Dr. Matthews was recruited to the University of Southern California faculty in 2007 to direct the Department of Interventional Cardiology. He brings 20 years of experience in high-level tertiary interventional cardiology to the institution. Dr. Matthews has emerged as a leader in the advancement of percutaneous treatment of peripheral vascular disease.

He remains very active in the clinical investigation and use of new devices and techniques for the treatment of coronary artery disease and carotid artery disease. In addition, Dr. Matthews was among the first in Los Angeles to percutaneously close structural cardiac defects, such as atrial septal defect and to patent foreman ovale. Dr. Matthews previously served as head of an interventional cardiology training program that trained over 50 interventional cardiologists, many have gone on to successful careers all over the world.