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Steven Siegel, MD, PhD

TitleProfessor and Chair, Psychiatry and The Behavioral Sciences
InstitutionUniversity of Southern California
DepartmentPsychiatry and The Behavioral Sciences
AddressCSC 2250 Alcazar St.
Health Sciences Campus
Los Angeles CA 90033
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    Collapse Research 
    Collapse Research Activities and Funding
    Mentored Career Development
    NIH/NCATS KL2TR001854Jul 1, 2016 - May 31, 2021
    Role: Principal Investigator
    Long-term neurobehavioral effects of ketamine exposure in adolescent mice
    NIH/NIDA R01DA023210Feb 1, 2008 - Jan 31, 2014
    Role: Principal Investigator
    Src mediates molecular alterations leading to NMDAR hypofunction in schizophrenia
    NIH/NIMH R01MH075916Dec 1, 2005 - Jan 31, 2020
    Role: Co-Principal Investigator
    An Implantable Semiannual Antipsychotic Delivery System
    NIH/NIMH R01MH074672Jul 1, 2005 - Nov 30, 2014
    Role: Principal Investigator
    Evoked potentials and vulnerability to ketamine in mice.
    NIH/NIDA R21DA017082Sep 30, 2003 - Jul 31, 2005
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help.
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    1. Forrest AD, Bang J, Featherstone RE, Bloom JH, Luminais MS, Zhang RV, Gajewski CR, McMullen MF, Liang Y, Siegel S. Pyramidal cell-selective GluN1 knockout causes impairments in salience attribution and related EEG activity. Exp Brain Res. 2018 Mar; 236(3):837-846. PMID: 29350251.
      View in: PubMed
    2. Featherstone RE, Melnychenko O, Siegel S. Mismatch negativity in preclinical models of schizophrenia. Schizophr Res. 2018 Jan; 191:35-42. PMID: 28768598.
      View in: PubMed
    3. Mihara T, Mensah-Brown K, Sobota R, Lin R, Featherstone R, Siegel S. Amygdala activity associated with social choice in mice. Behav Brain Res. 2017 08 14; 332:84-89. PMID: 28438555.
      View in: PubMed
    4. Choi CH, Schoenfeld BP, Bell AJ, Hinchey J, Rosenfelt C, Gertner MJ, Campbell SR, Emerson D, Hinchey P, Kollaros M, Ferrick NJ, Chambers DB, Langer S, Sust S, Malik A, Terlizzi AM, Liebelt DA, Ferreiro D, Sharma A, Koenigsberg E, Choi RJ, Louneva N, Arnold SE, Featherstone RE, Siegel S, Zukin RS, McDonald TV, Bolduc FV, Jongens TA, McBride SM. Multiple Drug Treatments That Increase cAMP Signaling Restore Long-Term Memory and Aberrant Signaling in Fragile X Syndrome Models. Front Behav Neurosci. 2016; 10:136. PMID: 27445731; PMCID: PMC4928101.
    5. Kogan JH, Gross AK, Featherstone RE, Shin R, Chen Q, Heusner CL, Adachi M, Lin A, Walton NM, Miyoshi S, Miyake S, Tajinda K, Ito H, Siegel S, Matsumoto M. Mouse Model of Chromosome 15q13.3 Microdeletion Syndrome Demonstrates Features Related to Autism Spectrum Disorder. J Neurosci. 2015 Dec 09; 35(49):16282-94. PMID: 26658876.
      View in: PubMed
    6. Featherstone RE, Siegel S. The Role of Nicotine in Schizophrenia. Int Rev Neurobiol. 2015; 124:23-78. PMID: 26472525.
      View in: PubMed
    7. Sobota R, Mihara T, Forrest A, Featherstone RE, Siegel S. Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism. Behav Neurosci. 2015 Aug; 129(4):389-98. PMID: 26214213; PMCID: PMC4518468.
    8. Featherstone RE, McMullen MF, Ward KR, Bang J, Xiao J, Siegel S. EEG biomarkers of target engagement, therapeutic effect, and disease process. Ann N Y Acad Sci. 2015 May; 1344:12-26. PMID: 25823856.
      View in: PubMed
    9. Featherstone RE, Shin R, Kogan JH, Liang Y, Matsumoto M, Siegel S. Mice with subtle reduction of NMDA NR1 receptor subunit expression have a selective decrease in mismatch negativity: Implications for schizophrenia prodromal population. Neurobiol Dis. 2015 Jan; 73:289-95. PMID: 25461194.
      View in: PubMed
    10. Tatard-Leitman VM, Jutzeler CR, Suh J, Saunders JA, Billingslea EN, Morita S, White R, Featherstone RE, Ray R, Ortinski PI, Banerjee A, Gandal MJ, Lin R, Alexandrescu A, Liang Y, Gur RE, Borgmann-Winter KE, Carlson GC, Hahn CG, Siegel S. Pyramidal cell selective ablation of N-methyl-D-aspartate receptor 1 causes increase in cellular and network excitability. Biol Psychiatry. 2015 Mar 15; 77(6):556-68. PMID: 25156700; PMCID: PMC4297754.
    11. Billingslea EN, Tatard-Leitman VM, Anguiano J, Jutzeler CR, Suh J, Saunders JA, Morita S, Featherstone RE, Ortinski PI, Gandal MJ, Lin R, Liang Y, Gur RE, Carlson GC, Hahn CG, Siegel S. Parvalbumin cell ablation of NMDA-R1 causes increased resting network excitability with associated social and self-care deficits. Neuropsychopharmacology. 2014 Jun; 39(7):1603-13. PMID: 24525709; PMCID: PMC4023157.
    12. Lin RE, Ambler L, Billingslea EN, Suh J, Batheja S, Tatard-Leitman V, Featherstone RE, Siegel S. Electroencephalographic and early communicative abnormalities in Brattleboro rats. Physiol Rep. 2013 Oct; 1(5):e00100. PMID: 24303172; PMCID: PMC3841036.
    13. Featherstone RE, M Tatard-Leitman V, Suh JD, Lin R, Lucki I, Siegel S. Electrophysiological and behavioral responses to ketamine in mice with reduced Akt1 expression. Psychopharmacology (Berl). 2013 Jun; 227(4):639-49. PMID: 23392353; PMCID: PMC3808977.
    14. Featherstone RE, Phillips JM, Thieu T, Ehrlichman RS, Halene TB, Leiser SC, Christian E, Johnson E, Lerman C, Siegel S. Nicotine receptor subtype-specific effects on auditory evoked oscillations and potentials. PLoS One. 2012; 7(7):e39775. PMID: 22911690; PMCID: PMC3401200.
    15. Featherstone RE, Liang Y, Saunders JA, Tatard-Leitman VM, Ehrlichman RS, Siegel S. Subchronic ketamine treatment leads to permanent changes in EEG, cognition and the astrocytic glutamate transporter EAAT2 in mice. Neurobiol Dis. 2012 Sep; 47(3):338-46. PMID: 22627142.
      View in: PubMed
    16. Cao YA, Featherstone RE, Gandal MJ, Liang Y, Jutzeler C, Saunders J, Tatard-Leitman V, Chen J, Weinberger DR, Lerman C, Siegel S. Nicotine normalizes event related potentials in COMT-Val-tg mice and increases gamma and theta spectral density. Behav Neurosci. 2012 Apr; 126(2):332-43. PMID: 22309446.
      View in: PubMed
    17. Dankert ME, Brensinger CM, Metzger KL, Li C, Koleva SG, Mesén A, Laprade B, Wiguna T, Han C, Farooq S, Severus WE, Gayares JG, Langosch JM, Lallart X, Tateno M, Mihai A, Nair SR, Belmaker R, Rybakowski J, Owe-Larsson B, Kane JM, Johnstone EC, MacIntyre DJ, Malhotra S, González-Pinto A, Mosquera F, Babb SM, Habib pour E, Fatemi SS, Swanson C, Adler C, Young A, Hoeft F, Sivakumar K, Radoeva PD, Lallart EA, Bilker WB, Siegel S. Attitudes of patients and family members towards implantable psychiatric medication. Schizophr Res. 2008 Oct; 105(1-3):279-86. PMID: 18571376.
      View in: PubMed
    18. Irani F, Platek SM, Panyavin IS, Calkins ME, Kohler C, Siegel S, Schachter M, Gur RE, Gur RC. Self-face recognition and theory of mind in patients with schizophrenia and first-degree relatives. Schizophr Res. 2006 Dec; 88(1-3):151-60. PMID: 16979876.
      View in: PubMed
    19. Gelber EI, Kohler CG, Bilker WB, Gur RC, Brensinger C, Siegel S, Gur RE. Symptom and demographic profiles in first-episode schizophrenia. Schizophr Res. 2004 Apr 01; 67(2-3):185-94. PMID: 14984877.
      View in: PubMed
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