Ray Matthews, MD

Title(s)Professor of Clinical Medicine
SchoolKeck School of Medicine of Usc
AddressHCC 322
Health Sciences Campus
Los Angeles CA 90089-9198
Phone+1 323 442 6130
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    Other Positions
    Title(s)Director of Interventional Cardiology and Catheterization Laboratories

    Title(s)Director, CVI Outreach & Network Development

    Collapse Biography 
    Collapse Awards and Honors
    American Heart Association1986Group Investigator Award
    Harbor-UCLA Medical Center1987Distinguished Teaching Award
    American Heart Association 1987First Place, Clinical Division, Laverne Titus Young Investigator Competition
    Division of Cardiovascular Medicine, Keck School of Medicine of USC2013Golden Apple Award for Outstanding Teaching

    Collapse Overview 
    Collapse Overview
    Dr Matthews was recruited in 2007 to build and lead the section of interventional cardiology at USC. He has 35 years of experience in the catheter based treatment of a wide variety of cardiac disease states. He is well recognized as a pioneer in the performance of coronary interventions in patients too ill for bypass surgery, by using temporary ventricular assist devices during coronary stenting. Dr Mathews was one of the first cardiologists to close congenital heart defects percutaneously in Los Angeles and has since accumulated a large experience in ASD, VSD and PFO closure. Dr Matthews developed a structural heart program at USC over the past decade where he helped USC lead in the early development of TAVR procedures and now has performed well over 1000 of these procedures himself. Through his leadership, USC now has robust programs to percutaneously replace aortic, pulmonic and mitral valves as well.

    Dr Matthews maintains a large practice of patients referred with cardiac abnormalities too challenging for community practitioners. He is also a dedicated teacher and scientist. He has trained over 80 interventional cardiologists who have gone on to successful practices all over the US and the world. He is a sought after speaker on the topic of structural heart disease and high risk coronary intervention. He is also involved in research projects to develop implantable sensors that are patient operated to detect heart failure at home and synthetically produced artificial TAVR valves. Dr Matthews continues to innovate and lead in interventional cardiology assisting in the development of numerous medical devices to facilitate the performance of cardiac procedures less invasively, safely and with excellent outcomes.

    Collapse ORNG Applications 
    Collapse Clinical Trials

    Collapse Bibliographic 
    Collapse Publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Researchers can login to make corrections and additions, or contact us for help. to make corrections and additions.
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    Altmetrics Details PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Instantaneous detection of acute myocardial infarction and ischaemia from a single carotid pressure waveform in rats. Eur Heart J Open. 2023 Sep; 3(5):oead099. Alavi R, Dai W, Matthews RV, Kloner RA, Pahlevan NM. PMID: 37849787; PMCID: PMC10578505.
      View in: PubMed   Mentions:
    2. The sleep, circadian, and cognitive performance consequences of watchkeeping schedules in submariners: A scoping review. Sleep Med Rev. 2023 Dec; 72:101845. Marando I, Lushington K, Owen M, Matthews RW, Banks S. PMID: 37677995.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    3. The addition of evolocumab to maximal tolerated statin therapy improves walking performance in patients with peripheral arterial disease and intermittent claudication (Evol-PAD study). Cardiovasc Revasc Med. 2023 10; 55:1-5. Clavijo LC, Caro J, Choi J, Caro JA, Tun H, Rowe V, Kumar SR, Shavelle DM, Matthews RV. PMID: 37142533.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    4. The effect of time on task, sleep deprivation, and time of day on simulated driving performance. Sleep. 2022 09 08; 45(9). Marando I, Matthews RW, Grosser L, Yates C, Banks S. PMID: 35867054; PMCID: PMC9453627.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    5. Abnormal left atrial body stiffness is predicted by appendage size: impact of appendage occlusion on left atrial mechanics assessed by pressure-volume analysis. Am J Physiol Heart Circ Physiol. 2022 09 01; 323(3):H559-H568. Bregasi A, Freeman JV, Curtis JP, Akar JG, Ortiz-Leon XA, Maia JH, Higgins AY, Matthews RV, Sinusas AJ, McNamara RL, Sugeng L, Lin BA. PMID: 35960632; PMCID: PMC9576173.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    6. Self-expanding intra-annular versus commercially available transcatheter heart valves in high and extreme risk patients with severe aortic stenosis (PORTICO IDE): a randomised, controlled, non-inferiority trial. Lancet. 2020 09 05; 396(10252):669-683. Makkar RR, Cheng W, Waksman R, Satler LF, Chakravarty T, Groh M, Abernethy W, Russo MJ, Heimansohn D, Hermiller J, Worthley S, Chehab B, Cunningham M, Matthews R, Ramana RK, Yong G, Ruiz CE, Chen C, Asch FM, Nakamura M, Jilaihawi H, Sharma R, Yoon SH, Pichard AD, Kapadia S, Reardon MJ, Bhatt DL, Fontana GP. PMID: 32593323.
      View in: PubMed   Mentions: 30     Fields:    Translation:Humans
    7. Factors Associated With the Use of Bare Metal Stents in Patients With ST Elevation Myocardial Infarction. Cardiovasc Revasc Med. 2020 12; 21(12):1489-1492. Raj L, Upadyhay R, Clavijo LC, Tun H, Mehra A, Hindoyan A, Matthews RV, Shavelle DM. PMID: 32448777.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    8. Time-of-day and days-on-shift predict increased fatigue over two-week offshore day-shifts. Appl Ergon. 2019 Jul; 78:157-163. Riethmeister V, Matthews RW, Dawson D, de Boer MR, Brouwer S, Bültmann U. PMID: 31046947.
      View in: PubMed   Mentions: 6     Fields:    Translation:Humans
    9. Working Time Society consensus statements: Individual differences in shift work tolerance and recommendations for research and practice. Ind Health. 2019 Apr 01; 57(2):201-212. Ritonja J, Aronson KJ, Matthews RW, Boivin DB, Kantermann T. PMID: 30700671; PMCID: PMC6449641.
      View in: PubMed   Mentions: 28     Fields:    Translation:Humans
    10. In-Hospital Outcomes of Rotational Atherectomy in High-Risk Patients With Severely Calcified Left Main Coronary Artery Disease: A Single-Center Experience. J Invasive Cardiol. 2019 04; 31(4):101-106. Dhillon AS, Narayanan MR, Tun H, Hindoyan A, Matthews R, Mehra A, Shavelle DM, Clavijo LC. PMID: 30643039.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    11. More than hours of work: fatigue management during high-intensity maritime operations. Chronobiol Int. 2019 01; 36(1):143-149. Thomas MJW, Paterson JL, Jay SM, Matthews RW, Ferguson SA. PMID: 30296184.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    12. Long-term outcomes of drug-eluting stents versus bare metal stents in saphenous vein graft interventions. Evidence from a meta-analysis of randomized controlled trials. Cardiovasc Revasc Med. 2018 12; 19(8):951-955. Nairooz R, Saad M, Dhillon AS, Yousaf H, Awar L, Mehra A, Matthews RV, Shavelle D, Clavijo L. PMID: 30078629.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    13. Incidence and treatment of severe primary mitral regurgitation in contemporary clinical practice. Cardiovasc Revasc Med. 2018 12; 19(8):960-963. Wu S, Chai A, Arimie S, Mehra A, Clavijo L, Matthews RV, Shavelle DM. PMID: 30060923.
      View in: PubMed   Mentions: 15     Fields:    Translation:Humans
    14. Comparison of devices used in carotid artery stenting: A vascular quality initiative analysis of commonly used carotid stents and embolic protection devices. Catheter Cardiovasc Interv. 2018 10 01; 92(4):743-749. Dhillon AS, Li S, Lewinger JP, Shavelle DM, Matthews RV, Clavijo LC, Weaver FA, Garg P. PMID: 30019819.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    15. Comparison of Outcomes of Percutaneous Coronary Intervention on Native Coronary Arteries Versus on Saphenous Venous Aorta Coronary Conduits in Patients With Low Left Ventricular Ejection Fraction and Impella Device Implantation Achieved or Attempted (from the PROTECT II Randomized Trial and the cVAD Registry). Am J Cardiol. 2018 09 15; 122(6):966-972. Shavelle DM, Banerjee S, Maini B, Schreiber TL, Kapasi N, O'Neill WW, Popma J, Matthews RV. PMID: 30057231.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    16. Driving when distracted and sleepy: The effect of phone and passenger conversations on driving performance. Chronobiol Int. 2018 06; 35(6):750-753. Matthews RW, Kontou TG, Naweed A, Sargent C, Roach GD. PMID: 29894206.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    17. Flat-out napping: The quantity and quality of sleep obtained in a seat during the daytime increase as the angle of recline of the seat increases. Chronobiol Int. 2018 06; 35(6):872-883. Roach GD, Matthews R, Naweed A, Kontou TG, Sargent C. PMID: 29889574.
      View in: PubMed   Mentions: 11     Fields:    Translation:Humans
    18. Prevalence of high on-treatment (aspirin and clopidogrel) platelet reactivity in patients with critical limb ischemia. Cardiovasc Revasc Med. 2018 07; 19(5 Pt A):516-520. Clavijo LC, Al-Asady N, Dhillon A, Matthews RV, Caro J, Tun H, Rowe V, Shavelle DM. PMID: 29221961.
      View in: PubMed   Mentions: 9     Fields:    Translation:HumansCells
    19. Switch to Ticagrelor in critical limb ischemia antiplatelet study (STT-CLIPS). Cardiovasc Revasc Med. 2018 Apr - May; 19(3 Pt B):319-323. Clavijo LC, Dhillon A, Al-Asady N, Matthews RV, Caro J, Tun H, Rowe V, Shavelle DM. PMID: 29329963.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCells
    20. Association of elevated triglycerides and acute myocardial infarction in young Hispanics. Cardiovasc Revasc Med. 2016 Dec; 17(8):510-514. Essilfie G, Shavelle DM, Tun H, Platt K, Kobayashi R, Mehra A, Matthews RV, Clavijo L, Gaglia MA. PMID: 27432210.
      View in: PubMed   Mentions: 4     Fields:    Translation:HumansCells
    21. Same-day discharge after coronary stenting and femoral artery device closure: A randomized study in stable and low-risk acute coronary syndrome patients. Cardiovasc Revasc Med. 2016 Apr-May; 17(3):155-61. Clavijo LC, Cortes GA, Jolly A, Tun H, Mehra A, Gaglia MA, Shavelle D, Matthews RV. PMID: 27157292.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    22. Impact of Surgical Consultation on Outcomes in Hemodynamically Supported High-Risk Percutaneous Coronary Intervention: Insights From PROTECT II Randomized Study. J Invasive Cardiol. 2016 May; 28(5):187-92. Shavelle DM, Kirtane AJ, Schreiber TL, Kapasi NK, O'Neill WW, Moses JW, Popma J, Matthews RV. PMID: 26887029.
      View in: PubMed   Mentions:    Fields:    Translation:HumansCTClinical Trials
    23. Daily Rhythms of Hunger and Satiety in Healthy Men during One Week of Sleep Restriction and Circadian Misalignment. Int J Environ Res Public Health. 2016 Jan 29; 13(2):170. Sargent C, Zhou X, Matthews RW, Darwent D, Roach GD. PMID: 26840322; PMCID: PMC4772190.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    24. Using interstimulus interval to maximise sensitivity of the Psychomotor Vigilance Test to fatigue. Accid Anal Prev. 2017 Feb; 99(Pt B):406-410. Matthews RW, Ferguson SA, Sargent C, Zhou X, Kosmadopoulos A, Roach GD. PMID: 26563739.
      View in: PubMed   Mentions: 3     Fields:    Translation:Humans
    25. The efficacy of objective and subjective predictors of driving performance during sleep restriction and circadian misalignment. Accid Anal Prev. 2017 Feb; 99(Pt B):445-451. Kosmadopoulos A, Sargent C, Zhou X, Darwent D, Matthews RW, Dawson D, Roach GD. PMID: 26534845.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    26. The Reply. Am J Med. 2015 Sep; 128(9):e35. Christianson L, Matthews RV, Rahimtoola SH. PMID: 26319666.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    27. Percutaneous left ventricular assist device for high-risk percutaneous coronary interventions: Real-world versus clinical trial experience. Am Heart J. 2015 Nov; 170(5):872-9. Cohen MG, Matthews R, Maini B, Dixon S, Vetrovec G, Wohns D, Palacios I, Popma J, Ohman EM, Schreiber T, O'Neill WW. PMID: 26542494.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    28. Early repolarization masquerading as STEMI. Am J Med. 2014 Nov; 127(11):e1-e2. Christianson L, Matthews RV, Rahimtoola SH. PMID: 25058864.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    29. Design and rationale of the ANALYZE ST study: a prospective, nonrandomized, multicenter ST monitoring study to detect acute coronary syndrome events in implantable cardioverter-defibrillator patients. Am Heart J. 2014 Oct; 168(4):424-429.e1. Gibson CM, Krucoff M, Kirtane AJ, Rao SV, Mackall JA, Matthews R, Saba S, Waksman R, Holmes D. PMID: 25262250.
      View in: PubMed   Mentions: 1     Fields:    Translation:HumansCTClinical Trials
    30. African-American patients are less likely to receive drug-eluting stents during percutaneous coronary intervention. Cardiovasc Revasc Med. 2014 Jun; 15(4):214-8. Gaglia MA, Shavelle DM, Tun H, Bhatt J, Mehra A, Matthews RV, Clavijo L. PMID: 24814420.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    31. Utility of fluoroscopy in teaching trainees groin puncture technique. J Invasive Cardiol. 2014 Jan; 26(1):18-20. Prasad M, Tun H, Matthews R. PMID: 24402807.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    32. Predictors of reperfusion delay in patients with ST elevation myocardial infarction self-transported to the hospital (from the American Heart Association's Mission: Lifeline Program). Am J Cardiol. 2014 Mar 01; 113(5):798-802. Shavelle DM, Chen AY, Matthews RV, Roe MT, de Lemos JA, Jollis J, Thomas JL, French WJ, ACTION-GWTG Investigators. PMID: 24393257.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    33. Transcatheter aortic valve replacement with CoreValve. Cardiol Clin. 2013 Aug; 31(3):351-61. Matthews RV, Shavelle DM. PMID: 23931099.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    34. Catheter intervention in structural heart disease. Preface. Cardiol Clin. 2013 Aug; 31(3):ix-x. Matthews RV. PMID: 23931108.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    35. Use of regadenoson for measurement of fractional flow reserve. Catheter Cardiovasc Interv. 2014 Feb 15; 83(3):369-74. Prasad A, Zareh M, Doherty R, Gopal A, Vora H, Somma K, Mehra A, Clavijo LC, Matthews RV, Shavelle DM. PMID: 23765847.
      View in: PubMed   Mentions: 12     Fields:    Translation:Humans
    36. Time of day variation in door-to-balloon time for STEMI patients in Los Angeles County: does time of day make a difference? Acute Card Care. 2013 Sep; 15(3):52-7. Shavelle DM, Zheng L, Ottochian M, Wagman B, Testa N, Hall S, Koenig W, Chan LS, Matthews RV. PMID: 23738606.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    37. Anomalous coronary arteries: cardiovascular computed tomographic angiography for surgical decisions and planning. World J Pediatr Congenit Heart Surg. 2013 Apr; 4(2):142-54. Shinbane JS, Shriki J, Fleischman F, Hindoyan A, Withey J, Lee C, Wilcox A, Cunningham M, Baker C, Matthews RV, Starnes V. PMID: 23799727.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    38. Enhanced replication of R5 HIV-1 isolates in vitro by a small-molecule reagent targeting HIV-1 protease. ChemMedChem. 2013 May; 8(5):719-21. Wardle NJ, Hudson HR, Matthews RW, Nunn CM, Vella C, Bligh SW. PMID: 23509042.
      View in: PubMed   Mentions:    Fields:    Translation:Cells
    39. Time-of-day mediates the influences of extended wake and sleep restriction on simulated driving. Chronobiol Int. 2012 Jun; 29(5):572-9. Matthews RW, Ferguson SA, Zhou X, Sargent C, Darwent D, Kennaway DJ, Roach GD. PMID: 22621353.
      View in: PubMed   Mentions: 5     Fields:    Translation:Humans
    40. Percutaneous left ventricular support for high-risk PCI and cardiogenic shock: who gets what? Cardiovasc Revasc Med. 2012 Mar-Apr; 13(2):101-5. Shah R, Thomson A, Atianzar K, Somma K, Mehra A, Clavijo L, Matthews RV, Shavelle DM. PMID: 22406055.
      View in: PubMed   Mentions: 4     Fields:    Translation:Humans
    41. Simulated driving under the influence of extended wake, time of day and sleep restriction. Accid Anal Prev. 2012 Mar; 45 Suppl:55-61. Matthews RW, Ferguson SA, Zhou X, Kosmadopoulos A, Kennaway DJ, Roach GD. PMID: 22239933.
      View in: PubMed   Mentions: 9     Fields:    Translation:Humans
    42. Percutaneous devices to support the left ventricle. Expert Rev Med Devices. 2011 Nov; 8(6):681-94. Shavelle DM, Clavijo L, Matthews RV. PMID: 22029466.
      View in: PubMed   Mentions:    Fields:    Translation:HumansAnimals
    43. Sleep, wake and phase dependent changes in neurobehavioral function under forced desynchrony. Sleep. 2011 Jul 01; 34(7):931-41. Zhou X, Ferguson SA, Matthews RW, Sargent C, Darwent D, Kennaway DJ, Roach GD. PMID: 21731143; PMCID: PMC3119835.
      View in: PubMed   Mentions: 32     Fields:    Translation:Humans
    44. Mismatch between subjective alertness and objective performance under sleep restriction is greatest during the biological night. J Sleep Res. 2012 Feb; 21(1):40-9. Zhou X, Ferguson SA, Matthews RW, Sargent C, Darwent D, Kennaway DJ, Roach GD. PMID: 21564364.
      View in: PubMed   Mentions: 29     Fields:    Translation:Humans
    45. Double-stent method: an alternative technique to treat coronary artery aneurysms. Catheter Cardiovasc Interv. 2011 Jun 01; 77(7):1036-41. Visrodia K, Matthews R, Shriki J. PMID: 21413134.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    46. Dynamics of neurobehavioral performance variability under forced desynchrony: evidence of state instability. Sleep. 2011 Jan 01; 34(1):57-63. Zhou X, Ferguson SA, Matthews RW, Sargent C, Darwent D, Kennaway DJ, Roach GD. PMID: 21203373; PMCID: PMC3001796.
      View in: PubMed   Mentions: 17     Fields:    Translation:Humans
    47. Contribution of core body temperature, prior wake time, and sleep stages to cognitive throughput performance during forced desynchrony. Chronobiol Int. 2010 Jul; 27(5):898-910. Darwent D, Ferguson SA, Sargent C, Paech GM, Williams L, Zhou X, Matthews RW, Dawson D, Kennaway DJ, Roach GD. PMID: 20636204.
      View in: PubMed   Mentions: 14     Fields:    Translation:Humans
    48. Interindividual differences in neurobehavioral performance in response to increasing homeostatic sleep pressure. Chronobiol Int. 2010 Jul; 27(5):922-33. Zhou X, Ferguson SA, Matthews RW, Sargent C, Darwent D, Kennaway DJ, Roach GD. PMID: 20636206.
      View in: PubMed   Mentions: 2     Fields:    Translation:Humans
    49. Use of drug-eluting versus bare-metal stents in ST-segment elevation myocardial infarction. J Invasive Cardiol. 2009 Nov; 21(11):E206-12. Chen SF, El-Bialy A, Matthews R, Clavijo L. PMID: 19901420.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    50. Intravascular ultrasound-guided central vein angioplasty and stenting without the use of radiographic contrast agents. J Clin Ultrasound. 2008 May; 36(4):254-6. Matthews R, Thomas J. PMID: 18286503.
      View in: PubMed   Mentions: 1     Fields:    Translation:Humans
    51. Percutaneous left atrial appendage obliteration. JACC Cardiovasc Imaging. 2008 Jan; 1(1):92-3. Hara H, Matthews R, Virmani R, Holmes DR, Schwartz RS. PMID: 19356411.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    52. Impact of moderate renal insufficiency on restenosis and adverse clinical events after paclitaxel-eluting and bare metal stent implantation: results from the TAXUS-IV Trial. Am Heart J. 2005 Dec; 150(6):1163-70. Halkin A, Mehran R, Casey CW, Gordon P, Matthews R, Wilson BH, Leon MB, Russell ME, Ellis SG, Stone GW. PMID: 16338253.
      View in: PubMed   Mentions: 19     Fields:    Translation:Humans
    53. Images in cardiology: Electron beam angiography of percutaneous atrial septal defect closure. Clin Cardiol. 2004 Dec; 27(12):702. Aboulhosn J, Shavelle DM, Matthews R, French WJ, Buljubasic N, Budoff MJ. PMID: 15628115; PMCID: PMC6654603.
      View in: PubMed   Mentions:    Fields:    Translation:Humans
    54. Erectile dysfunction in the cardiac patient: how common and should we treat? J Urol. 2003 Aug; 170(2 Pt 2):S46-50; discussion S50. Kloner RA, Mullin SH, Shook T, Matthews R, Mayeda G, Burstein S, Peled H, Pollick C, Choudhary R, Rosen R, Padma-Nathan H. PMID: 12853773.
      View in: PubMed   Mentions: 39     Fields:    Translation:Humans
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