Robert Featherstone, PhD

Photo of Robert Featherstone, PhD
Title(s)Assistant Professor of Research Psychiatry and the Behavioral Sciences
SchoolKeck School of Medicine of Usc
Address2250 Alcazar St.
Health Sciences Campus
Los Angeles CA 90033
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    Robert E. Featherstone, Ph.D., is an Assistant Professor of Research in the Department of Psychiatry and Behavioral Sciences at the University of Southern California. His research focuses on the neurobiology, cognitive dysfunction, and treatment of schizophrenia and depression, integrating both preclinical animal models and human clinical research.

    Dr. Featherstone's work examines the neural mechanisms underlying cognitive impairments associated with psychiatric illness and seeks to identify novel therapeutic strategies to improve cognitive and functional outcomes. His research combines behavioral neuroscience, neuropsychopharmacology, and electrophysiology, with particular expertise in EEG and event-related potential (ERP) biomarkers for psychiatric drug discovery and translational neuroscience.

    Current projects investigate glutamatergic signaling pathways, NMDA receptor function, and synaptic mechanisms that contribute to cognitive deficits in neuropsychiatric disorders. By integrating behavioral, molecular, and electrophysiological approaches across animal and human studies, his research aims to advance the development of mechanism-based treatments that improve both symptoms and cognitive functioning in individuals with serious mental illness.

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Protein-protein interaction-interfering peptide rescues dysregulated NMDA receptor signaling. JCI Insight. 2026 Jan 23; 11(2). Featherstone RE, Li H, Sengar AS, Borgmann-Winter KE, Melnychenko O, Crown LM, Gifford RL, Amirfathi F, Banerjee A, Tran A, Parekh K, Heller M, Zhang W, Gallop RJ, Marc AD, Komal P, Salter MW, Siegel SJ, Hahn CG. PMID: 41343242; PMCID: PMC12892891.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimalsCells
    2. Blocking Src-PSD-95 interaction rescues glutamatergic signaling dysregulation in schizophrenia. bioRxiv. 2024 Mar 08. Featherstone RE, Li H, Sengar A, Borgmann-Winter KE, Melnychenko O, Crown LM, Gifford RL, Amirfathi F, Banerjee A, Parekh K, Heller M, Zhang W, Marc AD, Salter MW, Siegel SJ, Hahn CG. PMID: 38496466; PMCID: PMC10942437.
      View in: PubMed   Mentions:
    3. The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview. Adv Neurobiol. 2024; 40:285-319. Crown LM, Featherstone RE, Sobell JL, Parekh K, Siegel SJ. PMID: 39562449.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    4. The impact of integrating behavioral health services into pediatric subspecialty care: A systematic review. J Pediatr Gastroenterol Nutr. 2024 01; 78(1):8-16. Sayegh CS, Chavannes M, Moss IK, Featherstone RE, Urquiza I. PMID: 38291688; PMCID: PMC10832298.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    5. The Power of Potentials. Am J Psychiatry. 2023 Jul 01; 180(7):470-472. Siegel S, Crown L, Featherstone R. PMID: 37392037.
      View in: PubMed   Mentions:    Fields:    
    6. Calcium/calmodulin-dependent protein kinase IIα heterozygous knockout mice show electroencephalogram and behavioral changes characteristic of a subpopulation of schizophrenia and intellectual impairment. Neuroscience. 2022 09 01; 499:104-117. Featherstone RE, Shimada T, Crown LM, Melnychenko O, Yi J, Matsumoto M, Tajinda K, Mihara T, Adachi M, Siegel SJ. PMID: 35901933.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansAnimals
    7. Frequency-specific medial septal nucleus deep brain stimulation improves spatial memory in MK-801-treated male rats. Neurobiol Dis. 2022 08; 170:105756. Zepeda NC, Crown LM, Medvidovic S, Choi W, Sheth M, Bergosh M, Gifford R, Folz C, Lam P, Lu G, Featherstone R, Liu CY, Siegel SJ, Lee DJ. PMID: 35584727; PMCID: PMC9343054.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    8. Early life social instability stress causes lasting cognitive decrement and elevated hippocampal stress-related gene expression. Exp Neurol. 2022 08; 354:114099. Featherstone RE, Gifford RL, Crown LM, Amirfathi F, Alaniz JP, Yi J, Tran A, Adomian D, Schwenk A, Melnychenko O, Duval C, Parekh K, Lee DJ, Siegel SJ. PMID: 35490720.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    9. High-beta/low-gamma frequency activity reflects top-down predictive coding during a spatial working memory test. Exp Brain Res. 2019 Jul; 237(7):1881-1888. Zhang RV, Featherstone RE, Melynchenko O, Gifford R, Weger R, Liang Y, Siegel SJ. PMID: 31093716.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    10. Parvalbumin Cell Ablation of NMDA-R1 Leads to Altered Phase, But Not Amplitude, of Gamma-Band Cross-Frequency Coupling. Brain Connect. 2019 04; 9(3):263-272. Port RG, Berman JI, Liu S, Featherstone RE, Roberts TPL, Siegel SJ. PMID: 30588822; PMCID: PMC6479236.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    11. Src deficient mice demonstrate behavioral and electrophysiological alterations relevant to psychiatric and developmental disease. Prog Neuropsychopharmacol Biol Psychiatry. 2019 07 13; 93:84-92. Ward KR, Featherstone RE, Naschek MJ, Melnychenko O, Banerjee A, Yi J, Gifford RL, Borgmann-Winter KE, Salter MW, Hahn CG, Siegel SJ. PMID: 30826459.
      View in: PubMed   Mentions: 8     Fields:    Translation:Animals
    12. Pyramidal cell-selective GluN1 knockout causes impairments in salience attribution and related EEG activity. Exp Brain Res. 2018 03; 236(3):837-846. Forrest AD, Bang J, Featherstone RE, Bloom JH, Luminais MS, Zhang RV, Gajewski CR, McMullen MF, Liang Y, Siegel SJ. PMID: 29350251.
      View in: PubMed   Mentions: 1     Fields:    Translation:AnimalsCells
    13. Mismatch negativity in preclinical models of schizophrenia. Schizophr Res. 2018 01; 191:35-42. Featherstone RE, Melnychenko O, Siegel SJ. PMID: 28768598.
      View in: PubMed   Mentions: 29     Fields:    Translation:HumansAnimals
    14. Amygdala activity associated with social choice in mice. Behav Brain Res. 2017 08 14; 332:84-89. Mihara T, Mensah-Brown K, Sobota R, Lin R, Featherstone R, Siegel SJ. PMID: 28438555.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    15. GABA-B Agonist Baclofen Normalizes Auditory-Evoked Neural Oscillations and Behavioral Deficits in the Fmr1 Knockout Mouse Model of Fragile X Syndrome. eNeuro. 2017 Jan-Feb; 4(1). Sinclair D, Featherstone R, Naschek M, Nam J, Du A, Wright S, Pance K, Melnychenko O, Weger R, Akuzawa S, Matsumoto M, Siegel SJ. PMID: 28451631; PMCID: PMC5394929.
      View in: PubMed   Mentions: 54     Fields:    Translation:Animals
    16. The mGluR2 positive allosteric modulator, SAR218645, improves memory and attention deficits in translational models of cognitive symptoms associated with schizophrenia. Sci Rep. 2016 10 13; 6:35320. Griebel G, Pichat P, Boulay D, Naimoli V, Potestio L, Featherstone R, Sahni S, Defex H, Desvignes C, Slowinski F, Vigé X, Bergis OE, Sher R, Kosley R, Kongsamut S, Black MD, Varty GB. PMID: 27734956; PMCID: PMC5062470.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansAnimalsCells
    17. Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models. Front Behav Neurosci. 2016; 10:136. Choi CH, Schoenfeld BP, Bell AJ, Hinchey J, Rosenfelt C, Gertner MJ, Campbell SR, Emerson D, Hinchey P, Kollaros M, Ferrick NJ, Chambers DB, Langer S, Sust S, Malik A, Terlizzi AM, Liebelt DA, Ferreiro D, Sharma A, Koenigsberg E, Choi RJ, Louneva N, Arnold SE, Featherstone RE, Siegel SJ, Zukin RS, McDonald TV, Bolduc FV, Jongens TA, McBride SM. PMID: 27445731; PMCID: PMC4928101.
      View in: PubMed   Mentions: 31  
    18. Mouse Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to Autism Spectrum Disorder. J Neurosci. 2015 Dec 09; 35(49):16282-94. Kogan JH, Gross AK, Featherstone RE, Shin R, Chen Q, Heusner CL, Adachi M, Lin A, Walton NM, Miyoshi S, Miyake S, Tajinda K, Ito H, Siegel SJ, Matsumoto M. PMID: 26658876; PMCID: PMC6605504.
      View in: PubMed   Mentions: 30     Fields:    Translation:HumansAnimalsCells
    19. Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice. Drug Alcohol Depend. 2015 Nov 01; 156:14-20. Dodman K, Featherstone RE, Bang J, Liang Y, Siegel SJ. PMID: 26442907; PMCID: PMC4633341.
      View in: PubMed   Mentions: 3     Fields:    Translation:AnimalsCells
    20. Delayed emergence of behavioral and electrophysiological effects following juvenile ketamine exposure in mice. Transl Psychiatry. 2015 Sep 15; 5:e635. Nagy LR, Featherstone RE, Hahn CG, Siegel SJ. PMID: 26371763; PMCID: PMC5068812.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    21. The Role of Nicotine in Schizophrenia. Int Rev Neurobiol. 2015; 124:23-78. Featherstone RE, Siegel SJ. PMID: 26472525.
      View in: PubMed   Mentions: 21     Fields:    Translation:HumansAnimals
    22. Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism. Behav Neurosci. 2015 Aug; 129(4):389-98. Sobota R, Mihara T, Forrest A, Featherstone RE, Siegel SJ. PMID: 26214213; PMCID: PMC4518468.
      View in: PubMed   Mentions: 30     Fields:    Translation:Animals
    23. EEG biomarkers of target engagement, therapeutic effect, and disease process. Ann N Y Acad Sci. 2015 May; 1344:12-26. Featherstone RE, McMullen MF, Ward KR, Bang J, Xiao J, Siegel SJ. PMID: 25823856.
      View in: PubMed   Mentions: 17     Fields:    Translation:HumansAnimals
    24. Mice with subtle reduction of NMDA NR1 receptor subunit expression have a selective decrease in mismatch negativity: Implications for schizophrenia prodromal population. Neurobiol Dis. 2015 Jan; 73:289-95. Featherstone RE, Shin R, Kogan JH, Liang Y, Matsumoto M, Siegel SJ. PMID: 25461194.
      View in: PubMed   Mentions: 28     Fields:    Translation:Animals
    25. Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry. 2015 Mar 15; 77(6):556-68. Tatard-Leitman VM, Jutzeler CR, Suh J, Saunders JA, Billingslea EN, Morita S, White R, Featherstone RE, Ray R, Ortinski PI, Banerjee A, Gandal MJ, Lin R, Alexandrescu A, Liang Y, Gur RE, Borgmann-Winter KE, Carlson GC, Hahn CG, Siegel SJ. PMID: 25156700; PMCID: PMC4297754.
      View in: PubMed   Mentions: 62     Fields:    Translation:AnimalsCells
    26. Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits. Neuropsychopharmacology. 2014 Jun; 39(7):1603-13. Billingslea EN, Tatard-Leitman VM, Anguiano J, Jutzeler CR, Suh J, Saunders JA, Morita S, Featherstone RE, Ortinski PI, Gandal MJ, Lin R, Liang Y, Gur RE, Carlson GC, Hahn CG, Siegel SJ. PMID: 24525709; PMCID: PMC4023157.
      View in: PubMed   Mentions: 70     Fields:    Translation:AnimalsCells
    27. Chronic exposure to a gambling-like schedule of reward predictive stimuli can promote sensitization to amphetamine in rats. Front Behav Neurosci. 2014; 8:36. Zack M, Featherstone RE, Mathewson S, Fletcher PJ. PMID: 24574987; PMCID: PMC3920462.
      View in: PubMed   Mentions: 26  
    28. Electroencephalographic and early communicative abnormalities in Brattleboro rats. Physiol Rep. 2013 Oct; 1(5):e00100. Lin RE, Ambler L, Billingslea EN, Suh J, Batheja S, Tatard-Leitman V, Featherstone RE, Siegel SJ. PMID: 24303172; PMCID: PMC3841036.
      View in: PubMed   Mentions: 5     Fields:    
    29. Juvenile exposure to ketamine causes delayed emergence of EEG abnormalities during adulthood in mice. Drug Alcohol Depend. 2014 Jan 01; 134:123-127. Featherstone RE, Nagy LR, Hahn CG, Siegel SJ. PMID: 24210161; PMCID: PMC4009692.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    30. Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression. Psychopharmacology (Berl). 2013 Jun; 227(4):639-49. Featherstone RE, M Tatard-Leitman V, Suh JD, Lin R, Lucki I, Siegel SJ. PMID: 23392353; PMCID: PMC3808977.
      View in: PubMed   Mentions: 9     Fields:    Translation:Animals
    31. Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials. PLoS One. 2012; 7(7):e39775. Featherstone RE, Phillips JM, Thieu T, Ehrlichman RS, Halene TB, Leiser SC, Christian E, Johnson E, Lerman C, Siegel SJ. PMID: 22911690; PMCID: PMC3401200.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansAnimalsCells
    32. Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice. Neurobiol Dis. 2012 Sep; 47(3):338-46. Featherstone RE, Liang Y, Saunders JA, Tatard-Leitman VM, Ehrlichman RS, Siegel SJ. PMID: 22627142.
      View in: PubMed   Mentions: 40     Fields:    Translation:AnimalsCells
    33. Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density. Behav Neurosci. 2012 Apr; 126(2):332-43. Cao YA, Featherstone RE, Gandal MJ, Liang Y, Jutzeler C, Saunders J, Tatard-Leitman V, Chen J, Weinberger DR, Lerman C, Siegel SJ. PMID: 22309446.
      View in: PubMed   Mentions: 7     Fields:    Translation:Animals
    34. AVE1625, a cannabinoid CB1 receptor antagonist, as a co-treatment with antipsychotics for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side effects in rodents. Psychopharmacology (Berl). 2011 May; 215(1):149-63. Black MD, Stevens RJ, Rogacki N, Featherstone RE, Senyah Y, Giardino O, Borowsky B, Stemmelin J, Cohen C, Pichat P, Arad M, Barak S, De Levie A, Weiner I, Griebel G, Varty GB. PMID: 21181124.
      View in: PubMed   Mentions: 25     Fields:    Translation:Animals
    35. Gestational treatment with methylazoxymethanol (MAM) that disrupts hippocampal-dependent memory does not alter behavioural response to cocaine. Pharmacol Biochem Behav. 2009 Oct; 93(4):382-90. Featherstone RE, Burton CL, Coppa-Hopman R, Rizos Z, Sinyard J, Kapur S, Fletcher PJ. PMID: 19467255.
      View in: PubMed   Mentions: 6     Fields:    Translation:Animals
    36. A sensitizing regimen of amphetamine that disrupts attentional set-shifting does not disrupt working or long-term memory. Behav Brain Res. 2008 May 16; 189(1):170-9. Featherstone RE, Rizos Z, Kapur S, Fletcher PJ. PMID: 18299157.
      View in: PubMed   Mentions: 29     Fields:    Translation:Animals
    37. The amphetamine-induced sensitized state as a model of schizophrenia. Prog Neuropsychopharmacol Biol Psychiatry. 2007 Nov 15; 31(8):1556-71. Featherstone RE, Kapur S, Fletcher PJ. PMID: 17884274.
      View in: PubMed   Mentions: 76     Fields:    Translation:HumansAnimals
    38. Lesions of the dorsolateral striatum impair the acquisition of a simplified stimulus-response dependent conditional discrimination task. Neuroscience. 2005; 136(2):387-95. Featherstone RE, McDonald RJ. PMID: 16226388.
      View in: PubMed   Mentions: 16     Fields:    Translation:Animals
    39. Dorsal striatum and stimulus-response learning: lesions of the dorsolateral, but not dorsomedial, striatum impair acquisition of a stimulus-response-based instrumental discrimination task, while sparing conditioned place preference learning. Neuroscience. 2004; 124(1):23-31. Featherstone RE, McDonald RJ. PMID: 14960336.
      View in: PubMed   Mentions: 38     Fields:    Translation:Animals
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