Joseph Landolph, PhD
|
Title(s) | Associate Professor of Molecular Microbiology & Immunology |
---|
Address | NTT4427A 1441 Eastlake Avenue Off Campus Los Angeles CA 90089
|
---|
Phone | +1 323 224 7781 |
---|
vCard | Download vCard |
---|
|
|
Biography Clifton Heights High School, Clifton Heights, Pennsylvania |
-
| l966 | Valedictorian | U. S. Army ROTC, Drexel University, Philadelphia, Pennsylvania |
-
| l971 | Superior Cadet Award | U. S. Army ROTC, Drexel University, Philadelphia, Pennsylvania |
-
| l971 | Commmission as 2nd Lieutenant, U. S. Army Reserve, served to rank of Captain | Dept. of Chemistry, Drexel University, Philadelphia, Pennsylvania |
-
| l971 | Merck Award in Chemistry | American Cancer Society, U. S. A. | l977
-
| l979 | American Cancer Society Postdoctoral Fellowship | Dept. of Pathology, Keck School of Medicine, Universtiy of Southern California, Los Angeles, Calif. |
-
| l985 | Cleland Excellence in Teaching Award | Society of Toxicology, U. S. A. |
-
| l990 | ICI Traveling Lectureship Award |
Overview Joseph R. Landolph, Jr., Ph. D.,was born and raised in Clifton Heights, Pennsylvania, a suburb of Philadelphia, Pennsylvania. He graduated from Clifton Heights High School in Clifton Heights, Pennsylvania, in June, l966, as Valedictorian of his class. Dr. Landolph received a B. S.Degree in Chemistry from Drexel University in Phila., Pa. in l971, graduating second in his class of Chemistry Majors. He then received a Ph. D. in Chemistry, majoring in Biophysical and Physical Chemistry, from the Univ. of California at Berkeley in l976, studying under the late Professor Melvin Calvin (Member of the U. S. National Academy of Sciences and a Nobel Laureate). For his Ph. D. thesis, Dr. Landolph studied BaP metabolism and BaP-induced cytotoxicity/morphological transformation in mouse liver epithelial/fibroblastic cells. He performed postdoctoral study in chemical mutagenesis and chemically induced morphological and neoplastic transformation and chemical carcinogenesis from l977-1980 at the University of Southern California (USC) under the late Professor Charles Heidelberger, who was a Member of the U. S. National Academy of Sciences. Dr. Landolph was appointed Assistant Professsor of Microbiology and Pathology in l982, and promoted to Associate Professor in l9787. He is currently Associate Professor of Molecular Microbiology and Immunology and Pathology, and a Member of the USC/Norris Comprehensive Cancer Center at the Keck School of Medicine, Associate Professor of Molecular Pharmacology and Pharmaceutical Sciences of the School of Pharmacy, and a Member of the Free Radical Institute, at USC in Los Angeles, California. His research interests include the molecular mechanisms of the carcinogenicity of insoluble, carcinogenic nickel compounds and of soluble and insoluble, carcinogenic Cr(VI) compounds, and activation of oncogenes/inactivation of tumor suppressor genes and de-regulation of global gene expression, in Ni-transformed C3H/10T1/2 (10T1/2) mouse mouse embryo cell lines. His laboratory has shown that 150 genes are differentially expressed in 10T1/2 cell lines transformed by insoluble green NiO and crystalline NiS. In these transformed cell lines, the ect-2 proto-oncogene is amplified and over-expressed, and the Wdr1 stress gene and the calnexin gene are over-expressed. We also found that the DRIP80 gene and the beta-centaurin-2 gene have become quiescent in the Ni-transformed 10T1/2 cell lines. Our current working model is that 6 proto-oncogenes have become activated, and 9 tumor suppressor genes have become quiescent, in Ni-transformed 10T1/2 cell lines. Each alternation of these 15 primary genes leads to differential expression of 10 additional genes, indicating that there are substantial changes in regulation of gene expression in Ni-transformed 10T1/2 mouse embryo cell lines. Dr. Landolph's laboratory has also studied the ability of insoluble nickel compounds and of soluble and insoluble Cr(VI) compounds to induce cytotoxicity and anchorage-independent transformation of cultured human diploid human fibroblasts. Dr. Landolph is an expert in chemically induced mutation and morphological/neoplastic transformation of mammalian cells. He has authored 65 scientific publications, given 204 invited scientific lectures, trained 105 B. S., 31 M. S., 5 Medical, and 14 Ph. D. students and 32 postdoctoral fellows, and hosted 10 faculty on sabbatical in his laboratory. He has reviewed grants for U. S. EPA, NIEHS, and Chemical Pathology/Al-Tox-4 Study Sections of NIH. He served as a member of: Carcinogen Identification Committee, Calif. EPA (1994-Present); Scientific Review Panel for Toxic Air Contaminants, Calif. Air Resources Board (2003-2011); Drinking Water (2003-2009), Human Health Research (2003), and STAA (2003-2006), Committees of U. S. EPA’s Science Advisory Board; U. S. EPA Board of Scientific Counselors’ Human Health Research Committee (2005-2006); and Natl. Acad. of Sciences Panel on U. S. EPA’s PCE Risk Assessment (2009-2010). He received the Merck Award in Chemistry (Drexel Univ.); ACS Postdoctoral Fellowship; and Edmundson Teaching Award (Dept. Path., USC). He has held research grants from EPA, NCI, and NIEHS.
Dr. Landolph has been a member of the Society of Toxicology from l985-Present. He received the ICI Traveling Lectureship Award from the Society of Toxicology in l990. He has served as a Member of the Graduate Student Awards Committee, Carcinogenesis Specialty Section, Society of Toxicology, from 1994-1999. He was elected Councilor, Carcinogenesis Specialty Section, Society of Toxicology, from 1997-1999. He was elected Vice-President Elect of the Metals Specialty Section for 1999-2000; Vice-President, Metals Specialty Section, 2000-2001; and President-Elect, Metals Specialty Section, 2001-2002. He also served as a Member of the Review Committee for Graduate Student/Postdoctoral Fellow Awards, 2000, Metals Specialty Section; Member of the Review Committee for Submissions to the SOT Program Committee from the Metals Specialty Section, 2002; President, Metals Specialty Section, 2002-2003; and Councilor, Metals Specialty Section, from 2003-2004. He was appointed a Member of the Regulatory Affairs and Legislative Assistance (RALA) Committee of the Society of Toxicology, from 2007-2010,
Research ORNG Applications Bibliographic
Altmetrics Details
PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media.
(Note that publications are often cited in additional ways that are not shown here.)
Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication.
Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.)
Click a Field or Translation tag to filter the publications.
-
Diabetes and cancer: epidemiological, clinical, and experimental perspectives. Exp Diabetes Res. 2012; 2012:101802.
Tseng CH, Chen CJ, Landolph JR. PMID: 23082075.
View in: PubMed Mentions: 4 Fields: Translation: HumansAnimals
-
XIII International Charles Heidelberger Symposium and 50 Years of Fluoropyrimidines in Cancer Therapy Held on september 6 to 8, 2007 at New York University Cancer Institute, Smilow Conference Center. . 2009 May; 8(5):992-9.
Muggia FM, Peters GJ, Landolph JR. PMID: 19417150.
View in: PubMed Mentions:
-
Amplification of the Ect2 proto-oncogene and over-expression of Ect2 mRNA and protein in nickel compound and methylcholanthrene-transformed 10T1/2 mouse fibroblast cell lines. Toxicol Appl Pharmacol. 2005 Aug 07; 206(2):138-49.
Clemens F, Verma R, Ramnath J, Landolph JR. PMID: 15967202.
View in: PubMed Mentions: 9 Fields: Translation: AnimalsCells
-
Human prostate cancer risk factors. Cancer. 2004 Nov 15; 101(10 Suppl):2371-490.
Bostwick DG, Burke HB, Djakiew D, Euling S, Ho SM, Landolph J, Morrison H, Sonawane B, Shifflett T, Waters DJ, Timms B. PMID: 15495199.
View in: PubMed Mentions: 139 Fields: Translation: HumansAnimals
-
Molecular biology of nickel carcinogenesis: identification of differentially expressed genes in morphologically transformed C3H10T1/2 Cl 8 mouse embryo fibroblast cell lines induced by specific insoluble nickel compounds. Mol Cell Biochem. 2004 Jan; 255(1-2):203-16.
Verma R, Ramnath J, Clemens F, Kaspin LC, Landolph JR. PMID: 14971661.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
-
Genotoxicity of samples of nickel refinery dust. Toxicol Sci. 2003 May; 73(1):114-23.
Clemens F, Landolph JR. PMID: 12657748.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
-
Molecular biology of deregulated gene expression in transformed C3H/10T1/2 mouse embryo cell lines induced by specific insoluble carcinogenic nickel compounds. Environ Health Perspect. 2002 Oct; 110 Suppl 5:845-50.
Landolph JR, Verma A, Ramnath J, Clemens F. PMID: 12426144.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
-
Cell transformation assays as predictors of human carcinogenicity. Altern Lab Anim. 1999 Sep-Oct; 27(5):745-67.
Combes R, Balls M, Curren R, Fischbach M, Fusenig N, Kirkland D, Lasne C, Landolph J, LeBoeuf R, Marquardt H, McCormick J, Müller L, Rivedal E, Sabbioni E, Tanaka N, Vasseur P, Yamasaki H. PMID: 25490287.
View in: PubMed Mentions: 6 Fields:
-
Role of free radicals in metal-induced carcinogenesis. Met Ions Biol Syst. 1999; 36:445-83.
Landolph JR. PMID: 10093933.
View in: PubMed Mentions: 7 Fields: Translation: HumansAnimalsCells
-
Molecular mechanisms of transformation of C3H/10T1/2 C1 8 mouse embryo cells and diploid human fibroblasts by carcinogenic metal compounds. Environ Health Perspect. 1994 Sep; 102 Suppl 3:119-25.
Landolph JR. PMID: 7843085.
View in: PubMed Mentions: 18 Fields: Translation: HumansAnimalsCells
-
Induction of chromosomal aberrations, cytotoxicity, and morphological transformation in mammalian cells by the antiparasitic drug flubendazole and the antineoplastic drug harringtonine. Fundam Appl Toxicol. 1994 Feb; 22(2):304-13.
Huang N, Cerepnalkoski L, Nwankwo JO, Dews M, Landolph JR. PMID: 8005380.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
-
Role of valence state and solubility of chromium compounds on induction of cytotoxicity, mutagenesis, and anchorage independence in diploid human fibroblasts. Cancer Res. 1990 Dec 15; 50(24):7835-42.
Biedermann KA, Landolph JR. PMID: 2253225.
View in: PubMed Mentions: 21 Fields: Translation: HumansCells
-
Molecular and cellular mechanisms of transformation of C3H/10T1/2 Cl 8 and diploid human fibroblasts by unique carcinogenic, nonmutagenic metal compounds. A review. Biol Trace Elem Res. 1989 Jul-Sep; 21:459-67.
Landolph JR. PMID: 2484628.
View in: PubMed Mentions: 11 Fields: Translation: HumansAnimalsCells
-
Soluble vs insoluble hexavalent chromate. Relationship of mutation to in vitro transformation and particle uptake. Biol Trace Elem Res. 1989 Jul-Sep; 21:469-74.
Patierno SR, Landolph JR. PMID: 2484629.
View in: PubMed Mentions: 6 Fields: Translation: AnimalsCells
-
Ouabain-resistant (Na+,K+)-ATPase enzyme activity in chemically induced ouabain-resistant C3H/10T1/2 cells. Mol Toxicol. 1989 Apr-Jun; 2(2):75-98.
Shibuya ML, Miura T, Lillehaug JR, Farley RA, Landolph JR. PMID: 2562032.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
-
Study of the ability of phenacetin, acetaminophen, and aspirin to induce cytotoxicity, mutation, and morphological transformation in C3H/10T1/2 clone 8 mouse embryo cells. Cancer Res. 1989 Feb 15; 49(4):1038-44.
Patierno SR, Lehman NL, Henderson BE, Landolph JR. PMID: 2912548.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
-
Analgesics, cigarette smoking, and other risk factors for cancer of the renal pelvis and ureter. Cancer Res. 1989 Feb 15; 49(4):1045-8.
Ross RK, Paganini-Hill A, Landolph J, Gerkins V, Henderson BE. PMID: 2912549.
View in: PubMed Mentions: 15 Fields: Translation: Humans
-
Morphological and neoplastic transformation of C3H/10T1/2 Cl 8 mouse embryo cells by insoluble carcinogenic nickel compounds. Environ Mol Mutagen. 1989; 14(2):65-78.
Miura T, Patierno SR, Sakuramoto T, Landolph JR. PMID: 2548861.
View in: PubMed Mentions: 16 Fields: Translation: AnimalsCells
-
Transformation of C3H/10T1/2 mouse embryo cells to focus formation and anchorage independence by insoluble lead chromate but not soluble calcium chromate: relationship to mutagenesis and internalization of lead chromate particles. Cancer Res. 1988 Sep 15; 48(18):5280-8.
Patierno SR, Banh D, Landolph JR. PMID: 3409252.
View in: PubMed Mentions: 31 Fields: Translation: AnimalsCells
-
DT-diaphorase activity and the cytotoxicity of quinones in C3H/10T1/2 mouse embryo cells. Biochem Pharmacol. 1988 Jun 15; 37(12):2451-9.
Atallah AS, Landolph JR, Ernster L, Hochstein P. PMID: 2455523.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
-
Increased expression of the glucose-regulated gene encoding the Mr 78,000 glucose-regulated protein in chemically and radiation-transformed C3H 10T1/2 mouse embryo cells. Cancer Res. 1987 Dec 01; 47(23):6220-4.
Patierno SR, Tuscano JM, Kim KS, Landolph JR, Lee AS. PMID: 2445468.
View in: PubMed Mentions: 3 Fields: Translation: Animals
-
Enhanced expression and state of the c-myc oncogene in chemically and X-ray-transformed C3H/10T1/2 Cl 8 mouse embryo fibroblasts. Cancer Res. 1987 Jul 15; 47(14):3643-9.
Billings PC, Shuin T, Lillehaug J, Miura T, Roy-Burman P, Landolph JR. PMID: 2439194.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
-
Induction of anchorage independence in human diploid foreskin fibroblasts by carcinogenic metal salts. Cancer Res. 1987 Jul 15; 47(14):3815-23.
Biedermann KA, Landolph JR. PMID: 3594439.
View in: PubMed Mentions: 29 Fields: Translation: HumansCells
-
Enhanced expression of c-myc and decreased expression of c-fos protooncogenes in chemically and radiation-transformed C3H/10T1/2 Cl 8 mouse embryo cell lines. Cancer Res. 1986 Oct; 46(10):5302-11.
Shuin T, Billings PC, Lillehaug JR, Patierno SR, Roy-Burman P, Landolph JR. PMID: 2875790.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
-
In vitro genotoxicity studies using complex hydrophobic mixtures: efficient delivery of a petroleum sample to cultured C3H/10T1/2 cells via lipid vesicle incorporation. Environ Mutagen. 1986; 8(4):589-609.
von Hofe EH, Billings PC, Heidelberger C, Landolph JR. PMID: 3732198.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
-
Molecular analysis of several classes of endogenous feline leukemia virus elements. J Virol. 1985 Dec; 56(3):701-10.
Soe LH, Shimizu RW, Landolph JR, Roy-Burman P. PMID: 2415715.
View in: PubMed Mentions: 13 Fields: Translation: AnimalsCells
-
Chemical transformation in C3H 10T1/2 Cl 8 mouse embryo fibroblasts: historical background, assessment of the transformation assay, and evolution and optimization of the transformation assay protocol. IARC Sci Publ. 1985; 67:185-203.
Landolph JR. PMID: 3913642.
View in: PubMed Mentions: 7 Fields: Translation: AnimalsCells
-
S-9 metabolic activation enhances aflatoxin-mediated transformation of C3H/10T1/2 cells. Toxicol Appl Pharmacol. 1985 Jan; 77(1):58-65.
Billings PC, Heidelberger C, Landolph JR. PMID: 3917582.
View in: PubMed Mentions: 2 Fields: Translation: AnimalsCells
-
Mechanisms of chemically induced multistep neoplastic transformation in C3H 10T 1/2 cells. Carcinog Compr Surv. 1985; 10:211-23.
Landolph JR. PMID: 4064004.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
-
Cytotoxicity and negligible genotoxicity of borax and borax ores to cultured mammalian cells. Am J Ind Med. 1985; 7(1):31-43.
Landolph JR. PMID: 3970022.
View in: PubMed Mentions: 3 Fields: Translation: HumansAnimalsCells
-
Morphological correlates of transformation in cultured C3H/10T1/2 mouse embryo cells. Carcinogenesis. 1984 Jul; 5(7):885-94.
Narayan KS, Young R, Heidelberger C, Landolph JR. PMID: 6733850.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
-
Microcell-mediated transfer of carcinogen-induced ouabain resistance from C3H/10T1/2 Cl 8 mouse fibroblasts to human cells. Mutat Res. 1983 Feb; 107(2):447-63.
Landolph JR, Fournier RE. PMID: 6865991.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
-
Induction of ouabain-resistant mutants by chemical carcinogens in rat prostate epithelial cells. Environ Mutagen. 1983; 5(1):33-48.
Link KH, Heidelberger C, Landolph JR. PMID: 6299722.
View in: PubMed Mentions: Fields: Translation: AnimalsCells
-
Genetic and probability aspects of cell transformation by chemical carcinogens. Prog Nucleic Acid Res Mol Biol. 1983; 29:87-98.
Heidelberger C, Landolph JR, Fournier RE, Fernandez A, Peterson AR. PMID: 6665178.
View in: PubMed Mentions: 1 Fields: Translation: HumansAnimalsCells
-
Induction of cytotoxicity, mutation, cytogenetic changes, and neoplastic transformation by benzo(a)pyrene and derivatives in C3H/10T1/2 clone 8 mouse fibroblasts. Cancer Res. 1982 May; 42(5):1866-75.
Gehly EB, Landolph JR, Heidelberger C, Nagasawa H, Little JB. PMID: 6279286.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
-
Mutagenicity of 5-azacytidine and related nucleosides in C3H/10T 1/2 clone 8 and V79 cells. Cancer Res. 1982 Mar; 42(3):817-23.
Landolph JR, Jones PA. PMID: 6174215.
View in: PubMed Mentions: 25 Fields: Translation: AnimalsCells
-
Oncogenic transformation and mutation of C3H/10T 1/2 clone 8 mouse embryo fibroblasts by alkylating agents. Cancer Res. 1981 Aug; 41(8):3095-9.
Peterson AR, Landolph JR, Peterson H, Spears CP, Heidelberger C. PMID: 7248967.
View in: PubMed Mentions: 3 Fields: Translation: AnimalsCells
-
Comparison of adriamycin- and ouabain-induced cytotoxicity and inhibition of 86rubidium transport in wild-type and ouabain-resistant C3H/10T1/2 mouse fibroblasts. Cancer Res. 1980 Dec; 40(12):4581-8.
Landolph JR, Bhatt RS, Telfer N, Heidelberger C. PMID: 7438092.
View in: PubMed Mentions: 5 Fields: Translation: AnimalsCells
-
Further evidence that ouabain-resistant variants induced by chemical carcinogens in transformable C3H/10T1/2 Cl 8 mouse fibroblasts are mutants. Mutat Res. 1980 Sep; 72(2):295-310.
Landolph JR, Telfer N, Heidelberger C. PMID: 7442697.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
-
Modulation of the cell cycle of cultured mouse liver cells by benzo(a)pyrene and its derivatives. Cancer Res. 1979 Jul; 39(7 Pt 1):2538-43.
Bartholomew JC, Pearlman AL, Landolph JR, Straub K. PMID: 445454.
View in: PubMed Mentions: 4 Fields: Translation: AnimalsCells
-
Chemical carcinogens produce mutations to ouabain resistance in transformable C3H/10T1/2 Cl 8 mouse fibroblasts. Proc Natl Acad Sci U S A. 1979 Feb; 76(2):930-4.
Landolph JR, Heidelberger C. PMID: 284417.
View in: PubMed Mentions: 17 Fields: Translation: AnimalsCells
-
Biochemical basis for the acquisition of resistance to benzo[a]pyrene in clones of mouse liver cells in culture. Chem Biol Interact. 1978 Dec; 23(3):331-44.
Landolph JR, Becker JF, Gamper H, Bartholomew JC, Calvin M. PMID: 719813.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
-
Mutagenesis of Chinese hamster cells is facilitated by thymidine and deoxycytidine. Nature. 1978 Nov 30; 276(5687):508-10.
Peterson AR, Landolph JR, Peterson H, Heidelberger C. PMID: 723933.
View in: PubMed Mentions: 9 Fields: Translation: Cells
-
Quantitative studies of the toxicity of benzo(a)pyrene to a mouse liver epithelial cell strain in culture. Cancer Res. 1976 Nov; 36(11 Pt 1):4143-51.
Landolph JR, Bartholomew JC, Calvin M. PMID: 975055.
View in: PubMed Mentions: 1 Fields: Translation: AnimalsCells
This graph shows the total number of publications by year. To see the data as text, click here.
This graph shows the total number of publications by year. To return to the graph, click here.
Year | Publications |
---|
1994 | 2 | 1999 | 2 | 2002 | 1 | 2003 | 1 | 2004 | 2 | 2005 | 1 | 2009 | 1 | 2012 | 1 |
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
This graph shows the number and percent of publications by field.
Fields are based on how the National Library of Medicine (NLM) classifies the publications' journals and might not represent the specific topics of the publications.
Note that an individual publication can be assigned to more than one field. As a result, the publication counts in this graph might add up to more than the number of publications the person has written.
To see the data as text, click here.
newest
oldest
line numbers
double spacing
all authors
publication IDs
|
Derived automatically from this person's publications.
_
People in Profiles who have published with this person.
_
People who share similar concepts with this person.
_
Search Department
_
|