial macrophages in atherosclerotic plaques using autofluorescence lifetime imaging. Atherosclerosis. 2019 Jun; 285:120-127. PMID: 31051415.
      View in: PubMed
    3. Dewey JB, Applegate BE, Oghalai JS. Amplification and Suppression of Traveling Waves along the Mouse Organ of Corti: Evidence for Spatial Variation in the Longitudinal Coupling of Outer Hair Cell-Generated Forces. J Neurosci. 2019 Mar 06; 39(10):1805-1816. PMID: 30651330.
      View in: PubMed
    4. Dong W, Xia A, Raphael PD, Puria S, Applegate B, Oghalai JS. Organ of Corti vibration within the intact gerbil cochlea measured by volumetric optical coherence tomography and vibrometry. J Neurophysiol. 2018 12 01; 120(6):2847-2857. PMID: 30281386.
      View in: PubMed
    5. Dewey JB, Xia A, Müller U, Belyantseva IA, Applegate BE, Oghalai JS. Mammalian Auditory Hair Cell Bundle Stiffness Affects Frequency Tuning by Increasing Coupling along the Length of the Cochlea. Cell Rep. 2018 06 05; 23(10):2915-2927. PMID: 29874579.
      View in: PubMed
    6. Kim J, Xia A, Grillet N, Applegate BE, Oghalai JS. Osmotic stabilization prevents cochlear synaptopathy after blast trauma. Proc Natl Acad Sci U S A. 2018 05 22; 115(21):E4853-E4860. PMID: 29735658.
      View in: PubMed
    7. Kim W, Kim S, Oghalai JS, Applegate BE. Endoscopic optical coherence tomography enables morphological and subnanometer vibratory imaging of the porcine cochlea through the round window. Opt Lett. 2018 May 01; 43(9):1966-1969. PMID: 29714773.
      View in: PubMed
    8. Mattison SP, Mondragon E, Kaunas R, Applegate BE. Hybrid nonlinear photoacoustic and reflectance confocal microscopy for label-free subcellular imaging with a single light source. Opt Lett. 2017 Oct 01; 42(19):4028-4031. PMID: 28957189.
      View in: PubMed
    9. Liu GS, Zhu MH, Kim J, Raphael P, Applegate BE, Oghalai JS. ELHnet: a convolutional neural network for classifying cochlear endolymphatic hydrops imaged with optical coherence tomography. Biomed Opt Express. 2017 Oct 01; 8(10):4579-4594. PMID: 29082086.
      View in: PubMed
    10. Thompson JV, Hokr BH, Kim W, Ballmann CW, Applegate BE, Jo J, Yamilov A, Cao H, Scully MO, Yakovlev VV. Enhanced coupling of light into a turbid medium through microscopic interface engineering. Proc Natl Acad Sci U S A. 2017 07 25; 114(30):7941-7946. PMID: 28701381.
      View in: PubMed
    11. Liu GS, Kim J, Applegate BE, Oghalai JS. Computer-aided detection and quantification of endolymphatic hydrops within the mouse cochlea in vivo using optical coherence tomography. J Biomed Opt. 2017 07 01; 22(7):76002. PMID: 28687821.
      View in: PubMed
    12. Xia A, Liu X, Raphael PD, Applegate BE, Oghalai JS. Hair cell force generation does not amplify or tune vibrations within the chicken basilar papilla. Nat Commun. 2016 10 31; 7:13133. PMID: 27796310.
      View in: PubMed
    13. Lee HY, Raphael PD, Xia A, Kim J, Grillet N, Applegate BE, Ellerbee Bowden AK, Oghalai JS. Two-Dimensional Cochlear Micromechanics Measured In Vivo Demonstrate Radial Tuning within the Mouse Organ of Corti. J Neurosci. 2016 08 03; 36(31):8160-73. PMID: 27488636.
      View in: PubMed
    14. Shrestha S, Serafino MJ, Rico-Jimenez J, Park J, Chen X, Zhaorigetu S, Walton BL, Jo JA, Applegate BE. Multimodal optical coherence tomography and fluorescence lifetime imaging with interleaved excitation sources for simultaneous endogenous and exogenous fluorescence. Biomed Opt Express. 2016 Sep 01; 7(9):3184-3197. PMID: 27699091.
      View in: PubMed
    15. Kim W, Chen X, Jo JA, Applegate BE. Lensless, ultra-wideband fiber optic rotary joint for biomedical applications. Opt Lett. 2016 May 01; 41(9):1973-6. PMID: 27128052.
      View in: PubMed
    16. Pande P, Shrestha S, Park J, Gimenez-Conti I, Brandon J, Applegate BE, Jo JA. Automated analysis of multimodal fluorescence lifetime imaging and optical coherence tomography data for the diagnosis of oral cancer in the hamster cheek pouch model. Biomed Opt Express. 2016 May 01; 7(5):2000-15. PMID: 27231638.
      View in: PubMed
    17. Kim S, Raphael PD, Oghalai JS, Applegate BE. High-speed spectral calibration by complex FIR filter in phase-sensitive optical coherence tomography. Biomed Opt Express. 2016 Apr 01; 7(4):1430-44. PMID: 27446666.
      View in: PubMed
    18. Jawadi Z, Applegate BE, Oghalai JS. Optical Coherence Tomography to Measure Sound-Induced Motions Within the Mouse Organ of Corti In Vivo. Methods Mol Biol. 2016; 1427:449-62. PMID: 27259941.
      View in: PubMed
    19. Pawlowski ME, Shrestha S, Park J, Applegate BE, Oghalai JS, Tkaczyk TS. Miniature, minimally invasive, tunable endoscope for investigation of the middle ear. Biomed Opt Express. 2015 Jun 01; 6(6):2246-57. PMID: 26114043.
      View in: PubMed
    20. Kim W, Applegate BE. In vivo molecular contrast OCT imaging of methylene blue. Opt Lett. 2015 Apr 01; 40(7):1426-9. PMID: 25831349.
      View in: PubMed
    21. Lee HY, Raphael PD, Park J, Ellerbee AK, Applegate BE, Oghalai JS. Noninvasive in vivo imaging reveals differences between tectorial membrane and basilar membrane traveling waves in the mouse cochlea. Proc Natl Acad Sci U S A. 2015 Mar 10; 112(10):3128-33. PMID: 25737536.
      View in: PubMed
    22. Jo JA, Park J, Pande P, Shrestha S, Serafino MJ, Rico Jimenez Jde J, Clubb F, Walton B, Buja LM, Phipps JE, Feldman MD, Adame J, Applegate BE. Simultaneous morphological and biochemical endogenous optical imaging of atherosclerosis. Eur Heart J Cardiovasc Imaging. 2015 Aug; 16(8):910-8. PMID: 25722204.
      View in: PubMed
    23. Park J, Carbajal EF, Chen X, Oghalai JS, Applegate BE. Phase-sensitive optical coherence tomography using an Vernier-tuned distributed Bragg reflector swept laser in the mouse middle ear. Opt Lett. 2014 Nov 01; 39(21):6233-6. PMID: 25361322.
      View in: PubMed
    24. Pande P, Shrestha S, Park J, Serafino MJ, Gimenez-Conti I, Brandon J, Cheng YS, Applegate BE, Jo JA. Automated classification of optical coherence tomography images for the diagnosis of oral malignancy in the hamster cheek pouch. J Biomed Opt. 2014 Aug; 19(8):086022. PMID: 25162909.
      View in: PubMed
    25. Mattison SP, Applegate BE. Simplified method for ultra high-resolution photoacoustic microscopy via transient absorption. Opt Lett. 2014 Aug 01; 39(15):4474-7. PMID: 25078206.
      View in: PubMed
    26. Mattison SP, Kim W, Park J, Applegate BE. Molecular Imaging in Optical Coherence Tomography. Curr Mol Imaging. 2014 Jul 01; 3(2):88-105. PMID: 25821718.
      View in: PubMed
    27. Gao SS, Wang R, Raphael PD, Moayedi Y, Groves AK, Zuo J, Applegate BE, Oghalai JS. Vibration of the organ of Corti within the cochlear apex in mice. J Neurophysiol. 2014 Sep 01; 112(5):1192-204. PMID: 24920025.
      View in: PubMed
    28. Shelton RL, Mattison SP, Applegate BE. Molecular specificity in photoacoustic microscopy by time-resolved transient absorption. Opt Lett. 2014 Jun 01; 39(11):3102-5. PMID: 24875987.
      View in: PubMed
    29. Carrasco-Zevallos O, Shelton RL, Kim W, Pearson J, Applegate BE. In vivo pump-probe optical coherence tomography imaging in Xenopus laevis. J Biophotonics. 2015 Jan; 8(1-2):25-35. PMID: 24282110.
      View in: PubMed
    30. Shelton RL, Mattison SP, Applegate BE. Volumetric imaging of erythrocytes using label-free multiphoton photoacoustic microscopy. J Biophotonics. 2014 Oct; 7(10):834-40. PMID: 23963621.
      View in: PubMed
    31. Mattison SP, Shelton RL, Maxson RT, Applegate BE. Continuous real-time photoacoustic demodulation via field programmable gate array for dynamic imaging of zebrafish cardiac cycle. Biomed Opt Express. 2013; 4(8):1451-63. PMID: 24010007.
      View in: PubMed
    32. Olsovsky C, Shelton R, Carrasco-Zevallos O, Applegate BE, Maitland KC. Chromatic confocal microscopy for multi-depth imaging of epithelial tissue. Biomed Opt Express. 2013 May 01; 4(5):732-40. PMID: 23667789.
      View in: PubMed
    33. Gao SS, Raphael PD, Wang R, Park J, Xia A, Applegate BE, Oghalai JS. In vivo vibrometry inside the apex of the mouse cochlea using spectral domain optical coherence tomography. Biomed Opt Express. 2013 Feb 01; 4(2):230-40. PMID: 23411442.
      View in: PubMed
    34. Pande P, Applegate BE, Jo JA. Application of non-negative matrix factorization to multispectral FLIM data analysis. Biomed Opt Express. 2012 Sep 01; 3(9):2244-62. PMID: 23024917.
      View in: PubMed
    35. Applegate BE, Shelton RL, Gao SS, Oghalai JS. Imaging high-frequency periodic motion in the mouse ear with coherently interleaved optical coherence tomography. Opt Lett. 2011 Dec 01; 36(23):4716-8. PMID: 22139294.
      View in: PubMed
    36. Park J, Pande P, Shrestha S, Clubb F, Applegate BE, Jo JA. Biochemical characterization of atherosclerotic plaques by endogenous multispectral fluorescence lifetime imaging microscopy. Atherosclerosis. 2012 Feb; 220(2):394-401. PMID: 22138141.
      View in: PubMed
    37. Gao SS, Xia A, Yuan T, Raphael PD, Shelton RL, Applegate BE, Oghalai JS. Quantitative imaging of cochlear soft tissues in wild-type and hearing-impaired transgenic mice by spectral domain optical coherence tomography. Opt Express. 2011 Aug 01; 19(16):15415-28. PMID: 21934905.
      View in: PubMed
    38. Wu Q, Applegate BE, Yeh AT. Cornea microstructure and mechanical responses measured with nonlinear optical and optical coherence microscopy using sub-10-fs pulses. Biomed Opt Express. 2011 Apr 11; 2(5):1135-46. PMID: 21559126.
      View in: PubMed
    39. Shelton RL, Applegate BE. Ultrahigh resolution photoacoustic microscopy via transient absorption. Biomed Opt Express. 2010 Aug 23; 1(2):676-686. PMID: 21258499.
      View in: PubMed
    40. Shrestha S, Applegate BE, Park J, Xiao X, Pande P, Jo JA. High-speed multispectral fluorescence lifetime imaging implementation for in vivo applications. Opt Lett. 2010 Aug 01; 35(15):2558-60. PMID: 20680057.
      View in: PubMed
    41. Jo JA, Applegate BE, Park J, Shrestha S, Pande P, Gimenez-Conti IB, Brandon JL. In vivo simultaneous morphological and biochemical optical imaging of oral epithelial cancer. IEEE Trans Biomed Eng. 2010 Oct; 57(10):2596-9. PMID: 20656649.
      View in: PubMed
    42. Park J, Jo JA, Shrestha S, Pande P, Wan Q, Applegate BE. A dual-modality optical coherence tomography and fluorescence lifetime imaging microscopy system for simultaneous morphological and biochemical tissue characterization. Biomed Opt Express. 2010 Jul 16; 1(1):186-200. PMID: 21258457.
      View in: PubMed
    43. Jacob D, Shelton RL, Applegate BE. Fourier domain Pump-Probe Optical Coherence Tomography imaging of melanin. Opt Express. 2010 Jun 07; 18(12):12399-410. PMID: 20588366.
      View in: PubMed
    44. Shelton RL, Applegate BE. Off-axis photoacoustic microscopy. IEEE Trans Biomed Eng. 2010 Aug; 57(8):1835-8. PMID: 20176531.
      View in: PubMed
    45. Wan Q, Applegate BE. Multiphoton coherence domain molecular imaging with pump-probe optical coherence microscopy. Opt Lett. 2010 Feb 15; 35(4):532-4. PMID: 20160808.
      View in: PubMed
    46. Shrestha S, Park J, Pande P, Applegate BE, Jo JA. Multimodal optical imaging for simultaneous in-vivo morphological and biochemical characterization of oral epithelial cancer. Conf Proc IEEE Eng Med Biol Soc. 2010; 2010:1970-3. PMID: 21096785.
      View in: PubMed
    47. Kim S, Schuler B, Terekhov A, Auer J, Mauer LJ, Perry L, Applegate B. A bioluminescence-based assay for enumeration of lytic bacteriophage. J Microbiol Methods. 2009 Oct; 79(1):18-22. PMID: 19628012.
      View in: PubMed
    48. McDowell EJ, Ellerbee AK, Choma MA, Applegate BE, Izatt JA. Spectral domain phase microscopy for local measurements of cytoskeletal rheology in single cells. J Biomed Opt. 2007 Jul-Aug; 12(4):044008. PMID: 17867812.
      View in: PubMed
    49. Applegate BE, Izatt JA. Molecular imaging of endogenous and exogenous chromophores using ground state recovery pump-probe optical coherence tomography. Opt Express. 2006 Oct 02; 14(20):9142-55. PMID: 19529295.
      View in: PubMed
    50. Sarunic MV, Applegate BE, Izatt JA. Real-time quadrature projection complex conjugate resolved Fourier domain optical coherence tomography. Opt Lett. 2006 Aug 15; 31(16):2426-8. PMID: 16880844.
      View in: PubMed
    51. Applegate B, Yang C, Izatt J. Theoretical comparison of the sensitivity of molecular contrast optical coherence tomography techniques. Opt Express. 2005 Oct 03; 13(20):8146-63. PMID: 19498844.
      View in: PubMed
    52. Sarunic MV, Applegate BE, Izatt JA. Spectral domain second-harmonic optical coherence tomography. Opt Lett. 2005 Sep 15; 30(18):2391-3. PMID: 16196329.
      View in: PubMed
    53. Applegate BE, Yang C, Rollins AM, Izatt JA. Polarization-resolved second-harmonic-generation optical coherence tomography in collagen. Opt Lett. 2004 Oct 01; 29(19):2252-4. PMID: 15524371.
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    54. Lewis WK, Applegate BE, Sztáray J, Sztáray B, Baer T, Bemish RJ, Miller RE. Electron impact ionization in helium nanodroplets: controlling fragmentation by active cooling of molecular ions. J Am Chem Soc. 2004 Sep 15; 126(36):11283-92. PMID: 15355110.
      View in: PubMed
    55. Yang C, McGuckin LE, Simon JD, Choma MA, Applegate BE, Izatt JA. Spectral triangulation molecular contrast optical coherence tomography with indocyanine green as the contrast agent. Opt Lett. 2004 Sep 01; 29(17):2016-8. PMID: 15455765.
      View in: PubMed
    56. Applegate BE, Barckholtz TA, Miller TA. Explorations of conical intersections and their ramifications for chemistry through the Jahn-Teller effect. Chem Soc Rev. 2003 Jan; 32(1):38-49. PMID: 12596544.
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    57. Lahey BB, Applegate B. Validity of DSM-IV ADHD. J Am Acad Child Adolesc Psychiatry. 2001 May; 40(5):502-4. PMID: 11349689.
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    58. Lahey BB, Goodman SH, Waldman ID, Bird H, Canino G, Jensen P, Regier D, Leaf PJ, Gordon R, Applegate B. Relation of age of onset to the type and severity of child and adolescent conduct problems. J Abnorm Child Psychol. 1999 Aug; 27(4):247-60. PMID: 10503644.
      View in: PubMed
    59. Lahey BB, Loeber R, Quay HC, Applegate B, Shaffer D, Waldman I, Hart EL, McBurnett K, Frick PJ, Jensen PS, Dulcan MK, Canino G, Bird HR. Validity of DSM-IV subtypes of conduct disorder based on age of onset. J Am Acad Child Adolesc Psychiatry. 1998 Apr; 37(4):435-42. PMID: 9549965.
      View in: PubMed
    60. Applegate B, Lahey BB, Hart EL, Biederman J, Hynd GW, Barkley RA, Ollendick T, Frick PJ, Greenhill L, McBurnett K, Newcorn JH, Kerdyk L, Garfinkel B, Waldman I, Shaffer D. Validity of the age-of-onset criterion for ADHD: a report from the DSM-IV field trials. J Am Acad Child Adolesc Psychiatry. 1997 Sep; 36(9):1211-21. PMID: 9291722.
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    61. Shaw JA, Applegate B, Schorr C. Twenty-one-month follow-up study of school-age children exposed to Hurricane Andrew. J Am Acad Child Adolesc Psychiatry. 1996 Mar; 35(3):359-64. PMID: 8714325.
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    62. Hart EL, Lahey BB, Loeber R, Applegate B, Frick PJ. Developmental change in attention-deficit hyperactivity disorder in boys: a four-year longitudinal study. J Abnorm Child Psychol. 1995 Dec; 23(6):729-49. PMID: 8609310.
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    63. Shaw JA, Applegate B, Tanner S, Perez D, Rothe E, Campo-Bowen AE, Lahey BL. Psychological effects of Hurricane Andrew on an elementary school population. J Am Acad Child Adolesc Psychiatry. 1995 Sep; 34(9):1185-92. PMID: 7559313.
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    64. Lahey BB, Applegate B, McBurnett K, Biederman J, Greenhill L, Hynd GW, Barkley RA, Newcorn J, Jensen P, Richters J. DSM-IV field trials for attention deficit hyperactivity disorder in children and adolescents. Am J Psychiatry. 1994 Nov; 151(11):1673-85. PMID: 7943460.
      View in: PubMed
    65. Lahey BB, Applegate B, Barkley RA, Garfinkel B, McBurnett K, Kerdyk L, Greenhill L, Hynd GW, Frick PJ, Newcorn J. DSM-IV field trials for oppositional defiant disorder and conduct disorder in children and adolescents. Am J Psychiatry. 1994 Aug; 151(8):1163-71. PMID: 8037251.
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    66. Frick PJ, Lahey BB, Applegate B, Kerdyck L, Ollendick T, Hynd GW, Garfinkel B, Greenhill L, Biederman J, Barkley RA. DSM-IV field trials for the disruptive behavior disorders: symptom utility estimates. J Am Acad Child Adolesc Psychiatry. 1994 May; 33(4):529-39. PMID: 8005906.
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    67. Shaw JA, Campo-Bowen AE, Applegate B, Perez D, Antoine LB, Hart EL, Lahey BB, Testa RJ, Devaney A. Young boys who commit serious sexual offenses: demographics, psychometrics, and phenomenology. Bull Am Acad Psychiatry Law. 1993; 21(4):399-408. PMID: 8054670.
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    68. Kaufman AS, Eller BF, Applegate B. An investigation of somatic anxiety and intelligence in children using the Kaufman-ABC and an Apple IIe program measuring heart rate. Percept Mot Skills. 1990 Apr; 70(2):387-94. PMID: 2342838.
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    69. Tomporowski PD, Hayden AM, Applegate B. Effects of background event rate on sustained attention of mentally retarded and nonretarded adults. Am J Ment Retard. 1990 Mar; 94(5):499-508. PMID: 2138465.
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    70. Herron MA, Barton CL, Applegate B. A modified technique for semen collection by electroejaculation in the domestic cat. Theriogenology. 1986 Sep; 26(3):357-64. PMID: 16726201.
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