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Janet Laurie Sobell, PhD

Title(s)Associate Professor of Research Psychiatry and the Behavioral Sciences
AddressZNI 401 1501 San Pablo Street
Health Sciences Campus
Los Angeles CA 90089-2821
Phone+1 424 240 9310
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    GENETIC EPIDEMIOLOGY OF SCHIZOPHRENIA--5 HT AND NM
    NIH/NIMH R01MH054232Sep 30, 1995 - May 31, 2001
    Role: Principal Investigator

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gene Expression in Patient-Derived Neural Progenitors Implicates WNT5A Signaling in the Etiology of Schizophrenia. Biol Psychiatry. 2020 Aug 01; 88(3):236-247. Evgrafov OV, Armoskus C, Wrobel BB, Spitsyna VN, Souaiaia T, Herstein JS, Walker CP, Nguyen JD, Camarena A, Weitz JR, Kim JMH, Lopez Duarte E, Wang K, Simpson GM, Sobell JL, Medeiros H, Pato MT, Pato CN, Knowles JA. PMID: 32143829.
      View in: PubMed   Mentions:    Fields:    
    2. Contributions of common genetic variants to risk of schizophrenia among individuals of African and Latino ancestry. Mol Psychiatry. 2019 Oct 07. Bigdeli TB, Genovese G, Georgakopoulos P, Meyers JL, Peterson RE, Iyegbe CO, Medeiros H, Valderrama J, Achtyes ED, Kotov R, Stahl EA, Abbott C, Azevedo MH, Belliveau RA, Bevilacqua E, Bromet EJ, Byerley W, Carvalho CB, Chapman SB, DeLisi LE, Dumont AL, O'Dushlaine C, Evgrafov OV, Fochtmann LJ, Gage D, Kennedy JL, Kinkead B, Macedo A, Moran JL, Morley CP, Dewan MJ, Nemesh J, Perkins DO, Purcell SM, Rakofsky JJ, Scolnick EM, Sklar BM, Sklar P, Smoller JW, Sullivan PF, Macciardi F, Marder SR, Gur RC, Gur RE, Braff DL, Nicolini H, Escamilla MA, Vawter MP, Sobell JL, Malaspina D, Lehrer DS, Buckley PF, Rapaport MH, Knowles JA, Fanous AH, Pato MT, McCarroll SA, Pato CN. PMID: 31591465.
      View in: PubMed   Mentions: 5     Fields:    
    3. Genome-wide association study identifies 30 loci associated with bipolar disorder. Nat Genet. 2019 05; 51(5):793-803. Stahl EA, Breen G, Forstner AJ, McQuillin A, Ripke S, Trubetskoy V, Mattheisen M, Wang Y, Coleman JRI, Gaspar HA, de Leeuw CA, Steinberg S, Pavlides JMW, Trzaskowski M, Byrne EM, Pers TH, Holmans PA, Richards AL, Abbott L, Agerbo E, Akil H, Albani D, Alliey-Rodriguez N, Als TD, Anjorin A, Antilla V, Awasthi S, Badner JA, Bækvad-Hansen M, Barchas JD, Bass N, Bauer M, Belliveau R, Bergen SE, Pedersen CB, Bøen E, Boks MP, Boocock J, Budde M, Bunney W, Burmeister M, Bybjerg-Grauholm J, Byerley W, Casas M, Cerrato F, Cervantes P, Chambert K, Charney AW, Chen D, Churchhouse C, Clarke TK, Coryell W, Craig DW, Cruceanu C, Curtis D, Czerski PM, Dale AM, de Jong S, Degenhardt F, Del-Favero J, DePaulo JR, Djurovic S, Dobbyn AL, Dumont A, Elvsåshagen T, Escott-Price V, Fan CC, Fischer SB, Flickinger M, Foroud TM, Forty L, Frank J, Fraser C, Freimer NB, Frisén L, Gade K, Gage D, Garnham J, Giambartolomei C, Pedersen MG, Goldstein J, Gordon SD, Gordon-Smith K, Green EK, Green MJ, Greenwood TA, Grove J, Guan W, Guzman-Parra J, Hamshere ML, Hautzinger M, Heilbronner U, Herms S, Hipolito M, Hoffmann P, Holland D, Huckins L, Jamain S, Johnson JS, Juréus A, Kandaswamy R, Karlsson R, Kennedy JL, Kittel-Schneider S, Knowles JA, Kogevinas M, Koller AC, Kupka R, Lavebratt C, Lawrence J, Lawson WB, Leber M, Lee PH, Levy SE, Li JZ, Liu C, Lucae S, Maaser A, MacIntyre DJ, Mahon PB, Maier W, Martinsson L, McCarroll S, McGuffin P, McInnis MG, McKay JD, Medeiros H, Medland SE, Meng F, Milani L, Montgomery GW, Morris DW, Mühleisen TW, Mullins N, Nguyen H, Nievergelt CM, Adolfsson AN, Nwulia EA, O'Donovan C, Loohuis LMO, Ori APS, Oruc L, Ösby U, Perlis RH, Perry A, Pfennig A, Potash JB, Purcell SM, Regeer EJ, Reif A, Reinbold CS, Rice JP, Rivas F, Rivera M, Roussos P, Ruderfer DM, Ryu E, Sánchez-Mora C, Schatzberg AF, Scheftner WA, Schork NJ, Shannon Weickert C, Shehktman T, Shilling PD, Sigurdsson E, Slaney C, Smeland OB, Sobell JL, Søholm Hansen C, Spijker AT, St Clair D, Steffens M, Strauss JS, Streit F, Strohmaier J, Szelinger S, Thompson RC, Thorgeirsson TE, Treutlein J, Vedder H, Wang W, Watson SJ, Weickert TW, Witt SH, Xi S, Xu W, Young AH, Zandi P, Zhang P, Zöllner S, Adolfsson R, Agartz I, Alda M, Backlund L, Baune BT, Bellivier F, Berrettini WH, Biernacka JM, Blackwood DHR, Boehnke M, Børglum AD, Corvin A, Craddock N, Daly MJ, Dannlowski U, Esko T, Etain B, Frye M, Fullerton JM, Gershon ES, Gill M, Goes F, Grigoroiu-Serbanescu M, Hauser J, Hougaard DM, Hultman CM, Jones I, Jones LA, Kahn RS, Kirov G, Landén M, Leboyer M, Lewis CM, Li QS, Lissowska J, Martin NG, Mayoral F, McElroy SL, McIntosh AM, McMahon FJ, Melle I, Metspalu A, Mitchell PB, Morken G, Mors O, Mortensen PB, Müller-Myhsok B, Myers RM, Neale BM, Nimgaonkar V, Nordentoft M, Nöthen MM, O'Donovan MC, Oedegaard KJ, Owen MJ, Paciga SA, Pato C, Pato MT, Posthuma D, Ramos-Quiroga JA, Ribasés M, Rietschel M, Rouleau GA, Schalling M, Schofield PR, Schulze TG, Serretti A, Smoller JW, Stefansson H, Stefansson K, Stordal E, Sullivan PF, Turecki G, Vaaler AE, Vieta E, Vincent JB, Werge T, Nurnberger JI, Wray NR, Di Florio A, Edenberg HJ, Cichon S, Ophoff RA, Scott LJ, Andreassen OA, Kelsoe J, Sklar P. PMID: 31043756.
      View in: PubMed   Mentions: 75     Fields:    Translation:Humans
    4. Genome-wide Burden of Rare Short Deletions Is Enriched in Major Depressive Disorder in Four Cohorts. Biol Psychiatry. 2019 06 15; 85(12):1065-1073. Zhang X, Abdellaoui A, Rucker J, de Jong S, Potash JB, Weissman MM, Shi J, Knowles JA, Pato C, Pato M, Sobell J, Smit JH, Hottenga JJ, de Geus EJC, Lewis CM, Buttenschøn HN, Craddock N, Jones I, Jones L, McGuffin P, Mors O, Owen MJ, Preisig M, Rietschel M, Rice JP, Rivera M, Uher R, Gejman PV, Sanders AR, Boomsma D, Penninx BWJH, Breen G, Levinson DF. PMID: 31003785.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    5. Contribution of Rare Copy Number Variants to Bipolar Disorder Risk Is Limited to Schizoaffective Cases. Biol Psychiatry. 2019 07 15; 86(2):110-119. Charney AW, Stahl EA, Green EK, Chen CY, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Knowles JA, Burdick KE, Jones I, Jones LA, Hultman CM, Perlis R, Purcell SM, McCarroll SA, Pato CN, Pato MT, Di Florio A, Craddock N, Landén M, Smoller JW, Ruderfer DM, Sklar P. PMID: 30686506.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    6. Evidence for genetic heterogeneity between clinical subtypes of bipolar disorder. Transl Psychiatry. 2017 01 10; 7(1):e993. Charney AW, Ruderfer DM, Stahl EA, Moran JL, Chambert K, Belliveau RA, Forty L, Gordon-Smith K, Di Florio A, Lee PH, Bromet EJ, Buckley PF, Escamilla MA, Fanous AH, Fochtmann LJ, Lehrer DS, Malaspina D, Marder SR, Morley CP, Nicolini H, Perkins DO, Rakofsky JJ, Rapaport MH, Medeiros H, Sobell JL, Green EK, Backlund L, Bergen SE, Juréus A, Schalling M, Lichtenstein P, Roussos P, Knowles JA, Jones I, Jones LA, Hultman CM, Perlis RH, Purcell SM, McCarroll SA, Pato CN, Pato MT, Craddock N, Landén M, Smoller JW, Sklar P. PMID: 28072414.
      View in: PubMed   Mentions: 31     Fields:    Translation:HumansCells
    7. Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study. JAMA Psychiatry. 2016 05 01; 73(5):506-14. Montano C, Taub MA, Jaffe A, Briem E, Feinberg JI, Trygvadottir R, Idrizi A, Runarsson A, Berndsen B, Gur RC, Moore TM, Perry RT, Fugman D, Sabunciyan S, Yolken RH, Hyde TM, Kleinman JE, Sobell JL, Pato CN, Pato MT, Go RC, Nimgaonkar V, Weinberger DR, Braff D, Gur RE, Fallin MD, Feinberg AP. PMID: 27074206.
      View in: PubMed   Mentions: 33     Fields:    Translation:HumansCells
    8. LINE1 insertions as a genomic risk factor for schizophrenia: Preliminary evidence from an affected family. . 2016 06; 171(4):534-45. Guffanti G, Gaudi S, Klengel T, Fallon JH, Mangalam H, Madduri R, Rodriguez A, DeCrescenzo P, Glovienka E, Sobell J, Klengel C, Pato M, Ressler KJ, Pato C, Macciardi F. PMID: 26990047.
      View in: PubMed   Mentions:
    9. Substance use associated with short sleep duration in patients with schizophrenia or schizoaffective disorder. . 2016 06; 171(4):525-33. Tang VK, Pato MT, Sobell JL, Hammond TC, Valdez MM, Lane CJ, Pato CN. PMID: 26345478.
      View in: PubMed   Mentions:
    10. Traumatic brain injury and bipolar psychosis in the Genomic Psychiatry Cohort. . 2016 06; 171(4):506-12. Cieslak K, Pato M, Buckley P, Pato C, Sobell JL, Medeiros H, Zhao Y, Ahn H, Malaspina D. PMID: 26224022.
      View in: PubMed   Mentions:
    11. Paternal age effect: Replication in schizophrenia with intriguing dissociation between bipolar with and without psychosis. . 2016 06; 171(4):495-505. Lehrer DS, Pato MT, Nahhas RW, Miller BR, Malaspina D, Buckley PF, Sobell JL, Walsh-Messinger J, Pato CN. PMID: 26183902.
      View in: PubMed   Mentions:
    12. Comorbidity of severe psychotic disorders with measures of substance use. JAMA Psychiatry. 2014 Mar; 71(3):248-54. Hartz SM, Pato CN, Medeiros H, Cavazos-Rehg P, Sobell JL, Knowles JA, Bierut LJ, Pato MT. PMID: 24382686.
      View in: PubMed   Mentions: 59     Fields:    Translation:Humans
    13. Transposable elements and psychiatric disorders. . 2014 Apr; 165B(3):201-16. Guffanti G, Gaudi S, Fallon JH, Sobell J, Potkin SG, Pato C, Macciardi F. PMID: 24585726.
      View in: PubMed   Mentions:
    14. The genomic psychiatry cohort: partners in discovery. . 2013 Jun; 162B(4):306-12. Pato MT, Sobell JL, Medeiros H, Abbott C, Sklar BM, Buckley PF, Bromet EJ, Escamilla MA, Fanous AH, Lehrer DS, Macciardi F, Malaspina D, McCarroll SA, Marder SR, Moran J, Morley CP, Nicolini H, Perkins DO, Purcell SM, Rapaport MH, Sklar P, Smoller JW, Knowles JA, Pato CN. PMID: 23650244.
      View in: PubMed   Mentions:
    15. A system architecture for sharing de-identified, research-ready brain scans and health information across clinical imaging centers. Stud Health Technol Inform. 2012; 175:19-28. Chervenak AL, van Erp TG, Kesselman C, D'Arcy M, Sobell J, Keator D, Dahm L, Murry J, Law M, Hasso A, Ames J, Macciardi F, Potkin SG. PMID: 22941984.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    16. Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples. Biol Psychiatry. 2006 Jul 15; 60(2):152-62. Talkowski ME, Seltman H, Bassett AS, Brzustowicz LM, Chen X, Chowdari KV, Collier DA, Cordeiro Q, Corvin AP, Deshpande SN, Egan MF, Gill M, Kendler KS, Kirov G, Heston LL, Levitt P, Lewis DA, Li T, Mirnics K, Morris DW, Norton N, O'Donovan MC, Owen MJ, Richard C, Semwal P, Sobell JL, St Clair D, Straub RE, Thelma BK, Vallada H, Weinberger DR, Williams NM, Wood J, Zhang F, Devlin B, Nimgaonkar VL. PMID: 16631129.
      View in: PubMed   Mentions: 24     Fields:    Translation:Humans
    17. Failure to confirm association between RGS4 haplotypes and schizophrenia in Caucasians. . 2005 Nov 05; 139B(1):23-7. Sobell JL, Richard C, Wirshing DA, Heston LL. PMID: 16082709.
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    18. Multiple missense mutations in the diazepam binding inhibitor (DBI) gene identified in schizophrenia but lack of disease association. . 2004 Feb 15; 125B(1):10-9. Niu N, Rice SR, Heston LL, Sobell JL. PMID: 14755437.
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    19. Genetics and etiopathophysiology of schizophrenia. Mayo Clin Proc. 2002 Oct; 77(10):1068-82. Sobell JL, Mikesell MJ, McMurray CT. PMID: 12374251.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    20. Alteration of branch site consensus sequence and enhanced pre-mRNA splicing of an NMDAR1 intron not associated with schizophrenia. Am J Med Genet. 2002 Aug 08; 114(6):631-6. Hammond L, Castanotto D, Rice SR, Nimgaonkar VL, Wirshing DA, Rossi JJ, Heston LL, Sobell JL. PMID: 12210277.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCells
    21. Identification of single nucleotide polymorphisms (SNPs) and other sequence changes and estimation of nucleotide diversity in coding and flanking regions of the NMDAR1 receptor gene in schizophrenic patients. Mol Psychiatry. 2001 May; 6(3):274-84. Rice SR, Niu N, Berman DB, Heston LL, Sobell JL. PMID: 11326295.
      View in: PubMed   Mentions: 7     Fields:    Translation:Humans
    22. Histamine N-methyltransferase functional polymorphism: lack of association with schizophrenia. Am J Med Genet. 2000 Jun 12; 96(3):404-6. Yan L, Szumlanski CL, Rice SR, Sobell JL, Lachman HM, Weinshilboum RM. PMID: 10898922.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    23. Variants in the alpha2A AR adrenergic receptor gene in psychiatric patients. Am J Med Genet. 1998 Sep 07; 81(5):405-10. Feng J, Sobell JL, Heston LL, Goldman D, Cook E, Kranzler HR, Gelernter J, Sommer SS. PMID: 9754626.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansAnimals
    24. Scanning of the dopamine D1 and D5 receptor genes by REF in neuropsychiatric patients reveals a novel missense change at a highly conserved amino acid. Am J Med Genet. 1998 Mar 28; 81(2):172-8. Feng J, Sobell JL, Heston LL, Cook EH, Goldman D, Sommer SS. PMID: 9613858.
      View in: PubMed   Mentions: 5     Fields:    Translation:HumansCells
    25. Gly(247)-->Asp proenkephalin A mutation is rare in schizophrenia populations. Am J Med Genet. 1997 Apr 18; 74(2):213-5. Mikesell MJ, Barron YD, Nimgaonkar VL, Sobell JL, Sommer SS, McMurray CT. PMID: 9129728.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    26. Screening the monoamine oxidase B gene in 100 male patients with schizophrenia: a cluster of polymorphisms in African-Americans but lack of functionally significant sequence changes. Am J Med Genet. 1997 Feb 21; 74(1):44-9. Sobell JL, Lind TJ, Hebrink DD, Heston LL, Sommer SS. PMID: 9034005.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    27. Identification of a missense mutation and several polymorphisms in the proenkephalin A gene of schizophrenic patients. Am J Med Genet. 1996 Sep 20; 67(5):459-67. Mikesell MJ, Sobell JL, Sommer SS, McMurray CT. PMID: 8886162.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    28. Genotype-to-phenotype analysis: search for clinical characteristics of a missense change in the GABAA-beta 1 receptor gene. Am J Med Genet. 1996 Feb 16; 67(1):81-4. Sobell JL, Sigurdson DC, Heston LL, Byerley WF, Sommer SS. PMID: 8678120.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Screening the dopamine D1 receptor gene in 131 schizophrenics and eight alcoholics: identification of polymorphisms but lack of functionally significant sequence changes. Am J Med Genet. 1995 Apr 24; 60(2):165-71. Liu Q, Sobell JL, Heston LL, Sommer SS. PMID: 7485254.
      View in: PubMed   Mentions: 3     Fields:    Translation:HumansCells
    30. The D5 dopamine receptor gene in schizophrenia: identification of a nonsense change and multiple missense changes but lack of association with disease. Hum Mol Genet. 1995 Apr; 4(4):507-14. Sobell JL, Lind TJ, Sigurdson DC, Zald DH, Snitz BE, Grove WM, Heston LL, Sommer SS. PMID: 7633397.
      View in: PubMed   Mentions: 7     Fields:    Translation:HumansCells
    31. S311C D2DR variant: no association with schizophrenia. Lancet. 1994 Aug 27; 344(8922):621-2. Sobell J, Sigurdson DC, Heston L, Sommer S. PMID: 7914994.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    32. Search for mutations in the beta 1 GABAA receptor subunit gene in patients with schizophrenia. Am J Med Genet. 1994 Mar 15; 54(1):12-20. Coon H, Sobell J, Heston L, Sommer S, Hoff M, Holik J, Umar F, Robertson M, Reimherr F, Wender P. PMID: 8178835.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    33. Screening the dystrophin gene suggests a high rate of polymorphism in general but no exonic deletions in schizophrenics. Am J Med Genet. 1994 Mar 15; 54(1):1-4. Lindor NM, Sobell JL, Heston LL, Thibodeau SN, Sommer SS. PMID: 7909988.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    34. A common exonic polymorphism in the human D5 dopamine receptor gene. Hum Genet. 1993 Dec; 92(6):633-4. Sommer SS, Sobell JL, Heston LL. PMID: 8262527.
      View in: PubMed   Mentions: 2     Fields:    Translation:HumansCells
    35. APP mutations and schizophrenia. Biol Psychiatry. 1993 Nov 15; 34(10):739-40. Arnholt JC, Sobell JL, Heston LL, Sommer SS. PMID: 8292675.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    36. Dopamine D4 receptor variants in unrelated schizophrenic cases and controls. Am J Med Genet. 1993 Jul 15; 48(2):90-3. Sommer SS, Lind TJ, Heston LL, Sobell JL. PMID: 8103294.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    37. Novel association approach for determining the genetic predisposition to schizophrenia: case-control resource and testing of a candidate gene. Am J Med Genet. 1993 May 01; 48(1):28-35. Sobell JL, Heston LL, Sommer SS. PMID: 8357034.
      View in: PubMed   Mentions: 11     Fields:    Translation:HumansCells
    38. Eight novel polymorphisms in the dystrophin gene of African-Americans: the rate of polymorphism is high. Hum Mutat. 1993; 2(6):485-8. Lindor NM, Sommer SS, Sobell J, Heston L, Thibodeau SN. PMID: 7906594.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    39. Delineation of genetic predisposition to multifactorial disease: a general approach on the threshold of feasibility. Genomics. 1992 Jan; 12(1):1-6. Sobell JL, Heston LL, Sommer SS. PMID: 1733846.
      View in: PubMed   Mentions: 13     Fields:    Translation:HumansAnimals
    40. Direct sequencing of the dopamine D2 receptor (DRD2) in schizophrenics reveals three polymorphisms but no structural change in the receptor. Genomics. 1991 Sep; 11(1):8-14. Sarkar G, Kapelner S, Grandy DK, Marchionni M, Civelli O, Sobell J, Heston L, Sommer SS. PMID: 1837284.
      View in: PubMed   Mentions: 14     Fields:    Translation:HumansCells
    41. A novel method for detecting point mutations or polymorphisms and its application to population screening for carriers of phenylketonuria. Mayo Clin Proc. 1989 Nov; 64(11):1361-72. Sommer SS, Cassady JD, Sobell JL, Bottema CD. PMID: 2687596.
      View in: PubMed   Mentions: 27     Fields:    Translation:HumansCells
    42. Application of DNA-based diagnosis to patient care: the example of hemophilia A. Mayo Clin Proc. 1987 May; 62(5):387-404. Sommer SS, Sobell JL. PMID: 3553754.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
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